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Olfactory receptor 2C3 (Olfactory receptor 2C4) (Olfactory receptor 2C5) (Olfactory receptor OR1-30)

 OR2C3_HUMAN             Reviewed;         320 AA.
Q8N628; Q5JQS4; Q6IEZ1; Q8NGW7;
26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
16-DEC-2008, sequence version 3.
30-AUG-2017, entry version 134.
RecName: Full=Olfactory receptor 2C3;
AltName: Full=Olfactory receptor 2C4;
AltName: Full=Olfactory receptor 2C5;
AltName: Full=Olfactory receptor OR1-30;
Name=OR2C3; Synonyms=OR2C4, OR2C5P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ALA-20 AND
SER-68.
TISSUE=Melanoma;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[5]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH30717.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=DAA04869.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2C3";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB065649; BAC05875.1; -; Genomic_DNA.
EMBL; AL606804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC030717; AAH30717.1; ALT_INIT; mRNA.
EMBL; BK004471; DAA04869.1; ALT_INIT; Genomic_DNA.
CCDS; CCDS1634.2; -.
RefSeq; NP_932340.3; NM_198074.4.
UniGene; Hs.730218; -.
ProteinModelPortal; Q8N628; -.
SMR; Q8N628; -.
STRING; 9606.ENSP00000355443; -.
BioMuta; OR2C3; -.
DMDM; 218512126; -.
PaxDb; Q8N628; -.
PRIDE; Q8N628; -.
DNASU; 81472; -.
Ensembl; ENST00000366487; ENSP00000355443; ENSG00000196242.
Ensembl; ENST00000617752; ENSP00000479757; ENSG00000196242.
GeneID; 81472; -.
KEGG; hsa:81472; -.
UCSC; uc009xgy.3; human.
CTD; 81472; -.
GeneCards; OR2C3; -.
HGNC; HGNC:15005; OR2C3.
HPA; HPA053920; -.
HPA; HPA058578; -.
neXtProt; NX_Q8N628; -.
PharmGKB; PA32149; -.
eggNOG; ENOG410IPMU; Eukaryota.
eggNOG; ENOG41113G3; LUCA.
GeneTree; ENSGT00760000118914; -.
HOGENOM; HOG000041362; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8N628; -.
KO; K04257; -.
OMA; MEMYLAS; -.
OrthoDB; EOG091G0CU6; -.
PhylomeDB; Q8N628; -.
TreeFam; TF336512; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR2C3; -.
GenomeRNAi; 81472; -.
PRO; PR:Q8N628; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000196242; -.
CleanEx; HS_OR2C3; -.
Genevisible; Q8N628; HS.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:HPA.
GO; GO:0005886; C:plasma membrane; IDA:HPA.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 320 Olfactory receptor 2C3.
/FTId=PRO_0000150466.
TOPO_DOM 1 26 Extracellular. {ECO:0000255}.
TRANSMEM 27 50 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 51 58 Cytoplasmic. {ECO:0000255}.
TRANSMEM 59 80 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 81 101 Extracellular. {ECO:0000255}.
TRANSMEM 102 121 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 122 140 Cytoplasmic. {ECO:0000255}.
TRANSMEM 141 159 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 160 196 Extracellular. {ECO:0000255}.
TRANSMEM 197 220 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 221 237 Cytoplasmic. {ECO:0000255}.
TRANSMEM 238 260 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 261 273 Extracellular. {ECO:0000255}.
TRANSMEM 274 293 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 294 320 Cytoplasmic. {ECO:0000255}.
CARBOHYD 6 6 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 98 190 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 20 20 T -> A (in dbSNP:rs6697472).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_025540.
VARIANT 68 68 P -> S (in dbSNP:rs6657127).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_025541.
VARIANT 129 129 R -> S (in dbSNP:rs34220133).
/FTId=VAR_046378.
VARIANT 289 289 L -> V (in dbSNP:rs6702693).
/FTId=VAR_062016.
SEQUENCE 320 AA; 35376 MW; 52C8143CB927E2FF CRC64;
MMEIANVSSP EVFVLLGFST RPSLETVLFI VVLSFYMVSI LGNGIIILVS HTDVHLHTPM
YFFLANLPFL DMSFTTSIVP QLLANLWGPQ KTISYGGCVV QFYISHWLGA TECVLLATMS
YDRYAAICRP LHYTVIMHPQ LCLGLALASW LGGLTTSMVG STLTMLLPLC GNNCIDHFFC
EMPLIMQLAC VDTSLNEMEM YLASFVFVVL PLGLILVSYG HIARAVLKIR SAEGRRKAFN
TCSSHVAVVS LFYGSIIFMY LQPAKSTSHE QGKFIALFYT VVTPALNPLI YTLRNTEVKS
ALRHMVLENC CGSAGKLAQI


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