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Nucleolysin TIA-1 (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1)

 TIA1_MOUSE              Reviewed;         386 AA.
P52912;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
07-JUN-2017, entry version 140.
RecName: Full=Nucleolysin TIA-1;
AltName: Full=RNA-binding protein TIA-1;
AltName: Full=T-cell-restricted intracellular antigen-1;
Short=TIA-1;
Name=Tia1; Synonyms=Tia;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Blood;
PubMed=8759725;
Lowin B., French L., Martinou J.-C., Tschopp J.;
"Expression of the CTL-associated protein TIA-1 during murine
embryogenesis.";
J. Immunol. 157:1448-1454(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8871565; DOI=10.1093/nar/24.19.3829;
Beck A.R.P., Medley O.G., O'Brien S., Anderson P., Streuli M.;
"Structure, tissue distribution and genomic organization of the murine
RRM-type RNA binding proteins TIA-1 and TIAR.";
Nucleic Acids Res. 24:3829-3836(1996).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[4]
STRUCTURE BY NMR OF 104-199.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the RNA binding domain in cytotoxic granule-
associated RNA binding protein 1.";
Submitted (SEP-2006) to the PDB data bank.
[5]
STRUCTURE BY NMR OF 105-199.
PubMed=18500819; DOI=10.1021/bi7024723;
Kuwasako K., Takahashi M., Tochio N., Abe C., Tsuda K., Inoue M.,
Terada T., Shirouzu M., Kobayashi N., Kigawa T., Taguchi S.,
Tanaka A., Hayashizaki Y., Guntert P., Muto Y., Yokoyama S.;
"Solution structure of the second RNA recognition motif (RRM) domain
of murine T cell intracellular antigen-1 (TIA-1) and its RNA
recognition mode.";
Biochemistry 47:6437-6450(2008).
-!- FUNCTION: Involved in alternative pre-RNA splicing and regulation
of mRNA translation by binding to AU-rich elements (AREs) located
in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic
activity against cytotoxic lymphocyte target cells. May be
involved in apoptosis (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasmic granule
{ECO:0000250|UniProtKB:P31483}. Nucleus
{ECO:0000250|UniProtKB:P31483}. Note=Accumulates in cytoplasmic
stress granules (SG) following cellular damage.
{ECO:0000250|UniProtKB:P31483}.
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EMBL; U00689; AAA03711.1; -; mRNA.
EMBL; U55862; AAC52871.1; -; mRNA.
CCDS; CCDS20312.1; -.
PIR; S72435; S72435.
RefSeq; NP_035715.1; NM_011585.4.
UniGene; Mm.333219; -.
PDB; 2DGO; NMR; -; A=87-199.
PDB; 2RNE; NMR; -; A=87-224.
PDBsum; 2DGO; -.
PDBsum; 2RNE; -.
ProteinModelPortal; P52912; -.
SMR; P52912; -.
BioGrid; 204190; 1.
IntAct; P52912; 1.
MINT; MINT-4593011; -.
STRING; 10090.ENSMUSP00000093425; -.
iPTMnet; P52912; -.
PhosphoSitePlus; P52912; -.
EPD; P52912; -.
PaxDb; P52912; -.
PRIDE; P52912; -.
Ensembl; ENSMUST00000095753; ENSMUSP00000093425; ENSMUSG00000071337.
GeneID; 21841; -.
KEGG; mmu:21841; -.
UCSC; uc009crp.2; mouse.
CTD; 7072; -.
MGI; MGI:107914; Tia1.
eggNOG; KOG0148; Eukaryota.
eggNOG; ENOG410XQ8U; LUCA.
GeneTree; ENSGT00870000136413; -.
HOGENOM; HOG000206748; -.
HOVERGEN; HBG105006; -.
InParanoid; P52912; -.
KO; K13201; -.
OMA; YEHRHAA; -.
OrthoDB; EOG091G0FH8; -.
PhylomeDB; P52912; -.
TreeFam; TF312915; -.
Reactome; R-MMU-6803529; FGFR2 alternative splicing.
EvolutionaryTrace; P52912; -.
PRO; PR:P52912; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000071337; -.
ExpressionAtlas; P52912; baseline and differential.
Genevisible; P52912; MM.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0010494; C:cytoplasmic stress granule; IDA:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0097165; C:nuclear stress granule; IDA:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0017091; F:AU-rich element binding; IDA:MGI.
GO; GO:0003723; F:RNA binding; ISO:MGI.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0042036; P:negative regulation of cytokine biosynthetic process; IMP:MGI.
GO; GO:0017148; P:negative regulation of translation; IMP:MGI.
GO; GO:1904037; P:positive regulation of epithelial cell apoptotic process; IEA:Ensembl.
GO; GO:1903608; P:protein localization to cytoplasmic stress granule; ISO:MGI.
GO; GO:0048024; P:regulation of mRNA splicing, via spliceosome; ISO:MGI.
CDD; cd12615; RRM1_TIA1; 1.
CDD; cd12618; RRM2_TIA1; 1.
CDD; cd12621; RRM3_TIA1; 1.
InterPro; IPR000504; RRM_dom.
InterPro; IPR003954; RRM_dom_euk.
InterPro; IPR034827; TIA-1_RRM1.
InterPro; IPR034830; TIA1_RRM2.
InterPro; IPR034832; TIA1_RRM3.
Pfam; PF00076; RRM_1; 3.
SMART; SM00360; RRM; 3.
SMART; SM00361; RRM_1; 3.
SUPFAM; SSF54928; SSF54928; 2.
PROSITE; PS50102; RRM; 3.
1: Evidence at protein level;
3D-structure; Acetylation; Apoptosis; Complete proteome; Nucleus;
Reference proteome; Repeat; RNA-binding.
CHAIN 1 386 Nucleolysin TIA-1.
/FTId=PRO_0000081977.
DOMAIN 7 83 RRM 1. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 106 184 RRM 2. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 214 286 RRM 3. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P31483}.
STRAND 106 112 {ECO:0000244|PDB:2DGO}.
HELIX 119 126 {ECO:0000244|PDB:2DGO}.
HELIX 127 129 {ECO:0000244|PDB:2DGO}.
STRAND 132 139 {ECO:0000244|PDB:2DGO}.
TURN 141 143 {ECO:0000244|PDB:2DGO}.
STRAND 146 156 {ECO:0000244|PDB:2DGO}.
HELIX 157 166 {ECO:0000244|PDB:2DGO}.
TURN 167 169 {ECO:0000244|PDB:2DGO}.
STRAND 178 183 {ECO:0000244|PDB:2DGO}.
SEQUENCE 386 AA; 42800 MW; 51BFFE90E046D3AE CRC64;
MEDEMPKTLY VGNLSRDVTE ALILQLFSQI GPCKNCKMIM DTAGNDPYCF VEFHEHRHAA
AALAAMNGRK IMGKEVKVNW ATTPSSQKKD TSSSTVVSTQ RSQDHFHVFV GDLSPEITTE
DIKAAFAPFG RISDARVVKD MATGKSKGYG FVSFFNKWDA ENAIQQMGGQ WLGGRQIRTN
WATRKPPAPK STYESNTKQL SYDEVVSQSS PNNCTVYCGG VTSGLTEQLM RQTFSPFGQI
MEIRVFPDKG YSFVRFSSHE SAAHAIVSVN GTTIEGHVVK CYWGKETLDM INPVQQQNQI
GYPPTYGQWG QWYGNAQQIG QYVPNGWQVP AYGVYGQPWS QQGFNQTQSS APWMGPNYSV
PPPQGQNGSM LPSQPAGYRV AGYETQ


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