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Nuclear factor, erythroid 2 like 2

 G3X1M4_SARHA            Unreviewed;       598 AA.
G3X1M4;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
22-NOV-2017, entry version 41.
SubName: Full=Nuclear factor, erythroid 2 like 2 {ECO:0000313|Ensembl:ENSSHAP00000021579};
Name=NFE2L2 {ECO:0000313|Ensembl:ENSSHAP00000021579};
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000021579, ECO:0000313|Proteomes:UP000007648};
[1] {ECO:0000313|Ensembl:ENSSHAP00000021579}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21709235; DOI=10.1073/pnas.1102838108;
Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
"Genetic diversity and population structure of the endangered
marsupial Sarcophilus harrisii (Tasmanian devil).";
Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
[2] {ECO:0000313|Ensembl:ENSSHAP00000021579}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the bZIP family.
{ECO:0000256|SAAS:SAAS00570935}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000021579}.
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EMBL; AEFK01112588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9305.ENSSHAP00000021579; -.
Ensembl; ENSSHAT00000021753; ENSSHAP00000021579; ENSSHAG00000018277.
eggNOG; ENOG410ISV3; Eukaryota.
eggNOG; ENOG41100FB; LUCA.
GeneTree; ENSGT00890000139356; -.
InParanoid; G3X1M4; -.
OMA; ALHIPFP; -.
OrthoDB; EOG091G02EB; -.
TreeFam; TF326681; -.
Proteomes; UP000007648; Unassembled WGS sequence.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0000785; C:chromatin; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IEA:Ensembl.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IEA:Ensembl.
GO; GO:0045454; P:cell redox homeostasis; IEA:Ensembl.
GO; GO:0035690; P:cellular response to drug; IEA:Ensembl.
GO; GO:0042149; P:cellular response to glucose starvation; IEA:Ensembl.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0071499; P:cellular response to laminar fluid shear stress; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:1902037; P:negative regulation of hematopoietic stem cell differentiation; IEA:Ensembl.
GO; GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IEA:Ensembl.
GO; GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0036499; P:PERK-mediated unfolded protein response; IEA:Ensembl.
GO; GO:0030194; P:positive regulation of blood coagulation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:1903788; P:positive regulation of glutathione biosynthetic process; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0036003; P:positive regulation of transcription from RNA polymerase II promoter in response to stress; IEA:Ensembl.
GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IEA:Ensembl.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
GO; GO:0045995; P:regulation of embryonic development; IEA:Ensembl.
GO; GO:2000121; P:regulation of removal of superoxide radicals; IEA:Ensembl.
Gene3D; 1.10.880.10; -; 1.
InterPro; IPR004827; bZIP.
InterPro; IPR004826; bZIP_Maf.
InterPro; IPR029845; Nrf2.
InterPro; IPR008917; TF_DNA-bd_sf.
PANTHER; PTHR24411:SF3; PTHR24411:SF3; 1.
Pfam; PF03131; bZIP_Maf; 1.
SMART; SM00338; BRLZ; 1.
SUPFAM; SSF47454; SSF47454; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
3: Inferred from homology;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000007648};
DNA-binding {ECO:0000256|SAAS:SAAS00086957};
Reference proteome {ECO:0000313|Proteomes:UP000007648};
Transcription {ECO:0000256|SAAS:SAAS00460296};
Transcription regulation {ECO:0000256|SAAS:SAAS00460296}.
DOMAIN 490 553 BZIP. {ECO:0000259|PROSITE:PS50217}.
COILED 45 69 {ECO:0000256|SAM:Coils}.
COILED 508 535 {ECO:0000256|SAM:Coils}.
SEQUENCE 598 AA; 68005 MW; 1395049A129DB52A CRC64;
RRQYFHIPQS VLKAKKDMNL IDILWRQDID LGAGREVFDF SQRRKEHELE KQKKLEKERQ
EQLQKEQEKA FLAQLQLDEE TGEFLPIQPA QHVEPSTSAN YSQVADIPKA DGLFFDDCMQ
LLAETFPFVE DDEVSSATFQ SLVPDHIDSN PVFVTSSQAQ LPGSTVLHSV EDSSMQDIEQ
VWEELLSIPE LQCLNIQNDK LTETTIVPSP EIKPTEIENS YNFYTSLSTM EKEVPSCSPD
FLHAFEDSFG NMLPAEDPIQ LRMNSLNSNT DFCEEFYSTF IAETNINNSM PSPTHIGQSL
SELLNEPIDI SDLSLCKAFN SNHPENIPEC NDSDSGISLN TSSNMASPEH SVESSIYGDT
PLGLSDSEME DVDNAPGSIH QSSTRTQPVP FQEDVTYPMS PTQAPTIPVP DMLQSVSTPK
KELPISPGHQ KTPFTKDKHS TRLESHFTRD EMRAKALHIP FPVEKIINLP VDDFNEMMSK
EQFNEAQLAL IRDIRRRGKN KVAAQNCRKR KLENIVELEQ DLDHLKDEKE KLLKEKGEND
KSLHLLKKQL STLYLEVFSM LRDENGEPYS PSEYSLQQTR DGNVFLVPKS KKPDIKRN


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