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Olfactory receptor 4D6 (Olfactory receptor OR11-250)

 OR4D6_HUMAN             Reviewed;         314 AA.
Q8NGJ1; B2RNP7; Q6IFF5; Q96R74;
10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
25-OCT-2017, entry version 124.
RecName: Full=Olfactory receptor 4D6;
AltName: Full=Olfactory receptor OR11-250;
Name=OR4D6;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLY-96.
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-96.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-280.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
[5]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[6]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4D6";
-----------------------------------------------------------------------
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EMBL; AB065803; BAC06022.1; -; Genomic_DNA.
EMBL; CH471076; EAW73845.1; -; Genomic_DNA.
EMBL; BC137028; AAI37029.1; -; mRNA.
EMBL; BC137029; AAI37030.1; -; mRNA.
EMBL; AF399569; AAK95054.1; -; Genomic_DNA.
EMBL; BK004307; DAA04705.1; -; Genomic_DNA.
CCDS; CCDS31562.1; -.
RefSeq; NP_001004708.1; NM_001004708.1.
UniGene; Hs.553650; -.
ProteinModelPortal; Q8NGJ1; -.
BioGrid; 128611; 2.
IntAct; Q8NGJ1; 1.
MINT; MINT-8201775; -.
STRING; 9606.ENSP00000300127; -.
PhosphoSitePlus; Q8NGJ1; -.
BioMuta; OR4D6; -.
DMDM; 38372703; -.
PaxDb; Q8NGJ1; -.
PRIDE; Q8NGJ1; -.
Ensembl; ENST00000300127; ENSP00000300127; ENSG00000166884.
GeneID; 219983; -.
KEGG; hsa:219983; -.
UCSC; uc010rku.3; human.
CTD; 219983; -.
EuPathDB; HostDB:ENSG00000166884.2; -.
GeneCards; OR4D6; -.
HGNC; HGNC:15175; OR4D6.
neXtProt; NX_Q8NGJ1; -.
OpenTargets; ENSG00000166884; -.
PharmGKB; PA32273; -.
eggNOG; ENOG410IFP2; Eukaryota.
eggNOG; ENOG4111DX6; LUCA.
GeneTree; ENSGT00760000119104; -.
HOGENOM; HOG000041362; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8NGJ1; -.
KO; K04257; -.
OMA; NTVITPM; -.
OrthoDB; EOG091G0AZH; -.
PhylomeDB; Q8NGJ1; -.
TreeFam; TF352732; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR4D6; -.
GenomeRNAi; 219983; -.
PRO; PR:Q8NGJ1; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000166884; -.
CleanEx; HS_OR4D6; -.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 314 Olfactory receptor 4D6.
/FTId=PRO_0000150540.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 49 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 50 57 Cytoplasmic. {ECO:0000255}.
TRANSMEM 58 79 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 80 100 Extracellular. {ECO:0000255}.
TRANSMEM 101 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 158 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 159 195 Extracellular. {ECO:0000255}.
TRANSMEM 196 219 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 220 235 Cytoplasmic. {ECO:0000255}.
TRANSMEM 236 258 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 259 269 Extracellular. {ECO:0000255}.
TRANSMEM 270 289 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 290 314 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 11 11 E -> Q (in dbSNP:rs17153766).
/FTId=VAR_034194.
VARIANT 59 59 M -> V (in dbSNP:rs1453544).
/FTId=VAR_053169.
VARIANT 96 96 D -> G (in dbSNP:rs1453543).
{ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.2}.
/FTId=VAR_024091.
VARIANT 102 102 F -> S (in dbSNP:rs17153770).
/FTId=VAR_034195.
VARIANT 111 111 D -> A (in dbSNP:rs17500380).
/FTId=VAR_034196.
VARIANT 151 151 S -> T (in dbSNP:rs1453542).
/FTId=VAR_024092.
VARIANT 263 263 M -> T (in dbSNP:rs1453541).
/FTId=VAR_024093.
SEQUENCE 314 AA; 35954 MW; FA70D423F278502E CRC64;
MDQINHTNVK EFFFLELTRS RELEFFLFVV FFAVYVATVL GNALIVVTIT CESRLHTPMY
FLLRNKSVLD IVFSSITVPK FLVDLLSDRK TISYNDCMAQ IFFFHFAGGA DIFFLSVMAY
DRYLAIAKPL HYVTMMRKEV WVALVVASWV SGGLHSIIQV ILMLPFPFCG PNTLDAFYCY
VLQVVKLACT DTFALELFMI SNNGLVTLLW FLLLLGSYTV ILVMLRSHSG EGRNKALSTC
TSHMLVVTLH FVPCVYIYCR PFMTLPMDTT ISINNTVITP MLNPIIYSLR NQEMKSAMQR
LQRRLGPSES RKWG


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