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Olfactory receptor 7C2 (Olfactory receptor 19-18) (OR19-18) (Olfactory receptor 7C3) (Olfactory receptor OR19-22)

 OR7C2_HUMAN             Reviewed;         319 AA.
O60412; O43881; Q6IFP9;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
17-OCT-2006, sequence version 4.
05-DEC-2018, entry version 146.
RecName: Full=Olfactory receptor 7C2;
AltName: Full=Olfactory receptor 19-18;
Short=OR19-18;
AltName: Full=Olfactory receptor 7C3;
AltName: Full=Olfactory receptor OR19-22;
Name=OR7C2; Synonyms=OR7C3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
PubMed=9500546; DOI=10.1038/ng0398-243;
Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
Demaille J.G., Giorgi D.;
"Distribution of olfactory receptor genes in the human genome.";
Nat. Genet. 18:243-250(1998).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
[4]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[5]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- SEQUENCE CAUTION:
Sequence=DAA04611.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7C2";
-----------------------------------------------------------------------
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EMBL; AC004659; AAC15755.1; -; Genomic_DNA.
EMBL; U86255; AAC39626.1; -; Genomic_DNA.
EMBL; AF399545; AAK95030.1; -; Genomic_DNA.
EMBL; BK004213; DAA04611.1; ALT_INIT; Genomic_DNA.
CCDS; CCDS12320.1; -.
RefSeq; NP_036509.1; NM_012377.1.
UniGene; Hs.589620; -.
ProteinModelPortal; O60412; -.
IntAct; O60412; 2.
STRING; 9606.ENSP00000248072; -.
BioMuta; OR7C2; -.
PaxDb; O60412; -.
PRIDE; O60412; -.
ProteomicsDB; 49394; -.
DNASU; 26658; -.
Ensembl; ENST00000248072; ENSP00000248072; ENSG00000127529.
GeneID; 26658; -.
KEGG; hsa:26658; -.
UCSC; uc010xoc.2; human.
CTD; 26658; -.
EuPathDB; HostDB:ENSG00000127529.7; -.
GeneCards; OR7C2; -.
HGNC; HGNC:8374; OR7C2.
HPA; HPA047295; -.
neXtProt; NX_O60412; -.
PharmGKB; PA32625; -.
eggNOG; ENOG410IVB1; Eukaryota.
eggNOG; ENOG410YBQN; LUCA.
GeneTree; ENSGT00940000162084; -.
HOGENOM; HOG000041365; -.
HOVERGEN; HBG017625; -.
InParanoid; O60412; -.
KO; K04257; -.
OMA; MITFAGC; -.
OrthoDB; EOG091G0B53; -.
PhylomeDB; O60412; -.
TreeFam; TF337210; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR7C2; -.
GenomeRNAi; 26658; -.
PRO; PR:O60412; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000127529; Expressed in 3 organ(s), highest expression level in putamen.
CleanEx; HS_OR7C2; -.
Genevisible; O60412; HS.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 319 Olfactory receptor 7C2.
/FTId=PRO_0000150647.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 46 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 47 54 Cytoplasmic. {ECO:0000255}.
TRANSMEM 55 75 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 76 99 Extracellular. {ECO:0000255}.
TRANSMEM 100 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 160 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 161 197 Extracellular. {ECO:0000255}.
TRANSMEM 198 217 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 218 236 Cytoplasmic. {ECO:0000255}.
TRANSMEM 237 257 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 258 270 Extracellular. {ECO:0000255}.
TRANSMEM 271 291 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 292 319 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 118 118 T -> M (in dbSNP:rs8113325).
/FTId=VAR_027808.
VARIANT 122 122 R -> H (in dbSNP:rs11883178).
/FTId=VAR_053234.
CONFLICT 168 168 F -> S (in Ref. 2; AAC39626 and 3;
AAK95030). {ECO:0000305}.
CONFLICT 200 200 Y -> C (in Ref. 2; AAC39626 and 3;
AAK95030). {ECO:0000305}.
CONFLICT 229 229 S -> SS (in Ref. 2; AAC39626 and 3;
AAK95030). {ECO:0000305}.
CONFLICT 238 238 S -> T (in Ref. 2; AAC39626 and 3;
AAK95030). {ECO:0000305}.
CONFLICT 277 277 Y -> H (in Ref. 2; AAC39626 and 3;
AAK95030). {ECO:0000305}.
SEQUENCE 319 AA; 35323 MW; 1FAF5A196B2B566C CRC64;
MERGNQTEVG NFLLLGFAED SDMQLLLHGL FLSMYLVTII GNLLIILTIS SDSHLHTPMY
FFLSNLSFAD ICFTSTTVPK MLVNIQTQSK MITFAGCLTQ IFFFIAFGCL DNLLLTMTAY
DRFVAICYPL HYTVIMNPRL CGLLVLGSWC ISVMGSLLET LTILRLSFCT NMEIPHFFCD
PSEVLKLACS DTFINNIVMY FVTIVLGVFP LCGILFSYSQ IFSSVLRVSA RGQHKAFSTC
GSHLSVVSLF YGTGLGVYLS SAVTPPSRTS LAASVMYTMV TPMLNPFIYS LRNKDMKGSL
GRLLLRATSL KEGTIAKLS


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