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Nuclear receptor subfamily 4 group A member 1 (Nuclear hormone receptor NUR/77) (Nuclear protein N10) (Orphan nuclear receptor HMR)

 NR4A1_MOUSE             Reviewed;         601 AA.
P12813;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 1.
27-SEP-2017, entry version 171.
RecName: Full=Nuclear receptor subfamily 4 group A member 1;
AltName: Full=Nuclear hormone receptor NUR/77;
AltName: Full=Nuclear protein N10;
AltName: Full=Orphan nuclear receptor HMR;
Name=Nr4a1; Synonyms=Gfrp, Hmr, N10, Nur77;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3186734; DOI=10.1073/pnas.85.22.8444;
Hazel T.G., Nathans D., Lau L.F.;
"A gene inducible by serum growth factors encodes a member of the
steroid and thyroid hormone receptor superfamily.";
Proc. Natl. Acad. Sci. U.S.A. 85:8444-8448(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Kidney, and Liver;
PubMed=2555161;
Ryseck R.P., Macdonald-Bravo H., Mattei M.-G., Ruppert S., Bravo R.;
"Structure, mapping and expression of a growth factor inducible gene
encoding a putative nuclear hormonal binding receptor.";
EMBO J. 8:3327-3335(1989).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Orphan nuclear receptor. May act concomitantly with
NURR1 in regulating the expression of delayed-early genes during
liver regeneration. Binds the NGFI-B response element (NBRE) 5'-
AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2.
Participates in energy homeostasis by sequestrating the kinase
STK11 in the nucleus, thereby attenuating cytoplasmic AMPK
activation (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with GADD45GIP1. Interacts with STK11. Binds
DNA as a monomer (By similarity). {ECO:0000250}.
-!- INTERACTION:
Q8VHR5:Gatad2b; NbExp=2; IntAct=EBI-10896863, EBI-3043880;
Q9R190:Mta2; NbExp=2; IntAct=EBI-10896863, EBI-904134;
Q7TPV4:Mybbp1a; NbExp=3; IntAct=EBI-10896863, EBI-1373622;
Q9DBD5:Pelp1; NbExp=3; IntAct=EBI-10896863, EBI-6909114;
Q62318:Trim28; NbExp=3; IntAct=EBI-10896863, EBI-346909;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus.
-!- TISSUE SPECIFICITY: Highest levels occur in the testis followed by
brain and muscle tissue.
-!- DEVELOPMENTAL STAGE: Highest levels are found in the adult with
barely detectable levels in pre- and early postnatal tissue.
-!- INDUCTION: By serum growth factors and during liver regeneration.
-!- PTM: Phosphorylated at Ser-354 by RPS6KA1 and RPS6KA3 in response
to mitogenic or stress stimuli. {ECO:0000250}.
-!- PTM: Acetylated by p300/CBP, acetylation increases stability.
Deacetylated by HDAC1 (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR4
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; J04113; AAA39843.1; -; mRNA.
EMBL; X16995; CAA34862.1; -; Genomic_DNA.
EMBL; X60132; CAA42718.1; -; mRNA.
EMBL; BC004770; AAH04770.1; -; mRNA.
CCDS; CCDS27848.1; -.
PIR; S06953; QRMSN1.
RefSeq; NP_034574.1; NM_010444.2.
RefSeq; XP_006520519.1; XM_006520456.1.
RefSeq; XP_006520521.1; XM_006520458.1.
RefSeq; XP_006520522.1; XM_006520459.3.
RefSeq; XP_017171925.1; XM_017316436.1.
UniGene; Mm.119; -.
ProteinModelPortal; P12813; -.
SMR; P12813; -.
BioGrid; 200346; 4.
CORUM; P12813; -.
DIP; DIP-61643N; -.
ELM; P12813; -.
IntAct; P12813; 14.
STRING; 10090.ENSMUSP00000023779; -.
iPTMnet; P12813; -.
PhosphoSitePlus; P12813; -.
PaxDb; P12813; -.
PRIDE; P12813; -.
Ensembl; ENSMUST00000023779; ENSMUSP00000023779; ENSMUSG00000023034.
GeneID; 15370; -.
KEGG; mmu:15370; -.
UCSC; uc007xsv.2; mouse.
CTD; 3164; -.
MGI; MGI:1352454; Nr4a1.
eggNOG; KOG4217; Eukaryota.
eggNOG; ENOG410YWNC; LUCA.
GeneTree; ENSGT00870000136372; -.
HOGENOM; HOG000230925; -.
HOVERGEN; HBG052663; -.
InParanoid; P12813; -.
KO; K04465; -.
OMA; TDRHGLQ; -.
OrthoDB; EOG091G0GUM; -.
PhylomeDB; P12813; -.
TreeFam; TF315430; -.
Reactome; R-MMU-198693; AKT phosphorylates targets in the nucleus.
Reactome; R-MMU-383280; Nuclear Receptor transcription pathway.
PRO; PR:P12813; -.
Proteomes; UP000000589; Chromosome 15.
Bgee; ENSMUSG00000023034; -.
CleanEx; MM_NR4A1; -.
ExpressionAtlas; P12813; baseline and differential.
Genevisible; P12813; MM.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0031965; C:nuclear membrane; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:BHF-UCL.
GO; GO:0035259; F:glucocorticoid receptor binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IPI:MGI.
GO; GO:0042803; F:protein homodimerization activity; IDA:MGI.
GO; GO:0004879; F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:MGI.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0006915; P:apoptotic process; IMP:MGI.
GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; ISO:MGI.
GO; GO:0071376; P:cellular response to corticotropin-releasing hormone stimulus; IDA:UniProtKB.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; ISO:MGI.
GO; GO:0071310; P:cellular response to organic substance; IDA:MGI.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; ISO:MGI.
GO; GO:0035767; P:endothelial cell chemotaxis; ISO:MGI.
GO; GO:0045444; P:fat cell differentiation; IDA:UniProtKB.
GO; GO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; IDA:MGI.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0061469; P:regulation of type B pancreatic cell proliferation; ISS:UniProtKB.
GO; GO:0010035; P:response to inorganic substance; ISO:MGI.
GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR003071; Nuc_orp_HMR_rcpt.
InterPro; IPR003070; Nuc_orph_rcpt.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR01285; HMRNUCRECPTR.
PRINTS; PR01284; NUCLEARECPTR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; Cytoplasm; DNA-binding; Metal-binding;
Nucleus; Phosphoprotein; Receptor; Reference proteome; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 601 Nuclear receptor subfamily 4 group A
member 1.
/FTId=PRO_0000053716.
DNA_BIND 267 342 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 270 290 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 306 330 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 412 462 Ligand-binding. {ECO:0000255}.
COMPBIAS 83 94 Poly-Ser.
COMPBIAS 186 190 Poly-Pro.
COMPBIAS 586 589 Poly-Pro.
MOD_RES 344 344 Phosphoserine; by PKA.
{ECO:0000250|UniProtKB:P22829}.
MOD_RES 354 354 Phosphoserine; by PKA, RPS6KA1 and
RPS6KA3. {ECO:0000250|UniProtKB:P22829}.
CONFLICT 45 45 A -> T (in Ref. 2; CAA42718).
{ECO:0000305}.
SEQUENCE 601 AA; 64738 MW; 8CFF45B58253887B CRC64;
MPCIQAQYGT PATSPGPRDH LTGDPLALEF GKPTMDLASP ETAPAAPATL PSFSTFMDGY
TGEFDTFLYQ LPGTTQPCSS ACSSASSTSS SSSSATSPAS ASFKFEDFQV YGCYPGTLSG
PLDETLSSSG SEYYGSPCSA PSPSTPNFQP SQLSPWDGSF GHFSPSQTYE GLWAWTEQLP
KASSGPPPPP TFFSFSPPTG PSPSLAQSSL KLFPPPATHQ LGEGESYSMP AAFPGLAPTS
PNRDTSGILD APVTSTKSRS GASGGSEGRC AVCGDNASCQ HYGVRTCEGC KGFFKRTVQK
SAKYICLANK DCPVDKRRRN RCQFCRFQKC LAVGMVKEVV RTDSLKGRRG RLPSKPKQPP
DASPTNLLTS LIRAHLDSGP STAKLDYSKF QELVLPRFGK EDAGDVQQFY DLLSGSLDVI
RKWAEKIPGF IELCPGDQDL LLESAFLELF ILRLAYRSKP GEGKLIFCSG LVLHQLQCAR
GFGDWIDNIL AFSRSLHSLG VDVPAFACLS ALVLITDRHG LQDPRRVEEL QNRIASCLKE
HMATVAGDPQ PASCLSRLLG KLPELRTLCT QGLQRIFCLK LEDLVPPPPI VDKIFMDTLS
F


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