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Nuclear egress protein 2

 Q2PJ40_HHV3             Unreviewed;       269 AA.
Q2PJ40;
24-MAR-2009, integrated into UniProtKB/TrEMBL.
24-MAR-2009, sequence version 1.
20-JUN-2018, entry version 36.
RecName: Full=Nuclear egress protein 2 {ECO:0000256|HAMAP-Rule:MF_04024};
Name=ORF24 {ECO:0000313|EMBL:AEL30838.1};
Synonyms=NEC2 {ECO:0000256|HAMAP-Rule:MF_04024},
ORF 24 {ECO:0000313|EMBL:AHJ08722.1};
ORFNames=HHV3_gp26 {ECO:0000313|EMBL:AGC94515.1},
HHV3gp26 {ECO:0000313|EMBL:CAI44867.1};
Human herpesvirus 3 (HHV-3) (Varicella-zoster virus).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Varicellovirus.
NCBI_TaxID=10335 {ECO:0000313|EMBL:CAI44867.1, ECO:0000313|Proteomes:UP000102159};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:CAI44867.1, ECO:0000313|Proteomes:UP000102159}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HJO {ECO:0000313|EMBL:CAI44867.1};
Fickenscher H.;
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Proteomes:UP000101424, ECO:0000313|Proteomes:UP000162445, ECO:0000313|Proteomes:UP000172922}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=03-500 {ECO:0000313|EMBL:ABF21816.1},
11 {ECO:0000313|EMBL:ABF21670.1}, and
22 {ECO:0000313|EMBL:ABF21743.1};
PubMed=16973589; DOI=10.1128/JVI.00715-06;
Peters G.A., Tyler S.D., Grose C., Severini A., Gray M.J., Upton C.,
Tipples G.A.;
"A full-genome phylogenetic analysis of varicella-zoster virus reveals
a novel origin of replication-based genotyping scheme and evidence of
recombination between major circulating clades.";
J. Virol. 80:9850-9860(2006).
[3] {ECO:0000313|EMBL:ABE67132.1}
NUCLEOTIDE SEQUENCE.
STRAIN=CA123 {ECO:0000313|EMBL:ABE67132.1};
Norberg P., Liljeqvist J., Bergstrom M.T., Schmid S., Loparev V.N.;
"A Complete Genome Phylogenetic Approach to Varicella-Zoster Virus
Evolution - Genetic Divergence and Recombination Event.";
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:ABE67132.1, ECO:0000313|Proteomes:UP000103704}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CA123 {ECO:0000313|EMBL:ABE67132.1};
PubMed=17898056; DOI=10.1128/JVI.01145-07;
Loparev V.N., Rubtcova E.N., Bostik V., Govil D., Birch C.J.,
Druce J.D., Schmid D.S., Croxson M.C.;
"Identification of five major and two minor genotypes of varicella-
zoster virus strains: a practical two-amplicon approach used to
genotype clinical isolates in Australia and New Zealand.";
J. Virol. 81:12758-12765(2007).
[5] {ECO:0000313|EMBL:AGL50981.1, ECO:0000313|Proteomes:UP000125218}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=84-7 {ECO:0000313|EMBL:AGL50981.1};
Li X.;
"Sequencing of Whole Genome of Varicella-Zoster Virus 84-7 Strain.";
Zhongguo Sheng Wu Zhi Pin Xue Za Zhi 23:1-8(2010).
[6] {ECO:0000313|EMBL:AEL30838.1, ECO:0000313|Proteomes:UP000141990}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MAV06 {ECO:0000313|EMBL:AEL30838.1};
PubMed=22176950;
Kim J.I., Jung G.S., Kim Y.Y., Ji G.Y., Kim H.S., Wang W.D.,
Park H.S., Park S.Y., Kim G.H., Kwon S.N., Lee K.M., Ahn J.H.,
Yoon Y., Lee C.H.;
"Sequencing and characterization of Varicella-zoster virus vaccine
strain SuduVax.";
Virol. J. 8:547-547(2011).
[7] {ECO:0000313|Proteomes:UP000109814, ECO:0000313|Proteomes:UP000110837, ECO:0000313|Proteomes:UP000116910}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1002/2008 {ECO:0000313|EMBL:AEW88505.1},
1003/2008 {ECO:0000313|EMBL:AEW88577.1},
VZVi/Erfurt.GER/11.07/V[5] {ECO:0000313|EMBL:AEW89225.1},
VZVi/Erfurt.GER/19.04/V[5] {ECO:0000313|EMBL:AEW89081.1},
VZVi/Erfurt.GER/20.00/V[5] {ECO:0000313|EMBL:AEW89009.1},
VZVi/Erfurt.GER/44.07/V[5] {ECO:0000313|EMBL:AEW89297.1},
VZVi/Heidelberg.GER/10.07/V[3] {ECO:0000313|EMBL:AEW88865.1},
VZVi/Jena.GER/02.07/Z[3] {ECO:0000313|EMBL:AEW88793.1},
VZVi/Jena.GER/06.08 {ECO:0000313|EMBL:AEW89441.1},
VZVi/Jena.GER/37.05/V[VIII] {ECO:0000313|EMBL:AEW89369.1},
VZVi/Jena.GER/47.03/V[3] {ECO:0000313|EMBL:AEW88649.1},
VZVi/Munich.GER/30.07/Z[3] {ECO:0000313|EMBL:AEW88937.1}, and
VZVi/Weimar.GER/04.05/V[5] {ECO:0000313|EMBL:AEW89153.1};
PubMed=22130537; DOI=10.1128/JVI.06233-11;
Zell R., Taudien S., Pfaff F., Wutzler P., Platzer M., Sauerbrei A.;
"Sequencing of 21 varicella-zoster virus genomes reveals two novel
genotypes and evidence of recombination.";
J. Virol. 86:1608-1622(2012).
[8] {ECO:0000313|EMBL:AFO85528.1, ECO:0000313|Proteomes:UP000148103, ECO:0000313|Proteomes:UP000148368}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Ellen {ECO:0000313|EMBL:AFO85528.1}, and
LAX1 {ECO:0000313|EMBL:AFO85601.1};
PubMed=22837206; DOI=10.1128/JVI.01067-12;
Peters G.A., Tyler S.D., Carpenter J.E., Jackson W., Mori Y.,
Arvin A.M., Grose C.;
"The attenuated genotype of varicella-zoster virus includes an ORF0
transitional stop codon mutation.";
J. Virol. 86:10695-10703(2012).
[9] {ECO:0000313|EMBL:AFJ68525.1}
NUCLEOTIDE SEQUENCE.
STRAIN=VZVi/Philadelphia.USA/73/V[3] {ECO:0000313|EMBL:AFJ68525.1};
Madupu R., Halpin R., Fedorova N., Stockwell T., Amedeo P., Bishop B.,
Edworthy P., Gupta N., Katzel D., Li K., Schobel S., Shrivastava S.,
Thovarai V., Wang S., Folster J., Radford K., Schmid S.,
Wentworth D.E., Bellini W.;
Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:AGC94515.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Var160 {ECO:0000313|EMBL:AGC94515.1};
Garces- Ayala F., Rodriguez-Castillo A., Ortiz-Alcantara J.M.,
Segura Candelas J.M., Perez-Agueros S.I., Gonzalez Duran E.,
Ramirez-Gonzalez J.E.;
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[11] {ECO:0000313|EMBL:AEL30838.1}
NUCLEOTIDE SEQUENCE.
STRAIN=MAV06 {ECO:0000313|EMBL:AEL30838.1};
Wentworth D.E., Dugan V., Halpin R., Lin X., Bera J., Ghedin E.,
Fedorova N., Tsitrin T., Stockwell T., Amedeo P., Bishop B.,
Edworthy P., Gupta N., Katzel D., Li K., Schobel S., Shrivastava S.,
Thovarai V., Wang S., van Doorn R., Mai L.Q., Hang N.L., Phuong H.V.,
Cuong V.D., Thanh L., Thach N.C., Quyen P.D., Bao Y., Sanders R.,
Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.;
"The NIAID Influenza Genome Sequencing Project.";
Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
[12] {ECO:0000313|EMBL:AGL50981.1}
NUCLEOTIDE SEQUENCE.
STRAIN=84-7 {ECO:0000313|EMBL:AGL50981.1};
Li X.;
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
[13] {ECO:0000313|EMBL:AIT52960.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Bandim1 {ECO:0000313|EMBL:AIT52960.1},
Bandim10 {ECO:0000313|EMBL:AIT53544.1},
Bandim11 {ECO:0000313|EMBL:AIT53617.1},
Bandim12 {ECO:0000313|EMBL:AIT53690.1},
Bandim13 {ECO:0000313|EMBL:AIT53763.1},
Bandim14 {ECO:0000313|EMBL:AIT53836.1},
Bandim15 {ECO:0000313|EMBL:AIT53909.1},
Bandim16 {ECO:0000313|EMBL:AIT53982.1},
Bandim17 {ECO:0000313|EMBL:AIT54055.1},
Bandim18 {ECO:0000313|EMBL:AIT54128.1},
Bandim19 {ECO:0000313|EMBL:AIT54201.1},
Bandim2 {ECO:0000313|EMBL:AIT53033.1},
Bandim20 {ECO:0000313|EMBL:AIT54274.1},
Bandim21 {ECO:0000313|EMBL:AIT54347.1},
Bandim22 {ECO:0000313|EMBL:AIT54420.1},
Bandim23 {ECO:0000313|EMBL:AIT54493.1},
Bandim24 {ECO:0000313|EMBL:AIT54566.1},
Bandim3 {ECO:0000313|EMBL:AIT53106.1},
Bandim4 {ECO:0000313|EMBL:AIT53179.1},
Bandim5 {ECO:0000313|EMBL:AIT53252.1},
Bandim6 {ECO:0000313|EMBL:AIT53325.1},
Bandim7 {ECO:0000313|EMBL:AIT53398.1}, and
Bandim8 {ECO:0000313|EMBL:AIT53471.1};
PubMed=25275123;
Depledge D., Gray E., Kundu S., Cooray S., Poulsen A., Aaby P.,
Breuer J.;
"Evolution of co-circulating varicella zoster virus genotypes during a
chickenpox outbreak in Guinea Bissau.";
J. Virol. 0:0-0(2014).
[14] {ECO:0000313|EMBL:AGY32906.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A182B {ECO:0000313|EMBL:AGY33645.1},
A185B {ECO:0000313|EMBL:AGY33719.1},
K11 {ECO:0000313|EMBL:AGY34385.1}, L53 {ECO:0000313|EMBL:AGY34237.1},
O27 {ECO:0000313|EMBL:AGY33275.1}, R73 {ECO:0000313|EMBL:AGY34089.1},
T17 {ECO:0000313|EMBL:AGY33423.1}, T25 {ECO:0000313|EMBL:AGY33497.1},
T61 {ECO:0000313|EMBL:AGY33349.1}, U14 {ECO:0000313|EMBL:AGY33127.1},
V76 {ECO:0000313|EMBL:AGY33571.1},
VariVax2008 {ECO:0000313|EMBL:AGY33793.1},
VariVax2010 {ECO:0000313|EMBL:AGY33867.1},
VariVax2012 {ECO:0000313|EMBL:AGY33941.1},
VR1 {ECO:0000313|EMBL:AGY33054.1}, VR2 {ECO:0000313|EMBL:AGY32980.1},
VR3 {ECO:0000313|EMBL:AGY34015.1}, VR4 {ECO:0000313|EMBL:AGY34163.1},
and ZR1 {ECO:0000313|EMBL:AGY32906.1};
PubMed=24162921; DOI=10.1093/molbev/mst210;
Depledge D.P., Kundu S., Jensen N.J., Gray E.R., Jones M.,
Steinberg S., Gershon A., Kinchington P.R., Schmid D.S., Balloux F.,
Nichols R.A., Breuer J.;
"Deep sequencing of viral genomes provides insight into the evolution
and pathogenesis of varicella zoster virus and its vaccine in
humans.";
Mol. Biol. Evol. 31:397-409(2014).
[15] {ECO:0000313|EMBL:AIH07061.1, ECO:0000313|Proteomes:UP000121874, ECO:0000313|Proteomes:UP000163083}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=YC01 {ECO:0000313|EMBL:AIH07061.1}, and
YC02 {ECO:0000313|EMBL:AIH07135.1};
Kim J.I., Ji G.Y., Park H.S., Lee C.H.;
"Molecular Analysis of Varicella-Zoster Viruses Isolated from Korean
Patients.";
Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
[16] {ECO:0000313|EMBL:AIJ28617.1}
NUCLEOTIDE SEQUENCE.
STRAIN=YC03 {ECO:0000313|EMBL:AIJ28617.1};
Kim J.I., Ji G.Y., Park H.S., Lee C.H.;
"Molecular Analysis of Varicella-Zoster Viruses Isolated from Korean
Patients.";
Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
[17] {ECO:0000313|EMBL:AIT52960.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Bandim1 {ECO:0000313|EMBL:AIT52960.1},
Bandim10 {ECO:0000313|EMBL:AIT53544.1},
Bandim11 {ECO:0000313|EMBL:AIT53617.1},
Bandim12 {ECO:0000313|EMBL:AIT53690.1},
Bandim13 {ECO:0000313|EMBL:AIT53763.1},
Bandim14 {ECO:0000313|EMBL:AIT53836.1},
Bandim15 {ECO:0000313|EMBL:AIT53909.1},
Bandim16 {ECO:0000313|EMBL:AIT53982.1},
Bandim17 {ECO:0000313|EMBL:AIT54055.1},
Bandim18 {ECO:0000313|EMBL:AIT54128.1},
Bandim19 {ECO:0000313|EMBL:AIT54201.1},
Bandim2 {ECO:0000313|EMBL:AIT53033.1},
Bandim20 {ECO:0000313|EMBL:AIT54274.1},
Bandim21 {ECO:0000313|EMBL:AIT54347.1},
Bandim22 {ECO:0000313|EMBL:AIT54420.1},
Bandim23 {ECO:0000313|EMBL:AIT54493.1},
Bandim24 {ECO:0000313|EMBL:AIT54566.1},
Bandim3 {ECO:0000313|EMBL:AIT53106.1},
Bandim4 {ECO:0000313|EMBL:AIT53179.1},
Bandim5 {ECO:0000313|EMBL:AIT53252.1},
Bandim6 {ECO:0000313|EMBL:AIT53325.1},
Bandim7 {ECO:0000313|EMBL:AIT53398.1}, and
Bandim8 {ECO:0000313|EMBL:AIT53471.1};
Depledge D.P.;
Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
[18] {ECO:0000313|EMBL:AGC94515.1, ECO:0000313|Proteomes:UP000175290}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Var160 {ECO:0000313|EMBL:AGC94515.1};
PubMed=26159533;
Garces-Ayala F., Rodriguez-Castillo A., Ortiz-Alcantara J.M.,
Gonzalez-Duran E., Segura-Candelas J.M., Perez-Agueros S.I.,
Escobar-Escamilla N., Mendez-Tenorio A., Diaz-Quinonez J.A.,
Ramirez-Gonzalez J.E.;
"Full-Genome Sequence of a Novel Varicella-Zoster Virus Clade Isolated
in Mexico.";
Genome Announc. 3:e00752-15(2015).
[19] {ECO:0000313|EMBL:AKG56093.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Cli/UK/CSF/2909/2011 {ECO:0000313|EMBL:AKG56093.1},
Cli/UK/CSF/3009/2011 {ECO:0000313|EMBL:AKG56166.1},
DE10-1515 {ECO:0000313|EMBL:AKG56239.1},
DE10-2660 {ECO:0000313|EMBL:AKG56385.1},
DE10-3378 {ECO:0000313|EMBL:AKG56531.1},
DE10-4367 {ECO:0000313|EMBL:AKG56604.1},
DE10-4582 {ECO:0000313|EMBL:AKG56677.1},
DE10-567 {ECO:0000313|EMBL:AKG56823.1},
KV8-1390 {ECO:0000313|EMBL:AKG57115.1},
Var/Cli/BAL/UK/2402/2009 {ECO:0000313|EMBL:AKG57188.1},
Var/Cli/UK/BAL/1001/2012 {ECO:0000313|EMBL:AKG57261.1},
Var/Cli/UK/BLD/1401/2012 {ECO:0000313|EMBL:AKG57334.1},
Var/Cli/UK/CSF/0102/2013 {ECO:0000313|EMBL:AKG57407.1},
Var/Cli/UK/Ves/0706/2013 {ECO:0000313|EMBL:AKG57626.1},
Var/Cli/Ves/FRA/98/2013 {ECO:0000313|EMBL:AKG57916.1},
Var/Cli/Ves/GER/31/2005 {ECO:0000313|EMBL:AKG57987.1},
Var/Cli/Ves/GER/43/2006 {ECO:0000313|EMBL:AKG58062.1},
Var/Cli/Ves/SING/1308/2008 {ECO:0000313|EMBL:AKG58281.1},
Ves/Cli/POR/Ves/5001 {ECO:0000313|EMBL:AKG58427.1},
Zos/Cli/CSF/SING/1008/2008 {ECO:0000313|EMBL:AKG58500.1},
Zos/Cli/GRE/Ves/03/2012 {ECO:0000313|EMBL:AKG58573.1},
Zos/Cli/Ves/NIG/9 {ECO:0000313|EMBL:AKG58646.1}, and
Zos/Cli/Ves/UK/1801/2012 {ECO:0000313|EMBL:AKG58719.1};
PubMed=25926648; DOI=10.1128/JVI.00437-15;
Norberg P., Depledge D.P., Kundu S., Atkinson C., Brown J., Haque T.,
Hussaini Y., MacMahon E., Molyneaux P., Papaevangelou V., Sengupta N.,
Koay E.S., Tang J.W., Underhill G.S., Grahn A., Studahl M., Breuer J.,
Bergstrom T.;
"Recombination of Globally Circulating Varicella-Zoster Virus.";
J. Virol. 89:7133-7146(2015).
[20] {ECO:0000313|EMBL:AHJ08722.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A171B {ECO:0000313|EMBL:AHJ08796.1},
B86 {ECO:0000313|EMBL:AHJ08722.1}, Q27 {ECO:0000313|EMBL:AHJ08870.1},
R3 {ECO:0000313|EMBL:AHJ08944.1}, R43 {ECO:0000313|EMBL:AHJ09018.1},
R52 {ECO:0000313|EMBL:AHJ09092.1}, VR5 {ECO:0000313|EMBL:AHJ09314.1},
ZR2 {ECO:0000313|EMBL:AHJ09166.1}, ZR3 {ECO:0000313|EMBL:AHJ09240.1},
ZR4 {ECO:0000313|EMBL:AHJ09388.1}, and
ZR5 {ECO:0000313|EMBL:AHJ09462.1};
PubMed=25568346; DOI=10.1093/molbev/msu406;
Weinert L.A., Depledge D.P., Kundu S., Gershon A.A., Nichols R.A.,
Balloux F., Welch J.J., Breuer J.;
"Rates of vaccine evolution show strong effects of latency:
implications for varicella zoster virus epidemiology.";
Mol. Biol. Evol. 32:1020-1028(2015).
[21] {ECO:0000313|EMBL:AIJ28617.1, ECO:0000313|Proteomes:UP000138315}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=YC03 {ECO:0000313|EMBL:AIJ28617.1};
PubMed=26473290; DOI=10.18632/oncotarget.6117;
Kim J.A., Park S.K., Kumar M., Lee C.H., Shin O.S.;
"Insights into the role of immunosenescence during varicella zoster
virus infection (shingles) in the aging cell model.";
Oncotarget 6:35324-35343(2015).
[22] {ECO:0000313|EMBL:AKE13361.1}
NUCLEOTIDE SEQUENCE.
STRAIN=VZVs/Pasadena.USA/11.13 {ECO:0000313|EMBL:AKE13361.1};
Jensen N., Rivailler P., Radford K.W., Folster J., Tseng H.-F.,
Harpaz R., Larussa P.S., Jacobsen S.J., Schmid S.D.;
"Phylogenetic analysis of complete genome sequences of Clade 6
isolates of varicella-zoster virus.";
Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
[23] {ECO:0000313|EMBL:ANS12896.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Ellen {ECO:0000313|EMBL:ANS12896.1},
MAV06 {ECO:0000313|EMBL:ANS12970.1},
VOka {ECO:0000313|EMBL:ANS13044.1},
YC01 {ECO:0000313|EMBL:ANS13192.1},
YC02 {ECO:0000313|EMBL:ANS13486.1}, and
YC03 {ECO:0000313|EMBL:ANS13634.1};
PubMed=27376245; DOI=10.1016/j.virol.2016.06.017;
Jeon J.S., Won Y.H., Kim I.K., Ahn J.H., Shin O.S., Kim J.H.,
Lee C.H.;
"Analysis of single nucleotide polymorphism among Varicella-Zoster
Virus and identification of vaccine-specific sites.";
Virology 496:277-286(2016).
[24] {ECO:0000313|EMBL:AVY51190.1}
NUCLEOTIDE SEQUENCE.
STRAIN=YC02 {ECO:0000313|EMBL:AVY51190.1};
Won Y.H., Park J.S., Kang J.H., Jeon J.S., Ahn J.H., Song M.J.,
Ok Sarah O.S., Lee C.H.;
"Next Generation Sequencing (NGS) Analysis Reveals Attenuating
Mutations in Varicella-Zoster Virus Following Extensive in vitro
Passaging.";
Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Plays an essential role in virion nuclear egress, the
first step of virion release from infected cell. Within the host
nucleus, NEC1 interacts with the newly formed capsid through the
vertexes and directs it to the inner nuclear membrane by
associating with NEC2. Induces the budding of the capsid at the
inner nuclear membrane as well as its envelopment into the
perinuclear space. There, the NEC1/NEC2 complex promotes the
fusion of the enveloped capsid with the outer nuclear membrane and
the subsequent release of the viral capsid into the cytoplasm
where it will reach the secondary budding sites in the host Golgi
or trans-Golgi network. {ECO:0000256|HAMAP-Rule:MF_04024}.
-!- SUBUNIT: Forms a heterohexameric complex with NEC1.
{ECO:0000256|HAMAP-Rule:MF_04024}.
-!- SUBCELLULAR LOCATION: Host nucleus inner membrane
{ECO:0000256|HAMAP-Rule:MF_04024}; Single-pass membrane protein
{ECO:0000256|HAMAP-Rule:MF_04024}. Note=Localizes also at the
transient membrane of perinuclear virions. {ECO:0000256|HAMAP-
Rule:MF_04024}.
-!- PTM: Phosphorylated. {ECO:0000256|HAMAP-Rule:MF_04024}.
-!- SIMILARITY: Belongs to the herpesviridae NEC2 protein family.
{ECO:0000256|HAMAP-Rule:MF_04024}.
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EMBL; DQ457052; ABE67132.1; -; Genomic_DNA.
EMBL; DQ479955; ABF21670.1; -; Genomic_DNA.
EMBL; DQ479956; ABF21743.1; -; Genomic_DNA.
EMBL; DQ479957; ABF21816.1; -; Genomic_DNA.
EMBL; JF306641; AEL30838.1; -; Genomic_DNA.
EMBL; JN704697; AEW88505.1; -; Genomic_DNA.
EMBL; JN704698; AEW88577.1; -; Genomic_DNA.
EMBL; JN704699; AEW88649.1; -; Genomic_DNA.
EMBL; JN704701; AEW88793.1; -; Genomic_DNA.
EMBL; JN704702; AEW88865.1; -; Genomic_DNA.
EMBL; JN704703; AEW88937.1; -; Genomic_DNA.
EMBL; JN704704; AEW89009.1; -; Genomic_DNA.
EMBL; JN704705; AEW89081.1; -; Genomic_DNA.
EMBL; JN704706; AEW89153.1; -; Genomic_DNA.
EMBL; JN704707; AEW89225.1; -; Genomic_DNA.
EMBL; JN704708; AEW89297.1; -; Genomic_DNA.
EMBL; JN704709; AEW89369.1; -; Genomic_DNA.
EMBL; JN704710; AEW89441.1; -; Genomic_DNA.
EMBL; JQ911599; AFJ68525.1; -; Genomic_DNA.
EMBL; JQ972913; AFO85528.1; -; Genomic_DNA.
EMBL; JQ972914; AFO85601.1; -; Genomic_DNA.
EMBL; KC112914; AGC94515.1; -; Genomic_DNA.
EMBL; KC847290; AGL50981.1; -; Genomic_DNA.
EMBL; KF558371; AGY32906.1; -; Genomic_DNA.
EMBL; KF558372; AGY32980.1; -; Genomic_DNA.
EMBL; KF558373; AGY33054.1; -; Genomic_DNA.
EMBL; KF558374; AGY33127.1; -; Genomic_DNA.
EMBL; KF558376; AGY33275.1; -; Genomic_DNA.
EMBL; KF558377; AGY33349.1; -; Genomic_DNA.
EMBL; KF558378; AGY33423.1; -; Genomic_DNA.
EMBL; KF558379; AGY33497.1; -; Genomic_DNA.
EMBL; KF558380; AGY33571.1; -; Genomic_DNA.
EMBL; KF558381; AGY33645.1; -; Genomic_DNA.
EMBL; KF558382; AGY33719.1; -; Genomic_DNA.
EMBL; KF558383; AGY33793.1; -; Genomic_DNA.
EMBL; KF558384; AGY33867.1; -; Genomic_DNA.
EMBL; KF558385; AGY33941.1; -; Genomic_DNA.
EMBL; KF558386; AGY34015.1; -; Genomic_DNA.
EMBL; KF558387; AGY34089.1; -; Genomic_DNA.
EMBL; KF558388; AGY34163.1; -; Genomic_DNA.
EMBL; KF558389; AGY34237.1; -; Genomic_DNA.
EMBL; KF558391; AGY34385.1; -; Genomic_DNA.
EMBL; KF853225; AHJ08722.1; -; Genomic_DNA.
EMBL; KF853226; AHJ08796.1; -; Genomic_DNA.
EMBL; KF853227; AHJ08870.1; -; Genomic_DNA.
EMBL; KF853228; AHJ08944.1; -; Genomic_DNA.
EMBL; KF853229; AHJ09018.1; -; Genomic_DNA.
EMBL; KF853230; AHJ09092.1; -; Genomic_DNA.
EMBL; KF853231; AHJ09166.1; -; Genomic_DNA.
EMBL; KF853232; AHJ09240.1; -; Genomic_DNA.
EMBL; KF853233; AHJ09314.1; -; Genomic_DNA.
EMBL; KF853234; AHJ09388.1; -; Genomic_DNA.
EMBL; KF853235; AHJ09462.1; -; Genomic_DNA.
EMBL; KJ767491; AIH07061.1; -; Genomic_DNA.
EMBL; KJ767492; AIH07135.1; -; Genomic_DNA.
EMBL; KJ808816; AIJ28617.1; -; Genomic_DNA.
EMBL; KM355696; AIT52960.1; -; Genomic_DNA.
EMBL; KM355697; AIT53033.1; -; Genomic_DNA.
EMBL; KM355698; AIT53106.1; -; Genomic_DNA.
EMBL; KM355699; AIT53179.1; -; Genomic_DNA.
EMBL; KM355700; AIT53252.1; -; Genomic_DNA.
EMBL; KM355701; AIT53325.1; -; Genomic_DNA.
EMBL; KM355702; AIT53398.1; -; Genomic_DNA.
EMBL; KM355703; AIT53471.1; -; Genomic_DNA.
EMBL; KM355704; AIT53544.1; -; Genomic_DNA.
EMBL; KM355705; AIT53617.1; -; Genomic_DNA.
EMBL; KM355706; AIT53690.1; -; Genomic_DNA.
EMBL; KM355707; AIT53763.1; -; Genomic_DNA.
EMBL; KM355708; AIT53836.1; -; Genomic_DNA.
EMBL; KM355709; AIT53909.1; -; Genomic_DNA.
EMBL; KM355710; AIT53982.1; -; Genomic_DNA.
EMBL; KM355711; AIT54055.1; -; Genomic_DNA.
EMBL; KM355712; AIT54128.1; -; Genomic_DNA.
EMBL; KM355713; AIT54201.1; -; Genomic_DNA.
EMBL; KM355714; AIT54274.1; -; Genomic_DNA.
EMBL; KM355715; AIT54347.1; -; Genomic_DNA.
EMBL; KM355716; AIT54420.1; -; Genomic_DNA.
EMBL; KM355717; AIT54493.1; -; Genomic_DNA.
EMBL; KM355718; AIT54566.1; -; Genomic_DNA.
EMBL; KP702725; AKE13361.1; -; Genomic_DNA.
EMBL; KP771889; AKG56093.1; -; Genomic_DNA.
EMBL; KP771890; AKG56166.1; -; Genomic_DNA.
EMBL; KP771891; AKG56239.1; -; Genomic_DNA.
EMBL; KP771893; AKG56385.1; -; Genomic_DNA.
EMBL; KP771895; AKG56531.1; -; Genomic_DNA.
EMBL; KP771896; AKG56604.1; -; Genomic_DNA.
EMBL; KP771897; AKG56677.1; -; Genomic_DNA.
EMBL; KP771899; AKG56823.1; -; Genomic_DNA.
EMBL; KP771903; AKG57115.1; -; Genomic_DNA.
EMBL; KP771904; AKG57188.1; -; Genomic_DNA.
EMBL; KP771905; AKG57261.1; -; Genomic_DNA.
EMBL; KP771906; AKG57334.1; -; Genomic_DNA.
EMBL; KP771907; AKG57407.1; -; Genomic_DNA.
EMBL; KP771910; AKG57626.1; -; Genomic_DNA.
EMBL; KP771914; AKG57916.1; -; Genomic_DNA.
EMBL; KP771915; AKG57987.1; -; Genomic_DNA.
EMBL; KP771916; AKG58062.1; -; Genomic_DNA.
EMBL; KP771919; AKG58281.1; -; Genomic_DNA.
EMBL; KP771921; AKG58427.1; -; Genomic_DNA.
EMBL; KP771922; AKG58500.1; -; Genomic_DNA.
EMBL; KP771923; AKG58573.1; -; Genomic_DNA.
EMBL; KP771924; AKG58646.1; -; Genomic_DNA.
EMBL; KP771925; AKG58719.1; -; Genomic_DNA.
EMBL; KU926311; ANS12896.1; -; Genomic_DNA.
EMBL; KU926312; ANS12970.1; -; Genomic_DNA.
EMBL; KU926313; ANS13044.1; -; Genomic_DNA.
EMBL; KU926314; ANS13118.1; -; Genomic_DNA.
EMBL; KU926315; ANS13192.1; -; Genomic_DNA.
EMBL; KU926316; ANS13266.1; -; Genomic_DNA.
EMBL; KU926317; ANS13340.1; -; Genomic_DNA.
EMBL; KU926318; ANS13413.1; -; Genomic_DNA.
EMBL; KU926319; ANS13486.1; -; Genomic_DNA.
EMBL; KU926320; ANS13560.1; -; Genomic_DNA.
EMBL; KU926321; ANS13634.1; -; Genomic_DNA.
EMBL; KU926322; ANS13708.1; -; Genomic_DNA.
EMBL; MF004348; AVY51190.1; -; Genomic_DNA.
EMBL; AJ871403; CAI44867.1; -; Genomic_DNA.
Proteomes; UP000101424; Genome.
Proteomes; UP000102159; Genome.
Proteomes; UP000103704; Genome.
Proteomes; UP000109814; Genome.
Proteomes; UP000110837; Genome.
Proteomes; UP000116910; Genome.
Proteomes; UP000118042; Genome.
Proteomes; UP000118112; Genome.
Proteomes; UP000118125; Genome.
Proteomes; UP000119103; Genome.
Proteomes; UP000121535; Genome.
Proteomes; UP000121874; Genome.
Proteomes; UP000125218; Genome.
Proteomes; UP000138315; Genome.
Proteomes; UP000140732; Genome.
Proteomes; UP000141990; Genome.
Proteomes; UP000145398; Genome.
Proteomes; UP000148103; Genome.
Proteomes; UP000148368; Genome.
Proteomes; UP000154414; Genome.
Proteomes; UP000157471; Genome.
Proteomes; UP000159019; Genome.
Proteomes; UP000162445; Genome.
Proteomes; UP000163083; Genome.
Proteomes; UP000172922; Genome.
Proteomes; UP000175290; Genome.
GO; GO:0044201; C:host cell nuclear inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
HAMAP; MF_04024; HSV_NEC2; 1.
InterPro; IPR007626; Herpesvirus_viron_egress-type.
Pfam; PF04541; Herpes_U34; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000101424,
ECO:0000313|Proteomes:UP000102159, ECO:0000313|Proteomes:UP000103704,
ECO:0000313|Proteomes:UP000109814};
Host membrane {ECO:0000256|HAMAP-Rule:MF_04024};
Host nucleus {ECO:0000256|HAMAP-Rule:MF_04024};
Late protein {ECO:0000256|HAMAP-Rule:MF_04024};
Membrane {ECO:0000256|HAMAP-Rule:MF_04024};
Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_04024};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_04024};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_04024}.
TRANSMEM 250 268 Helical. {ECO:0000256|HAMAP-
Rule:MF_04024}.
SEQUENCE 269 AA; 30438 MW; 02901F8595C169DD CRC64;
MSRRTYVRSE RRRGCGDNLL QRIRLVVPSA LQCCDGDLPI FDPQRPPARC VFQFNGEDNV
SEAFPVEYIM RLMANWAQVD CDPYIKIQNT GVSVLFQGFF FRPTNAPVAE VSIDSNNVIL
SSTLSTGINL SALESIKRGG GIDRRPLQAL MWVNCFVRMP YVQLSFRFMG PEDPSRTIKL
MARATDAYMY KETGNNLDEY IRWRPSFRSP PENGSPNTSV QMQSDIKPAL PDTQTTRVWK
LALPVANVTY ALFVVIVLVV VLGAVLFWK


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