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Olfactory receptor 5B3 (Olfactory receptor 5B13) (Olfactory receptor OR11-239)

 OR5B3_HUMAN             Reviewed;         314 AA.
Q8NH48; Q6IEV6;
10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
05-DEC-2018, entry version 133.
RecName: Full=Olfactory receptor 5B3;
AltName: Full=Olfactory receptor 5B13;
AltName: Full=Olfactory receptor OR11-239;
Name=OR5B3; Synonyms=OR5B13;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[3]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5B3";
-----------------------------------------------------------------------
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EMBL; AB065545; BAC05790.1; -; Genomic_DNA.
EMBL; BK004506; DAA04904.1; -; Genomic_DNA.
CCDS; CCDS31549.1; -.
RefSeq; NP_001005469.1; NM_001005469.1.
UniGene; Hs.553826; -.
ProteinModelPortal; Q8NH48; -.
STRING; 9606.ENSP00000308270; -.
iPTMnet; Q8NH48; -.
PhosphoSitePlus; Q8NH48; -.
BioMuta; OR5B3; -.
DMDM; 38372807; -.
PaxDb; Q8NH48; -.
PeptideAtlas; Q8NH48; -.
PRIDE; Q8NH48; -.
ProteomicsDB; 73657; -.
Ensembl; ENST00000309403; ENSP00000308270; ENSG00000172769.
Ensembl; ENST00000641865; ENSP00000493217; ENSG00000172769.
GeneID; 441608; -.
KEGG; hsa:441608; -.
UCSC; uc010rkf.3; human.
CTD; 441608; -.
EuPathDB; HostDB:ENSG00000172769.2; -.
GeneCards; OR5B3; -.
HGNC; HGNC:8324; OR5B3.
neXtProt; NX_Q8NH48; -.
PharmGKB; PA32491; -.
eggNOG; ENOG410IVUX; Eukaryota.
eggNOG; ENOG41117FD; LUCA.
GeneTree; ENSGT00940000153053; -.
HOGENOM; HOG000041364; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8NH48; -.
KO; K04257; -.
OMA; QMYIFVA; -.
OrthoDB; EOG091G0AZH; -.
PhylomeDB; Q8NH48; -.
TreeFam; TF352753; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR5B3; -.
GenomeRNAi; 441608; -.
PRO; PR:Q8NH48; -.
Proteomes; UP000005640; Chromosome 11.
CleanEx; HS_OR5B3; -.
ExpressionAtlas; Q8NH48; baseline and differential.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0005549; F:odorant binding; IBA:GO_Central.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 314 Olfactory receptor 5B3.
/FTId=PRO_0000150586.
TOPO_DOM 1 23 Extracellular. {ECO:0000255}.
TRANSMEM 24 44 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 45 52 Cytoplasmic. {ECO:0000255}.
TRANSMEM 53 73 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 74 97 Extracellular. {ECO:0000255}.
TRANSMEM 98 118 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 119 131 Cytoplasmic. {ECO:0000255}.
TRANSMEM 132 152 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 153 194 Extracellular. {ECO:0000255}.
TRANSMEM 195 215 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 216 235 Cytoplasmic. {ECO:0000255}.
TRANSMEM 236 256 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 257 269 Extracellular. {ECO:0000255}.
TRANSMEM 270 290 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 291 314 Cytoplasmic. {ECO:0000255}.
CARBOHYD 3 3 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 17 17 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 153 153 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 95 187 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 30 30 P -> L (in dbSNP:rs17152661).
/FTId=VAR_053183.
VARIANT 35 35 I -> F (in dbSNP:rs17152659).
/FTId=VAR_053184.
VARIANT 49 49 W -> R (in dbSNP:rs11229413).
/FTId=VAR_053185.
VARIANT 170 170 N -> S (in dbSNP:rs12280114).
/FTId=VAR_053186.
VARIANT 181 181 A -> T (in dbSNP:rs11229411).
/FTId=VAR_053187.
VARIANT 198 198 I -> V (in dbSNP:rs11229410).
/FTId=VAR_053188.
VARIANT 247 247 G -> A (in dbSNP:rs11229409).
/FTId=VAR_053189.
VARIANT 296 296 K -> R (in dbSNP:rs12279895).
/FTId=VAR_053190.
SEQUENCE 314 AA; 35258 MW; 4E856ECC1F1154CF CRC64;
MENKTEVTQF ILLGLTNDSE LQVPLFITFP FIYIITLVGN LGIIVLIFWD SCLHNPMYFF
LSNLSLVDFC YSSAVTPIVM AGFLIEDKVI SYNACAAQMY IFVAFATVEN YLLASMAYDR
YAAVCKPLHY TTTMTTTVCA RLAIGSYLCG FLNASIHTGD TFSLSFCKSN EVHHFFCDIP
AVMVLSCSDR HISELVLIYV VSFNIFIALL VILISYTFIF ITILKMHSAS VYQKPLSTCA
SHFIAVGIFY GTIIFMYLQP SSSHSMDTDK MAPVFYTMVI PMLNPLVYSL RNKEVKSAFK
KVVEKAKLSV GWSV


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