GENTAUR Molecular Products.

 A0A172QYW8_9INFA        Unreviewed;       121 AA.
 A0A172QYW8;
 07-SEP-2016, integrated into UniProtKB/TrEMBL.
 07-SEP-2016, sequence version 1.
 28-MAR-2018, entry version 12.
 RecName: Full=Nuclear export protein {ECO:0000256|HAMAP-Rule:MF_04067};
          Short=NEP {ECO:0000256|HAMAP-Rule:MF_04067};
 AltName: Full=Non-structural protein 2 {ECO:0000256|HAMAP-Rule:MF_04067};
          Short=NS2 {ECO:0000256|HAMAP-Rule:MF_04067};
 Name=NEP {ECO:0000313|EMBL:ANE05851.1};
 Synonyms=NS {ECO:0000256|HAMAP-Rule:MF_04067,
 ECO:0000256|RuleBase:RU362104};
 Influenza A virus (A/mallard/Southcentral
 Alaska/15ML00249/2015(H7N3)).
 Viruses; ssRNA viruses; ssRNA negative-strand viruses;
 Orthomyxoviridae; Influenzavirus A.
 NCBI_TaxID=1821133 {ECO:0000313|EMBL:ANE05851.1};
 [1] {ECO:0000313|EMBL:ANE05851.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=A/mallard/Southcentral Alaska/15ML00249/2015
 {ECO:0000313|EMBL:ANE05851.1};
 Das S.R., Halpin R.A., Lin X., Simenauer A., Akopov A., Fedorova N.,
 Puri V., Stockwell T., Amedeo P., Katzel D., Schobel S.,
 Shrivastava S., Hill N., Bao Y., Sanders R., Zhdanov S., Kiryutin B.,
 Lipman D.J., Tatusova T., Runstadler J.;
 "The NIAID Influenza Genome Sequencing Project.";
 Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
 [2] {ECO:0000313|EMBL:ANE05851.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=A/mallard/Southcentral Alaska/15ML00249/2015
 {ECO:0000313|EMBL:ANE05851.1};
 The NIAID Influenza Genome Sequencing Consortium;
 Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
 -!- FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs
     (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs
     complexes and the nuclear export machinery of the cell. Possesses
     no intrinsic RNA-binding activity, but includes a C-terminal M1-
     binding domain. This domain is believed to allow recognition of
     RNPs bound to the protein M1. Since protein M1 is not available in
     large quantities before late stages of infection, such an indirect
     recognition mechanism probably ensures that genomic RNPs are not
     exported from the host nucleus until sufficient quantities of
     viral mRNA and progeny genomic RNA have been synthesized.
     Furthermore, the RNPs enter the host cytoplasm only when
     associated with the M1 protein that is necessary to guide them to
     the plasma membrane. May down-regulate viral RNA synthesis when
     overproduced. {ECO:0000256|HAMAP-Rule:MF_04067,
     ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967765}.
 -!- SUBUNIT: Binds M1 protein. May interact with host nucleoporin
     RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|RuleBase:RU362104}.
 -!- SUBUNIT: Interacts with protein M1. May interact with host
     nucleoporin RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|HAMAP-
     Rule:MF_04067, ECO:0000256|SAAS:SAAS00967740}.
 -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|HAMAP-
     Rule:MF_04067, ECO:0000256|RuleBase:RU362104,
     ECO:0000256|SAAS:SAAS00967743}. Virion {ECO:0000256|HAMAP-
     Rule:MF_04067, ECO:0000256|RuleBase:RU362104}.
 -!- SIMILARITY: Belongs to the influenza viruses NEP family.
     {ECO:0000256|HAMAP-Rule:MF_04067, ECO:0000256|RuleBase:RU362104,
     ECO:0000256|SAAS:SAAS00967755}.
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 EMBL; CY206842; ANE05851.1; -; Viral_cRNA.
 GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
 GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
 GO; GO:0039675; P:exit of virus from host cell nucleus through nuclear pore; IEA:UniProtKB-UniRule.
 GO; GO:0006405; P:RNA export from nucleus; IEA:UniProtKB-UniRule.
 HAMAP; MF_04067; INFV_NEP; 1.
 InterPro; IPR000968; Flu_NS2.
 Pfam; PF00601; Flu_NS2; 1.
 3: Inferred from homology;
 Host nucleus {ECO:0000256|HAMAP-Rule:MF_04067,
 ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967751};
 Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04067,
 ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967764};
 Transport {ECO:0000256|HAMAP-Rule:MF_04067,
 ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967760};
 Virion {ECO:0000256|HAMAP-Rule:MF_04067,
 ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967746}.
 MOTIF        12     21       Nuclear export signal.
                              {ECO:0000256|HAMAP-Rule:MF_04067}.
 MOTIF        85     94       Nuclear export signal.
                              {ECO:0000256|HAMAP-Rule:MF_04067}.
 SEQUENCE   121 AA;  14348 MW;  CA7DE09AE67376E6 CRC64;
 MDPNTVSSFQ DILMRMSKMQ LGSSSEDLNG MITQFESLKL YRDSLGEAVM RMGDLHSLQS
 RNGKWREQLS QKFEEIRWLI EEVRHRLKIT ENSFEQITFM QALQLLLEVE QEIRTFSFQL
 I

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