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Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) (xN-CoR)

 NCOR1_XENLA             Reviewed;        2498 AA.
Q8QG78;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
22-NOV-2017, entry version 81.
RecName: Full=Nuclear receptor corepressor 1;
Short=N-CoR;
Short=N-CoR1;
Short=xN-CoR;
Name=ncor1;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RXRA AND THRB,
DEVELOPMENTAL STAGE, AND INDUCTION.
PubMed=12446772; DOI=10.1128/MCB.22.24.8527-8538.2002;
Sachs L.M., Jones P.L., Havis E., Rouse N., Demeneix B.A., Shi Y.-B.;
"Nuclear receptor corepressor recruitment by unliganded thyroid
hormone receptor in gene repression during Xenopus laevis
development.";
Mol. Cell. Biol. 22:8527-8538(2002).
[2]
INTERACTION WITH HDAC1; HDAC2; RBBP4; RXRA; SIN3A; SIN3B AND THRB.
PubMed=11254656; DOI=10.1074/jbc.C000879200;
Jones P.L., Sachs L.M., Rouse N., Wade P.A., Shi Y.-B.;
"Multiple N-CoR complexes contain distinct histone deacetylases.";
J. Biol. Chem. 276:8807-8811(2001).
[3]
PROMOTER BINDING.
PubMed=11914274; DOI=10.1101/gad.962502;
Li J., Lin Q., Wang W., Wade P.A., Wong J.;
"Specific targeting and constitutive association of histone
deacetylase complexes during transcriptional repression.";
Genes Dev. 16:687-692(2002).
[4]
FUNCTION.
PubMed=12947412; DOI=10.1038/sj.embor.embor908;
Havis E., Sachs L.M., Demeneix B.A.;
"Metamorphic T3-response genes have specific co-regulator
requirements.";
EMBO Rep. 4:883-888(2003).
[5]
FUNCTION, AND INTERACTION WITH RARA; RXRA AND TBL1XR1-A.
PubMed=12794076; DOI=10.1074/jbc.M303309200;
Tomita A., Buchholz D.R., Obata K., Shi Y.-B.;
"Fusion protein of retinoic acid receptor-alpha with promyelocytic
leukemia protein or promyelocytic leukemia zinc finger protein
recruits N-CoR-TBLR1 corepressor complex to repress transcription in
vivo.";
J. Biol. Chem. 278:30788-30795(2003).
[6]
FUNCTION, INTERACTION WITH RXRA; THRB AND TBL1XR1-A, AND DEVELOPMENTAL
STAGE.
PubMed=15060155; DOI=10.1128/MCB.24.8.3337-3346.2004;
Tomita A., Buchholz D.R., Shi Y.-B.;
"Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded
thyroid hormone receptor for gene repression during frog
development.";
Mol. Cell. Biol. 24:3337-3346(2004).
[7]
FUNCTION, AND INTERACTION WITH ZBTB33.
PubMed=15935774; DOI=10.1016/j.devcel.2005.04.010;
Park J.-I., Kim S.-W., Lyons J.P., Ji H., Nguyen T.T., Cho K.,
Barton M.C., Deroo T., Vleminckx K., Moon R.T., McCrea P.D.;
"Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately
regulate canonical Wnt gene targets.";
Dev. Cell 8:843-854(2005).
-!- FUNCTION: Mediates transcriptional repression by certain nuclear
receptors. Participates in complexes which promote histone
deacetylation and the formation of repressive chromatin structures
which may impede access by the basal transcription machinery.
{ECO:0000269|PubMed:12446772, ECO:0000269|PubMed:12794076,
ECO:0000269|PubMed:12947412, ECO:0000269|PubMed:15060155,
ECO:0000269|PubMed:15935774}.
-!- SUBUNIT: Forms a large corepressor complex that contains sin3a/b,
histone deacetylases hdac1 and hdac2, rbbp4 and possibly rbbp7.
Interacts with the thyroid receptor (TR, composed of rxra and
thrb) and the retinoid acid receptor (RAR, composed of rxra and
rara) in the absence of ligand. Interacts with tbl1xr1-A and
possibly tbl1xr1-B. Interacts with zbtb33/kaiso.
{ECO:0000269|PubMed:11254656, ECO:0000269|PubMed:12446772,
ECO:0000269|PubMed:12794076, ECO:0000269|PubMed:15060155,
ECO:0000269|PubMed:15935774}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00624}.
-!- DEVELOPMENTAL STAGE: Expressed in the developing intestine both
prior to and during remodeling (stages NF54 to NF66). Also
expressed at high levels in the tail during tail regression
(stages NF62 and NF64) and in the hindlimbs during hindlimb
morphogenesis (stage NF56). {ECO:0000269|PubMed:12446772,
ECO:0000269|PubMed:15060155}.
-!- INDUCTION: By thyroid hormone in the developing intestine and
tail. {ECO:0000269|PubMed:12446772}.
-!- DOMAIN: The CORNR box motifs in the C-terminal region may be
necessary and sufficient for binding to unligated nuclear hormone
receptors. Sequences flanking these motifs may determine the
precise nuclear hormone receptor specificity (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors
family. {ECO:0000305}.
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EMBL; AF495886; AAM12658.1; -; mRNA.
RefSeq; NP_001082225.1; NM_001088756.1.
UniGene; Xl.2761; -.
ProteinModelPortal; Q8QG78; -.
SMR; Q8QG78; -.
BioGrid; 99637; 5.
GeneID; 398304; -.
KEGG; xla:398304; -.
CTD; 398304; -.
Xenbase; XB-GENE-864966; ncor1.
HOVERGEN; HBG052587; -.
KO; K04650; -.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0016569; P:covalent chromatin modification; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00167; SANT; 2.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR031557; N-CoR_GPS2_interact.
InterPro; IPR001005; SANT/Myb.
InterPro; IPR017884; SANT_dom.
Pfam; PF15784; GPS2_interact; 1.
Pfam; PF00249; Myb_DNA-binding; 1.
SMART; SM00717; SANT; 2.
SUPFAM; SSF46689; SSF46689; 2.
SUPFAM; SSF81296; SSF81296; 1.
PROSITE; PS51293; SANT; 2.
1: Evidence at protein level;
Chromatin regulator; Coiled coil; DNA-binding; Nucleus; Repeat;
Repressor; Transcription; Transcription regulation.
CHAIN 1 2498 Nuclear receptor corepressor 1.
/FTId=PRO_0000055620.
DOMAIN 427 478 SANT 1. {ECO:0000255|PROSITE-
ProRule:PRU00624}.
DOMAIN 628 665 SANT 2. {ECO:0000255|PROSITE-
ProRule:PRU00624}.
REGION 154 304 Interaction with tbl1xr1-A.
COILED 168 208 {ECO:0000255}.
COILED 502 552 {ECO:0000255}.
COILED 1765 1804 {ECO:0000255}.
MOTIF 2012 2016 CORNR box 1.
MOTIF 2123 2127 CORNR box 2.
MOTIF 2326 2330 CORNR box 3.
COMPBIAS 504 540 Glu-rich.
COMPBIAS 610 626 Pro-rich.
SEQUENCE 2498 AA; 277828 MW; 8A026610EB227C93 CRC64;
MSSSGYPPNQ GAFSTEQGRY SSHPVQYTFP SSRHQQEYSV SEYRTAHLEA SQLIQQQQLR
RRPSLLSEFH PVSDRPQDRR SGYDQQYHSI SQNEHEALES KRPRLDQVSD SHYRLNPAMV
LLVPTIQEGV RVQSEVKKEQ GLSSKHESSS SPLSGQPGDD QDASPSKLSK EELIQSMDRV
DREIAKVEQQ ILKLKKKQQQ LEEEAAKPPE PEKPVSPPPV EQKHRSVVQI IYDENRKKAE
EAHKFLEGLG PKVELPLYNQ PSDTKVYHEN IKTNQVMRKK LILFFKRRNH ARKLREQNIC
QRYDQLMEAW EKKVDRIENN PRRKAKESKT REYYEKQFPE IRKQREQQER FQRVGQRGTG
MSATIARSEH EISEIIDGLS EQENNEKQMR QLSVIPPMMF DAEQRRVKFI NTNGLMEDPM
KVYKDRQFMN VWTDHEKEIF KEKFVRHPKN FGLIASYLER KNVSDCVLYY YLTKKNENLK
SLVRRNYPKR RGRNQQQITR PSQEEKEIEK VEEEKADRND KKEDERREEE EKEEKEELRE
GAKDKIDAVA EDGDEKDQSM PRGRKTANNQ GRRKGRVTRS MASEAAAANA VTTATTAPVT
TTSTATTVAP VPVAPPPEEP TPPPPPQEQS LVDHGRNWGA IAKMVGSKSE SQCKNFYFNY
KRRHNLDNLL QQHKQKSSRR PREERDVSQC DSIASTVSAQ EDDENEASNE EENPEDSEGA
ENSSDTESAP SPSPAEAARL GDDSVDRTTS SVSMEAPPEQ DAASKPASDS SPSPIVENTK
PPETQYAELK VKEEISTENE QTMEVEERSQ SAELKSALNL QVQTKAEPYE TEAKPTESTT
QVKTEVDSKE DDSMERLMDR AEAADMGYAP PQNISQARQE SQPDNDSSAT CSADEEVDGE
PDRPRMYSFG SRPSLLNQAG TFLKQGPMDL QQLQHRAAVI PPMTSCSPCN LTTGTAIAAS
NFSMYQRHLY ENSLLEEQRQ RQEQLTLENR MSASPGNMSK SPNMDWEGKS VYMPYTEVKH
PFEHEAQMQN VARSVSPYRL SPRDVGRVSP QVDMNPSRYC VPPVLQPAPH QVITSLSDSA
RLPVTRPTRP PPPLIPSSKT SATSSDKPSF ITGGSISQGT PGTYLASLSQ PYSQETLKPS
VGSISLGLPR QHESTKIGCV TYIKQEEFPS RGQSSQPEGL LVRAQHEGVV RGSMAAIQEG
SIARGTPATK VPLEAVSTLR GSITQGTPAL SQSGIAADVL LKSTITRLAA EDIGSPERCR
EDTSAKGHVI YEGKSGHIVS YDTIKNMREG TRSPRTAPEV ALKRAYDTME GNIKQAMSVR
EAAVSGPMEG LICRTLPKGS PHPELKDRQV LSGSIMKGTP RTTSDNFDDG LKYAKQIKLE
SPPIRSFEGA ISKGKPYEGV TTIKELGRSI HEIPRQDLVS QESRKTPESS RQIMEGSISQ
GTPIKYESTS GQSAIKHNVK SLITGPSNLS WGVPQMDNMP ENLKMGERSK HEDTKSSDAI
RSRHTSVVSS GPSVLRSTLH EASKSQLSPG IYEDNNARRT PVNYPSPMSR SSPMARSAEG
CLTPSKSSSH ERKSTLTPTQ RESIVVKSPV PGVDPSAAHS PFDTHLRSAP PGDVYRAHLP
PHLDPALQFH RPLDPAAAAY LFQRQLSPTP GYPSQYQLYA MENTRQTILN DYITSQQMQV
NLRPDVARGL SPRDQGLGIP YPGARGIIDL TNMPPAILVP HPGGTSTPPM DRITYIPGTQ
LAFPPRPYNP ASMSPGHPAH LANSVSAERE RERERERERD REREKEQRER ESDRERERDR
LAHAAAAAAA ASAPSEHYLR PVSEQPSRPS SRPSSHGYVR SPSPSVRAQE SIMQQRPSIF
LGTNGKSVIT PLDAAQFRIM PPTPGAASIT QGIPASRYST AADALAALVD AATSAPQMEV
AKPKESKNDS ARSEENLSRR NALEQQQQID CERRVMQSPY TSSSFSSSKS QSQPSSAVYS
EAGKERTAHT KSRYVEELRM RGKTTITAAN FIDVIITQQI ASDKDGRERN SQSSDASSSH
SSHRYEAPRE TIEVISPANS PVQEKESYPQ EMPKSSQTET GEGSRKYDGQ PNRYRQQQES
PPQQTIPGHV PQTHRLITLA DHICHIITQD FARNQPVNQP LQQPPASTFQ STNPTSTAVR
TKASSRFSPE SQVQPMHSPR PASRVSPENI PDKPRGRPGK SPDRGHISEP YEPISPPQAP
MLHTKQDNMM LLSQRQEPPE QRNDSRSPGN INYLPSFFTK LENTSPMVMY KKQEIFRKLN
SSGGGDSDMA AAQPGTEIFN LPAVTTSGAI SSRGHSFADP ASNLGLEDII RKALMGNFDD
KSEDHGVLVG VPQGNQSGTP NSEARREEAN PSPNSGGGTH KQKLISKYGS RKTKSPISGS
QTYLGAERPS SVSSVHSEGD YRQASAWAWE DRPSSTGSTQ FPYNPLTMGM LNSTPPSSMS
CIPTSMTQTS AHQQSRIWER EPAPLLSEQY ETLSDSDE


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