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Olfactory receptor 1D2 (Olfactory receptor 17-4) (OR17-4) (Olfactory receptor OR17-6) (Olfactory receptor-like protein HGMP07E)

 OR1D2_HUMAN             Reviewed;         312 AA.
P34982; Q6IFL8; Q96RA4; Q9UM78;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
07-JUN-2005, sequence version 2.
27-SEP-2017, entry version 164.
RecName: Full=Olfactory receptor 1D2;
AltName: Full=Olfactory receptor 17-4;
Short=OR17-4;
AltName: Full=Olfactory receptor OR17-6;
AltName: Full=Olfactory receptor-like protein HGMP07E;
Name=OR1D2; Synonyms=OLFR1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-25.
PubMed=8097991;
Schurmans S., Muscatelli F., Miot F., Mattei M.-G., Vassart G.,
Parmentier M.;
"The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps
to the 17p13-->p12 region of the human genome and reveals an MspI
restriction fragment length polymorphism.";
Cytogenet. Cell Genet. 63:200-204(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-25.
PubMed=10673334; DOI=10.1006/geno.1999.6030;
Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
"Sequence, structure, and evolution of a complete human olfactory
receptor gene cluster.";
Genomics 63:227-245(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-214.
Ferraz C., Demaille J.G.;
"Sequence of cosmid ICRF105cF06137 of the human chromosome 17p13.3
olfactory receptor gene cluster.";
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-282.
PubMed=8004088; DOI=10.1093/hmg/3.2.229;
Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
"Olfactory receptor gene cluster on human chromosome 17: possible
duplication of an ancestral receptor repertoire.";
Hum. Mol. Genet. 3:229-235(1994).
[7]
FUNCTION IN SPERM CHEMOTAXIS, AND TISSUE SPECIFICITY.
PubMed=12663925; DOI=10.1126/science.1080376;
Spehr M., Gisselmann G., Poplawski A., Riffell J.A., Wetzel C.H.,
Zimmer R.K., Hatt H.;
"Identification of a testicular odorant receptor mediating human sperm
chemotaxis.";
Science 299:2054-2058(2003).
[8]
FUNCTION IN OLFACTORY RECEPTION, AND TISSUE SPECIFICITY.
PubMed=15458659; DOI=10.1016/j.cub.2004.09.034;
Spehr M., Schwane K., Heilmann S., Gisselmann G., Hummel T., Hatt H.;
"Dual capacity of a human olfactory receptor.";
Curr. Biol. 14:R832-R833(2004).
[9]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[10]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
[11]
FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND MUTAGENESIS OF
SER-230; SER-232; SER-239 AND THR-312.
PubMed=16820410; DOI=10.1242/jcs.03046;
Neuhaus E.M., Mashukova A., Barbour J., Wolters D., Hatt H.;
"Novel function of beta-arrestin2 in the nucleus of mature
spermatozoa.";
J. Cell Sci. 119:3047-3056(2006).
-!- FUNCTION: Odorant receptor which may be involved in sperm
chemotaxis. Bourgeonal is a strong chemoattractant for sperm in
vitro and is shown to be a strong agonist for OR1D2 in vitro. May
also function in olfactory reception.
{ECO:0000269|PubMed:12663925, ECO:0000269|PubMed:15458659,
ECO:0000269|PubMed:16820410}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16820410};
Multi-pass membrane protein {ECO:0000269|PubMed:16820410}. Note=In
spermatazoa is localized in the midpiece and is translocated to
the head region upon receptor stimulation with bourgeonal.
-!- TISSUE SPECIFICITY: Expressed in testis. Expressed in spermatozoa
(at protein level). Expressed in olfactory epithelium.
{ECO:0000269|PubMed:12663925, ECO:0000269|PubMed:15458659,
ECO:0000269|PubMed:16820410}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=Love at first smell
- Issue 115 of March 2010;
URL="http://web.expasy.org/spotlight/back_issues/115";
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1D2";
-----------------------------------------------------------------------
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EMBL; X65857; CAA46687.1; -; Genomic_DNA.
EMBL; AF087917; AAF37310.1; -; Genomic_DNA.
EMBL; BC069552; AAH69552.1; -; mRNA.
EMBL; BC106735; AAI06736.1; -; mRNA.
EMBL; BC106736; AAI06737.1; -; mRNA.
EMBL; U53583; AAC99554.1; -; Genomic_DNA.
EMBL; AF399535; AAK95020.1; -; Genomic_DNA.
EMBL; U04678; AAA18343.1; -; Genomic_DNA.
EMBL; BK004244; DAA04642.1; -; Genomic_DNA.
CCDS; CCDS11019.1; -.
PIR; A48413; A48413.
PIR; I38471; I38471.
RefSeq; NP_002539.2; NM_002548.2.
UniGene; Hs.532771; -.
ProteinModelPortal; P34982; -.
DIP; DIP-46308N; -.
IntAct; P34982; 1.
MINT; MINT-7295783; -.
STRING; 9606.ENSP00000327585; -.
iPTMnet; P34982; -.
PhosphoSitePlus; P34982; -.
BioMuta; OR1D2; -.
DMDM; 67477446; -.
PaxDb; P34982; -.
PRIDE; P34982; -.
Ensembl; ENST00000331459; ENSP00000327585; ENSG00000184166.
GeneID; 4991; -.
KEGG; hsa:4991; -.
UCSC; uc010vrb.2; human.
CTD; 4991; -.
EuPathDB; HostDB:ENSG00000184166.1; -.
GeneCards; OR1D2; -.
HGNC; HGNC:8183; OR1D2.
MIM; 164342; gene.
neXtProt; NX_P34982; -.
OpenTargets; ENSG00000184166; -.
PharmGKB; PA32057; -.
eggNOG; ENOG410IH29; Eukaryota.
eggNOG; ENOG41116CF; LUCA.
GeneTree; ENSGT00880000137947; -.
HOGENOM; HOG000041364; -.
HOVERGEN; HBG017625; -.
InParanoid; P34982; -.
KO; K04257; -.
OMA; CMVYLKP; -.
OrthoDB; EOG091G0AZH; -.
PhylomeDB; P34982; -.
TreeFam; TF337210; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR1D2; -.
GenomeRNAi; 4991; -.
PRO; PR:P34982; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000184166; -.
CleanEx; HS_OR1D2; -.
ExpressionAtlas; P34982; baseline and differential.
Genevisible; P34982; HS.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:UniProtKB.
GO; GO:0006928; P:movement of cell or subcellular component; TAS:ProtInc.
GO; GO:0000060; P:protein import into nucleus, translocation; IMP:UniProtKB.
GO; GO:0007608; P:sensory perception of smell; TAS:ProtInc.
GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Cell membrane; Chemotaxis; Complete proteome; Disulfide bond;
Fertilization; G-protein coupled receptor; Glycoprotein; Membrane;
Olfaction; Polymorphism; Receptor; Reference proteome;
Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 312 Olfactory receptor 1D2.
/FTId=PRO_0000150418.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 49 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 50 57 Cytoplasmic. {ECO:0000255}.
TRANSMEM 58 79 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 80 100 Extracellular. {ECO:0000255}.
TRANSMEM 101 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 158 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 159 196 Extracellular. {ECO:0000255}.
TRANSMEM 197 219 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 220 236 Cytoplasmic. {ECO:0000255}.
TRANSMEM 237 259 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 260 271 Extracellular. {ECO:0000255}.
TRANSMEM 272 291 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 292 312 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 195 195 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 25 25 R -> Q (in dbSNP:rs769423).
{ECO:0000269|PubMed:10673334,
ECO:0000269|PubMed:8097991}.
/FTId=VAR_019630.
VARIANT 31 31 F -> Y (in dbSNP:rs9916628).
/FTId=VAR_057534.
VARIANT 214 214 V -> M (in dbSNP:rs55803944).
/FTId=VAR_062008.
VARIANT 240 240 T -> I (in dbSNP:rs4300683).
/FTId=VAR_057535.
MUTAGEN 230 230 S->A: Abolishes nuclear translocation of
ARRB2; when associated with A-232 and A-
239. {ECO:0000269|PubMed:16820410}.
MUTAGEN 232 232 S->A: Abolishes nuclear translocation of
ARRB2; when associated with A-230 and A-
239. {ECO:0000269|PubMed:16820410}.
MUTAGEN 239 239 S->A: Abolishes nuclear translocation of
ARRB2; when associated with A-230 and A-
232. {ECO:0000269|PubMed:16820410}.
MUTAGEN 312 312 T->A: Abolishes nuclear translocation of
ARRB2. {ECO:0000269|PubMed:16820410}.
SEQUENCE 312 AA; 35240 MW; 71B05367C0AA135B CRC64;
MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSRLHTPVY
FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ LYFLVSLVAL DNLILAVMAY
DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE
MYVLLRMACS NIQINHTVLI ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST
CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL
GRLLDKHFKR LT


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