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Odorant receptor 63a

 OR63A_DROME             Reviewed;         420 AA.
Q9VZW8;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 2.
30-AUG-2017, entry version 126.
RecName: Full=Odorant receptor 63a;
Name=Or63a; ORFNames=CG9969;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[3]
FUNCTION.
PubMed=21857978; DOI=10.1371/journal.pone.0022996;
Hoare D.J., Humble J., Jin D., Gilding N., Petersen R., Cobb M.,
McCrohan C.;
"Modeling peripheral olfactory coding in Drosophila larvae.";
PLoS ONE 6:E22996-E22996(2011).
-!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
behavior, depending on its substrates. The odorant receptor
repertoire encodes a large collection of odor stimuli that vary
widely in identity, intensity, and duration. May form a complex
with Orco to form odorant-sensing units, providing sensitive and
prolonged odorant signaling and calcium permeability. Involved in
the behavioral responses to butyl acetate, isoamyl acetate, and
hexanoic acid. {ECO:0000269|PubMed:21857978}.
-!- SUBUNIT: Interacts with Orco. Complexes exist early in the
endomembrane system in olfactory sensory neurons (OSNs), coupling
these complexes to the conserved ciliary trafficking pathway (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- MISCELLANEOUS: The atypical heteromeric and topological design of
the odorant receptors appears to be an insect-specific solution
for odor recognition, making the OR/Orco complex an attractive
target for the development of highly selective insect repellents
to disrupt olfactory-mediated host-seeking behaviors of insect
disease vectors. Odor-evoked OR currents are independent of known
G-protein-coupled second messenger pathways.
-!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
Heteromeric odorant receptor channel (TC 1.A.69) family. Or63a
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AE014296; AAF47697.2; -; Genomic_DNA.
RefSeq; NP_523895.2; NM_079171.4.
UniGene; Dm.23964; -.
SMR; Q9VZW8; -.
STRING; 7227.FBpp0072847; -.
PaxDb; Q9VZW8; -.
PRIDE; Q9VZW8; -.
EnsemblMetazoa; FBtr0072977; FBpp0072847; FBgn0035382.
GeneID; 38354; -.
KEGG; dme:Dmel_CG9969; -.
CTD; 38354; -.
FlyBase; FBgn0035382; Or63a.
eggNOG; ENOG410JF0C; Eukaryota.
eggNOG; ENOG410YKTV; LUCA.
GeneTree; ENSGT00730000113992; -.
InParanoid; Q9VZW8; -.
KO; K08471; -.
OMA; CYNGQRF; -.
OrthoDB; EOG091G06PL; -.
PhylomeDB; Q9VZW8; -.
GenomeRNAi; 38354; -.
PRO; PR:Q9VZW8; -.
Proteomes; UP000000803; Chromosome 3L.
Bgee; FBgn0035382; -.
ExpressionAtlas; Q9VZW8; differential.
Genevisible; Q9VZW8; DM.
GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005549; F:odorant binding; ISS:FlyBase.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
InterPro; IPR004117; 7tm6_olfct_rcpt.
PANTHER; PTHR21137; PTHR21137; 1.
Pfam; PF02949; 7tm_6; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Glycoprotein; Membrane; Olfaction;
Receptor; Reference proteome; Sensory transduction; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 420 Odorant receptor 63a.
/FTId=PRO_0000174258.
TOPO_DOM 1 43 Cytoplasmic. {ECO:0000255}.
TRANSMEM 44 64 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 65 76 Extracellular. {ECO:0000255}.
TRANSMEM 77 97 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 98 150 Cytoplasmic. {ECO:0000255}.
TRANSMEM 151 171 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 172 217 Extracellular. {ECO:0000255}.
TRANSMEM 218 238 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 239 296 Cytoplasmic. {ECO:0000255}.
TRANSMEM 297 317 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 318 320 Extracellular. {ECO:0000255}.
TRANSMEM 321 341 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 342 387 Cytoplasmic. {ECO:0000255}.
TRANSMEM 388 408 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 409 420 Extracellular. {ECO:0000255}.
CARBOHYD 318 318 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 420 AA; 49611 MW; 310A925CDE0F72A4 CRC64;
MYSPEEAAEL KRRNYRSIRE MIRLSYTVGF NLLDPSRCGQ VLRIWTIVLS VSSLASLYGH
WQMLARYIHD IPRIGETAGT ALQFLTSIAK MWYFLFAHRQ IYELLRKARC HELLQKCELF
ERMSDLPVIK EIRQQVESTM NRYWASTRRQ ILIYLYSCIC ITTNYFINSF VINLYRYFTK
PKGSYDIMLP LPSLYPAWEH KGLEFPYYHI QMYLETCSLY ICGMCAVSFD GVFIVLCLHS
VGLMRSLNQM VEQATSELVP PDRRVEYLRC CIYQYQRVAN FATEVNNCFR HITFTQFLLS
LFNWGLALFQ MSVGLGNNSS ITMIRMTMYL VAAGYQIVVY CYNGQRFATA SEEIANAFYQ
VRWYGESREF RHLIRMMLMR TNRGFRLDVS WFMQMSLPTL MAMVRTSGQY FLLLQNVNQK


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