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Olfactory receptor 143 (Odorant receptor K18) (Olfactory receptor 170-6) (Olfactory receptor 7A)

 OL143_MOUSE             Reviewed;         313 AA.
P34985; Q9EQB3;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
24-JAN-2006, sequence version 2.
30-AUG-2017, entry version 121.
RecName: Full=Olfactory receptor 143;
AltName: Full=Odorant receptor K18;
AltName: Full=Olfactory receptor 170-6;
AltName: Full=Olfactory receptor 7A;
Name=Olfr143; Synonyms=Mor170-6, Olfr7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/SvJ;
PubMed=11130974; DOI=10.1007/s003350010217;
Xie S.Y., Feinstein P., Mombaerts P.;
"Characterization of a cluster comprising 100 odorant receptor genes
in mouse.";
Mamm. Genome 11:1070-1078(2000).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11802173; DOI=10.1038/nn800;
Zhang X., Firestein S.;
"The olfactory receptor gene superfamily of the mouse.";
Nat. Neurosci. 5:124-133(2002).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11875048; DOI=10.1093/hmg/11.5.535;
Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
Trask B.J.;
"Different evolutionary processes shaped the mouse and human olfactory
receptor gene families.";
Hum. Mol. Genet. 11:535-546(2002).
[4]
ERRATUM.
Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
Trask B.J.;
Hum. Mol. Genet. 11:1683-1683(2002).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 125-285.
STRAIN=C57BL/6J; TISSUE=Liver;
PubMed=7683976; DOI=10.1016/0092-8674(93)90145-G;
Ressler K.J., Sullivan S.L., Buck L.B.;
"A zonal organization of odorant receptor gene expression in the
olfactory epithelium.";
Cell 73:597-609(1993).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Olfactory epithelium.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
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EMBL; AF282276; AAG39861.1; -; Genomic_DNA.
EMBL; AY073288; AAL60951.1; -; Genomic_DNA.
EMBL; AY318078; AAP71370.1; -; Genomic_DNA.
EMBL; L14568; AAA39852.1; -; Genomic_DNA.
CCDS; CCDS23002.1; -.
PIR; A40745; A40745.
UniGene; Mm.377698; -.
ProteinModelPortal; P34985; -.
STRING; 10090.ENSMUSP00000091388; -.
iPTMnet; P34985; -.
PhosphoSitePlus; P34985; -.
PaxDb; P34985; -.
PRIDE; P34985; -.
MGI; MGI:2177526; Olfr143.
eggNOG; ENOG410JAE8; Eukaryota.
eggNOG; ENOG41117AS; LUCA.
HOGENOM; HOG000041364; -.
HOVERGEN; HBG017625; -.
InParanoid; P34985; -.
PhylomeDB; P34985; -.
PRO; PR:P34985; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_OLFR143; -.
GO; GO:0016021; C:integral component of membrane; ISA:MGI.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0005549; F:odorant binding; IBA:GO_Central.
GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISA:MGI.
GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Receptor; Reference proteome; Sensory transduction; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 313 Olfactory receptor 143.
/FTId=PRO_0000150820.
TOPO_DOM 1 27 Extracellular. {ECO:0000255}.
TRANSMEM 28 48 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 49 59 Cytoplasmic. {ECO:0000255}.
TRANSMEM 60 80 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 81 96 Extracellular. {ECO:0000255}.
TRANSMEM 97 117 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 118 136 Cytoplasmic. {ECO:0000255}.
TRANSMEM 137 157 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 158 208 Extracellular. {ECO:0000255}.
TRANSMEM 209 229 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 230 239 Cytoplasmic. {ECO:0000255}.
TRANSMEM 240 260 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 261 274 Extracellular. {ECO:0000255}.
TRANSMEM 275 295 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 296 313 Cytoplasmic. {ECO:0000255}.
CARBOHYD 8 8 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 100 192 {ECO:0000255|PROSITE-ProRule:PRU00521}.
SEQUENCE 313 AA; 35201 MW; C6EEC999DB3FC000 CRC64;
MMQITMENKS SVSEFILMGL TDQPELQLPL FVLFLMNYTA TVMGNLTLMN LICLNSNLHT
PMYFFLFNLS FIDFCYSMVF TPKMLMSFIL EKNTISFGGC MAQLFFFLFF VNSESYVLTA
MAYDRYVAIC KPLTYKVIMS PKICCLLIFS SYLMGFASAM AHTGCMIRLS FCDSNIINHY
MCDIFPLLPL SCSSTYVNEL MSSVVVGSAI ILCCLIILIS YAMILFNIIH MSSGKGWSKA
LGTCGSHIIT VSLFYGSGLL AYVKPSSAKT VGQGKFFSVF YTLLVPMLNP LIYSLRNKDV
KLAVKKTWKR ITS


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