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Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) (xN-CoR)

 NCOR1_XENTR             Reviewed;        2494 AA.
Q4KKX4;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
02-AUG-2005, sequence version 1.
25-APR-2018, entry version 80.
RecName: Full=Nuclear receptor corepressor 1;
Short=N-CoR;
Short=N-CoR1;
Short=xN-CoR;
Name=ncor1;
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Silurana.
NCBI_TaxID=8364;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Mediates transcriptional repression by certain nuclear
receptors. Participates in complexes which promote histone
deacetylation and the formation of repressive chromatin structures
which may impede access by the basal transcription machinery (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Forms a large corepressor complex that contains sin3a/b,
histone deacetylases hdac1 and hdac2, rbbp4 and possibly rbbp7.
Interacts with the thyroid receptor (TR, composed of rxra and
thrb) and the retinoid acid receptor (RAR, composed of rxra and
rara) in the absence of ligand. Interacts with tbl1xr1. Interacts
with zbtb33/kaiso (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00624}.
-!- DOMAIN: The CORNR box motifs in the C-terminal region may be
necessary and sufficient for binding to unligated nuclear hormone
receptors. Sequences flanking these motifs may determine the
precise nuclear hormone receptor specificity (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors
family. {ECO:0000305}.
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EMBL; BC099620; AAH99620.1; -; mRNA.
RefSeq; NP_001027513.1; NM_001032342.1.
UniGene; Str.46503; -.
ProteinModelPortal; Q4KKX4; -.
SMR; Q4KKX4; -.
STRING; 8364.ENSXETP00000014702; -.
PaxDb; Q4KKX4; -.
GeneID; 613105; -.
KEGG; xtr:613105; -.
CTD; 9611; -.
Xenbase; XB-GENE-483288; ncor1.
eggNOG; KOG1878; Eukaryota.
eggNOG; ENOG410YDXP; LUCA.
HOGENOM; HOG000113746; -.
HOVERGEN; HBG052587; -.
InParanoid; Q4KKX4; -.
KO; K04650; -.
Proteomes; UP000008143; Unassembled WGS sequence.
GO; GO:0016580; C:Sin3 complex; IBA:GO_Central.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0016922; F:ligand-dependent nuclear receptor binding; IBA:GO_Central.
GO; GO:0046966; F:thyroid hormone receptor binding; IBA:GO_Central.
GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00167; SANT; 2.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR031557; N-CoR_GPS2_interact.
InterPro; IPR001005; SANT/Myb.
InterPro; IPR017884; SANT_dom.
Pfam; PF15784; GPS2_interact; 1.
Pfam; PF00249; Myb_DNA-binding; 1.
SMART; SM00717; SANT; 2.
SUPFAM; SSF46689; SSF46689; 2.
PROSITE; PS51293; SANT; 2.
2: Evidence at transcript level;
Chromatin regulator; Coiled coil; Complete proteome; DNA-binding;
Nucleus; Reference proteome; Repeat; Repressor; Transcription;
Transcription regulation.
CHAIN 1 2494 Nuclear receptor corepressor 1.
/FTId=PRO_0000055621.
DOMAIN 427 478 SANT 1. {ECO:0000255|PROSITE-
ProRule:PRU00624}.
DOMAIN 622 668 SANT 2. {ECO:0000255|PROSITE-
ProRule:PRU00624}.
REGION 154 304 Interaction with tbl1xr1. {ECO:0000250}.
COILED 168 208 {ECO:0000255}.
COILED 502 549 {ECO:0000255}.
COILED 698 726 {ECO:0000255}.
COILED 1771 1810 {ECO:0000255}.
MOTIF 2008 2012 CORNR box 1.
MOTIF 2119 2123 CORNR box 2.
MOTIF 2322 2326 CORNR box 3.
COMPBIAS 504 537 Glu-rich.
COMPBIAS 594 611 Thr-rich.
SEQUENCE 2494 AA; 277212 MW; 7E862943961012FA CRC64;
MSSSGYPPNQ GAFSTEQGRY SSHPVQYTFP SSRHQQEFPV PEYRSSHLEA SQLLQQQQLR
RRPSLLSEFH PVSDRPQDRR QGYEQQYHSV TQNEHEALES KRPRLDVSDS HYRVGAASVV
PLVPTIQEGV RVQSEVKKEQ GLPSKHETTS SPLSGQPGEE QEASPSKLSK EELIQSMDRV
DREIAKVEQQ ILKLKKKQQQ LEEEAAKPPE PEKPVSPPPV EQKHRSIVQI IYDENRKKAE
EAHKILEGLG PKVELPLYNQ PSDTKVYHEN IKTNQVMRKK LILFFKRRNH ARKLREQNIC
QRYDQLMEAW EKKVDRIENN PRRKAKESKT REYYEKQFPE IRKQREQQER FQRVGQRGAG
LSATIARSEH EISEIIDGLS EQENNEKQMR QLSVIPPMMF DAEQRRVKFI NMNGLMEDPM
KVYKDRQFMN VWTDHEKEIF KEKFVQHPKN FGLIASYLER KTVSDCVLYY YLTKKNENFK
ALVRRNYPKR RGRNQQQITR PAQEEKEIEK VEEEKAERND KKEEERREEE EKEEKEELRD
GTKDRTDAIA EDGEDKEQST PRGRKTANSQ GRRKGRITRS MASEAAAAAN AASTATTAPA
TTTSTTATTT TAALVPVAPP PEEPTPPPTQ EQSLVEHGRN WGAIAKMVGS KSESQCKNFY
FNYKRRHNLD NLLQQHKQKS SRRPREERDV SQCESVASTV SAQEDEENEA SNEEENAEDS
EGAENSSDTE SAPSPSPAEA AKLGDDAVDR TTSSVSIEAP PEQDAASKSV SDSSPTPTVE
NIKPPETQYT ELKVKEEIST ETEEAMEVEE RSQGAEIKST LSLPVQTKAE PDEVESKPSE
SAEVKIEEDT KDQDMERLMD RAEATDMVYA PPLHISRGRQ ESQSDNDSSA TCSADEEVDG
EPERPRIYTL DSKPSLLNPA GTILISSSMK QGPMDLQQLQ HRAAVIPPMA SCSPCNITTG
TSNFSMYQRH LYENNLLEEQ RQRQEQLSLE SRMSASPGNM SKSPNMDWEG KSVYMPYTEV
KRAFEHEAQM QNVARSVSPY RLSPREVSRA SPQVDMNPAR YCVPPVLQPA PHQVITSLSD
GARLPVTRPT RPPPPLIPSS KTSATSSDKP SFITGGSISQ GTPGTYLTSL SQSYSQETVK
PSVGSISLGL PRQQESAKTG SVTYIKQEEF SPRGQSSQPE GLLVRAQHEG VVRGTMTAIQ
EGSITRGTPA TKVPIEAVST LRGSITQGTP ALSQSGIAAD VLLKTTITRL ATEDIGSPER
CRDETSAKGH VIYEGKSGHI VSYDTAIKNM REGTRSPRTA PEVTLKRTFD TMEGNIKQAM
SVREAAVSGP MEGLICRTLP KGSTHAEIKD RQVLSGSIMK GTPRTTSDSF EDGLKYAKQI
KLESPPIRSF EGAISKGKPY ECVTTIKEMG RSIHEIPRQD LGSQESRKTP ESSRQIIEGS
ISQGTPIKYE GTSGQSAIKH NVKSLITGPS NLSRGLPQME VMPENLKMGE RSKYEDTKSS
EAIRSRHTSV VSSGPSVLRS TLHEASKSQL SPGVYEDNNA RRTPVNYPSP MSRSSPMARS
AEVGLTPGKS SSHERKSTLT PTQRENIVVK SPVPGVDPTA AHSPFDPHLR GAPPGDVYRT
HLPPHLDPAL QFHRPLDPAA AAAYLFQRQL SPTPGYPSQY QLYAMENTRQ TILNDYITSQ
QMQVNLRPDV ARGLSPRDQG LAIPYPGARG IIDLTNMPPA ILVPHPGGTS TPPMDRITYI
PGTQLAFPPR PYNPASMSPG HPTHLAAANS VSAERERERE RDRERDRERE KEQRERERDR
ERERERLAAA PSDHYLRPVS EQPGRPGSHG FVRSPSPSVR AQESIMQQRP SIFQGTNGKS
VITPLDAAQL RIMPPTPGAA SITQGIPASR YSTAADALAA LVDAAASAPQ MEVVKPKEMK
HDPARSEESL SRRNVLEQQQ QQQQIDCERR VMQSPYTSSS FSGSKSQGQP SPAVYSEAGK
EKTAHTKSRY VEELRMRGKT TITAANFIDV IITQQIASDK DGRDRNSQSS DSSSSHSSHR
YDAPRDTIEV ISPANSPVQE KESYPPEIPK SSQTESESSR KYEGQPNRYR QQQESPSPQQ
TIPGHVPQTH RLITLADHIC QIITQDFARN QPVNQALQQP PASTFQSTNP SSTPVRTKAS
SRFSPESQVQ PVHNQRPASR VSPENVLDRP RGRPGKSPDR GHISEPYEPI SPPQAPLLHA
KQDSMLLLSQ RQEPPEQRND SRSPGNISYL PSFFTKLENT SPMVMYKKQE IFRKLNSSGG
GDSEMAAAQP GTEIFNLPAV TTSGAISSRG HSFADPASNL GLEDIIRKAL MGNFDDKSED
HSVLVGVAQG NPSGTQNSEA RREEANPSPN SGGGTHKQKL ISKYGSRKTK SPISGSQTYL
GAERPSSVSS VHSEGDYRQA SAWAWEDRPS STGSTQFPYN PLTMGMLNST PPSSMSCAPT
SMTQTSAHQQ SRIWEREPAP LLSEQYETLS DSDE


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