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Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein) (Fragment)

 NCOA6_RAT               Reviewed;         418 AA.
Q9JLI4; Q9JIH6;
12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
12-FEB-2003, sequence version 2.
10-MAY-2017, entry version 95.
RecName: Full=Nuclear receptor coactivator 6;
AltName: Full=Activating signal cointegrator 2;
Short=ASC-2;
AltName: Full=Amplified in breast cancer protein 3;
AltName: Full=Cancer-amplified transcriptional coactivator ASC-2;
AltName: Full=Nuclear receptor coactivator RAP250;
Short=NRC;
AltName: Full=Nuclear receptor-activating protein, 250 kDa;
AltName: Full=Peroxisome proliferator-activated receptor-interacting protein;
Short=PPAR-interacting protein;
Short=PRIP;
AltName: Full=Thyroid hormone receptor-binding protein;
Flags: Fragment;
Name=Ncoa6; Synonyms=Aib3, Rap250, Trbp;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-285, AND INTERACTION WITH THRB.
TISSUE=Pituitary;
PubMed=10823961; DOI=10.1073/pnas.97.11.6212;
Ko L., Cardona G.R., Chin W.W.;
"Thyroid hormone receptor-binding protein, an LXXLL motif-containing
protein, functions as a general coactivator.";
Proc. Natl. Acad. Sci. U.S.A. 97:6212-6217(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 135-418, INTERACTION WITH THRA; THRB;
RAR; RXR; ESR; VDR; NR3C1, AND MUTAGENESIS OF 174-LEU--LEU-178.
STRAIN=Sprague-Dawley; TISSUE=Pituitary;
PubMed=10866662; DOI=10.1128/MCB.20.14.5048-5063.2000;
Mahajan M.A., Samuels H.H.;
"A new family of nuclear receptor coregulators that integrates nuclear
receptor signaling through CBP.";
Mol. Cell. Biol. 20:5048-5063(2000).
-!- FUNCTION: Nuclear receptor coactivator that directly binds nuclear
receptors and stimulates the transcriptional activities in a
hormone-dependent fashion. Coactivate expression in an
agonist- and AF2-dependent manner. May coactivate expression via a
remodeling of chromatin and its interaction with histone
acetyltransferase proteins. Involved in the coactivation of
different nuclear receptors, such as for steroids (GR and ERs),
retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR)
and prostanoids (PPARs). Probably functions as a general
coactivator, rather than just a nuclear receptor coactivator. May
also be involved in the coactivation of the NF-kappa-B pathway (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer and homodimer. Interacts in vitro with the basal
transcription factors GTF2A and TBP, suggesting an autonomous
transactivation function. Interacts with NCOA1, CRSP3, RBM14, the
histone acetyltransferase proteins EP300 and CREBBP, and with
methyltransferase proteins NCOA6IP and PRMT2 (By similarity).
Component of the MLL2/3 complex (also named ASCOM complex), at
least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5,
NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-
tubulin (By similarity). Interacts with ZNF335; may enhance
ligand-dependent transcriptional activation by nuclear hormone
receptors (By similarity). {ECO:0000250}.
-!- INTERACTION:
P03372:ESR1 (xeno); NbExp=2; IntAct=EBI-286271, EBI-78473;
P10912:GHR (xeno); NbExp=2; IntAct=EBI-286271, EBI-286316;
P19793:RXRA (xeno); NbExp=2; IntAct=EBI-286271, EBI-78598;
P10827:THRA (xeno); NbExp=2; IntAct=EBI-286271, EBI-286285;
P11473:VDR (xeno); NbExp=2; IntAct=EBI-286271, EBI-286357;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- DOMAIN: Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which is
essential for the association with nuclear receptors.
-!- PTM: Phosphorylated. {ECO:0000250}.
-----------------------------------------------------------------------
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EMBL; AF228043; AAF76422.1; -; mRNA.
EMBL; AF176351; AAF71830.1; -; mRNA.
UniGene; Rn.234544; -.
UniGene; Rn.9077; -.
IntAct; Q9JLI4; 9.
STRING; 10116.ENSRNOP00000024714; -.
PhosphoSitePlus; Q9JLI4; -.
PaxDb; Q9JLI4; -.
PRIDE; Q9JLI4; -.
UCSC; RGD:620111; rat.
RGD; 620111; Ncoa6.
eggNOG; ENOG410IK20; Eukaryota.
eggNOG; ENOG410XW4F; LUCA.
HOGENOM; HOG000113745; -.
InParanoid; Q9JLI4; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0035097; C:histone methyltransferase complex; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0043234; C:protein complex; IDA:RGD.
GO; GO:0005667; C:transcription factor complex; IBA:GO_Central.
GO; GO:0035259; F:glucocorticoid receptor binding; IPI:RGD.
GO; GO:0016922; F:ligand-dependent nuclear receptor binding; IDA:RGD.
GO; GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:RGD.
GO; GO:0035257; F:nuclear hormone receptor binding; IPI:RGD.
GO; GO:0042975; F:peroxisome proliferator activated receptor binding; IPI:RGD.
GO; GO:0019904; F:protein domain specific binding; IMP:RGD.
GO; GO:0042803; F:protein homodimerization activity; IDA:RGD.
GO; GO:0042974; F:retinoic acid receptor binding; IPI:RGD.
GO; GO:0046965; F:retinoid X receptor binding; IPI:RGD.
GO; GO:0046966; F:thyroid hormone receptor binding; IPI:RGD.
GO; GO:0030099; P:myeloid cell differentiation; ISS:UniProtKB.
GO; GO:0001541; P:ovarian follicle development; IEP:RGD.
GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:RGD.
GO; GO:0002793; P:positive regulation of peptide secretion; IMP:RGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:RGD.
GO; GO:0009725; P:response to hormone; IBA:GO_Central.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
1: Evidence at protein level;
Activator; Complete proteome; Methylation; Nucleus; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation.
CHAIN <1 418 Nuclear receptor coactivator 6.
/FTId=PRO_0000094415.
REGION <1 418 NCOA1-binding region. {ECO:0000250}.
REGION <1 352 CREBBP-binding region. {ECO:0000250}.
REGION <1 215 TBP/GTF2A-binding region. {ECO:0000250}.
REGION 60 214 NCOA6IP-binding region. {ECO:0000250}.
MOTIF 174 178 LXXLL motif.
COMPBIAS 200 205 Poly-Lys.
COMPBIAS 301 308 Poly-Pro.
COMPBIAS 310 327 Poly-Gln.
COMPBIAS 328 334 Poly-Met.
MOD_RES 171 171 Phosphoserine.
{ECO:0000250|UniProtKB:Q14686}.
MOD_RES 342 342 Asymmetric dimethylarginine.
{ECO:0000250|UniProtKB:Q9JL19}.
MOD_RES 353 353 Asymmetric dimethylarginine.
{ECO:0000250|UniProtKB:Q9JL19}.
MOD_RES 391 391 Asymmetric dimethylarginine.
{ECO:0000250|UniProtKB:Q9JL19}.
MUTAGEN 174 178 LVNLL->AVNAA: Abolishes interaction with
nuclear receptors.
{ECO:0000269|PubMed:10866662}.
NON_TER 1 1
SEQUENCE 418 AA; 45574 MW; A90D7C4111C67CAE CRC64;
EQIMTNQMQG NKAQFNSQNQ SNVMPGPAQI MRGPTPNMQG NMVQFTGQMS GQMLPQQGPV
SNSPSQVMGI QGQVLRPPGP SPHMAQQHTD PATTANNDVN LSQMMPDVSM QQTSMVPPHV
QSMQGNSASG SHFSGHGVSF NAPFGGAPNG TQMSCGQNPG FPVNKDVTLT SPLLVNLLQS
DISAGHFGVN NKQNNTNANK QKKKKPPRKK KNCHQDLNTP DSRPAGLEEV DQQSLPGEQG
INLDNTGPKL PDFSNRPPGY PTQPVEQRPL QQMPPQLMQH VAPPPQPPQQ QPQPQLPQQQ
PQPQPPPPSQ PQSQQQQQQQ QQQQQQQMMM MLMMQQDPKS IRLPVSQNVH PPRGPLNPDS
QRVPMQQSGN VPVMVSLQGP ASVPPSPDKQ RMPMPVNTPL GSNSRKMVYQ ESPQNSSS


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