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Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1)

 NR0B1_MACMU             Reviewed;         470 AA.
Q9BG93;
06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
23-MAY-2018, entry version 90.
RecName: Full=Nuclear receptor subfamily 0 group B member 1;
AltName: Full=Nuclear receptor DAX-1;
Name=NR0B1; Synonyms=DAX1;
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11112659; DOI=10.1086/316932;
Patel M., Dorman K.S., Zhang Y.-H., Huang B.-L., Arnold A.P.,
Sinsheimer J.S., Vilain E., McCabe E.R.B.;
"Primate DAX1, SRY, and SOX9: evolutionary stratification of sex-
determination pathway.";
Am. J. Hum. Genet. 68:275-280(2001).
-!- FUNCTION: Orphan nuclear receptor. Component of a cascade required
for the development of the hypothalamic-pituitary-adrenal-gonadal
axis. Acts as a coregulatory protein that inhibits the
transcriptional activity of other nuclear receptors through
heterodimeric interactions. May also have a role in the
development of the embryo and in the maintenance of embryonic stem
cell pluripotency (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with
COPS2 (By similarity). Interacts with ESRRB; represses ESRRB
activity at the GATA6 promoter (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:Q61066}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
{ECO:0000250}. Note=Shuttles between the cytoplasm and nucleus.
Homodimers exits in the cytoplasm and in the nucleus (By
similarity). {ECO:0000250}.
-!- DOMAIN: Homodimerization involved an interaction between amino and
carboxy termini involving LXXLL motifs and steroid binding domain
(AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-
terminal LXXLL motifs (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR0
subfamily. {ECO:0000305}.
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EMBL; AF322896; AAK01647.1; -; mRNA.
UniGene; Mmu.3542; -.
ProteinModelPortal; Q9BG93; -.
SMR; Q9BG93; -.
STRING; 9544.ENSMMUP00000016782; -.
PRIDE; Q9BG93; -.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
HOGENOM; HOG000231151; -.
HOVERGEN; HBG005453; -.
InParanoid; Q9BG93; -.
Proteomes; UP000006718; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0016020; C:membrane; ISS:BHF-UCL.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0032448; F:DNA hairpin binding; ISS:UniProtKB.
GO; GO:0004879; F:nuclear receptor activity; ISS:BHF-UCL.
GO; GO:0019904; F:protein domain specific binding; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0035258; F:steroid hormone receptor binding; ISS:UniProtKB.
GO; GO:0030325; P:adrenal gland development; ISS:UniProtKB.
GO; GO:0008406; P:gonad development; ISS:UniProtKB.
GO; GO:0008584; P:male gonad development; ISS:UniProtKB.
GO; GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0008104; P:protein localization; ISS:UniProtKB.
GO; GO:0006694; P:steroid biosynthetic process; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR033544; NR0B1.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR025900; Nuclear_receptor_repeat.
PANTHER; PTHR24081:SF1; PTHR24081:SF1; 5.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF14046; NR_Repeat; 4.
PRINTS; PR00398; STRDHORMONER.
SMART; SM00430; HOLI; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Nucleus; Receptor; Reference proteome;
Repeat; Repressor; Transcription; Transcription regulation.
CHAIN 1 470 Nuclear receptor subfamily 0 group B
member 1.
/FTId=PRO_0000280116.
REPEAT 1 67 1.
REPEAT 68 133 2.
REPEAT 134 200 3.
REPEAT 201 253 4; truncated.
DOMAIN 205 469 NR LBD. {ECO:0000255|PROSITE-
ProRule:PRU01189}.
REGION 1 253 4 X 67 AA tandem repeats.
MOTIF 13 17 LXXLL motif 1.
MOTIF 80 84 LXXLL motif 2.
MOTIF 146 150 LXXLL motif 3.
MOTIF 461 466 AF-2 motif.
SEQUENCE 470 AA; 51879 MW; 8FC9C4768D6721EB CRC64;
MAGENHQWQG SILYNMLMSA KQTRAAPEAP ETRLVDQCWG CSCGDEPGVG REGLLGGRNV
SLLYRCCFCG KDHPRQGSIL YSMLTNAKQT YAAPKAPEAT LGPCWGCSCG SDPGVGRTGL
PGGRPVALLY RCCFCGEDHP RQGSILYSLL TSAKQTHVAP AAPEARPGGA WWDRSYFAQR
PGGREALPGG RAMGLLYRCC FCGEDHPQQG STLYCMPTST NQAQAAPEER PRAPWWDTSS
GALRPVALKN PQVVCEAASA GLLKTLRFVK YLPCFQVLPL DQQLVLVRNC WASLLMLELA
QDRLQFETVE VSEPSMLQKI LTTRRRETGG DEPLPVPTLQ HHLAPPAEAR KVPSASQVQA
IKCFLSKCWS LNISTKEYAY LKGTVLFNPD VPGLQCVKYI QGLQWGTQQI LSEHTRMTHQ
GPHDRFIELN STLFLLRFIN ANVIAELFFR PIIGTVSMDD MMLEMLCTKL


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