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Olfactory receptor 1N1 (Olfactory receptor 1-26) (OR1-26) (Olfactory receptor 1N3) (Olfactory receptor OR9-22)

 OR1N1_HUMAN             Reviewed;         311 AA.
Q8NGS0; A3KFM1; O43870; Q6IF16; Q96R93;
10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
27-SEP-2017, entry version 130.
RecName: Full=Olfactory receptor 1N1;
AltName: Full=Olfactory receptor 1-26;
Short=OR1-26;
AltName: Full=Olfactory receptor 1N3;
AltName: Full=Olfactory receptor OR9-22;
Name=OR1N1; Synonyms=OR1N3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164053; DOI=10.1038/nature02465;
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
Rogers J., Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
PubMed=9500546; DOI=10.1038/ng0398-243;
Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
Demaille J.G., Giorgi D.;
"Distribution of olfactory receptor genes in the human genome.";
Nat. Genet. 18:243-250(1998).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
[6]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[7]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
[8]
VARIANT [LARGE SCALE ANALYSIS] ASN-190.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1N1";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB065719; BAC05940.1; -; Genomic_DNA.
EMBL; AL359636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471090; EAW87534.1; -; Genomic_DNA.
EMBL; U86216; AAC39612.1; -; Genomic_DNA.
EMBL; AF399547; AAK95032.1; -; Genomic_DNA.
EMBL; BK004446; DAA04844.1; -; Genomic_DNA.
CCDS; CCDS6844.1; -.
RefSeq; NP_036495.1; NM_012363.1.
UniGene; Hs.553604; -.
ProteinModelPortal; Q8NGS0; -.
STRING; 9606.ENSP00000306974; -.
BioMuta; OR1N1; -.
DMDM; 38372759; -.
PaxDb; Q8NGS0; -.
PRIDE; Q8NGS0; -.
DNASU; 138883; -.
Ensembl; ENST00000304880; ENSP00000306974; ENSG00000171505.
GeneID; 138883; -.
KEGG; hsa:138883; -.
UCSC; uc004bmn.1; human.
CTD; 138883; -.
EuPathDB; HostDB:ENSG00000171505.5; -.
GeneCards; OR1N1; -.
HGNC; HGNC:8221; OR1N1.
neXtProt; NX_Q8NGS0; -.
OpenTargets; ENSG00000171505; -.
PharmGKB; PA32090; -.
eggNOG; ENOG410J9R3; Eukaryota.
eggNOG; ENOG41113AW; LUCA.
GeneTree; ENSGT00860000133676; -.
HOGENOM; HOG000041365; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8NGS0; -.
KO; K04257; -.
OMA; FSAYLCP; -.
PhylomeDB; Q8NGS0; -.
TreeFam; TF337210; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
ChiTaRS; OR1N1; human.
GeneWiki; OR1N1; -.
GenomeRNAi; 138883; -.
PRO; PR:Q8NGS0; -.
Proteomes; UP000005640; Chromosome 9.
Bgee; ENSG00000171505; -.
CleanEx; HS_OR1N1; -.
ExpressionAtlas; Q8NGS0; baseline and differential.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 311 Olfactory receptor 1N1.
/FTId=PRO_0000150448.
TOPO_DOM 1 23 Extracellular. {ECO:0000255}.
TRANSMEM 24 47 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 48 55 Cytoplasmic. {ECO:0000255}.
TRANSMEM 56 77 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 78 98 Extracellular. {ECO:0000255}.
TRANSMEM 99 118 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 119 137 Cytoplasmic. {ECO:0000255}.
TRANSMEM 138 156 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 157 194 Extracellular. {ECO:0000255}.
TRANSMEM 195 217 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 218 234 Cytoplasmic. {ECO:0000255}.
TRANSMEM 235 257 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 258 270 Extracellular. {ECO:0000255}.
TRANSMEM 271 290 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 291 311 Cytoplasmic. {ECO:0000255}.
CARBOHYD 3 3 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 95 187 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 18 18 P -> S (in dbSNP:rs10818708).
/FTId=VAR_024089.
VARIANT 190 190 T -> N (in a breast cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036208.
VARIANT 227 227 R -> Q (in dbSNP:rs58226717).
/FTId=VAR_062011.
CONFLICT 91 91 S -> T (in Ref. 4; AAC39612).
{ECO:0000305}.
SEQUENCE 311 AA; 34650 MW; 6B82AE0B4A836180 CRC64;
MENQSSISEF FLRGISAPPE QQQSLFGIFL CMYLVTLTGN LLIILAIGSD LHLHTPMYFF
LANLSFVDMG LTSSTVTKML VNIQTRHHTI SYTGCLTQMY FFLMFGDLDS FFLAAMAYDR
YVAICHPLCY STVMRPQVCA LMLALCWVLT NIVALTHTFL MARLSFCVTG EIAHFFCDIT
PVLKLSCSDT HINEMMVFVL GGTVLIVPFL CIVTSYIHIV PAILRVRTRG GVGKAFSTCS
SHLCVVCVFY GTLFSAYLCP PSIASEEKDI AAAAMYTIVT PMLNPFIYSL RNKDMKGALK
RLFSHRSIVS S


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