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Olfactory receptor 2B6 (Hs6M1-32) (Olfactory receptor 2B1) (Olfactory receptor 2B5) (Olfactory receptor 5-40) (OR5-40) (Olfactory receptor 6-31) (OR6-31) (Olfactory receptor OR6-4)

 OR2B6_HUMAN             Reviewed;         313 AA.
P58173; O43883; Q6IF89; Q9H5B0;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
20-JUN-2001, sequence version 1.
30-AUG-2017, entry version 138.
RecName: Full=Olfactory receptor 2B6;
AltName: Full=Hs6M1-32;
AltName: Full=Olfactory receptor 2B1;
AltName: Full=Olfactory receptor 2B5;
AltName: Full=Olfactory receptor 5-40;
Short=OR5-40;
AltName: Full=Olfactory receptor 6-31;
Short=OR6-31;
AltName: Full=Olfactory receptor OR6-4;
Name=OR2B6; Synonyms=OR2B1, OR2B1P, OR2B5, OR2B6P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
PubMed=9500546; DOI=10.1038/ng0398-243;
Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
Demaille J.G., Giorgi D.;
"Distribution of olfactory receptor genes in the human genome.";
Nat. Genet. 18:243-250(1998).
[4]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[5]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2B6";
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AL133267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC109251; AAI09252.1; -; mRNA.
EMBL; BC110457; AAI10458.1; -; mRNA.
EMBL; U86270; AAC39628.1; -; Genomic_DNA.
EMBL; BK004373; DAA04771.1; -; Genomic_DNA.
CCDS; CCDS4642.1; -.
RefSeq; NP_036499.1; NM_012367.1.
UniGene; Hs.532145; -.
ProteinModelPortal; P58173; -.
STRING; 9606.ENSP00000244623; -.
iPTMnet; P58173; -.
PhosphoSitePlus; P58173; -.
BioMuta; OR2B6; -.
DMDM; 14423785; -.
PaxDb; P58173; -.
PeptideAtlas; P58173; -.
PRIDE; P58173; -.
Ensembl; ENST00000244623; ENSP00000244623; ENSG00000124657.
GeneID; 26212; -.
KEGG; hsa:26212; -.
UCSC; uc011dkx.2; human.
CTD; 26212; -.
GeneCards; OR2B6; -.
HGNC; HGNC:8241; OR2B6.
neXtProt; NX_P58173; -.
OpenTargets; ENSG00000124657; -.
PharmGKB; PA32144; -.
eggNOG; ENOG410JAX5; Eukaryota.
eggNOG; ENOG411179Z; LUCA.
GeneTree; ENSGT00740000115013; -.
HOGENOM; HOG000041362; -.
HOVERGEN; HBG017625; -.
InParanoid; P58173; -.
KO; K04257; -.
OMA; VWLSTLT; -.
OrthoDB; EOG091G0CU6; -.
PhylomeDB; P58173; -.
TreeFam; TF336512; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR2B6; -.
GenomeRNAi; 26212; -.
PRO; PR:P58173; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000124657; -.
CleanEx; HS_OR2B6; -.
ExpressionAtlas; P58173; baseline and differential.
Genevisible; P58173; HS.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 313 Olfactory receptor 2B6.
/FTId=PRO_0000150462.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 49 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 50 57 Cytoplasmic. {ECO:0000255}.
TRANSMEM 58 79 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 80 100 Extracellular. {ECO:0000255}.
TRANSMEM 101 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 158 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 159 195 Extracellular. {ECO:0000255}.
TRANSMEM 196 219 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 220 236 Cytoplasmic. {ECO:0000255}.
TRANSMEM 237 259 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 260 272 Extracellular. {ECO:0000255}.
TRANSMEM 273 292 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 293 313 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 117 117 V -> I (in dbSNP:rs7767176).
/FTId=VAR_053131.
VARIANT 270 270 Q -> R (in dbSNP:rs9380030).
/FTId=VAR_024090.
SEQUENCE 313 AA; 35414 MW; 71D459541ACF5301 CRC64;
MNWVNDSIIQ EFILLGFSDR PWLEFPLLVV FLISYTVTIF GNLTIILVSR LDTKLHTPMY
FFLTNLSLLD LCYTTCTVPQ MLVNLCSIRK VISYRGCVAQ LFIFLALGAT EYLLLAVMSF
DRFVAICRPL HYSVIMHQRL CLQLAAASWV TGFSNSVWLS TLTLQLPLCD PYVIDHFLCE
VPALLKLSCV ETTANEAELF LVSELFHLIP LTLILISYAF IVRAVLRIQS AEGRQKAFGT
CGSHLIVVSL FYSTAVSVYL QPPSPSSKDQ GKMVSLFYGI IAPMLNPLIY TLRNKEVKEG
FKRLVARVFL IKK


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