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Olfactory receptor 7C1 (Olfactory receptor 7C4) (Olfactory receptor OR19-16) (Olfactory receptor TPCR86)

 OR7C1_HUMAN             Reviewed;         320 AA.
O76099; Q15621; Q6IFP2; Q96R94;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
20-JUN-2018, entry version 155.
RecName: Full=Olfactory receptor 7C1;
AltName: Full=Olfactory receptor 7C4;
AltName: Full=Olfactory receptor OR19-16;
AltName: Full=Olfactory receptor TPCR86;
Name=OR7C1; Synonyms=OR7C4;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, AND VARIANT LYS-171.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 126-282, AND VARIANTS LYS-171 AND
PRO-210.
TISSUE=Testis;
PubMed=9119360; DOI=10.1006/geno.1996.4490;
Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
"Specific repertoire of olfactory receptor genes in the male germ
cells of several mammalian species.";
Genomics 39:239-246(1997).
[4]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[5]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7C1";
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AC005255; AAC25625.1; -; Genomic_DNA.
EMBL; AF399546; AAK95031.1; -; Genomic_DNA.
EMBL; X89676; CAA61823.1; -; mRNA.
EMBL; BK004220; DAA04618.1; -; Genomic_DNA.
CCDS; CCDS12317.1; -.
PIR; S58004; S58004.
RefSeq; NP_945182.1; NM_198944.1.
RefSeq; XP_005259910.1; XM_005259853.3.
UniGene; Hs.466053; -.
ProteinModelPortal; O76099; -.
BioGrid; 117779; 1.
STRING; 9606.ENSP00000248073; -.
iPTMnet; O76099; -.
PhosphoSitePlus; O76099; -.
BioMuta; OR7C1; -.
PaxDb; O76099; -.
PRIDE; O76099; -.
ProteomicsDB; 50416; -.
Ensembl; ENST00000248073; ENSP00000248073; ENSG00000127530.
Ensembl; ENST00000641666; ENSP00000493429; ENSG00000127530.
Ensembl; ENST00000642000; ENSP00000493248; ENSG00000127530.
Ensembl; ENST00000642030; ENSP00000493026; ENSG00000127530.
GeneID; 26664; -.
KEGG; hsa:26664; -.
UCSC; uc010xnz.3; human.
CTD; 26664; -.
EuPathDB; HostDB:ENSG00000127530.2; -.
GeneCards; OR7C1; -.
HGNC; HGNC:8373; OR7C1.
HPA; HPA047127; -.
neXtProt; NX_O76099; -.
OpenTargets; ENSG00000127530; -.
PharmGKB; PA32624; -.
eggNOG; ENOG410IVB1; Eukaryota.
eggNOG; ENOG410YBQN; LUCA.
GeneTree; ENSGT00760000118801; -.
HOGENOM; HOG000041362; -.
HOVERGEN; HBG017625; -.
InParanoid; O76099; -.
KO; K04257; -.
OMA; KFITYAG; -.
OrthoDB; EOG091G0B53; -.
PhylomeDB; O76099; -.
TreeFam; TF337210; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR7C1; -.
GenomeRNAi; 26664; -.
PRO; PR:O76099; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000127530; -.
CleanEx; HS_OR7C1; -.
ExpressionAtlas; O76099; baseline and differential.
Genevisible; O76099; HS.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 320 Olfactory receptor 7C1.
/FTId=PRO_0000150646.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 46 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 47 54 Cytoplasmic. {ECO:0000255}.
TRANSMEM 55 75 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 76 99 Extracellular. {ECO:0000255}.
TRANSMEM 100 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 160 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 161 197 Extracellular. {ECO:0000255}.
TRANSMEM 198 217 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 218 237 Cytoplasmic. {ECO:0000255}.
TRANSMEM 238 258 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 259 271 Extracellular. {ECO:0000255}.
TRANSMEM 272 292 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 293 313 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 99 99 S -> G (in dbSNP:rs17230134).
/FTId=VAR_053232.
VARIANT 126 126 V -> I (in dbSNP:rs10415562).
/FTId=VAR_024111.
VARIANT 171 171 E -> K (in dbSNP:rs10415312).
{ECO:0000269|PubMed:12213199,
ECO:0000269|PubMed:9119360}.
/FTId=VAR_053233.
VARIANT 210 210 S -> P (in dbSNP:rs16979912).
{ECO:0000269|PubMed:9119360}.
/FTId=VAR_024112.
CONFLICT 247 247 V -> L (in Ref. 3; CAA61823).
{ECO:0000305}.
SEQUENCE 320 AA; 35519 MW; BBDCC409721D70C4 CRC64;
METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC SDSHLHTPMY
FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ IFFFTSFGCL DNLLLTVMAY
DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC ISVMGSLLET LTVLRLSFCT EMEIPHFFCD
LLEVLKLACS DTFINNVVIY FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST
CGSHLSVVTL FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA
LGRLLSRATF FNGDITAGLS


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