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Nuclear export protein (NEP) (Non-structural protein 2)
A0A172QYW8_9INFA Unreviewed; 121 AA.
A0A172QYW8;
07-SEP-2016, integrated into UniProtKB/TrEMBL.
07-SEP-2016, sequence version 1.
28-MAR-2018, entry version 12.
RecName: Full=Nuclear export protein {ECO:0000256|HAMAP-Rule:MF_04067};
Short=NEP {ECO:0000256|HAMAP-Rule:MF_04067};
AltName: Full=Non-structural protein 2 {ECO:0000256|HAMAP-Rule:MF_04067};
Short=NS2 {ECO:0000256|HAMAP-Rule:MF_04067};
Name=NEP {ECO:0000313|EMBL:ANE05851.1};
Synonyms=NS {ECO:0000256|HAMAP-Rule:MF_04067,
ECO:0000256|RuleBase:RU362104};
Influenza A virus (A/mallard/Southcentral
Alaska/15ML00249/2015(H7N3)).
Viruses; ssRNA viruses; ssRNA negative-strand viruses;
Orthomyxoviridae; Influenzavirus A.
NCBI_TaxID=1821133 {ECO:0000313|EMBL:ANE05851.1};
[1] {ECO:0000313|EMBL:ANE05851.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A/mallard/Southcentral Alaska/15ML00249/2015
{ECO:0000313|EMBL:ANE05851.1};
Das S.R., Halpin R.A., Lin X., Simenauer A., Akopov A., Fedorova N.,
Puri V., Stockwell T., Amedeo P., Katzel D., Schobel S.,
Shrivastava S., Hill N., Bao Y., Sanders R., Zhdanov S., Kiryutin B.,
Lipman D.J., Tatusova T., Runstadler J.;
"The NIAID Influenza Genome Sequencing Project.";
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:ANE05851.1}
NUCLEOTIDE SEQUENCE.
STRAIN=A/mallard/Southcentral Alaska/15ML00249/2015
{ECO:0000313|EMBL:ANE05851.1};
The NIAID Influenza Genome Sequencing Consortium;
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs
(ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs
complexes and the nuclear export machinery of the cell. Possesses
no intrinsic RNA-binding activity, but includes a C-terminal M1-
binding domain. This domain is believed to allow recognition of
RNPs bound to the protein M1. Since protein M1 is not available in
large quantities before late stages of infection, such an indirect
recognition mechanism probably ensures that genomic RNPs are not
exported from the host nucleus until sufficient quantities of
viral mRNA and progeny genomic RNA have been synthesized.
Furthermore, the RNPs enter the host cytoplasm only when
associated with the M1 protein that is necessary to guide them to
the plasma membrane. May down-regulate viral RNA synthesis when
overproduced. {ECO:0000256|HAMAP-Rule:MF_04067,
ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967765}.
-!- SUBUNIT: Binds M1 protein. May interact with host nucleoporin
RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|RuleBase:RU362104}.
-!- SUBUNIT: Interacts with protein M1. May interact with host
nucleoporin RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|HAMAP-
Rule:MF_04067, ECO:0000256|SAAS:SAAS00967740}.
-!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|HAMAP-
Rule:MF_04067, ECO:0000256|RuleBase:RU362104,
ECO:0000256|SAAS:SAAS00967743}. Virion {ECO:0000256|HAMAP-
Rule:MF_04067, ECO:0000256|RuleBase:RU362104}.
-!- SIMILARITY: Belongs to the influenza viruses NEP family.
{ECO:0000256|HAMAP-Rule:MF_04067, ECO:0000256|RuleBase:RU362104,
ECO:0000256|SAAS:SAAS00967755}.
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EMBL; CY206842; ANE05851.1; -; Viral_cRNA.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
GO; GO:0039675; P:exit of virus from host cell nucleus through nuclear pore; IEA:UniProtKB-UniRule.
GO; GO:0006405; P:RNA export from nucleus; IEA:UniProtKB-UniRule.
HAMAP; MF_04067; INFV_NEP; 1.
InterPro; IPR000968; Flu_NS2.
Pfam; PF00601; Flu_NS2; 1.
3: Inferred from homology;
Host nucleus {ECO:0000256|HAMAP-Rule:MF_04067,
ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967751};
Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04067,
ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967764};
Transport {ECO:0000256|HAMAP-Rule:MF_04067,
ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967760};
Virion {ECO:0000256|HAMAP-Rule:MF_04067,
ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967746}.
MOTIF 12 21 Nuclear export signal.
{ECO:0000256|HAMAP-Rule:MF_04067}.
MOTIF 85 94 Nuclear export signal.
{ECO:0000256|HAMAP-Rule:MF_04067}.
SEQUENCE 121 AA; 14348 MW; CA7DE09AE67376E6 CRC64;
MDPNTVSSFQ DILMRMSKMQ LGSSSEDLNG MITQFESLKL YRDSLGEAVM RMGDLHSLQS
RNGKWREQLS QKFEEIRWLI EEVRHRLKIT ENSFEQITFM QALQLLLEVE QEIRTFSFQL
I
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Pathways :
WP1502: Mitochondrial biogenesis
WP1692: Protein export
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining
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