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Nuclear pore complex protein Nup154 (154 kDa nucleoporin) (Nucleoporin Nup154) (Tulipan)

 NU154_DROME             Reviewed;        1365 AA.
Q9V463; O62536; O62610; O62613; Q9VKL5;
20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
12-SEP-2018, entry version 136.
RecName: Full=Nuclear pore complex protein Nup154 {ECO:0000305};
AltName: Full=154 kDa nucleoporin {ECO:0000305};
AltName: Full=Nucleoporin Nup154 {ECO:0000303|PubMed:9732281};
AltName: Full=Tulipan {ECO:0000303|PubMed:9732281};
Name=Nup154 {ECO:0000303|PubMed:9732281,
ECO:0000312|FlyBase:FBgn0021761};
Synonyms=Nup155 {ECO:0000303|PubMed:22718353,
ECO:0000312|EMBL:AAF53051.1};
ORFNames=CG4579 {ECO:0000312|FlyBase:FBgn0021761};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
[1] {ECO:0000312|EMBL:CAA76635.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
DEVELOPMENTAL STAGE.
STRAIN=Oregon-R {ECO:0000312|EMBL:CAA76635.1};
TISSUE=Embryo {ECO:0000312|EMBL:CAA76635.1};
PubMed=9732281; DOI=10.1083/jcb.142.5.1195;
Gigliotti S., Callaini G., Andone S., Riparbelli M.G.,
Pernas-Alonso R., Hoffmann G., Graziani F., Malva C.;
"Nup154, a new Drosophila gene essential for male and female
gametogenesis is related to the nup155 vertebrate nucleoporin gene.";
J. Cell Biol. 142:1195-1207(1998).
[2] {ECO:0000312|EMBL:AAC05385.1, ECO:0000312|EMBL:AAC05386.1, ECO:0000312|EMBL:AAC06247.1, ECO:0000312|EMBL:AAC06248.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DEVELOPMENTAL
STAGE, AND DISRUPTION PHENOTYPE.
PubMed=10511559;
Kiger A.A., Gigliotti S., Fuller M.T.;
"Developmental genetics of the essential Drosophila nucleoporin
nup154: allelic differences due to an outward-directed promoter in the
P-element 3' end.";
Genetics 153:799-812(1999).
[3] {ECO:0000312|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4] {ECO:0000312|Proteomes:UP000000803}
GENOME REANNOTATION.
STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5] {ECO:0000312|EMBL:AAD46884.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley {ECO:0000312|EMBL:AAD46884.1};
TISSUE=Embryo {ECO:0000312|EMBL:AAD46884.1};
PubMed=10731138; DOI=10.1126/science.287.5461.2222;
Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E.,
Stapleton M., Harvey D.A.;
"A Drosophila complementary DNA resource.";
Science 287:2222-2224(2000).
[6] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
PubMed=17410542; DOI=10.1002/cm.20206;
Riparbelli M.G., Gigliotti S., Callaini G.;
"The Drosophila nucleoporin gene nup154 is required for correct
microfilament dynamics and cell death during oogenesis.";
Cell Motil. Cytoskeleton 64:590-604(2007).
[7] {ECO:0000305}
FUNCTION, INTERACTION WITH CUP, SUBCELLULAR LOCATION, AND
DEVELOPMENTAL STAGE.
PubMed=17277377; DOI=10.1534/genetics.106.062844;
Grimaldi M.R., Cozzolino L., Malva C., Graziani F., Gigliotti S.;
"nup154 genetically interacts with cup and plays a cell-type-specific
function during Drosophila melanogaster egg-chamber development.";
Genetics 175:1751-1759(2007).
[8] {ECO:0000305}
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=21696798; DOI=10.1016/j.tice.2011.05.001;
Colozza G., Montembault E., Quenerch'du E., Riparbelli M.G.,
D'Avino P.P., Callaini G.;
"Drosophila nucleoporin Nup154 controls cell viability, proliferation
and nuclear accumulation of Mad transcription factor.";
Tissue Cell 43:254-261(2011).
[9] {ECO:0000305}
FUNCTION, INTERACTION WITH NUP93-1 AND NUP35, AND SUBCELLULAR
LOCATION.
PubMed=22718353; DOI=10.1242/jcs.105809;
Busayavalasa K., Chen X., Farrants A.K., Wagner N., Sabri N.;
"The Nup155-mediated organisation of inner nuclear membrane proteins
is independent of Nup155 anchoring to the metazoan nuclear pore
complex.";
J. Cell Sci. 125:4214-4218(2012).
[10] {ECO:0000305}
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=26341556; DOI=10.1101/gad.264341.115;
Breuer M., Ohkura H.;
"A negative loop within the nuclear pore complex controls global
chromatin organization.";
Genes Dev. 29:1789-1794(2015).
-!- FUNCTION: Component of the nuclear pore complex (PubMed:17410542).
Has a role in the organization of the inner nuclear membrane
proteins at the nuclear envelope (PubMed:22718353). In germ cells,
plays a role in the nuclear localization of components of the dpp
signaling pathways, such as Medea and phosphorylated Mad
(PubMed:21696798). Binds to chromatin, and together with Nup62 and
Nup93-1, contributes to karyosome morphology and chromatin
organization including attachment to the nuclear envelope in
oocytes and nurse cells (PubMed:22718353, PubMed:26341556). Has a
role in female fertility including egg chamber development; in
nurse cells, has a role in the organization of F-actin in
subcortical and cytoplasmic actin filaments important for the
transfer of cytoplasm from nurse cells to the growing oocytes
(PubMed:9732281, PubMed:10511559, PubMed:17410542,
PubMed:17277377). Has a role in male spermatogenesis and fertility
(PubMed:9732281, PubMed:10511559). Has a role in germ line cell
proliferation (PubMed:21696798). {ECO:0000269|PubMed:10511559,
ECO:0000269|PubMed:17277377, ECO:0000269|PubMed:17410542,
ECO:0000269|PubMed:21696798, ECO:0000269|PubMed:22718353,
ECO:0000269|PubMed:26341556, ECO:0000269|PubMed:9732281,
ECO:0000303|PubMed:17410542}.
-!- SUBUNIT: Interacts (via N-terminus) with Nup93-1
(PubMed:22718353). Interacts with Nup35 (PubMed:22718353).
Interacts with cup (PubMed:17277377).
{ECO:0000269|PubMed:17277377, ECO:0000269|PubMed:22718353}.
-!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
{ECO:0000269|PubMed:17410542}. Chromosome
{ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:9732281}. Nucleus
{ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:9732281}. Nucleus
membrane {ECO:0000269|PubMed:17277377,
ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353,
ECO:0000269|PubMed:9732281}; Peripheral membrane protein
{ECO:0000269|PubMed:17410542}; Cytoplasmic side
{ECO:0000269|PubMed:17410542}. Nucleus membrane
{ECO:0000269|PubMed:17277377, ECO:0000269|PubMed:17410542,
ECO:0000269|PubMed:22718353, ECO:0000269|PubMed:9732281};
Peripheral membrane protein {ECO:0000269|PubMed:17410542};
Nucleoplasmic side {ECO:0000269|PubMed:17410542}. Cytoplasm
{ECO:0000269|PubMed:17410542, ECO:0000269|PubMed:22718353}.
Note=Increased localization to chromatin before interphase
(PubMed:22718353). Distributed along filamentous structures that
extend radially on the nuclear side of the pore complex
(PubMed:17410542). {ECO:0000269|PubMed:17410542,
ECO:0000269|PubMed:22718353}.
-!- DEVELOPMENTAL STAGE: Expressed in embryo (at protein level)
(PubMed:9732281). Expressed in ovaries; more specifically in the
germarium and throughout egg chamber development both in germ line
and nurse cells (at protein level) (PubMed:9732281,
PubMed:17410542, PubMed:17277377). Expressed in spermatocytes (at
protein level) (PubMed:9732281). In embryos, detected during germ-
band elongation and in the developing mesoderm (PubMed:10511559).
At stage 11, mostly prominent in the central nervous system and
gut (PubMed:10511559). By stage 14, detected in the brain and
dorsal vessel (PubMed:10511559). At the end of embryogenesis
restricted to lymph glands (hematopoietic organ), gonadal germline
and specific neurons in the brain (PubMed:10511559). In larvae,
detected in the imaginal disks, certain regions of the brain and
all tissues containing dividing cells (PubMed:10511559). In
larval, detected in testes and in all germline cells up through
the meiotic stages (PubMed:10511559). In adult, detected in
testes, ovaries in germanium region 2 and throughout later stage
of oogenesis (PubMed:10511559). {ECO:0000269|PubMed:10511559,
ECO:0000269|PubMed:17277377, ECO:0000269|PubMed:17410542,
ECO:0000269|PubMed:9732281}.
-!- DISRUPTION PHENOTYPE: Embryonic lethal (PubMed:10511559). RNAi-
mediated knockdown results in failed nuclear import of
phosphorylated Mad in response to activation of the dpp signaling
cascade (PubMed:21696798). RNAi-mediated knockdown results in
altered karyosome morphology, in the reduction of Nup62
association with the nuclear envelope and its accumulation in the
cytoplasm (PubMed:26341556). RNAi-mediated knockdown of Nup62 in
combination with Nup154 rescues the phenotype of the Nup62
knockdown restablishing correct kariosome morphology and chromatin
detachment from the nuclear envelope (PubMed:26341556).
{ECO:0000269|PubMed:10511559, ECO:0000269|PubMed:21696798,
ECO:0000269|PubMed:26341556}.
-!- SIMILARITY: Belongs to the non-repetitive/WGA-negative nucleoporin
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAC05385.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=AAC06248.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; Y17111; CAA76635.1; -; mRNA.
EMBL; AF051397; AAC05385.1; ALT_SEQ; mRNA.
EMBL; AF051398; AAC05386.1; -; mRNA.
EMBL; AF051396; AAC06247.1; -; Genomic_DNA.
EMBL; AF051396; AAC06248.1; ALT_SEQ; Genomic_DNA.
EMBL; AE014134; AAF53050.3; -; Genomic_DNA.
EMBL; AE014134; AAF53051.1; -; Genomic_DNA.
EMBL; AE014134; AHN54341.1; -; Genomic_DNA.
EMBL; AF160944; AAD46884.1; -; mRNA.
PIR; T13031; T13031.
PIR; T13991; T13991.
RefSeq; NP_001285827.1; NM_001298898.1.
RefSeq; NP_477287.1; NM_057939.4.
RefSeq; NP_477288.3; NM_057940.4.
UniGene; Dm.404; -.
SMR; Q9V463; -.
IntAct; Q9V463; 3.
MINT; Q9V463; -.
STRING; 7227.FBpp0088820; -.
PaxDb; Q9V463; -.
PRIDE; Q9V463; -.
EnsemblMetazoa; FBtr0089881; FBpp0088820; FBgn0021761.
EnsemblMetazoa; FBtr0340224; FBpp0309199; FBgn0021761.
EnsemblMetazoa; FBtr0340225; FBpp0309200; FBgn0021761.
GeneID; 34527; -.
KEGG; dme:Dmel_CG4579; -.
UCSC; CG4579-RA; d. melanogaster.
UCSC; CG4579-RB; d. melanogaster.
CTD; 34527; -.
FlyBase; FBgn0021761; Nup154.
eggNOG; KOG1900; Eukaryota.
eggNOG; COG5308; LUCA.
GeneTree; ENSGT00390000016532; -.
KO; K14312; -.
OMA; TRYVENP; -.
OrthoDB; EOG091G00T9; -.
Reactome; R-DME-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
Reactome; R-DME-191859; snRNP Assembly.
Reactome; R-DME-3301854; Nuclear Pore Complex (NPC) Disassembly.
Reactome; R-DME-3371453; Regulation of HSF1-mediated heat shock response.
Reactome; R-DME-4085377; SUMOylation of SUMOylation proteins.
Reactome; R-DME-4551638; SUMOylation of chromatin organization proteins.
Reactome; R-DME-5578749; Transcriptional regulation by small RNAs.
GenomeRNAi; 34527; -.
PRO; PR:Q9V463; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0021761; Expressed in 31 organ(s), highest expression level in oocyte.
ExpressionAtlas; Q9V463; baseline and differential.
GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; IEA:GOC.
GO; GO:0005635; C:nuclear envelope; IDA:UniProtKB.
GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO; GO:0034399; C:nuclear periphery; IDA:UniProtKB.
GO; GO:0044611; C:nuclear pore inner ring; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0003682; F:chromatin binding; IDA:FlyBase.
GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
GO; GO:0007015; P:actin filament organization; IMP:UniProtKB.
GO; GO:0055050; P:astral spindle assembly involved in male meiosis; IMP:UniProtKB.
GO; GO:0007303; P:cytoplasmic transport, nurse cell to oocyte; IMP:UniProtKB.
GO; GO:0001654; P:eye development; IMP:UniProtKB.
GO; GO:0007281; P:germ cell development; IMP:UniProtKB.
GO; GO:0007295; P:growth of a germarium-derived egg chamber; IMP:UniProtKB.
GO; GO:0007140; P:male meiotic nuclear division; IMP:UniProtKB.
GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
GO; GO:0001555; P:oocyte growth; IMP:UniProtKB.
GO; GO:0030715; P:oocyte growth in germarium-derived egg chamber; IGI:UniProtKB.
GO; GO:0030717; P:oocyte karyosome formation; IMP:UniProtKB.
GO; GO:0048477; P:oogenesis; IMP:UniProtKB.
GO; GO:1905938; P:positive regulation of germ cell proliferation; IMP:UniProtKB.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IMP:UniProtKB.
GO; GO:1900182; P:positive regulation of protein localization to nucleus; IDA:UniProtKB.
GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
GO; GO:0036228; P:protein localization to nuclear inner membrane; IMP:FlyBase.
GO; GO:0045477; P:regulation of nurse cell apoptotic process; IMP:UniProtKB.
GO; GO:1905879; P:regulation of oogenesis; IMP:UniProtKB.
GO; GO:1905475; P:regulation of protein localization to membrane; IMP:UniProtKB.
GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
GO; GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IBA:GO_Central.
GO; GO:0035220; P:wing disc development; IMP:UniProtKB.
InterPro; IPR007187; Nucleoporin_Nup133/Nup155_C.
InterPro; IPR014908; Nucleoporin_Nup133/Nup155_N.
InterPro; IPR004870; Nucleoporin_Nup155.
PANTHER; PTHR10350; PTHR10350; 1.
Pfam; PF03177; Nucleoporin_C; 1.
Pfam; PF08801; Nucleoporin_N; 1.
1: Evidence at protein level;
Chromosome; Complete proteome; Cytoplasm; Membrane; mRNA transport;
Nuclear pore complex; Nucleus; Protein transport; Reference proteome;
Translocation; Transport.
CHAIN 1 1365 Nuclear pore complex protein Nup154.
{ECO:0000305}.
/FTId=PRO_0000442728.
REGION 1 508 Required for binding to Nup93-1 and
anchoring to the nuclear pore complex.
{ECO:0000269|PubMed:22718353}.
REGION 508 986 Required for binding to chromatin.
{ECO:0000269|PubMed:22718353}.
CONFLICT 1003 1003 V -> E (in Ref. 1; CAA76635).
{ECO:0000305}.
CONFLICT 1291 1291 A -> P (in Ref. 2; AAC05385/AAC05386/
AAC06247/AAC06248). {ECO:0000305}.
SEQUENCE 1365 AA; 153895 MW; 0ADFC7E8B6BD18B3 CRC64;
MTLPQAQLDF FTTATSMLEW HYNLERNKPG LLELTGVSQH GRATMSGLND YDYQSLSFLK
SDRTHNLQQM RTVTKSAIPN EILEHFKHIK CHCTMGLFPE IGRAWLTIDS EIYIWTFNQT
RDVAYYDGLS HLIVSVGLVK PKPGVFVQDV KYLLVLTTPI EVIVLGVTFG ESSYNEMQLM
NRPVFVIGTD NVSISVIKGT DDGRIFLGGR DGCLYEIYYQ AESSWFGKRC KKINLSQGLV
SYMVPSFLKV FSEVDPIEHI EIDNSRKLLY VLTEKGVIEA WDISTSYTTA RRLGRITQND
ITNQAVSLIT TVDPSIFKSV KAICPLSADD ADKLHLVAVT QCGVRLFFST TSLNVKQQFG
PAVPCSPGEN TGFGQPAVQP PLSPNAEAPK GLYLLHVRLP PGYTPNATTN KPKQVHAAHY
TEGTMLMITT QQHEQDLLWS LSSAPSVNFT YLVESTALES LDGVVWGLAE VHEPSTPQRK
SPLNSARHAR KVALLTNQGT HIIEVLKMVD VLRQILLSCN GPHHEEVKMF FQSQNQREAC
VTALLLATSD TYRGSDVALW AAQAFMLYGG EPCYQHQKFL NASNRNMANQ TLGPNTTNVR
ERQSMFMSTP MPNSVANSPV GFPGSQFNQP ISPIGNMQPP QVAVSNENSP IVFSAKHDGL
YMYVSRMLHS VWQMRCVNEQ FCSNLSQSEC ALLLSDLRSL RSFLEVHSVH DISSTTRVSF
DNHLDRTNSY NTIMMGNTLL PIPEQRVLSE QAQVEETRSL SALNLFVKHA CEVISLWNIL
NSHSFQLICV QLSPEHQKLL TCSTFRDLLI TRSEVCAFLI ISLINLYLKD AAGVSEVSKN
LRENCPNLYR HEDDVTYKAT ELLMNAKNCT SATEKEHMLR TTLHMCKEAA PTLPLHSICM
QFISADFFEG VIELSAVCAS KSDPEEVGVH FYNNGEPADD REGYTCFATR MAYYKEVQLM
LDHIYQRVCN KTHVQDKSIN PLKGTAKASD AKNGATQTIP KIVAHTLKVK DPLIHITLYE
WLLAHDMLKE LLDVVEPSLG EFLRRSVSQN VDNVVLIDLL WKYYEKNSHH SQAAHILDNL
AMTRSENINL EQRIEYLVRA VMCMRNGNVG SSLSNGIFLK ELEDKLDIAR VQKSVLAAMT
ELASDKLEAA TAVKELNYAL YDITQLYQHF AEPFDLWECQ LSILNCSHHN DPLLIESVWG
QIINSVVDKP GTTSERCNRL FTKIEILVRE YGESGVCFPF AFLIRELEVK ACQLRFPEGI
VPEKLVSMNL DIELLLEYYS RMISMNERVW ANEGNEWHLI QSVIRVVSLL ADNAQSIWYR
SKRRIVGKAQ DIVAGCLNIC YQKPDTNRLQ HSLKELQSQL QRLLI


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EIAAB28280 50 kDa nucleoporin,Npap60,Nuclear pore complex protein Nup50,Nuclear pore-associated protein 60 kDa-like,Nucleoporin Nup50,Nup50,Rat,Rattus norvegicus
EIAAB28282 50 kDa nucleoporin,Mouse,Mus musculus,Npap60,Nuclear pore complex protein Nup50,Nuclear pore-associated protein 60 kDa-like,Nucleoporin Nup50,Nup50
EIAAB28284 35 kDa nucleoporin,Nuclear pore complex protein Nup53,Nucleoporin Nup35,Nucleoporin NUP53,Nup35,Nup53,Rat,Rattus norvegicus
EIAAB28298 88 kDa nucleoporin,Nuclear pore complex protein Nup88,Nucleoporin Nup84,Nucleoporin Nup88,Nup84,Nup88,Rat,Rattus norvegicus
EIAAB28108 205 kDa nucleoporin,C7orf14,Homo sapiens,Human,KIAA0225,Nuclear pore complex protein Nup205,Nucleoporin Nup205,NUP205
EIAAB28292 85 kDa nucleoporin,FROUNT,Mouse,Mus musculus,Nuclear pore complex protein Nup85,Nucleoporin Nup85,Nup85,Pcnt1,Pericentrin-1
EIAAB28097 160 kDa nucleoporin,Homo sapiens,Human,KIAA0197,Nuclear pore complex protein Nup160,Nucleoporin Nup160,NUP120,NUP160
EIAAB28294 85 kDa nucleoporin,Nuclear pore complex protein Nup85,Nucleoporin Nup85,Nup85,Pcnt1,Pericentrin-1,Rat,Rattus norvegicus
EIAAB28302 93 kDa nucleoporin,Homo sapiens,Human,KIAA0095,Nuclear pore complex protein Nup93,Nucleoporin Nup93,NUP93
EIAAB28093 155 kDa nucleoporin,Homo sapiens,Human,KIAA0791,Nuclear pore complex protein Nup155,Nucleoporin Nup155,NUP155
EIAAB28110 214 kDa nucleoporin,Kiaa0023,Mouse,Mus musculus,Nuclear pore complex protein Nup214,Nucleoporin Nup214,Nup214
EIAAB28087 107 kDa nucleoporin,Nuclear pore complex protein Nup107,Nucleoporin Nup107,Nup107,p105,Rat,Rattus norvegicus
EIAAB28088 107 kDa nucleoporin,Homo sapiens,Human,Nuclear pore complex protein Nup107,Nucleoporin Nup107,NUP107
EIAAB28095 155 kDa nucleoporin,Nuclear pore complex protein Nup155,Nucleoporin Nup155,Nup155,P140,Rat,Rattus norvegicus
EIAAB28089 133 kDa nucleoporin,Homo sapiens,Human,Nuclear pore complex protein Nup133,Nucleoporin Nup133,NUP133
EIAAB28297 88 kDa nucleoporin,Homo sapiens,Human,Nuclear pore complex protein Nup88,Nucleoporin Nup88,NUP88
EIAAB28092 153 kDa nucleoporin,Homo sapiens,Human,Nuclear pore complex protein Nup153,Nucleoporin Nup153,NUP153
EIAAB28096 160 kDa nucleoporin,Gene trap locus 1-13 protein,Gtl1-13,GTL-13,Kiaa0197,Mouse,Mus musculus,Nuclear pore complex protein Nup160,Nucleoporin Nup160,Nup160
EIAAB28287 54 kDa nucleoporin,Mouse,Mus musculus,Nuclear pore complex protein Nup54,Nucleoporin Nup54,Nup54
EIAAB28286 54 kDa nucleoporin,Nuclear pore complex protein Nup54,Nucleoporin Nup54,Nup54,Rat,Rattus norvegicus
EIAAB28296 88 kDa nucleoporin,Mouse,Mus musculus,Nuclear pore complex protein Nup88,Nucleoporin Nup88,Nup88


 

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