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Olfactory receptor 51V1 (Odorant receptor HOR3'beta1) (Olfactory receptor 51A12) (Olfactory receptor OR11-36)

 O51V1_HUMAN             Reviewed;         321 AA.
Q9H2C8;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
18-MAY-2010, sequence version 2.
20-JUN-2018, entry version 127.
RecName: Full=Olfactory receptor 51V1;
AltName: Full=Odorant receptor HOR3'beta1;
AltName: Full=Olfactory receptor 51A12;
AltName: Full=Olfactory receptor OR11-36;
Name=OR51V1; Synonyms=OR51A12;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11121057; DOI=10.1073/pnas.97.26.14560;
Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M.,
Felsenfeld G., Groudine M., Hardison R.;
"Comparative structural and functional analysis of the olfactory
receptor genes flanking the human and mouse beta-globin gene
clusters.";
Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16554811; DOI=10.1038/nature04632;
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene
identification.";
Nature 440:497-500(2006).
[3]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[4]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
[5]
VARIANT VAL-211.
PubMed=26282398; DOI=10.1186/s13023-015-0316-8;
Dahmani M., Ammar-Khodja F., Bonnet C., Lefevre G.M., Hardelin J.P.,
Ibrahim H., Mallek Z., Petit C.;
"EPS8L2 is a new causal gene for childhood onset autosomal recessive
progressive hearing loss.";
Orphanet J. Rare Dis. 10:96-96(2015).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR51V1";
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; AF289203; AAG42364.1; -; Genomic_DNA.
EMBL; AC104389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BK004432; DAA04830.1; -; Genomic_DNA.
CCDS; CCDS31375.1; -.
RefSeq; NP_001004760.2; NM_001004760.2.
UniGene; Hs.553670; -.
ProteinModelPortal; Q9H2C8; -.
BioGrid; 129462; 1.
STRING; 9606.ENSP00000321729; -.
iPTMnet; Q9H2C8; -.
PhosphoSitePlus; Q9H2C8; -.
BioMuta; OR51V1; -.
DMDM; 296439246; -.
PaxDb; Q9H2C8; -.
PeptideAtlas; Q9H2C8; -.
PRIDE; Q9H2C8; -.
ProteomicsDB; 80529; -.
DNASU; 283111; -.
Ensembl; ENST00000321255; ENSP00000321729; ENSG00000176742.
GeneID; 283111; -.
KEGG; hsa:283111; -.
UCSC; uc010qyz.2; human.
CTD; 283111; -.
EuPathDB; HostDB:ENSG00000176742.1; -.
GeneCards; OR51V1; -.
HGNC; HGNC:19597; OR51V1.
neXtProt; NX_Q9H2C8; -.
OpenTargets; ENSG00000176742; -.
PharmGKB; PA134873075; -.
eggNOG; ENOG410IIYI; Eukaryota.
eggNOG; ENOG4111DWS; LUCA.
GeneTree; ENSGT00920000149003; -.
HOGENOM; HOG000041363; -.
HOVERGEN; HBG017625; -.
InParanoid; Q9H2C8; -.
KO; K04257; -.
OMA; HKLFQTC; -.
OrthoDB; EOG091G0AZH; -.
PhylomeDB; Q9H2C8; -.
TreeFam; TF342735; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR51V1; -.
GenomeRNAi; 283111; -.
PRO; PR:Q9H2C8; -.
Proteomes; UP000005640; Chromosome 11.
CleanEx; HS_OR51V1; -.
GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 321 Olfactory receptor 51V1.
/FTId=PRO_0000150764.
TOPO_DOM 1 34 Extracellular. {ECO:0000255}.
TRANSMEM 35 55 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 56 63 Cytoplasmic. {ECO:0000255}.
TRANSMEM 64 84 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 85 108 Extracellular. {ECO:0000255}.
TRANSMEM 109 129 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 130 148 Cytoplasmic. {ECO:0000255}.
TRANSMEM 149 169 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 170 205 Extracellular. {ECO:0000255}.
TRANSMEM 206 226 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 227 246 Cytoplasmic. {ECO:0000255}.
TRANSMEM 247 267 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 268 282 Extracellular. {ECO:0000255}.
TRANSMEM 283 303 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 304 321 Cytoplasmic. {ECO:0000255}.
CARBOHYD 18 18 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 106 188 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 211 211 L -> V. {ECO:0000269|PubMed:26282398}.
/FTId=VAR_079498.
VARIANT 233 233 S -> L (in dbSNP:rs7933549).
/FTId=VAR_057580.
CONFLICT 36 36 L -> F (in Ref. 1; AAG42364).
{ECO:0000305}.
CONFLICT 96 96 G -> R (in Ref. 1; AAG42364).
{ECO:0000305}.
SEQUENCE 321 AA; 36749 MW; 3CF758D12EB5B1A0 CRC64;
MFLSSRMITS VSPSTSTNSS FLLTGFSGME QQYPWLSIPF SSIYAMVLLG NCMVLHVIWT
EPSLHQPMFY FLSMLALTDL CMGLSTVYTV LGILWGIIRE ISLDSCIAQS YFIHGLSFME
SSVLLTMAFD RYIAICNPLR YSSILTNSRI IKIGLTIIGR SFFFITPPII CLKFFNYCHF
HILSHSFCLH QDLLRLACSD IRFNSYYALM LVICILLLDA ILILFSYILI LKSVLAVASQ
EERHKLFQTC ISHICAVLVF YIPIISLTMV HRFGKHLSPV AHVLIGNIYI LFPPLMNPII
YSVKTQQIHT RMLRLFSLKR Y


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