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Odorant receptor 85b

 OR85B_DROME             Reviewed;         390 AA.
Q9VHQ7;
01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 2.
30-AUG-2017, entry version 117.
RecName: Full=Odorant receptor 85b;
Name=Or85b; ORFNames=CG11735;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[3]
TISSUE SPECIFICITY.
PubMed=10943836; DOI=10.1016/S0092-8674(00)00021-0;
Vosshall L.B., Wong A.M., Axel R.;
"An olfactory sensory map in the fly brain.";
Cell 102:147-159(2000).
[4]
FUNCTION.
PubMed=16615896; DOI=10.1016/j.cell.2006.01.050;
Hallem E.A., Carlson J.R.;
"Coding of odors by a receptor repertoire.";
Cell 125:143-160(2006).
[5]
INTERACTION WITH ORCO, FUNCTION, DOMAIN, AND MUTAGENESIS OF PHE-142;
ASN-143; CYS-208 AND CYS-278.
PubMed=20147286; DOI=10.1074/jbc.M109.058321;
Nichols A.S., Luetje C.W.;
"Transmembrane segment 3 of Drosophila melanogaster odorant receptor
subunit 85b contributes to ligand-receptor interactions.";
J. Biol. Chem. 285:11854-11862(2010).
-!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
behavior, depending on its substrates. The odorant receptor
repertoire encodes a large collection of odor stimuli that vary
widely in identity, intensity, and duration. Forms a complex with
Orco to form odorant-sensing units, providing sensitive and
prolonged odorant signaling and calcium permeability. Involved in
the behavioral responses to 2-heptanone, amyl acetate, and butyl
acetate. {ECO:0000269|PubMed:16615896,
ECO:0000269|PubMed:20147286}.
-!- SUBUNIT: Interacts with Orco. Complexes exist early in the
endomembrane system in olfactory sensory neurons (OSNs), coupling
these complexes to the conserved ciliary trafficking pathway.
{ECO:0000269|PubMed:20147286}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in olfactory sensory neurons in the
antenna. {ECO:0000269|PubMed:10943836}.
-!- DOMAIN: Residues 146 to 150 play a role in odorant (2-heptanone)
activation. {ECO:0000269|PubMed:20147286}.
-!- MISCELLANEOUS: The atypical heteromeric and topological design of
the odorant receptors appears to be an insect-specific solution
for odor recognition, making the OR/Orco complex an attractive
target for the development of highly selective insect repellents
to disrupt olfactory-mediated host-seeking behaviors of insect
disease vectors. Odor-evoked OR currents are independent of known
G-protein-coupled second messenger pathways.
-!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
Heteromeric odorant receptor channel (TC 1.A.69) family. Or49a
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AE014297; AAF54244.2; -; Genomic_DNA.
RefSeq; NP_524279.2; NM_079555.2.
UniGene; Dm.23308; -.
IntAct; Q9VHQ7; 3.
STRING; 7227.FBpp0081383; -.
PaxDb; Q9VHQ7; -.
PRIDE; Q9VHQ7; -.
EnsemblMetazoa; FBtr0081900; FBpp0081383; FBgn0037590.
GeneID; 41007; -.
KEGG; dme:Dmel_CG11735; -.
CTD; 41007; -.
FlyBase; FBgn0037590; Or85b.
eggNOG; ENOG410JCY3; Eukaryota.
eggNOG; ENOG410YNVX; LUCA.
GeneTree; ENSGT00560000077544; -.
InParanoid; Q9VHQ7; -.
KO; K08471; -.
OMA; MEYWVYD; -.
OrthoDB; EOG091G082V; -.
PhylomeDB; Q9VHQ7; -.
GenomeRNAi; 41007; -.
PRO; PR:Q9VHQ7; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0037590; -.
ExpressionAtlas; Q9VHQ7; differential.
Genevisible; Q9VHQ7; DM.
GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
GO; GO:0016021; C:integral component of membrane; IDA:FlyBase.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005549; F:odorant binding; IPI:FlyBase.
GO; GO:0004984; F:olfactory receptor activity; IDA:FlyBase.
GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IDA:FlyBase.
InterPro; IPR004117; 7tm6_olfct_rcpt.
PANTHER; PTHR21137; PTHR21137; 1.
Pfam; PF02949; 7tm_6; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Glycoprotein; Membrane; Olfaction;
Receptor; Reference proteome; Sensory transduction; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 390 Odorant receptor 85b.
/FTId=PRO_0000174275.
TOPO_DOM 1 30 Cytoplasmic. {ECO:0000255}.
TRANSMEM 31 51 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 52 66 Extracellular. {ECO:0000255}.
TRANSMEM 67 87 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 88 126 Cytoplasmic. {ECO:0000255}.
TRANSMEM 127 147 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 148 200 Extracellular. {ECO:0000255}.
TRANSMEM 201 221 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 222 260 Cytoplasmic. {ECO:0000255}.
TRANSMEM 261 281 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 282 291 Extracellular. {ECO:0000255}.
TRANSMEM 292 312 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 313 360 Cytoplasmic. {ECO:0000255}.
TRANSMEM 361 381 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 382 390 Extracellular. {ECO:0000255}.
CARBOHYD 179 179 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
MUTAGEN 142 142 F->C: Leads to altered odorant
preference.
{ECO:0000269|PubMed:20147286}.
MUTAGEN 143 143 N->C: Leads to altered odorant
preference.
{ECO:0000269|PubMed:20147286}.
MUTAGEN 208 208 C->S: Increases odorant sensitivity.
{ECO:0000269|PubMed:20147286}.
MUTAGEN 278 278 C->S: Increases odorant sensitivity.
{ECO:0000269|PubMed:20147286}.
SEQUENCE 390 AA; 45665 MW; A0E338F8838AC3F3 CRC64;
MEKLMKYASF FYTAVGIRPY TNGEESKMNK LIFHIVFWSN VINLSFVGLF ESIYVYSAFM
DNKFLEAVTA LSYIGFVTVG MSKMFFIRWK KTAITELINE LKEIYPNGLI REERYNLPMY
LGTCSRISLI YSLLYSVLIW TFNLFCVMEY WVYDKWLNIR VVGKQLPYLM YIPWKWQDNW
SYYPLLFSQN FAGYTSAAGQ ISTDVLLCAV ATQLVMHFDF LSNSMERHEL SGDWKKDSRF
LVDIVRYHER ILRLSDAVND IFGIPLLLNF MVSSFVICFV GFQMTVGVPP DIVVKLFLFL
VSSMSQVYLI CHYGQLVADA SYGFSVATYN QKWYKADVRY KRALVIIIAR SQKVTFLKAT
IFLDITRSTM TDLLQISYKF FALLRTMYTQ


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