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Olfactory receptor 1E1 (Olfactory receptor 13-66) (OR13-66) (Olfactory receptor 17-2/17-32) (OR17-2) (OR17-32) (Olfactory receptor 1E5) (Olfactory receptor 1E6) (Olfactory receptor 5-85) (OR5-85) (Olfactory receptor OR17-18) (Olfactory receptor-like protein HGMP07I)

 OR1E1_HUMAN             Reviewed;         314 AA.
P30953; O43884; P47882; P47885; Q6IFA9; Q6IFM5; Q9UBJ1; Q9UM60;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
27-SEP-2017, entry version 155.
RecName: Full=Olfactory receptor 1E1;
AltName: Full=Olfactory receptor 13-66;
Short=OR13-66;
AltName: Full=Olfactory receptor 17-2/17-32;
Short=OR17-2;
Short=OR17-32;
AltName: Full=Olfactory receptor 1E5;
AltName: Full=Olfactory receptor 1E6;
AltName: Full=Olfactory receptor 5-85;
Short=OR5-85;
AltName: Full=Olfactory receptor OR17-18;
AltName: Full=Olfactory receptor-like protein HGMP07I;
Name=OR1E1; Synonyms=OR1E5, OR1E6, OR1E9P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Testis;
PubMed=1370859; DOI=10.1038/355453a0;
Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J.,
Grootegoed A., Vassart G.;
"Expression of members of the putative olfactory receptor gene family
in mammalian germ cells.";
Nature 355:453-455(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10673334; DOI=10.1006/geno.1999.6030;
Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
"Sequence, structure, and evolution of a complete human olfactory
receptor gene cluster.";
Genomics 63:227-245(2000).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Ferraz C., Vidal S., Brun C., Demaille J.G.;
"DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the
olfactory receptor gene cluster of human chromosome 17p13.3,
containing OR genes 2, 201, 93 and pseudogene 1.";
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Ferraz C., Demaille J.G.;
"Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3
olfactory receptor gene cluster, containing genes OR17-32 and OR17-
201-1, and pseudogene OR17-01.";
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Ferraz C., Vidal S., Brun C., Demaille J.G.;
"Sequence of cosmid L53 of human chromosome 17p13.3 olfactory receptor
gene cluster, containing the OR17-32 gene and the OR17-01
pseudogene.";
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
PubMed=8004088; DOI=10.1093/hmg/3.2.229;
Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
"Olfactory receptor gene cluster on human chromosome 17: possible
duplication of an ancestral receptor repertoire.";
Hum. Mol. Genet. 3:229-235(1994).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
PubMed=9500546; DOI=10.1038/ng0398-243;
Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
Demaille J.G., Giorgi D.;
"Distribution of olfactory receptor genes in the human genome.";
Nat. Genet. 18:243-250(1998).
[9]
IDENTIFICATION, AND VARIANT THR-143.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[10]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1E1";
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X64994; CAA46127.1; -; Genomic_DNA.
EMBL; AF087916; AAF37309.1; -; Genomic_DNA.
EMBL; AF095725; AAF03261.1; -; Genomic_DNA.
EMBL; U78308; AAD00276.1; -; Genomic_DNA.
EMBL; AF052041; AAD17495.1; -; Genomic_DNA.
EMBL; U04642; AAA17447.1; -; Genomic_DNA.
EMBL; U04682; AAA18346.1; -; Genomic_DNA.
EMBL; AF399550; AAK95035.1; -; Genomic_DNA.
EMBL; U86222; AAC39613.1; -; Genomic_DNA.
EMBL; U86274; AAC39629.1; -; Genomic_DNA.
EMBL; BK004237; DAA04635.1; -; Genomic_DNA.
EMBL; BK004353; DAA04751.1; -; Genomic_DNA.
CCDS; CCDS11024.1; -.
PIR; I38470; I38470.
PIR; I38474; I38474.
PIR; S20572; S20572.
RefSeq; NP_003544.2; NM_003553.2.
UniGene; Hs.278485; -.
ProteinModelPortal; P30953; -.
SMR; P30953; -.
STRING; 9606.ENSP00000313384; -.
TCDB; 9.A.14.8.1; the g-protein-coupled receptor (gpcr) family.
iPTMnet; P30953; -.
PhosphoSitePlus; P30953; -.
BioMuta; OR1E1; -.
DMDM; 400671; -.
PaxDb; P30953; -.
PRIDE; P30953; -.
DNASU; 8387; -.
Ensembl; ENST00000322608; ENSP00000313384; ENSG00000180016.
GeneID; 8387; -.
KEGG; hsa:8387; -.
UCSC; uc002fvj.2; human.
CTD; 8387; -.
DisGeNET; 8387; -.
EuPathDB; HostDB:ENSG00000180016.2; -.
GeneCards; OR1E1; -.
H-InvDB; HIX0039264; -.
HGNC; HGNC:8189; OR1E1.
neXtProt; NX_P30953; -.
PharmGKB; PA32062; -.
eggNOG; ENOG410J9M4; Eukaryota.
eggNOG; ENOG41113B1; LUCA.
GeneTree; ENSGT00860000133705; -.
HOVERGEN; HBG017625; -.
InParanoid; P30953; -.
KO; K04257; -.
OMA; RVICKRQ; -.
OrthoDB; EOG091G0EOH; -.
PhylomeDB; P30953; -.
TreeFam; TF337210; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR1E1; -.
GenomeRNAi; 8387; -.
PRO; PR:P30953; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000180016; -.
CleanEx; HS_OR1E1; -.
Genevisible; P30953; HS.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; NAS:UniProtKB.
GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; G-protein coupled receptor;
Glycoprotein; Membrane; Olfaction; Polymorphism; Receptor;
Reference proteome; Sensory transduction; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 314 Olfactory receptor 1E1.
/FTId=PRO_0000150425.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 49 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 50 57 Cytoplasmic. {ECO:0000255}.
TRANSMEM 58 79 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 80 100 Extracellular. {ECO:0000255}.
TRANSMEM 101 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 158 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 159 195 Extracellular. {ECO:0000255}.
TRANSMEM 196 219 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 220 236 Cytoplasmic. {ECO:0000255}.
TRANSMEM 237 259 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 260 272 Extracellular. {ECO:0000255}.
TRANSMEM 273 292 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 293 314 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 129 129 P -> L (in dbSNP:rs1735011).
/FTId=VAR_053119.
VARIANT 143 143 A -> T (in dbSNP:rs150989).
{ECO:0000269|PubMed:14983052}.
/FTId=VAR_010226.
VARIANT 262 262 S -> P (in dbSNP:rs379856).
/FTId=VAR_053120.
CONFLICT 178 178 F -> L (in Ref. 6; AAA17447).
{ECO:0000305}.
CONFLICT 221 221 I -> V (in Ref. 8; AAC39629).
{ECO:0000305}.
SEQUENCE 314 AA; 35264 MW; BA24A1E6F60A208E CRC64;
MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR LDSHLHTPMY
LFLSNLSFSD LCFSSVTIPK LLQNMQNQDP SIPYADCLTQ MYFFLLFGDL ESFLLVAMAY
DRYVAICFPL HYTAIMSPML CLALVALSWV LTTFHAMLHT LLMARLCFCA DNVIPHFFCD
MSALLKLAFS DTRVNEWVIF IMGGLILVIP FLLILGSYAR IVSSILKVPS SKGICKAFST
CGSHLSVVSL FYGTVIGLYL CSSANSSTLK DTVMAMMYTV VTPMLNPFIY SLRNRDMKGA
LSRVIHQKKT FFSL


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