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Odorant receptor 35a

 OR35A_DROME             Reviewed;         409 AA.
Q9V3Q2; Q8IP41;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
07-JUN-2004, sequence version 3.
12-SEP-2018, entry version 124.
RecName: Full=Odorant receptor 35a;
Name=Or35a; ORFNames=CG17868;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10471707;
Ashburner M., Misra S., Roote J., Lewis S.E., Blazej R.G., Davis T.,
Doyle C., Galle R.F., George R.A., Harris N.L., Hartzell G.,
Harvey D.A., Hong L., Houston K.A., Hoskins R.A., Johnson G.,
Martin C., Moshrefi A.R., Palazzolo M., Reese M.G., Spradling A.C.,
Tsang G., Wan K.H., Whitelaw K., Celniker S.E., Rubin G.M.;
"An exploration of the sequence of a 2.9-Mb region of the genome of
Drosophila melanogaster: the Adh region.";
Genetics 153:179-219(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
TISSUE SPECIFICITY.
PubMed=10943836; DOI=10.1016/S0092-8674(00)00021-0;
Vosshall L.B., Wong A.M., Axel R.;
"An olfactory sensory map in the fly brain.";
Cell 102:147-159(2000).
[5]
TISSUE SPECIFICITY, AND FUNCTION.
PubMed=16162917; DOI=10.1523/JNEUROSCI.2432-05.2005;
Yao C.A., Ignell R., Carlson J.R.;
"Chemosensory coding by neurons in the coeloconic sensilla of the
Drosophila antenna.";
J. Neurosci. 25:8359-8367(2005).
[6]
FUNCTION.
PubMed=16615896; DOI=10.1016/j.cell.2006.01.050;
Hallem E.A., Carlson J.R.;
"Coding of odors by a receptor repertoire.";
Cell 125:143-160(2006).
[7]
INTERACTION WITH ORCO, AND FUNCTION.
PubMed=21677030; DOI=10.1093/chemse/bjr053;
Nichols A.S., Chen S., Luetje C.W.;
"Subunit contributions to insect olfactory receptor function: channel
block and odorant recognition.";
Chem. Senses 36:781-790(2011).
[8]
FUNCTION.
PubMed=21613503; DOI=10.1523/JNEUROSCI.6254-10.2011;
Montague S.A., Mathew D., Carlson J.R.;
"Similar odorants elicit different behavioral and physiological
responses, some supersustained.";
J. Neurosci. 31:7891-7899(2011).
[9]
FUNCTION.
PubMed=21857978; DOI=10.1371/journal.pone.0022996;
Hoare D.J., Humble J., Jin D., Gilding N., Petersen R., Cobb M.,
McCrohan C.;
"Modeling peripheral olfactory coding in Drosophila larvae.";
PLoS ONE 6:E22996-E22996(2011).
[10]
FUNCTION.
PubMed=22038943; DOI=10.1093/chemse/bjr097;
Richgels P.K., Rollmann S.M.;
"Genetic variation in odorant receptors contributes to variation in
olfactory behavior in a natural population of Drosophila
melanogaster.";
Chem. Senses 37:229-240(2012).
-!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
behavior, depending on its substrates. The odorant receptor
repertoire encodes a large collection of odor stimuli that vary
widely in identity, intensity, and duration. Forms a complex with
Orco to form odorant-sensing units, providing sensitive and
prolonged odorant signaling and calcium permeability. Involved in
the behavioral responses to esters. Involved in the behavioral
responses to butanol, pentanol, hexanol, octanol, propyl acetate,
and butyl acetate. {ECO:0000269|PubMed:16162917,
ECO:0000269|PubMed:16615896, ECO:0000269|PubMed:21613503,
ECO:0000269|PubMed:21677030, ECO:0000269|PubMed:21857978,
ECO:0000269|PubMed:22038943}.
-!- SUBUNIT: Interacts with Orco. Complexes exist early in the
endomembrane system in olfactory sensory neurons (OSNs), coupling
these complexes to the conserved ciliary trafficking pathway.
{ECO:0000269|PubMed:21677030}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in ac3B olfactory sensory neurons in
the antenna. {ECO:0000269|PubMed:10943836,
ECO:0000269|PubMed:16162917}.
-!- MISCELLANEOUS: The atypical heteromeric and topological design of
the odorant receptors appears to be an insect-specific solution
for odor recognition, making the OR/Orco complex an attractive
target for the development of highly selective insect repellents
to disrupt olfactory-mediated host-seeking behaviors of insect
disease vectors. Odor-evoked OR currents are independent of known
G-protein-coupled second messenger pathways.
-!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AE014134; AAN10901.1; -; Genomic_DNA.
RefSeq; NP_723916.1; NM_165117.2.
STRING; 7227.FBpp0080339; -.
PaxDb; Q9V3Q2; -.
PRIDE; Q9V3Q2; -.
EnsemblMetazoa; FBtr0080781; FBpp0080339; FBgn0028946.
GeneID; 34918; -.
KEGG; dme:Dmel_CG17868; -.
CTD; 34918; -.
FlyBase; FBgn0028946; Or35a.
eggNOG; ENOG410KBWJ; Eukaryota.
eggNOG; ENOG4110MV2; LUCA.
GeneTree; ENSGT00560000077948; -.
InParanoid; Q9V3Q2; -.
KO; K08471; -.
OMA; KDFLYSM; -.
OrthoDB; EOG091G07C0; -.
PhylomeDB; Q9V3Q2; -.
GenomeRNAi; 34918; -.
PRO; PR:Q9V3Q2; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0028946; Expressed in 6 organ(s), highest expression level in antenna.
ExpressionAtlas; Q9V3Q2; differential.
Genevisible; Q9V3Q2; DM.
GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
GO; GO:0016021; C:integral component of membrane; HDA:FlyBase.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005549; F:odorant binding; ISS:FlyBase.
GO; GO:0004984; F:olfactory receptor activity; HDA:FlyBase.
GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; HDA:FlyBase.
InterPro; IPR004117; 7tm6_olfct_rcpt.
PANTHER; PTHR21137; PTHR21137; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Glycoprotein; Membrane; Olfaction;
Receptor; Reference proteome; Sensory transduction; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 409 Odorant receptor 35a.
/FTId=PRO_0000174241.
TOPO_DOM 1 35 Cytoplasmic. {ECO:0000255}.
TRANSMEM 36 56 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 57 64 Extracellular. {ECO:0000255}.
TRANSMEM 65 85 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 86 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 160 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 161 177 Extracellular. {ECO:0000255}.
TRANSMEM 178 198 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 199 273 Cytoplasmic. {ECO:0000255}.
TRANSMEM 274 294 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 295 302 Extracellular. {ECO:0000255}.
TRANSMEM 303 323 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 324 379 Cytoplasmic. {ECO:0000255}.
TRANSMEM 380 400 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 401 409 Extracellular. {ECO:0000255}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 409 AA; 47388 MW; EB1EB3ACDCF9581E CRC64;
MVRYVPRFAD GQKVKLAWPL AVFRLNHIFW PLDPSTGKWG RYLDKVLAVA MSLVFMQHND
AELRYLRFEA SNRNLDAFLT GMPTYLILVE AQFRSLHILL HFEKLQKFLE IFYANIYIDP
RKEPEMFRKV DGKMIINRLV SAMYGAVISL YLIAPVFSII NQSKDFLYSM IFPFDSDPLY
IFVPLLLTNV WVGIVIDTMM FGETNLLCEL IVHLNGSYML LKRDLQLAIE KILVARDRPH
MAKQLKVLIT KTLRKNVALN QFGQQLEAQY TVRVFIMFAF AAGLLCALSF KAYTNPMANY
IYAIWFGAKT VELLSLGQIG SDLAFTTDSL STMYYLTHWE QILQYSTNPS ENLRLLKLIN
LAIEMNSKPF YVTGLKYFRV SLQAGLKILQ ASFSYFTFLT SMQRRQMSN


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