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Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37)

 NUP37_HUMAN             Reviewed;         326 AA.
Q8NFH4; Q9H644;
27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
23-MAY-2018, entry version 148.
RecName: Full=Nucleoporin Nup37;
Short=p37;
AltName: Full=Nup107-160 subcomplex subunit Nup37;
Name=NUP37;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
PubMed=12196509; DOI=10.1083/jcb.200206106;
Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., Matunis M.J.;
"Proteomic analysis of the mammalian nuclear pore complex.";
J. Cell Biol. 158:915-927(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-326.
TISSUE=Small intestine;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
IDENTIFICATION IN THE NUP107-160 COMPLEX, AND SUBCELLULAR LOCATION.
PubMed=15146057; DOI=10.1091/mbc.E03-12-0878;
Loieodice I., Alves A., Rabut G., Van Overbeek M., Ellenberg J.,
Sibarita J.-B., Doye V.;
"The entire Nup107-160 complex, including three new members, is
targeted as one entity to kinetochores in mitosis.";
Mol. Biol. Cell 15:3333-3344(2004).
[5]
FUNCTION OF THE NUP107-160 COMPLEX.
PubMed=17363900; DOI=10.1038/sj.emboj.7601642;
Zuccolo M., Alves A., Galy V., Bolhy S., Formstecher E., Racine V.,
Sibarita J.-B., Fukagawa T., Shiekhattar R., Yen T., Doye V.;
"The human Nup107-160 nuclear pore subcomplex contributes to proper
kinetochore functions.";
EMBO J. 26:1853-1864(2007).
[6]
IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
NUP107-160 COMPLEX.
PubMed=17360435; DOI=10.1073/pnas.0700058104;
Glavy J.S., Krutchinsky A.N., Cristea I.M., Berke I.C., Boehmer T.,
Blobel G., Chait B.T.;
"Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160
subcomplex.";
Proc. Natl. Acad. Sci. U.S.A. 104:3811-3816(2007).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
-!- FUNCTION: Component of the Nup107-160 subcomplex of the nuclear
pore complex (NPC). The Nup107-160 subcomplex is required for the
assembly of a functional NPC. The Nup107-160 subcomplex is also
required for normal kinetochore microtubule attachment, mitotic
progression and chromosome segregation.
{ECO:0000269|PubMed:17363900}.
-!- SUBUNIT: Component of the Nup107-160 subcomplex of the nuclear
pore complex (NPC). The Nup107-160 subcomplex includes NUP160,
NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.
{ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17360435}.
-!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore.
Nucleus, nuclear pore complex.
-!- SEQUENCE CAUTION:
Sequence=BAB15422.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AF514994; AAM76705.1; -; mRNA.
EMBL; BC000861; AAH00861.2; -; mRNA.
EMBL; AK026271; BAB15422.1; ALT_INIT; mRNA.
CCDS; CCDS9089.1; -.
RefSeq; NP_076962.2; NM_024057.3.
UniGene; Hs.444276; -.
PDB; 5A9Q; EM; 23.00 A; 2/K/T/b=1-326.
PDBsum; 5A9Q; -.
ProteinModelPortal; Q8NFH4; -.
BioGrid; 122491; 24.
CORUM; Q8NFH4; -.
IntAct; Q8NFH4; 18.
MINT; Q8NFH4; -.
STRING; 9606.ENSP00000251074; -.
TCDB; 1.I.1.1.3; the eukaryotic nuclear pore complex (e-npc) family.
iPTMnet; Q8NFH4; -.
PhosphoSitePlus; Q8NFH4; -.
BioMuta; NUP37; -.
DMDM; 27923820; -.
EPD; Q8NFH4; -.
MaxQB; Q8NFH4; -.
PaxDb; Q8NFH4; -.
PeptideAtlas; Q8NFH4; -.
PRIDE; Q8NFH4; -.
Ensembl; ENST00000251074; ENSP00000251074; ENSG00000075188.
Ensembl; ENST00000552283; ENSP00000448054; ENSG00000075188.
GeneID; 79023; -.
KEGG; hsa:79023; -.
UCSC; uc001tjc.4; human.
CTD; 79023; -.
DisGeNET; 79023; -.
EuPathDB; HostDB:ENSG00000075188.8; -.
GeneCards; NUP37; -.
HGNC; HGNC:29929; NUP37.
HPA; HPA056300; -.
HPA; HPA073708; -.
MIM; 609264; gene.
neXtProt; NX_Q8NFH4; -.
OpenTargets; ENSG00000075188; -.
PharmGKB; PA134948997; -.
eggNOG; ENOG410IQ10; Eukaryota.
eggNOG; ENOG410XSZQ; LUCA.
GeneTree; ENSGT00390000010777; -.
HOGENOM; HOG000007266; -.
HOVERGEN; HBG052695; -.
InParanoid; Q8NFH4; -.
KO; K14302; -.
OMA; CWHPEEA; -.
OrthoDB; EOG091G0NYD; -.
PhylomeDB; Q8NFH4; -.
TreeFam; TF325769; -.
Reactome; R-HSA-1169408; ISG15 antiviral mechanism.
Reactome; R-HSA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
Reactome; R-HSA-159227; Transport of the SLBP independent Mature mRNA.
Reactome; R-HSA-159230; Transport of the SLBP Dependant Mature mRNA.
Reactome; R-HSA-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
Reactome; R-HSA-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
Reactome; R-HSA-165054; Rev-mediated nuclear export of HIV RNA.
Reactome; R-HSA-168271; Transport of Ribonucleoproteins into the Host Nucleus.
Reactome; R-HSA-168276; NS1 Mediated Effects on Host Pathways.
Reactome; R-HSA-168325; Viral Messenger RNA Synthesis.
Reactome; R-HSA-168333; NEP/NS2 Interacts with the Cellular Export Machinery.
Reactome; R-HSA-170822; Regulation of Glucokinase by Glucokinase Regulatory Protein.
Reactome; R-HSA-180746; Nuclear import of Rev protein.
Reactome; R-HSA-180910; Vpr-mediated nuclear import of PICs.
Reactome; R-HSA-191859; snRNP Assembly.
Reactome; R-HSA-2467813; Separation of Sister Chromatids.
Reactome; R-HSA-2500257; Resolution of Sister Chromatid Cohesion.
Reactome; R-HSA-3108214; SUMOylation of DNA damage response and repair proteins.
Reactome; R-HSA-3301854; Nuclear Pore Complex (NPC) Disassembly.
Reactome; R-HSA-3371453; Regulation of HSF1-mediated heat shock response.
Reactome; R-HSA-4551638; SUMOylation of chromatin organization proteins.
Reactome; R-HSA-4570464; SUMOylation of RNA binding proteins.
Reactome; R-HSA-4615885; SUMOylation of DNA replication proteins.
Reactome; R-HSA-5578749; Transcriptional regulation by small RNAs.
Reactome; R-HSA-5663220; RHO GTPases Activate Formins.
Reactome; R-HSA-6784531; tRNA processing in the nucleus.
Reactome; R-HSA-68877; Mitotic Prometaphase.
SignaLink; Q8NFH4; -.
ChiTaRS; NUP37; human.
GenomeRNAi; 79023; -.
PRO; PR:Q8NFH4; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000075188; -.
CleanEx; HS_NUP37; -.
ExpressionAtlas; Q8NFH4; baseline and differential.
Genevisible; Q8NFH4; HS.
GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005635; C:nuclear envelope; TAS:Reactome.
GO; GO:0031080; C:nuclear pore outer ring; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; HDA:UniProtKB.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
GO; GO:0006406; P:mRNA export from nucleus; TAS:Reactome.
GO; GO:0016032; P:viral process; TAS:Reactome.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR037626; NUP37.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
InterPro; IPR036322; WD40_repeat_dom_sf.
PANTHER; PTHR22806; PTHR22806; 1.
Pfam; PF00400; WD40; 1.
SMART; SM00320; WD40; 3.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00678; WD_REPEATS_1; 1.
PROSITE; PS50082; WD_REPEATS_2; 1.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
3D-structure; Cell cycle; Cell division; Centromere; Chromosome;
Chromosome partition; Complete proteome; Kinetochore; Mitosis;
mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
Reference proteome; Repeat; Translocation; Transport; WD repeat.
CHAIN 1 326 Nucleoporin Nup37.
/FTId=PRO_0000051109.
REPEAT 6 54 WD 1.
REPEAT 61 109 WD 2.
REPEAT 115 154 WD 3.
REPEAT 159 195 WD 4.
REPEAT 199 237 WD 5.
REPEAT 242 282 WD 6.
REPEAT 287 324 WD 7.
SEQUENCE 326 AA; 36708 MW; 188E6D9D0CDF2DD7 CRC64;
MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT FQEEEADVEG
IQYKTLRTFH HGVRVDGIAW SPETRLDSLP PVIKFCTSAA DMKIRLFTSD LQDKNEYKVL
EGHTDFINGL VFDPKEGQEI ASVSDDHTCR IWNLEGVQTA HFVLHSPGMS VCWHPEETFK
LMVAEKNGTI RFYDLLAQQA ILSLESEQVP LMSAHWCLKN TFKVGAVAGN DWLIWDITRS
SYPQNKRPVH MDRACLFRWS TISENLFATT GYPGKMASQF QIHHLGHPQP ILMGSVAVGS
GLSWHRTLPL CVIGGDHKLL FWVTEV


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