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Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

 NCAP_CVHSA              Reviewed;         422 AA.
P59595; Q7T3Z4; Q7TA14; Q7TF99; Q80E50;
23-APR-2003, integrated into UniProtKB/Swiss-Prot.
23-APR-2003, sequence version 1.
12-SEP-2018, entry version 111.
RecName: Full=Nucleoprotein {ECO:0000255|HAMAP-Rule:MF_04096};
AltName: Full=Nucleocapsid protein {ECO:0000255|HAMAP-Rule:MF_04096};
Short=NC {ECO:0000255|HAMAP-Rule:MF_04096};
Short=Protein N {ECO:0000255|HAMAP-Rule:MF_04096};
Name=N {ECO:0000255|HAMAP-Rule:MF_04096}; ORFNames=9a;
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome
coronavirus).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Nidovirales; Coronaviridae; Coronavirinae; Betacoronavirus.
NCBI_TaxID=227859;
NCBI_TaxID=9606; Homo sapiens (Human).
NCBI_TaxID=9675; Paguma larvata (Masked palm civet).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Urbani;
PubMed=12730500; DOI=10.1126/science.1085952;
Rota P.A., Oberste M.S., Monroe S.S., Nix W.A., Campagnoli R.,
Icenogle J.P., Penaranda S., Bankamp B., Maher K., Chen M.-H.,
Tong S., Tamin A., Lowe L., Frace M., DeRisi J.L., Chen Q., Wang D.,
Erdman D.D., Peret T.C.T., Burns C., Ksiazek T.G., Rollin P.E.,
Sanchez A., Liffick S., Holloway B., Limor J., McCaustland K.,
Olsen-Rasmussen M., Fouchier R., Guenther S., Osterhaus A.D.M.E.,
Drosten C., Pallansch M.A., Anderson L.J., Bellini W.J.;
"Characterization of a novel coronavirus associated with severe acute
respiratory syndrome.";
Science 300:1394-1399(2003).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Tor2;
PubMed=12730501; DOI=10.1126/science.1085953;
Marra M.A., Jones S.J.M., Astell C.R., Holt R.A., Brooks-Wilson A.,
Butterfield Y.S.N., Khattra J., Asano J.K., Barber S.A., Chan S.Y.,
Cloutier A., Coughlin S.M., Freeman D., Girn N., Griffith O.L.,
Leach S.R., Mayo M., McDonald H., Montgomery S.B., Pandoh P.K.,
Petrescu A.S., Robertson A.G., Schein J.E., Siddiqui A., Smailus D.E.,
Stott J.M., Yang G.S., Plummer F., Andonov A., Artsob H., Bastien N.,
Bernard K., Booth T.F., Bowness D., Czub M., Drebot M., Fernando L.,
Flick R., Garbutt M., Gray M., Grolla A., Jones S., Feldmann H.,
Meyers A., Kabani A., Li Y., Normand S., Stroher U., Tipples G.A.,
Tyler S., Vogrig R., Ward D., Watson B., Brunham R.C., Krajden M.,
Petric M., Skowronski D.M., Upton C., Roper R.L.;
"The genome sequence of the SARS-associated coronavirus.";
Science 300:1399-1404(2003).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate CUHK-Su10, and Isolate CUHK-W1;
PubMed=12853594; DOI=10.1056/NEJM200307103490216;
Tsui S.K.W., Chim S.S.C., Lo Y.M.D.;
"Coronavirus genomic-sequence variations and the epidemiology of the
severe acute respiratory syndrome.";
N. Engl. J. Med. 349:187-188(2003).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate GZ50, and Isolate HKU-36871;
PubMed=12958366; DOI=10.1126/science.1087139;
Guan Y., Zheng B.J., He Y.Q., Liu X.L., Zhuang Z.X., Cheung C.L.,
Luo S.W., Li P.H., Zhang L.J., Guan Y.J., Butt K.M., Wong K.L.,
Chan K.W., Lim W., Shortridge K.F., Yuen K.Y., Peiris J.S.M.,
Poon L.L.M.;
"Isolation and characterization of viruses related to the SARS
coronavirus from animals in southern China.";
Science 302:276-278(2003).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate HKU-39849;
PubMed=12876307; DOI=10.1177/15353702-0322807-13;
Zeng F.Y., Chan C.W., Chan M.N., Chen J.D., Chow K.Y.C., Hon C.C.C.,
Hui R.K.H., Li J., Li V.Y.Y., Wang C.Y., Wang P.Y., Guan Y., Zheng B.,
Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M., Leung F.C.;
"The complete genome sequence of severe acute respiratory syndrome
coronavirus strain HKU-39849 (HK-39).";
Exp. Biol. Med. 228:866-873(2003).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Sin2500, Isolate Sin2677, Isolate Sin2679,
Isolate Sin2748, and Isolate sin2774;
PubMed=12781537; DOI=10.1016/S0140-6736(03)13414-9;
Ruan Y., Wei C.L., Ling A.E., Vega V.B., Thoreau H., Se Thoe S.Y.,
Chia J.-M., Ng P., Chiu K.P., Lim L., Zhang T., Chan K.P., Oon L.E.L.,
Ng M.L., Leo S.Y., Ng L.F.P., Ren E.C., Stanton L.W., Long P.M.,
Liu E.T.;
"Comparative full-length genome sequence analysis of 14 SARS
coronavirus isolates and common mutations associated with putative
origins of infection.";
Lancet 361:1779-1785(2003).
[7]
ERRATUM.
Ruan Y., Wei C.L., Ling A.E., Vega V.B., Thoreau H., Se Thoe S.Y.,
Chia J.-M., Ng P., Chiu K.P., Lim L., Zhang T., Chan K.P., Oon L.E.L.,
Ng M.L., Leo S.Y., Ng L.F.P., Ren E.C., Stanton L.W., Long P.M.,
Liu E.T.;
Lancet 361:1832-1832(2003).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate BJ01, Isolate BJ02, Isolate BJ03, Isolate BJ04, and
Isolate GD01;
Qin E., Zhu Q., Yu M., Fan B., Chang G., Si B., Yang B., Peng W.,
Jiang T., Liu B., Deng Y., Liu H., Zhang Y., Wang C., Li Y., Gan Y.,
Li X., Lu F., Tan G., Yang R., Cao W.S., Wang J., Chen W., Cong L.,
Deng Y., Dong W., Han Y., Hu W., Lei M., Li C., Li G., Li G., Li H.,
Li S., Li S., Li W., Li W., Lin W., Liu J., Liu Z., Lu H., Ni P.,
Qi Q., Sun Y., Tang L., Tong Z., Wang J., Wang X., Wu Q., Xi Y.,
Xu Z., Yang L., Ye C., Ye J., Zhang B., Zhang F., Zhang J., Zhang X.,
Zhou J., Yang H.;
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate TW1;
Yeh S.-H., Kao C.-L., Tsai C.-Y., Liu C.-J., Chen D.-S., Chen P.-J.;
"The complete genome of SARS coronavirus clone TW1.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate FRA;
Eickmann M., Becker S., Klenk H.-D., Doerr H.W., Stadler K.,
Censini S., Guidotti S., Masignani V., Scarselli M., Mora M.,
Donati C., Han J., Song H.C., Abrignani S., Covacci A., Rappuoli R.;
"SARS virus is a close relative of type II coronaviruses.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Frankfurt 1;
PubMed=12917450; DOI=10.1099/vir.0.19424-0;
Thiel V., Ivanov K.A., Putics A., Hertzig T., Schelle B., Bayer S.,
Weissbrich B., Snijder E.J., Rabenau H., Doerr H.W., Gorbalenya A.E.,
Ziebuhr J.;
"Mechanisms and enzymes involved in SARS coronavirus genome
expression.";
J. Gen. Virol. 84:2305-2315(2003).
[12]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
Sun K., Anwar A., Gupta V., Tabiin M.T., Atkinson R.,
Chandrasekarn A., August T.J.;
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[13]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate ZJ01;
PubMed=14527350;
Li L., Wang Z., Lu Y., Bao Q., Chen S., Wu N., Cheng S., Weng J.,
Zhang Y., Yan J., Mei L., Wang X., Zhu H., Yu Y., Zhang M., Li M.,
Yao J., Lu Q., Yao P., Bo X., Wo J., Wang S., Hu S.;
"Severe acute respiratory syndrome-associated coronavirus genotype and
its characterization.";
Chin. Med. J. 116:1288-1292(2003).
[14]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate TWC;
Yang J.-Y., Lin J.-H., Chiu S.-C., Wang S.-F., Lee S.C., Lin Y.-C.,
Hsu C.-K., Chen H.-Y., Chang J.G., Chen P.-J., Su I.-J.;
"Genomic sequence of SARS isolate from the first fatal case in
Taiwan.";
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[15]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Shanghai LY;
Yuan Z., Zhang X., Hu Y., Lan S., Wang H., Zhou Z., Wen Y.;
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[16]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Taiwan TC1, Isolate Taiwan TC2, and Isolate Taiwan TC3;
Chang J.-G.C., Lin T.-H., Chen C.-M., Lin C.-S., Chan W.-L.,
Shih M.-C.;
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[17]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate TWH, Isolate TWJ, Isolate TWK, Isolate TWS, and
Isolate TWY;
Shu H.Y., Wu K.M., Tsai S.F.;
"The complete genome of SARS coronavirus TWH.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[18]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate HSR 1;
Canducci F., Clementi M., Poli G., Vicenzi E.;
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[19]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate TWC2, and Isolate TWC3;
Yang J.-Y., Lin J.-H., Chiu S.-C., Wang S.-F., Lee H.-C., Lin Y.-C.,
Hsu C.-K., Chen H.-Y., Chen P.-J., Su I.-J.;
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
[20]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate AS;
Balotta C., Corvasce S., Violin M., Galli M., Moroni M.,
Vigevani G.M., Ruan Y.J., Salemi M.;
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[21]
INTERACTION WITH MEMBRANE PROTEIN M.
PubMed=15351485; DOI=10.1016/j.virusres.2004.05.002;
He R., Leeson A., Ballantine M., Andonov A., Baker L., Dobie F.,
Li Y., Bastien N., Feldmann H., Strocher U., Theriault S., Cutts T.,
Cao J., Booth T.F., Plummer F.A., Tyler S., Li X.;
"Characterization of protein-protein interactions between the
nucleocapsid protein and membrane protein of the SARS coronavirus.";
Virus Res. 105:121-125(2004).
[22]
INTERACTION WITH HOST HNRNPA1.
PubMed=15862300; DOI=10.1016/j.febslet.2005.03.080;
Luo H., Chen Q., Chen J., Chen K., Shen X., Jiang H.;
"The nucleocapsid protein of SARS coronavirus has a high binding
affinity to the human cellular heterogeneous nuclear ribonucleoprotein
A1.";
FEBS Lett. 579:2623-2628(2005).
[23]
SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=17210170; DOI=10.1016/j.virol.2006.11.027;
Stertz S., Reichelt M., Spiegel M., Kuri T., Martinez-Sobrido L.,
Garcia-Sastre A., Weber F., Kochs G.;
"The intracellular sites of early replication and budding of SARS-
coronavirus.";
Virology 361:304-315(2007).
[24]
PHOSPHORYLATION AT SER-177 BY HOST GSK3A AND GSK3B, AND SUBCELLULAR
LOCATION.
PubMed=19106108; DOI=10.1074/jbc.M805747200;
Wu C.H., Yeh S.H., Tsay Y.G., Shieh Y.H., Kao C.L., Chen Y.S.,
Wang S.H., Kuo T.J., Chen D.S., Chen P.J.;
"Glycogen synthase kinase-3 regulates the phosphorylation of severe
acute respiratory syndrome coronavirus nucleocapsid protein and viral
replication.";
J. Biol. Chem. 284:5229-5239(2009).
[25]
INTERACTION WITH ENVELOPE SMALL MEMBRANE PROTEIN E.
PubMed=24766657; DOI=10.1186/1423-0127-21-34;
Tseng Y.T., Wang S.M., Huang K.J., Wang C.T.;
"SARS-CoV envelope protein palmitoylation or nucleocapid association
is not required for promoting virus-like particle production.";
J. Biomed. Sci. 21:34-34(2014).
[26]
STRUCTURE BY NMR OF 45-181.
PubMed=15147189; DOI=10.1021/bi036155b;
Huang Q., Yu L., Petros A.M., Gunasekera A., Liu Z., Xu N., Hajduk P.,
Mack J., Fesik S.W., Olejniczak E.T.;
"Structure of the N-terminal RNA-binding domain of the SARS CoV
nucleocapsid protein.";
Biochemistry 43:6059-6063(2004).
[27]
X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 362-370.
PubMed=16041067; DOI=10.1107/S0907444905013090;
Blicher T., Kastrup J.S., Buus S., Gajhede M.;
"High-resolution structure of HLA-A*1101 in complex with SARS
nucleocapsid peptide.";
Acta Crystallogr. D 61:1031-1040(2005).
[28]
X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 270-370.
PubMed=16627473; DOI=10.1074/jbc.M602107200;
Yu I.M., Oldham M.L., Zhang J., Chen J.;
"Crystal structure of the severe acute respiratory syndrome (SARS)
coronavirus nucleocapsid protein dimerization domain reveals
evolutionary linkage between corona- and arteriviridae.";
J. Biol. Chem. 281:17134-17139(2006).
[29]
X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 248-365.
PubMed=17379242; DOI=10.1016/j.jmb.2007.02.069;
Chen C.Y., Chang C.K., Chang Y.W., Sue S.C., Bai H.I., Riang L.,
Hsiao C.D., Huang T.H.;
"Structure of the SARS coronavirus nucleocapsid protein RNA-binding
dimerization domain suggests a mechanism for helical packaging of
viral RNA.";
J. Mol. Biol. 368:1075-1086(2007).
[30]
RNA-BINDING, AND X-RAY CRYSTALLOGRAPHY (1.17 ANGSTROMS) OF 49-129.
STRAIN=Isolate Tor2;
PubMed=17229691; DOI=10.1128/JVI.02236-06;
Saikatendu K.S., Joseph J.S., Subramanian V., Neuman B.W.,
Buchmeier M.J., Stevens R.C., Kuhn P.;
"Ribonucleocapsid formation of severe acute respiratory syndrome
coronavirus through molecular action of the N-terminal domain of N
protein.";
J. Virol. 81:3913-3921(2007).
[31]
STRUCTURE BY NMR OF 248-365.
PubMed=18561946; DOI=10.1016/j.jmb.2007.11.093;
Takeda M., Chang C.K., Ikeya T., Guentert P., Chang Y.H., Hsu Y.L.,
Huang T.H., Kainosho M.;
"Solution structure of the c-terminal dimerization domain of SARS
coronavirus nucleocapsid protein solved by the SAIL-NMR method.";
J. Mol. Biol. 380:608-622(2008).
[32]
X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 346-354.
PubMed=20844028; DOI=10.1128/JVI.01464-10;
Liu J., Wu P., Gao F., Qi J., Kawana-Tachikawa A., Xie J.,
Vavricka C.J., Iwamoto A., Li T., Gao G.F.;
"Novel immunodominant peptide presentation strategy: a featured HLA-
A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by
intrachain hydrogen bonds from severe acute respiratory syndrome
coronavirus nucleocapsid protein.";
J. Virol. 84:11849-11857(2010).
-!- FUNCTION: Packages the positive strand viral genome RNA into a
helical ribonucleocapsid (RNP) and plays a fundamental role during
virion assembly through its interactions with the viral genome and
membrane protein M. Plays an important role in enhancing the
efficiency of subgenomic viral RNA transcription as well as viral
replication. {ECO:0000255|HAMAP-Rule:MF_04096,
ECO:0000269|PubMed:17210170}.
-!- SUBUNIT: Homooligomer. Both monomeric and oligomeric forms
interact with RNA. Interacts with protein M. Interacts with NSP3;
this interaction serves to tether the genome to the newly
translated replicase-transcriptase complex at a very early stage
of infection. {ECO:0000255|HAMAP-Rule:MF_04096,
ECO:0000269|PubMed:15351485, ECO:0000269|PubMed:15862300,
ECO:0000269|PubMed:24766657}.
-!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04096,
ECO:0000269|PubMed:17210170, ECO:0000269|PubMed:19106108}. Host
endoplasmic reticulum-Golgi intermediate compartment
{ECO:0000255|HAMAP-Rule:MF_04096, ECO:0000269|PubMed:17210170}.
Host Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_04096,
ECO:0000269|PubMed:17210170}. Host cytoplasm, host perinuclear
region {ECO:0000269|PubMed:17210170}. Note=Located inside the
virion, complexed with the viral RNA. Probably associates with ER-
derived membranes where it participates in viral RNA synthesis and
virus budding. {ECO:0000255|HAMAP-Rule:MF_04096}.
-!- PTM: ADP-ribosylated. The ADP-ribosylation is retained in the
virion during infection. {ECO:0000255|HAMAP-Rule:MF_04096}.
-!- PTM: Phosphorylated on serine and threonine residues (By
similarity). Phosphorylated by host GSK3A and GSK3B.
Phosphorylation allows recruitment of host RNA helicase DDX1 which
facilitates template readthrough and enables longer subgenomic
mRNA synthesis. {ECO:0000255|HAMAP-Rule:MF_04096,
ECO:0000269|PubMed:19106108, ECO:0000269|PubMed:24766657}.
-!- SIMILARITY: Belongs to the betacoronavirus nucleocapsid protein
family. {ECO:0000255|HAMAP-Rule:MF_04096}.
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EMBL; AY278741; AAP13445.1; -; Genomic_RNA.
EMBL; AY274119; AAP41047.1; -; Genomic_RNA.
EMBL; AY278554; AAP13814.1; -; Genomic_RNA.
EMBL; AY282752; AAP30714.1; -; Genomic_RNA.
EMBL; AY304492; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY304495; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY278491; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY283794; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY283795; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY283796; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY283797; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY278487; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY278488; AAP30037.1; -; Genomic_RNA.
EMBL; AY278489; AAP51234.1; -; Genomic_RNA.
EMBL; AY278490; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY279354; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY291451; AAP37024.1; -; Genomic_RNA.
EMBL; AY310120; AAP50495.1; -; Genomic_RNA.
EMBL; AY291315; AAP33707.1; -; Genomic_RNA.
EMBL; AY307165; AAP49024.1; -; Genomic_RNA.
EMBL; AY290752; AAP44772.1; -; Genomic_RNA.
EMBL; AY321118; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY322208; AAP82974.1; -; Genomic_RNA.
EMBL; AY338174; AAQ01605.1; -; Genomic_RNA.
EMBL; AY338175; AAQ01617.1; -; Genomic_RNA.
EMBL; AY348314; AAP97890.1; -; Genomic_RNA.
EMBL; AP006557; BAC81358.1; -; Genomic_RNA.
EMBL; AP006558; BAC81372.1; -; Genomic_RNA.
EMBL; AP006559; BAC81386.1; -; Genomic_RNA.
EMBL; AP006560; BAC81400.1; -; Genomic_RNA.
EMBL; AP006561; BAC81414.1; -; Genomic_RNA.
EMBL; AY323977; AAP72984.1; -; Genomic_RNA.
EMBL; AY362698; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY362699; -; NOT_ANNOTATED_CDS; Genomic_RNA.
EMBL; AY427439; AAQ94070.1; -; Genomic_RNA.
RefSeq; NP_828858.1; NC_004718.3.
PDB; 1SSK; NMR; -; A=45-181.
PDB; 1X7Q; X-ray; 1.45 A; C=362-370.
PDB; 2CJR; X-ray; 2.50 A; A/B/C/D/E/F/G/H=248-365.
PDB; 2GIB; X-ray; 1.75 A; A/B=270-370.
PDB; 2JW8; NMR; -; A/B=248-365.
PDB; 2OFZ; X-ray; 1.17 A; A=49-174.
PDB; 2OG3; X-ray; 1.85 A; A=49-174.
PDB; 3I6L; X-ray; 2.40 A; F=346-354.
PDBsum; 1SSK; -.
PDBsum; 1X7Q; -.
PDBsum; 2CJR; -.
PDBsum; 2GIB; -.
PDBsum; 2JW8; -.
PDBsum; 2OFZ; -.
PDBsum; 2OG3; -.
PDBsum; 3I6L; -.
DisProt; DP00948; -.
ProteinModelPortal; P59595; -.
SMR; P59595; -.
MINT; P59595; -.
PRIDE; P59595; -.
GeneID; 1489678; -.
KEGG; vg:1489678; -.
OrthoDB; VOG0900008T; -.
EvolutionaryTrace; P59595; -.
Proteomes; UP000000354; Genome.
Proteomes; UP000103670; Genome.
Proteomes; UP000109640; Genome.
Proteomes; UP000116947; Genome.
Proteomes; UP000121636; Genome.
Proteomes; UP000131569; Genome.
Proteomes; UP000131955; Genome.
Proteomes; UP000137377; Genome.
Proteomes; UP000138690; Genome.
Proteomes; UP000143093; Genome.
Proteomes; UP000145651; Genome.
Proteomes; UP000146108; Genome.
Proteomes; UP000146181; Genome.
Proteomes; UP000146296; Genome.
Proteomes; UP000148194; Genome.
Proteomes; UP000153467; Genome.
Proteomes; UP000160648; Genome.
Proteomes; UP000172416; Genome.
GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
HAMAP; MF_04096; BETA_CORONA_NCAP; 1.
InterPro; IPR001218; Corona_nucleocap.
InterPro; IPR037179; Nucleocapsid_C.
InterPro; IPR037195; Nucleocapsid_N.
Pfam; PF00937; Corona_nucleoca; 1.
PIRSF; PIRSF003888; Corona_nucleocap; 1.
SUPFAM; SSF103068; SSF103068; 1.
SUPFAM; SSF110304; SSF110304; 1.
1: Evidence at protein level;
3D-structure; ADP-ribosylation; Complete proteome; Host cytoplasm;
Host Golgi apparatus; Phosphoprotein; Reference proteome;
Ribonucleoprotein; RNA-binding; Transcription;
Transcription regulation; Viral nucleoprotein; Virion.
CHAIN 1 422 Nucleoprotein.
/FTId=PRO_0000106003.
REGION 42 187 RNA-binding. {ECO:0000255|HAMAP-
Rule:MF_04096}.
REGION 45 181 RNA-binding.
REGION 259 362 Dimerization. {ECO:0000255|HAMAP-
Rule:MF_04096}.
COMPBIAS 181 213 Ser-rich.
COMPBIAS 220 225 Poly-Leu.
COMPBIAS 240 245 Poly-Gln.
COMPBIAS 370 376 Poly-Lys.
MOD_RES 177 177 Phosphoserine; by host.
{ECO:0000255|HAMAP-Rule:MF_04096,
ECO:0000269|PubMed:19106108}.
VARIANT 50 50 T -> I (in strain: Isolate Frankfurt 1
and Isolate FRA).
VARIANT 154 154 N -> Y (in strain: Isolate BJ03).
VARIANT 193 193 G -> C (in strain: Isolate CUHK-Su10).
VARIANT 325 326 VT -> AA (in strain: Isolate Shanghai
LY).
STRAND 56 59 {ECO:0000244|PDB:1SSK}.
STRAND 61 63 {ECO:0000244|PDB:2OG3}.
STRAND 77 79 {ECO:0000244|PDB:1SSK}.
HELIX 81 83 {ECO:0000244|PDB:2OFZ}.
STRAND 85 91 {ECO:0000244|PDB:2OFZ}.
STRAND 94 96 {ECO:0000244|PDB:2OFZ}.
TURN 98 100 {ECO:0000244|PDB:1SSK}.
STRAND 102 104 {ECO:0000244|PDB:2OFZ}.
STRAND 108 113 {ECO:0000244|PDB:2OFZ}.
TURN 118 121 {ECO:0000244|PDB:2OFZ}.
STRAND 131 135 {ECO:0000244|PDB:2OFZ}.
STRAND 140 142 {ECO:0000244|PDB:2OFZ}.
TURN 145 147 {ECO:0000244|PDB:2OFZ}.
TURN 152 154 {ECO:0000244|PDB:2OFZ}.
STRAND 254 258 {ECO:0000244|PDB:2CJR}.
HELIX 260 262 {ECO:0000244|PDB:2CJR}.
HELIX 271 275 {ECO:0000244|PDB:2GIB}.
TURN 282 284 {ECO:0000244|PDB:2JW8}.
HELIX 290 295 {ECO:0000244|PDB:2GIB}.
HELIX 296 298 {ECO:0000244|PDB:2GIB}.
HELIX 302 306 {ECO:0000244|PDB:2GIB}.
HELIX 312 318 {ECO:0000244|PDB:2GIB}.
STRAND 319 325 {ECO:0000244|PDB:2GIB}.
STRAND 330 340 {ECO:0000244|PDB:2GIB}.
HELIX 347 357 {ECO:0000244|PDB:2GIB}.
HELIX 360 363 {ECO:0000244|PDB:2GIB}.
SEQUENCE 422 AA; 46025 MW; 43FC8750F1253034 CRC64;
MSDNGPQSNQ RSAPRITFGG PTDSTDNNQN GGRNGARPKQ RRPQGLPNNT ASWFTALTQH
GKEELRFPRG QGVPINTNSG PDDQIGYYRR ATRRVRGGDG KMKELSPRWY FYYLGTGPEA
SLPYGANKEG IVWVATEGAL NTPKDHIGTR NPNNNAATVL QLPQGTTLPK GFYAEGSRGG
SQASSRSSSR SRGNSRNSTP GSSRGNSPAR MASGGGETAL ALLLLDRLNQ LESKVSGKGQ
QQQGQTVTKK SAAEASKKPR QKRTATKQYN VTQAFGRRGP EQTQGNFGDQ DLIRQGTDYK
HWPQIAQFAP SASAFFGMSR IGMEVTPSGT WLTYHGAIKL DDKDPQFKDN VILLNKHIDA
YKTFPPTEPK KDKKKKTDEA QPLPQRQKKQ PTVTLLPAAD MDDFSRQLQN SMSGASADST
QA


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