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Odorant receptor 46a, isoform A

 OR46A_DROME             Reviewed;         381 AA.
P81919; Q9U6X9; Q9V5H3;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
15-DEC-2003, sequence version 4.
23-MAY-2018, entry version 132.
RecName: Full=Odorant receptor 46a, isoform A;
Name=Or46a;
Synonyms=AN8, AN9, dor19, DOR46F, DOR46F.1, Or46b, OR46F, Or46F.1,
Or46F.2; ORFNames=CG33478;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10458908; DOI=10.1006/geno.1999.5894;
Gao Q., Chess A.;
"Identification of candidate Drosophila olfactory receptors from
genomic DNA sequence.";
Genomics 60:31-39(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4]
IDENTIFICATION, AND TISSUE SPECIFICITY.
PubMed=10069338; DOI=10.1016/S0896-6273(00)81093-4;
Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R.;
"A novel family of divergent seven-transmembrane proteins: candidate
odorant receptors in Drosophila.";
Neuron 22:327-338(1999).
[5]
TISSUE SPECIFICITY.
PubMed=10943836; DOI=10.1016/S0092-8674(00)00021-0;
Vosshall L.B., Wong A.M., Axel R.;
"An olfactory sensory map in the fly brain.";
Cell 102:147-159(2000).
[6]
IDENTIFICATION OF ALTERNATIVE SPLICING.
PubMed=14608037; DOI=10.1073/pnas.2335847100;
Robertson H.M., Warr C.G., Carlson J.R.;
"Molecular evolution of the insect chemoreceptor gene superfamily in
Drosophila melanogaster.";
Proc. Natl. Acad. Sci. U.S.A. 100:14537-14542(2003).
-!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
behavior, depending on its substrates. The odorant receptor
repertoire encodes a large collection of odor stimuli that vary
widely in identity, intensity, and duration. May form a complex
with Orco to form odorant-sensing units, providing sensitive and
prolonged odorant signaling and calcium permeability (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with Orco. Complexes exist early in the
endomembrane system in olfactory sensory neurons (OSNs), coupling
these complexes to the conserved ciliary trafficking pathway (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=A;
IsoId=P81919-1; Sequence=Displayed;
Note=No experimental confirmation available.;
Name=B;
IsoId=Q9V3N2-1; Sequence=External;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Isoform A is expressed in a subset of 17
olfactory receptor neurons in the maxillary palp.
{ECO:0000269|PubMed:10069338, ECO:0000269|PubMed:10943836}.
-!- MISCELLANEOUS: The atypical heteromeric and topological design of
the odorant receptors appears to be an insect-specific solution
for odor recognition, making the OR/Orco complex an attractive
target for the development of highly selective insect repellents
to disrupt olfactory-mediated host-seeking behaviors of insect
disease vectors. Odor-evoked OR currents are independent of known
G-protein-coupled second messenger pathways.
-!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AE013599; AAF58834.3; -; Genomic_DNA.
RefSeq; NP_995794.1; NM_206072.2. [P81919-1]
UniGene; Dm.26891; -.
TCDB; 1.A.69.1.1; the heteromeric odorant receptor channel (horc) family.
PRIDE; P81919; -.
EnsemblMetazoa; FBtr0088330; FBpp0089407; FBgn0026388. [P81919-1]
GeneID; 2768728; -.
CTD; 2768728; -.
FlyBase; FBgn0026388; Or46a.
GeneTree; ENSGT00530000064740; -.
OMA; PATCIID; -.
OrthoDB; EOG091G05PQ; -.
GenomeRNAi; 2768728; -.
Proteomes; UP000000803; Chromosome 2R.
Bgee; FBgn0026388; -.
ExpressionAtlas; P81919; differential.
Genevisible; P81919; DM.
GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
GO; GO:0016021; C:integral component of membrane; ISM:FlyBase.
GO; GO:0005549; F:odorant binding; ISS:FlyBase.
GO; GO:0004984; F:olfactory receptor activity; IMP:FlyBase.
GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IMP:FlyBase.
GO; GO:0007608; P:sensory perception of smell; ISS:FlyBase.
InterPro; IPR004117; 7tm6_olfct_rcpt.
PANTHER; PTHR21137; PTHR21137; 1.
Pfam; PF02949; 7tm_6; 1.
2: Evidence at transcript level;
Alternative splicing; Cell membrane; Complete proteome; Glycoprotein;
Membrane; Olfaction; Receptor; Reference proteome;
Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 381 Odorant receptor 46a, isoform A.
/FTId=PRO_0000174248.
TOPO_DOM 1 37 Cytoplasmic. {ECO:0000255}.
TRANSMEM 38 58 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 59 65 Extracellular. {ECO:0000255}.
TRANSMEM 66 86 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 87 127 Cytoplasmic. {ECO:0000255}.
TRANSMEM 128 148 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 149 170 Extracellular. {ECO:0000255}.
TRANSMEM 171 191 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 192 255 Cytoplasmic. {ECO:0000255}.
TRANSMEM 256 276 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 277 287 Extracellular. {ECO:0000255}.
TRANSMEM 288 308 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 309 355 Cytoplasmic. {ECO:0000255}.
TRANSMEM 356 376 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 377 381 Extracellular. {ECO:0000255}.
CARBOHYD 59 59 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 381 AA; 44068 MW; 8A2AB426B08F95FA CRC64;
MSKGVEIFYK GQKAFLNILS LWPQIERRWR IIHQVNYVHV IVFWVLLFDL LLVLHVMANL
SYMSEVVKAI FILATSAGHT TKLLSIKANN VQMEELFRRL DNEEFRPRGA NEELIFAAAC
ERSRKLRDFY GALSFAALSM ILIPQFALDW SHLPLKTYNP LGENTGSPAY WLLYCYQCLA
LSVSCITNIG FDSLCSSLFI FLKCQLDILA VRLDKIGRLI TTSGGTVEQQ LKENIRYHMT
IVELSKTVER LLCKPISVQI FCSVLVLTAN FYAIAVLSDE RLELFKYVTY QACMLIQIFI
LCYYAGEVTQ RSLDLPHELY KTSWVDWDYR SRRIALLFMQ RLHSTLRIRT LNPSLGFDLM
LFSSIVNCSY SYFALLKRVN S


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