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Olfactory receptor 4L1 (Olfactory receptor 4L2) (Olfactory receptor OR14-28)

 OR4L1_HUMAN             Reviewed;         312 AA.
Q8NH43; Q6IEZ5;
10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
12-SEP-2018, entry version 125.
RecName: Full=Olfactory receptor 4L1;
AltName: Full=Olfactory receptor 4L2;
AltName: Full=Olfactory receptor OR14-28;
Name=OR4L1; Synonyms=OR4L2P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[3]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4L1";
-----------------------------------------------------------------------
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EMBL; AB065558; BAC05796.1; -; Genomic_DNA.
EMBL; BK004467; DAA04865.1; -; Genomic_DNA.
CCDS; CCDS32029.1; -.
RefSeq; NP_001004717.1; NM_001004717.1.
UniGene; Hs.553574; -.
ProteinModelPortal; Q8NH43; -.
STRING; 9606.ENSP00000319217; -.
iPTMnet; Q8NH43; -.
PhosphoSitePlus; Q8NH43; -.
BioMuta; OR4L1; -.
DMDM; 38372806; -.
PaxDb; Q8NH43; -.
PRIDE; Q8NH43; -.
ProteomicsDB; 73656; -.
TopDownProteomics; Q8NH43; -.
Ensembl; ENST00000315683; ENSP00000319217; ENSG00000176246.
GeneID; 122742; -.
KEGG; hsa:122742; -.
UCSC; uc001vwn.1; human.
CTD; 122742; -.
EuPathDB; HostDB:ENSG00000176246.1; -.
GeneCards; OR4L1; -.
HGNC; HGNC:15356; OR4L1.
neXtProt; NX_Q8NH43; -.
PharmGKB; PA32325; -.
eggNOG; ENOG410IFT7; Eukaryota.
eggNOG; ENOG4111DAI; LUCA.
GeneTree; ENSGT00900000140841; -.
HOGENOM; HOG000041362; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8NH43; -.
KO; K04257; -.
OMA; HKTISVW; -.
OrthoDB; EOG091G0CY9; -.
PhylomeDB; Q8NH43; -.
TreeFam; TF336512; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR4L1; -.
GenomeRNAi; 122742; -.
PRO; PR:Q8NH43; -.
Proteomes; UP000005640; Chromosome 14.
Bgee; ENSG00000176246; Expressed in 2 organ(s), highest expression level in blood.
CleanEx; HS_OR4L1; -.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 312 Olfactory receptor 4L1.
/FTId=PRO_0000150560.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 49 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 50 57 Cytoplasmic. {ECO:0000255}.
TRANSMEM 58 79 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 80 100 Extracellular. {ECO:0000255}.
TRANSMEM 101 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 158 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 159 195 Extracellular. {ECO:0000255}.
TRANSMEM 196 219 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 220 235 Cytoplasmic. {ECO:0000255}.
TRANSMEM 236 258 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 259 269 Extracellular. {ECO:0000255}.
TRANSMEM 270 289 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 290 312 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 268 268 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 2 2 D -> N (in dbSNP:rs1958715).
/FTId=VAR_034201.
VARIANT 16 16 G -> V (in dbSNP:rs45584133).
/FTId=VAR_062036.
VARIANT 40 40 M -> V (in dbSNP:rs1958716).
/FTId=VAR_034202.
VARIANT 52 52 R -> S (in dbSNP:rs1959630).
/FTId=VAR_024094.
VARIANT 93 93 S -> F (in dbSNP:rs10139756).
/FTId=VAR_034203.
VARIANT 101 101 M -> K (in dbSNP:rs2775253).
/FTId=VAR_034204.
VARIANT 109 109 G -> S (in dbSNP:rs2775254).
/FTId=VAR_034205.
VARIANT 160 160 I -> T (in dbSNP:rs45585336).
/FTId=VAR_062037.
SEQUENCE 312 AA; 35264 MW; C7BFE135301F56F1 CRC64;
MDLKNGSLVT EFILLGFFGR WELQIFFFVT FSLIYGATVM GNILIMVTVT CRSTLHSPLY
FLLGNLSFLD MCLSTATTPK MIIDLLTDHK TISVWGCVTQ MFFMHFFGGA EMTLLIIMAF
DRYVAICKPL HYRTIMSHKL LKGFAILSWI IGFLHSISQI VLTMNLPFCG HNVINNIFCD
LPLVIKLACI ETYTLELFVI ADSGLLSFTC FILLLVSYIV ILVSVPKKSS HGLSKALSTL
SAHIIVVTLF FGPCIFIYVW PFSSLASNKT LAVFYTVITP LLNPSIYTLR NKKMQEAIRK
LRFQYVSSAQ NF


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