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Olfactory receptor 56A1 (Olfactory receptor OR11-75)

 O56A1_HUMAN             Reviewed;         318 AA.
Q8NGH5; B2RNI2; Q6IFL0;
10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
05-MAY-2009, sequence version 3.
12-SEP-2018, entry version 125.
RecName: Full=Olfactory receptor 56A1;
AltName: Full=Olfactory receptor OR11-75;
Name=OR56A1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16554811; DOI=10.1038/nature04632;
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene
identification.";
Nature 440:497-500(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[5]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator.
{ECO:0000305}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR56A1";
-----------------------------------------------------------------------
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EMBL; AB065821; BAC06040.1; -; Genomic_DNA.
EMBL; AC111177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC136904; AAI36905.1; -; mRNA.
EMBL; BC136911; AAI36912.1; -; mRNA.
EMBL; BK004252; DAA04650.1; -; Genomic_DNA.
CCDS; CCDS31405.1; -.
RefSeq; NP_001001917.2; NM_001001917.2.
UniGene; Hs.553543; -.
ProteinModelPortal; Q8NGH5; -.
STRING; 9606.ENSP00000321246; -.
iPTMnet; Q8NGH5; -.
PhosphoSitePlus; Q8NGH5; -.
BioMuta; OR56A1; -.
DMDM; 229462958; -.
PaxDb; Q8NGH5; -.
PeptideAtlas; Q8NGH5; -.
PRIDE; Q8NGH5; -.
ProteomicsDB; 73512; -.
Ensembl; ENST00000316650; ENSP00000321246; ENSG00000180934.
GeneID; 120796; -.
KEGG; hsa:120796; -.
UCSC; uc010qzw.2; human.
CTD; 120796; -.
EuPathDB; HostDB:ENSG00000180934.5; -.
GeneCards; OR56A1; -.
H-InvDB; HIX0036119; -.
HGNC; HGNC:14781; OR56A1.
neXtProt; NX_Q8NGH5; -.
PharmGKB; PA32443; -.
eggNOG; ENOG410II2D; Eukaryota.
eggNOG; ENOG410YAIE; LUCA.
GeneTree; ENSGT00550000074576; -.
HOGENOM; HOG000041363; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8NGH5; -.
KO; K04257; -.
OMA; RFKAEGA; -.
OrthoDB; EOG091G0H8A; -.
PhylomeDB; Q8NGH5; -.
TreeFam; TF344049; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR56A1; -.
GenomeRNAi; 120796; -.
PRO; PR:Q8NGH5; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000180934; Expressed in 3 organ(s), highest expression level in testis.
CleanEx; HS_OR56A1; -.
ExpressionAtlas; Q8NGH5; baseline and differential.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
GO; GO:0035240; F:dopamine binding; IBA:GO_Central.
GO; GO:0001591; F:dopamine neurotransmitter receptor activity, coupled via Gi/Go; IBA:GO_Central.
GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
GO; GO:0007195; P:adenylate cyclase-inhibiting dopamine receptor signaling pathway; IBA:GO_Central.
GO; GO:0071875; P:adrenergic receptor signaling pathway; IEA:GOC.
GO; GO:0048148; P:behavioral response to cocaine; IBA:GO_Central.
GO; GO:0048149; P:behavioral response to ethanol; IBA:GO_Central.
GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IBA:GO_Central.
GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; IBA:GO_Central.
GO; GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
GO; GO:1901386; P:negative regulation of voltage-gated calcium channel activity; IBA:GO_Central.
GO; GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IBA:GO_Central.
GO; GO:0014059; P:regulation of dopamine secretion; IBA:GO_Central.
GO; GO:0043266; P:regulation of potassium ion transport; IBA:GO_Central.
GO; GO:0042493; P:response to drug; IBA:GO_Central.
GO; GO:0009636; P:response to toxic substance; IBA:GO_Central.
GO; GO:0001963; P:synaptic transmission, dopaminergic; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Receptor; Reference proteome; Sensory transduction; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 318 Olfactory receptor 56A1.
/FTId=PRO_0000150793.
TOPO_DOM 1 32 Extracellular. {ECO:0000255}.
TRANSMEM 33 53 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 54 61 Cytoplasmic. {ECO:0000255}.
TRANSMEM 62 82 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 83 106 Extracellular. {ECO:0000255}.
TRANSMEM 107 127 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 128 146 Cytoplasmic. {ECO:0000255}.
TRANSMEM 147 167 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 168 203 Extracellular. {ECO:0000255}.
TRANSMEM 204 224 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 225 244 Cytoplasmic. {ECO:0000255}.
TRANSMEM 245 265 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 266 280 Extracellular. {ECO:0000255}.
TRANSMEM 281 301 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 302 318 Cytoplasmic. {ECO:0000255}.
CARBOHYD 10 10 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 188 188 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 198 198 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 104 196 {ECO:0000255|PROSITE-ProRule:PRU00521}.
CONFLICT 22 22 I -> T (in Ref. 1; BAC06040).
{ECO:0000305}.
SEQUENCE 318 AA; 35823 MW; D0174EFA5005C677 CRC64;
MIQPMASPSN SSTVPVSEFL LICFPNFQSW QHWLSLPLSL LFLLAMGANT TLLITIQLEA
SLHQPLYYLL SLLSLLDIVL CLTVIPKVLA IFWYDLRSIS FPACFLQMFI MNSFLPMESC
TFMVMAYDRY VAICHPLRYP SIITNQFVAK ASVFIVVRNA LLTAPIPILT SLLHYCGENV
IENCICANLS VSRLSCDNFT LNRIYQFVAG WTLLGSDLFL IFLSYTFILR AVLRFKAEGA
AVKALSTCGS HFILILFFST ILLVVVLTNV ARKKVPMDIL ILLNVLHHLI PPALNPIVYG
VRTKEIKQGI QKLLQRGR


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