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OX-2 membrane glycoprotein (MRC OX-2 antigen) (CD antigen CD200)

 OX2G_RAT                Reviewed;         278 AA.
P04218;
20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
20-MAR-1987, sequence version 1.
07-NOV-2018, entry version 141.
RecName: Full=OX-2 membrane glycoprotein;
AltName: Full=MRC OX-2 antigen;
AltName: CD_antigen=CD200;
Flags: Precursor;
Name=Cd200; Synonyms=Mox2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2862025;
Clark M.J., Gagnon J., Williams A.F., Barclay A.N.;
"MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a
structure like a single immunoglobulin light chain.";
EMBO J. 4:113-118(1985).
-!- FUNCTION: Costimulates T-cell proliferation. May regulate myeloid
cell activity in a variety of tissues.
-!- SUBUNIT: CD200 and CD200R1 interact via their respective N-
terminal Ig-like domains.
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein.
-!- TISSUE SPECIFICITY: Found on the surface of neurons, thymocytes,
B-cells and follicular dendritic cells.
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EMBL; X01785; CAA25925.1; -; mRNA.
PIR; A02114; TDRTOX.
UniGene; Rn.7085; -.
ProteinModelPortal; P04218; -.
SMR; P04218; -.
IntAct; P04218; 1.
STRING; 10116.ENSRNOP00000055253; -.
PaxDb; P04218; -.
PRIDE; P04218; -.
UCSC; RGD:3104; rat.
RGD; 3104; Cd200.
eggNOG; ENOG410IWZ9; Eukaryota.
eggNOG; ENOG410YRD3; LUCA.
HOGENOM; HOG000035940; -.
HOVERGEN; HBG031790; -.
InParanoid; P04218; -.
PhylomeDB; P04218; -.
PRO; PR:P04218; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0009986; C:cell surface; IDA:ARUK-UCL.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043005; C:neuron projection; IDA:ARUK-UCL.
GO; GO:0043025; C:neuronal cell body; IDA:ARUK-UCL.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0086080; F:protein binding involved in heterotypic cell-cell adhesion; IPI:ARUK-UCL.
GO; GO:0098609; P:cell-cell adhesion; IGI:ARUK-UCL.
GO; GO:0034113; P:heterotypic cell-cell adhesion; IGI:ARUK-UCL.
GO; GO:1900165; P:negative regulation of interleukin-6 secretion; IGI:ARUK-UCL.
GO; GO:0043031; P:negative regulation of macrophage activation; IEA:InterPro.
GO; GO:1905522; P:negative regulation of macrophage migration; IGI:ARUK-UCL.
GO; GO:0150079; P:negative regulation of neuroinflammatory response; IGI:ARUK-UCL.
GO; GO:1901215; P:negative regulation of neuron death; IGI:ARUK-UCL.
GO; GO:2000405; P:negative regulation of T cell migration; IGI:ARUK-UCL.
GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
GO; GO:0150077; P:regulation of neuroinflammatory response; IGI:ARUK-UCL.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR033321; CD200.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
InterPro; IPR013151; Immunoglobulin.
PANTHER; PTHR23277:SF72; PTHR23277:SF72; 1.
Pfam; PF00047; ig; 2.
SMART; SM00409; IG; 1.
SMART; SM00406; IGv; 1.
SUPFAM; SSF48726; SSF48726; 2.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Reference proteome; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 30 {ECO:0000255}.
CHAIN 31 278 OX-2 membrane glycoprotein.
/FTId=PRO_0000015126.
TOPO_DOM 31 232 Extracellular. {ECO:0000255}.
TRANSMEM 233 259 Helical. {ECO:0000255}.
TOPO_DOM 260 278 Cytoplasmic. {ECO:0000255}.
DOMAIN 31 141 Ig-like V-type.
DOMAIN 142 232 Ig-like C2-type.
CARBOHYD 95 95 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 103 103 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 110 110 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 157 157 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 181 181 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 190 190 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 51 121 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 118 136 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 160 214 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 278 AA; 31088 MW; B5A72DBE7B3116CD CRC64;
MGSPVFRRPF CHLSTYSLLW AIAAVALSTA QVEVVTQDER KLLHTTASLR CSLKTTQEPL
IVTWQKKKAV GPENMVTYSK AHGVVIQPTY KDRINITELG LLNTSITFWN TTLDDEGCYM
CLFNMFGSGK VSGTACLTLY VQPIVHLHYN YFEDHLNITC SATARPAPAI SWKGTGSGIE
NSTESHSHSN GTTSVTSILR VKDPKTQVGK EVICQVLYLG NVIDYKQSLD KGFWFSVPLL
LSIVSLVILL VLISILLYWK RHRNQERGES SQGMQRMK


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