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Olfactory receptor 3A3 (Olfactory receptor 17-201) (OR17-201) (Olfactory receptor 3A6) (Olfactory receptor 3A7) (Olfactory receptor 3A8) (Olfactory receptor OR17-22)

 OR3A3_HUMAN             Reviewed;         321 AA.
P47888; Q2VPE4; Q6IFM6; Q9P1Q4; Q9UBE7;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
14-APR-2009, sequence version 3.
27-SEP-2017, entry version 151.
RecName: Full=Olfactory receptor 3A3;
AltName: Full=Olfactory receptor 17-201;
Short=OR17-201;
AltName: Full=Olfactory receptor 3A6;
AltName: Full=Olfactory receptor 3A7;
AltName: Full=Olfactory receptor 3A8;
AltName: Full=Olfactory receptor OR17-22;
Name=OR3A3; Synonyms=OR3A6, OR3A7, OR3A8P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-317.
PubMed=10673334; DOI=10.1006/geno.1999.6030;
Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
"Sequence, structure, and evolution of a complete human olfactory
receptor gene cluster.";
Genomics 63:227-245(2000).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-317.
Ferraz C., Vidal S., Brun C., Demaille J.G.;
"DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the
olfactory receptor gene cluster of human chromosome 17p13.3,
containing OR genes 2, 201, 93 and pseudogene 1.";
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-317.
Ferraz C., Demaille J.G.;
"Sequence of cosmid ICRF105cH07155 of the olfactory receptor gene
cluster of human chromosome 17p13.3.";
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-317.
Ferraz C., Demaille J.G.;
"Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3
olfactory receptor gene cluster, containing genes OR17-32 and OR17-
201-1, and pseudogene OR17-01.";
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-317.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-292.
PubMed=8004088; DOI=10.1093/hmg/3.2.229;
Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
"Olfactory receptor gene cluster on human chromosome 17: possible
duplication of an ancestral receptor repertoire.";
Hum. Mol. Genet. 3:229-235(1994).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-292.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
[9]
IDENTIFICATION, AND VARIANT GLU-317.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[10]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAI08922.2; Type=Erroneous initiation; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR3A3";
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AC007194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AF087926; AAF37316.1; -; Genomic_DNA.
EMBL; AF095725; AAF03262.1; -; Genomic_DNA.
EMBL; U76377; AAD00250.1; -; Genomic_DNA.
EMBL; U78308; AAD00277.1; -; Genomic_DNA.
EMBL; AC025125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC069415; AAH69415.1; -; mRNA.
EMBL; BC108921; AAI08922.2; ALT_INIT; mRNA.
EMBL; U04688; AAA18351.1; -; Genomic_DNA.
EMBL; AF399620; AAK95105.1; -; Genomic_DNA.
EMBL; BK004236; DAA04634.1; -; Genomic_DNA.
CCDS; CCDS11025.1; -.
PIR; I38480; I38480.
RefSeq; NP_036505.2; NM_012373.2.
UniGene; Hs.532689; -.
ProteinModelPortal; P47888; -.
STRING; 9606.ENSP00000291231; -.
iPTMnet; P47888; -.
PhosphoSitePlus; P47888; -.
BioMuta; OR3A3; -.
DMDM; 226694174; -.
PaxDb; P47888; -.
PeptideAtlas; P47888; -.
PRIDE; P47888; -.
Ensembl; ENST00000291231; ENSP00000291231; ENSG00000159961.
GeneID; 8392; -.
KEGG; hsa:8392; -.
UCSC; uc010vrd.2; human.
CTD; 8392; -.
DisGeNET; 8392; -.
EuPathDB; HostDB:ENSG00000159961.1; -.
GeneCards; OR3A3; -.
H-InvDB; HIX0039209; -.
HGNC; HGNC:8284; OR3A3.
neXtProt; NX_P47888; -.
OpenTargets; ENSG00000159961; -.
PharmGKB; PA32225; -.
eggNOG; ENOG410IKVP; Eukaryota.
eggNOG; ENOG411141Z; LUCA.
GeneTree; ENSGT00840000129832; -.
HOGENOM; HOG000041364; -.
HOVERGEN; HBG017625; -.
InParanoid; P47888; -.
KO; K04257; -.
OMA; DVQGALC; -.
OrthoDB; EOG091G0AZH; -.
PhylomeDB; P47888; -.
TreeFam; TF352732; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR3A3; -.
GenomeRNAi; 8392; -.
PRO; PR:P47888; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000159961; -.
CleanEx; HS_OR3A3; -.
Genevisible; P47888; HS.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; NAS:ProtInc.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 321 Olfactory receptor 3A3.
/FTId=PRO_0000150520.
TOPO_DOM 1 34 Extracellular. {ECO:0000255}.
TRANSMEM 35 58 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 59 66 Cytoplasmic. {ECO:0000255}.
TRANSMEM 67 88 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 89 109 Extracellular. {ECO:0000255}.
TRANSMEM 110 129 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 130 149 Cytoplasmic. {ECO:0000255}.
TRANSMEM 150 167 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 168 205 Extracellular. {ECO:0000255}.
TRANSMEM 206 228 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 229 245 Cytoplasmic. {ECO:0000255}.
TRANSMEM 246 268 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 269 281 Extracellular. {ECO:0000255}.
TRANSMEM 282 301 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 302 321 Cytoplasmic. {ECO:0000255}.
CARBOHYD 14 14 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 106 198 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 132 132 L -> F (in dbSNP:rs769432).
/FTId=VAR_054961.
VARIANT 158 158 W -> L (in dbSNP:rs916039).
/FTId=VAR_054962.
VARIANT 287 287 M -> V (in dbSNP:rs12939997).
/FTId=VAR_054963.
VARIANT 317 317 K -> E (in dbSNP:rs227787).
{ECO:0000269|PubMed:10673334,
ECO:0000269|PubMed:14983052,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.2, ECO:0000269|Ref.3,
ECO:0000269|Ref.4}.
/FTId=VAR_054964.
CONFLICT 48 48 T -> I (in Ref. 1; AAF37316/AC007194, 2;
AAF03262, 3; AAD00250, 4; AAD00277 and 6;
AAH69415). {ECO:0000305}.
CONFLICT 171 171 A -> G (in Ref. 7; AAA18351).
{ECO:0000305}.
CONFLICT 189 189 D -> E (in Ref. 7; AAA18351).
{ECO:0000305}.
CONFLICT 193 193 L -> V (in Ref. 7; AAA18351).
{ECO:0000305}.
SEQUENCE 321 AA; 34963 MW; DA67FD99DE730A66 CRC64;
MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG NLSILAAVLV
EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST ISYDACLSQL FFFHLLAGMD
CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ RMLVAASWAC AFTNALTHTV AMSTLNFCGP
NEVNHFYCDL PQLFQLSCSS TQLNELLLFV AAAFMAVAPL VFISVSYAHV VAAVLQIRSA
EGRKKAFSTC GSHLTVVGIF YGTGVFSYMR LGSVESSDKD KGVGVFMTVI NPMLNPLIYS
LRNTDVQGAL CQLLVGKRSL T


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