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Nuclear receptor subfamily 4 group A member 3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma)

 NR4A3_MOUSE             Reviewed;         627 AA.
Q9QZB6; Q9QZB5;
26-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
25-OCT-2017, entry version 131.
RecName: Full=Nuclear receptor subfamily 4 group A member 3;
AltName: Full=Orphan nuclear receptor TEC;
AltName: Full=Translocated in extraskeletal chondrosarcoma;
Name=Nr4a3; Synonyms=Tec;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
PubMed=10701778; DOI=10.1089/104454900314636;
Maltais A., Labelle Y.;
"Structure and expression of the mouse gene encoding the orphan
nuclear receptor TEC.";
DNA Cell Biol. 19:121-130(2000).
[2]
FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
PubMed=11784868; DOI=10.1128/MCB.22.3.935-945.2002;
Ponnio T., Burton Q., Pereira F.A., Wu D.K., Conneely O.M.;
"The nuclear receptor Nor-1 is essential for proliferation of the
semicircular canals of the mouse inner ear.";
Mol. Cell. Biol. 22:935-945(2002).
[3]
FUNCTION, REGION, DOMAIN, AND INTERACTION WITH NCOA1; NCOA2; NCOA3;
KAT2B; MED1 AND EP300.
PubMed=12709428; DOI=10.1074/jbc.M300088200;
Wansa K.D., Harris J.M., Yan G., Ordentlich P., Muscat G.E.;
"The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-
activation, coactivator recruitment, and activation by the purine
anti-metabolite 6-mercaptopurine.";
J. Biol. Chem. 278:24776-24790(2003).
[4]
FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
PubMed=13129926; DOI=10.1074/jbc.M307496200;
DeYoung R.A., Baker J.C., Cado D., Winoto A.;
"The orphan steroid receptor Nur77 family member Nor-1 is essential
for early mouse embryogenesis.";
J. Biol. Chem. 278:47104-47109(2003).
[5]
FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
PubMed=15456880; DOI=10.1128/MCB.24.20.9070-9078.2004;
Ponnio T., Conneely O.M.;
"nor-1 regulates hippocampal axon guidance, pyramidal cell survival,
and seizure susceptibility.";
Mol. Cell. Biol. 24:9070-9078(2004).
[6]
FUNCTION.
PubMed=18325999; DOI=10.1210/en.2007-1202;
Pearen M.A., Myers S.A., Raichur S., Ryall J.G., Lynch G.S.,
Muscat G.E.;
"The orphan nuclear receptor, NOR-1, a target of beta-adrenergic
signaling, regulates gene expression that controls oxidative
metabolism in skeletal muscle.";
Endocrinology 149:2853-2865(2008).
[7]
FUNCTION.
PubMed=18945812; DOI=10.1210/me.2008-0161;
Chao L.C., Bensinger S.J., Villanueva C.J., Wroblewski K.,
Tontonoz P.;
"Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1.";
Mol. Endocrinol. 22:2596-2608(2008).
[8]
FUNCTION.
PubMed=19523439; DOI=10.1016/j.bbrc.2009.06.023;
Nonogaki K., Kaji T., Ohba Y., Sumii M., Wakameda M., Tamari T.;
"Serotonin 5-HT2C receptor-independent expression of hypothalamic
NOR1, a novel modulator of food intake and energy balance, in mice.";
Biochem. Biophys. Res. Commun. 386:311-315(2009).
[9]
FUNCTION.
PubMed=19153266; DOI=10.1161/CIRCULATIONAHA.108.822056;
Nomiyama T., Zhao Y., Gizard F., Findeisen H.M., Heywood E.B.,
Jones K.L., Conneely O.M., Bruemmer D.;
"Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates
neointima formation after vascular injury.";
Circulation 119:577-586(2009).
[10]
FUNCTION, AND INDUCTION.
PubMed=20558821; DOI=10.1161/CIRCRESAHA.110.222083;
Zhao Y., Howatt D.A., Gizard F., Nomiyama T., Findeisen H.M.,
Heywood E.B., Jones K.L., Conneely O.M., Daugherty A., Bruemmer D.;
"Deficiency of the NR4A orphan nuclear receptor NOR1 decreases
monocyte adhesion and atherosclerosis.";
Circ. Res. 107:501-511(2010).
[11]
FUNCTION.
PubMed=20566846; DOI=10.1073/pnas.1007088107;
Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L.,
Silvaggi J., Spiegelman B.M., Perlmann T.;
"NR4A orphan nuclear receptors as mediators of CREB-dependent
neuroprotection.";
Proc. Natl. Acad. Sci. U.S.A. 107:12317-12322(2010).
[12]
FUNCTION.
PubMed=21868379; DOI=10.1074/jbc.M111.295840;
Gizard F., Zhao Y., Findeisen H.M., Qing H., Cohn D., Heywood E.B.,
Jones K.L., Nomiyama T., Bruemmer D.;
"Transcriptional regulation of S phase kinase-associated protein 2 by
NR4A orphan nuclear receptor NOR1 in vascular smooth muscle cells.";
J. Biol. Chem. 286:35485-35493(2011).
[13]
FUNCTION, INDUCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=23897430; DOI=10.1128/MCB.00385-13;
Kim S.G., Lee B., Kim D.H., Kim J., Lee S., Lee S.K., Lee J.W.;
"Control of energy balance by hypothalamic gene circuitry involving
two nuclear receptors, neuron-derived orphan receptor 1 and
glucocorticoid receptor.";
Mol. Cell. Biol. 33:3826-3834(2013).
[14]
FUNCTION.
PubMed=24586680; DOI=10.1371/journal.pone.0089311;
Garcia-Faroldi G., Melo F.R., Bruemmer D., Conneely O.M., Pejler G.,
Lundequist A.;
"Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and
granule content.";
PLoS ONE 9:E89311-E89311(2014).
[15]
FUNCTION.
PubMed=24806827; DOI=10.1002/stem.1747;
Qing H., Liu Y., Zhao Y., Aono J., Jones K.L., Heywood E.B.,
Howatt D., Binkley C.M., Daugherty A., Liang Y., Bruemmer D.;
"Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic
stem cells accelerates atherosclerosis.";
Stem Cells 32:2419-2429(2014).
-!- FUNCTION: Transcriptional activator that binds to regulatory
elements in promoter regions in a cell- and response element
(target)-specific manner (PubMed:12709428). Induces gene
expression by binding as monomers to the NR4A1 response element
(NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response
element (NurRE) site in the promoter of their regulated target
genes (By similarity). Plays a role in the regulation of
proliferation, survival and differentiation of many different cell
types and also in metabolism and inflammation. Mediates
proliferation of vascular smooth muscle, myeloid progenitor cell
and type B pancreatic cells; promotes mitogen-induced vascular
smooth muscle cell proliferation through transactivation of SKP2
promoter by binding a NBRE site (PubMed:21868379). Upon PDGF
stimulation, stimulates vascular smooth muscle cell proliferation
by regulating CCND1 and CCND2 expression. In islets, induces type
B pancreatic cell proliferation through up-regulation of genes
that activate cell cycle, as well as genes that cause degradation
of the CDKN1A (By similarity). Negatively regulates myeloid
progenitor cell proliferation by repressing RUNX1 in a NBRE site-
independent manner (PubMed:24806827). During inner ear, plays a
role as a key mediator of the proliferative growth phase of
semicircular canal development (PubMed:11784868). Mediates also
survival of neuron and smooth muscle cells; mediates CREB-induced
neuronal survival, and during hippocampus development, plays a
critical role in pyramidal cell survival and axonal guidance
(PubMed:20566846, PubMed:15456880). Is required for S phase entry
of the cell cycle and survival of smooth muscle cells by inducing
CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in
CCND1 promoter, resulting in the activation of the promoter and
CCND1 transcription (PubMed:19153266). Plays also a role in
inflammation; upon TNF stimulation, mediates monocyte adhesion by
inducing the expression of VCAM1 and ICAM1 by binding to the NBRE
consensus site (PubMed:20558821). In mast cells activated by Fc-
epsilon receptor cross-linking, promotes the synthesis and release
of cytokines but impairs events leading to degranulation
(PubMed:24586680). Plays also a role in metabolism; by modulating
feeding behavior; and by playing a role in energy balance by
inhibiting the glucocorticoid-induced orexigenic neuropeptides
AGRP expression, at least in part by forming a complex with
activated NR3C1 on the AGRP- glucocorticoid response element
(GRE), and thus weakening the DNA binding activity of NR3C1
(PubMed:23897430, PubMed:19523439). Upon catecholamines
stimulation, regulates gene expression that controls oxidative
metabolism in skeletal muscle (PubMed:18325999). Plays a role in
glucose transport by regulating translocation of the SLC2A4
glucose transporter to the cell surface (By similarity). Finally,
during gastrulation plays a crucial role in the formation of
anterior mesoderm by controlling cell migration (PubMed:13129926).
Inhibits adipogenesis (PubMed:18945812). Also participates in
cardiac hypertrophy by activating PARP1 (By similarity).
{ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q92570,
ECO:0000269|PubMed:11784868, ECO:0000269|PubMed:12709428,
ECO:0000269|PubMed:13129926, ECO:0000269|PubMed:15456880,
ECO:0000269|PubMed:18325999, ECO:0000269|PubMed:18945812,
ECO:0000269|PubMed:19153266, ECO:0000269|PubMed:19523439,
ECO:0000269|PubMed:20558821, ECO:0000269|PubMed:20566846,
ECO:0000269|PubMed:21868379, ECO:0000269|PubMed:23897430,
ECO:0000269|PubMed:24586680, ECO:0000269|PubMed:24806827}.
-!- SUBUNIT: Interacts with SIX3 (via homeobox); differentially
regulates the transcriptional activities of NR4A3. Interacts with
NCOA2; potentiates the activity of the NR4A3 (PubMed:12709428).
Interacts with NCOA1, NCOA3, MED1 and KAT2B. Interacts with EP300
and NCOA2; mediates the recruitment of MED1 in the coactivator
complex (PubMed:12709428). Interacts with the constituents of DNA-
PK heterotrimer PRKDC, XRCC6 and XRCC5; phosphorylates and
prevents NR4A3 ubiquitinylation and degradation (By similarity).
Interacts with NR3C1 (via nuclear receptor DNA-binding domain);
the interactions represses transcription activity of NR4A3 on the
POMC promoter Nur response element (NurRE). Interacts with TRIM28;
the interactions potentiates NR4A3 activity on NurRE promoter.
Binds DNA as a monomer and homodimer. Interacts with PARP1;
activates PARP1 by improving acetylation of PARP1 and suppressing
the interaction between PARP1 and SIRT1 (By similarity).
{ECO:0000250|UniProtKB:P51179, ECO:0000250|UniProtKB:Q92570,
ECO:0000269|PubMed:12709428}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00407}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Long;
IsoId=Q9QZB6-1; Sequence=Displayed;
Name=2; Synonyms=Short, TECdeltaC;
IsoId=Q9QZB6-2; Sequence=VSP_010083, VSP_010084;
-!- TISSUE SPECIFICITY: Ubiquitous. Highest levels of expression in
brain. Widely expressed throughout the arcuate nucleus region of
the hypothalamus, namely in AgRP neurons.
-!- DEVELOPMENTAL STAGE: Not expressed during the earliest stages of
vesicle formation (E10.5). Expression begins coincidentally with
the initiation of regional shape changes in the otic vesicle at
E11.5 and is restricted to the dorsolateral region. At E13.5,
expression is limited to the inner edge of the semicircular canal
epithelium, flanking the site of fusion, and this restricted
expression continues at P1 (PubMed:11784868). At E14.5 expression
is observed in the primitive plexiform layer of the hippocampus.
At P0, expression is observed in both the pyramidal and granule
cell layers. Expression persistes in these cells in the adult
hippocampus after their postnatal maturation. In addition,
expression is also observed in the hilar mossy cells of the
dentate gyrus (PubMed:15456880). At E7.5 dpc expression is
ubiquitous, whereas at E9 and E9.5 dpc, expression is restricted
to the brain (PubMed:13129926). {ECO:0000269|PubMed:11784868,
ECO:0000269|PubMed:13129926, ECO:0000269|PubMed:15456880}.
-!- INDUCTION: Induced by inflammatory stimuli (PubMed:20558821). Up-
regulated by the anorexigenic signal leptin via the transcription
factor cyclic AMP response element-binding protein (CREB).
Suppressed by orexigenic signal glucocorticoid that mobilizes
NR3C1 to inhibit NR4A3 expression by antagonizing the action of
CREB (PubMed:23897430). {ECO:0000269|PubMed:20558821,
ECO:0000269|PubMed:23897430}.
-!- DOMAIN: The AF-1 domain mediates transcription activation. The N-
terminal region (1-292) directly interacts with the C-terminal LBD
(380-627): the interaction is potentiated by AF-1-mediated
recruitment of NCOA2. {ECO:0000269|PubMed:12709428}.
-!- PTM: Phosphorylated by PRKDC. {ECO:0000250|UniProtKB:Q92570}.
-!- DISRUPTION PHENOTYPE: Nr4a3 homozygous knockout mice are viable
and normal in appearance; however, abnormal hyperactive and
partial bidirectional circling behavior is observed by 3 weeks of
age in 15% of these mice. The circling behavior is interspersed
with noncircling periods of feeding, grooming, and sleep
(PubMed:11784868). A small percentage of adult Nr4a3 homozygotes
displayes brief freezing spells with tonic posturing that are
exacerbated with handling (PubMed:15456880). The overall food
consumption of Nr4a3 homozygous knockout mice is higher. Moreover,
Nr4a3 homozygous mice lose more body weight upon fasting but
clearly consumed more food during refeeding. By the end of the
fasting period, Nr4a3 homozygous mice display signs of exhaustion
(PubMed:23897430). Nr4a3 homozygous leads to embryonic lethality
around E8.5 of gestation (PubMed:13129926).
{ECO:0000269|PubMed:11784868, ECO:0000269|PubMed:13129926,
ECO:0000269|PubMed:15456880, ECO:0000269|PubMed:23897430}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR4
subfamily. {ECO:0000305}.
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EMBL; AF191211; AAF05622.1; -; mRNA.
EMBL; AF191212; AAF05623.1; -; mRNA.
CCDS; CCDS18163.1; -. [Q9QZB6-1]
RefSeq; NP_001294918.1; NM_001307989.1. [Q9QZB6-2]
RefSeq; NP_056558.1; NM_015743.3. [Q9QZB6-1]
RefSeq; XP_006537719.1; XM_006537656.3. [Q9QZB6-1]
RefSeq; XP_006537720.1; XM_006537657.3. [Q9QZB6-1]
RefSeq; XP_006537721.1; XM_006537658.1. [Q9QZB6-1]
UniGene; Mm.247261; -.
UniGene; Mm.487935; -.
ProteinModelPortal; Q9QZB6; -.
SMR; Q9QZB6; -.
BioGrid; 201804; 3.
STRING; 10090.ENSMUSP00000030025; -.
PhosphoSitePlus; Q9QZB6; -.
PaxDb; Q9QZB6; -.
PRIDE; Q9QZB6; -.
DNASU; 18124; -.
Ensembl; ENSMUST00000030025; ENSMUSP00000030025; ENSMUSG00000028341. [Q9QZB6-1]
GeneID; 18124; -.
KEGG; mmu:18124; -.
UCSC; uc008suu.1; mouse. [Q9QZB6-1]
UCSC; uc008suv.1; mouse. [Q9QZB6-2]
CTD; 8013; -.
MGI; MGI:1352457; Nr4a3.
eggNOG; KOG4217; Eukaryota.
eggNOG; ENOG410YWNC; LUCA.
GeneTree; ENSGT00760000118887; -.
HOGENOM; HOG000230925; -.
HOVERGEN; HBG052663; -.
InParanoid; Q9QZB6; -.
KO; K08559; -.
PhylomeDB; Q9QZB6; -.
TreeFam; TF315430; -.
Reactome; R-MMU-383280; Nuclear Receptor transcription pathway.
PRO; PR:Q9QZB6; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000028341; -.
CleanEx; MM_NR4A3; -.
ExpressionAtlas; Q9QZB6; baseline and differential.
Genevisible; Q9QZB6; MM.
GO; GO:0042629; C:mast cell granule; IEA:GOC.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0035259; F:glucocorticoid receptor binding; IEA:Ensembl.
GO; GO:0035035; F:histone acetyltransferase binding; IPI:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0004879; F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0001223; F:transcription coactivator binding; IPI:UniProtKB.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:UniProtKB.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0030534; P:adult behavior; IMP:MGI.
GO; GO:0031100; P:animal organ regeneration; IEA:Ensembl.
GO; GO:0007411; P:axon guidance; IMP:MGI.
GO; GO:0045333; P:cellular respiration; IMP:UniProtKB.
GO; GO:0071870; P:cellular response to catecholamine stimulus; IDA:UniProtKB.
GO; GO:0071376; P:cellular response to corticotropin-releasing hormone stimulus; IDA:UniProtKB.
GO; GO:0044320; P:cellular response to leptin stimulus; IDA:UniProtKB.
GO; GO:0035726; P:common myeloid progenitor cell proliferation; IMP:UniProtKB.
GO; GO:0097009; P:energy homeostasis; IMP:UniProtKB.
GO; GO:0045444; P:fat cell differentiation; IDA:UniProtKB.
GO; GO:0007369; P:gastrulation; IMP:UniProtKB.
GO; GO:0021766; P:hippocampus development; IMP:MGI.
GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
GO; GO:0043303; P:mast cell degranulation; IMP:UniProtKB.
GO; GO:0001707; P:mesoderm formation; IMP:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
GO; GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IMP:UniProtKB.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
GO; GO:1903204; P:negative regulation of oxidative stress-induced neuron death; IGI:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
GO; GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.
GO; GO:0045787; P:positive regulation of cell cycle; IMP:MGI.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:UniProtKB.
GO; GO:0046321; P:positive regulation of fatty acid oxidation; IMP:UniProtKB.
GO; GO:2000253; P:positive regulation of feeding behavior; IMP:UniProtKB.
GO; GO:0010828; P:positive regulation of glucose transport; ISS:UniProtKB.
GO; GO:2000108; P:positive regulation of leukocyte apoptotic process; IMP:MGI.
GO; GO:0038097; P:positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway; IMP:UniProtKB.
GO; GO:0032765; P:positive regulation of mast cell cytokine production; IMP:UniProtKB.
GO; GO:1900625; P:positive regulation of monocyte aggregation; IMP:UniProtKB.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0009444; P:pyruvate oxidation; IMP:UniProtKB.
GO; GO:2000505; P:regulation of energy homeostasis; IMP:UniProtKB.
GO; GO:0048660; P:regulation of smooth muscle cell proliferation; ISS:UniProtKB.
GO; GO:0061469; P:regulation of type B pancreatic cell proliferation; ISS:UniProtKB.
GO; GO:0042542; P:response to hydrogen peroxide; IMP:MGI.
GO; GO:0048752; P:semicircular canal morphogenesis; IMP:MGI.
GO; GO:0060005; P:vestibular reflex; IMP:MGI.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR_like_domain.
InterPro; IPR003072; NOR1_rcpt.
InterPro; IPR003070; Nuc_orph_rcpt.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR01286; NORNUCRECPTR.
PRINTS; PR01284; NUCLEARECPTR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
Nucleus; Receptor; Reference proteome; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 627 Nuclear receptor subfamily 4 group A
member 3.
/FTId=PRO_0000053723.
DNA_BIND 290 365 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 293 313 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 329 353 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 1 292 Interaction with NCOA1, NCOA2, NCOA3 and
KAT2B. {ECO:0000269|PubMed:12709428}.
REGION 1 139 Required for DNA-PK heterotrimer.
{ECO:0000250|UniProtKB:Q92570}.
REGION 1 112 Activation function (AF)-1 domain.
{ECO:0000269|PubMed:12709428}.
REGION 380 627 Interaction with KAT2B.
{ECO:0000269|PubMed:12709428}.
REGION 441 491 Ligand-binding. {ECO:0000255}.
COMPBIAS 99 111 Poly-His.
COMPBIAS 112 115 Poly-Gln.
COMPBIAS 285 288 Poly-Ser.
VAR_SEQ 420 429 YCPTDQATAG -> VSSMNAFEPL (in isoform 2).
{ECO:0000303|PubMed:10701778}.
/FTId=VSP_010083.
VAR_SEQ 430 627 Missing (in isoform 2).
{ECO:0000303|PubMed:10701778}.
/FTId=VSP_010084.
SEQUENCE 627 AA; 68454 MW; 2F49CB4C8DE315A8 CRC64;
MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYTKLTM DLGSTGIMAT ATTSLPSFST
FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH HHHHHHHHHH HQQQQPSIPP
PSGPEDEVLP STSMYFKQSP PSTPTTPGFP PQAGALWDDE LPSAPGCIAP GPLLDPQMKA
VPPMAAAARF PIFFKPSPPH PPAPSPAGGH HLGYDPTAAA ALSLPLGAAA AAGSQAAALE
GHPYGLPLAK RTATLTFPPL GLTASPTASS LLGESPSLPS PPNRSSSSGE GTCAVCGDNA
ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF QKCLSVGMVK
EVVRTDSLKG RRGRLPSKPK SPLQQEPSQP SPPSPPICMM NALVRALTDA TPRDLDYSRY
CPTDQATAGT DAEHVQQFYN LLTASIDVSR SWAEKIPGFT DLPKEDQTLL IESAFLELFV
LRLSIRSNTA EDKFVFCNGL VLHRLQCLRG FGEWLDSIKD FSLNLQSLNL DIQALACLSA
LSMITERHGL KEPKRVEELC TKITSSLKDH QRKGQALEPS EPKVLRALVE LRKICTQGLQ
RIFYLKLEDL VPPPSVIDKL FLDTLPF


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Catalog number Product name Quantity
EIAAB27818 Mouse,Mus musculus,Nr4a3,Nuclear receptor subfamily 4 group A member 3,Orphan nuclear receptor TEC,Tec,Translocated in extraskeletal chondrosarcoma
EIAAB27785 Homo sapiens,Human,NR1I2,Nuclear receptor subfamily 1 group I member 2,Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,PXR,Steroid and xenobiotic receptor,SXR
EIAAB27820 CHN,CSMF,Homo sapiens,Human,MINOR,Mitogen-induced nuclear orphan receptor,Neuron-derived orphan receptor 1,NOR1,NR4A3,Nuclear hormone receptor NOR-1,Nuclear receptor subfamily 4 group A member 3,TEC
EIAAB27812 Early response protein NAK1,GFRP1,HMR,Homo sapiens,Human,NAK1,NR4A1,Nuclear hormone receptor NUR_77,Nuclear receptor subfamily 4 group A member 1,Nur77,Orphan nuclear receptor HMR,Orphan nuclear recep
EIAAB27815 Hzf-3,Nr4a2,Nuclear orphan receptor HZF-3,Nuclear receptor subfamily 4 group A member 2,Nurr1,NUR-related factor 1,Orphan nuclear receptor NURR1,Rat,Rattus norvegicus,Regenerating liver nuclear recept
EIAAB27810 Gfrp,Hmr,Mouse,Mus musculus,N10,Nr4a1,Nuclear hormone receptor NUR_77,Nuclear protein N10,Nuclear receptor subfamily 4 group A member 1,Nur77,Orphan nuclear receptor HMR
EIAAB27794 Homo sapiens,Human,NR2C2,Nuclear receptor subfamily 2 group C member 2,Orphan nuclear receptor TAK1,Orphan nuclear receptor TR4,TAK1,Testicular receptor 4,TR4
EIAAB27795 Mouse,Mtr2r1,Mus musculus,Nr2c2,Nuclear receptor subfamily 2 group C member 2,Orphan nuclear receptor TAK1,Orphan nuclear receptor TR4,Tak1,Testicular receptor 4,Tr4
EIAAB35718 Mouse,Mus musculus,Nr1f3,Nuclear receptor ROR-gamma,Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,Retinoid-related orphan receptor-gamma,Rorc,Rorg,Thor,Thymus orphan recepto
EIAAB27782 Liver X receptor beta,Lxrb,Nr1h2,Nuclear receptor subfamily 1 group H member 2,Orphan nuclear receptor OR-1,Oxysterols receptor LXR-beta,Rat,Rattus norvegicus,Ubiquitously-expressed nuclear receptor,U
EIAAB27814 Homo sapiens,Human,Immediate-early response protein NOT,NOT,NR4A2,Nuclear receptor subfamily 4 group A member 2,NURR1,Orphan nuclear receptor NURR1,TINUR,Transcriptionally-inducible nuclear receptor
EIAAB35717 Homo sapiens,Human,NR1F3,Nuclear receptor ROR-gamma,Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,Retinoid-related orphan receptor-gamma,RORC,RORG,RZRG
EIAAB35715 Homo sapiens,Human,NR1F2,Nuclear receptor ROR-beta,Nuclear receptor RZR-beta,Nuclear receptor subfamily 1 group F member 2,Retinoid-related orphan receptor-beta,RORB,RZRB
EIAAB35712 Homo sapiens,Human,NR1F1,Nuclear receptor ROR-alpha,Nuclear receptor RZR-alpha,Nuclear receptor subfamily 1 group F member 1,Retinoid-related orphan receptor-alpha,RORA,RZRA
EIAAB27793 Homo sapiens,Human,NR2C1,Nuclear receptor subfamily 2 group C member 1,Orphan nuclear receptor TR2,Testicular receptor 2,TR2
EIAAB27790 Mouse,mTR2,Mus musculus,Nr2c1,Nuclear receptor subfamily 2 group C member 1,Orphan nuclear receptor TR2,Testicular receptor 2,Tr2,Tr2-11
EIAAB27787 CAR,Car,Constitutive androstane receptor,Mouse,Mus musculus,Nr1i3,Nuclear receptor subfamily 1 group I member 3,Orphan nuclear receptor MB67
EIAAB35716 Nr1f2,Nuclear receptor ROR-beta,Nuclear receptor RZR-beta,Nuclear receptor subfamily 1 group F member 2,Rat,Rattus norvegicus,Retinoid-related orphan receptor-beta,Rorb,Rzrb
EIAAB35713 Mouse,Mus musculus,Nr1f1,Nuclear receptor ROR-alpha,Nuclear receptor RZR-alpha,Nuclear receptor subfamily 1 group F member 1,Retinoid-related orphan receptor-alpha,Rora,Rzra
EIAAB27811 Canis familiaris,Canis lupus familiaris,Dog,HMR,NR4A1,Nuclear receptor subfamily 4 group A member 1,Orphan nuclear receptor HMR,Orphan nuclear receptor NGFI-B
EIAAB27784 Mouse,Mus musculus,Nr1i2,Nuclear receptor subfamily 1 group I member 2,Orphan nuclear receptor PXR,Pregnane X receptor,Pxr
EIAAB27792 Nr2c1,Nuclear receptor subfamily 2 group C member 1,Orphan nuclear receptor TR2,Rat,Rattus norvegicus,Testicular receptor 2,Tr2
EIAAB27796 Nr2c2,Nuclear receptor subfamily 2 group C member 2,Orphan nuclear receptor TR4,Rat,Rattus norvegicus,Testicular receptor 4,Tr4
EIAAB27786 Nr1i2,Nuclear receptor subfamily 1 group I member 2,Orphan nuclear receptor PXR,Pregnane X receptor,Pxr,Rat,Rattus norvegicus
EIAAB27819 Neuron-derived orphan receptor 1_2,Nor1,Nr4a3,Nuclear hormone receptor NOR-1_NOR-2,Nuclear receptor subfamily 4 group A member 3,Rat,Rattus norvegicus


 

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