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Olfactory receptor 7D4 (OR19-B) (Odorant receptor family subfamily D member 4RT) (Olfactory receptor OR19-7)

 OR7D4_HUMAN             Reviewed;         312 AA.
Q8NG98; A8CAH8; A8CAH9; A8CAI0; A8CAI1; B9EH79;
19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
27-SEP-2017, entry version 120.
RecName: Full=Olfactory receptor 7D4;
AltName: Full=OR19-B;
AltName: Full=Odorant receptor family subfamily D member 4RT;
AltName: Full=Olfactory receptor OR19-7;
Name=OR7D4; Synonyms=OR7D4P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-52; CYS-75;
LEU-79; ASN-84; TRP-88; GLN-131; MET-133; ILE-136; ARG-139; TYR-139;
PRO-162; ASP-279 AND MET-292.
PubMed=17873857; DOI=10.1038/nature06162;
Keller A., Zhuang H., Chi Q., Vosshall L.B., Matsunami H.;
"Genetic variation in a human odorant receptor alters odour
perception.";
Nature 449:468-472(2007).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[6]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
[7]
TISSUE SPECIFICITY.
PubMed=17509148; DOI=10.1186/gb-2007-8-5-r86;
Zhang X., De la Cruz O., Pinto J.M., Nicolae D., Firestein S.,
Gilad Y.;
"Characterizing the expression of the human olfactory receptor gene
family using a novel DNA microarray.";
Genome Biol. 8:R86.1-R86.10(2007).
-!- FUNCTION: Odorant receptor. Selectively activated by androstenone
and the related odorous steroid androstadienone.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Nasal olfactory epithelium.
{ECO:0000269|PubMed:17509148}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7D4";
-!- WEB RESOURCE: Name=Protein Spotlight; Note=The selfish smell
- Issue 94 of May 2008;
URL="http://web.expasy.org/spotlight/back_issues/094";
-----------------------------------------------------------------------
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EMBL; EU049291; ABV66282.1; -; Genomic_DNA.
EMBL; EU049292; ABV66283.1; -; Genomic_DNA.
EMBL; EU049293; ABV66284.1; -; Genomic_DNA.
EMBL; EU049294; ABV66285.1; -; Genomic_DNA.
EMBL; AB065929; BAC06144.1; -; Genomic_DNA.
EMBL; CH471106; EAW84021.1; -; Genomic_DNA.
EMBL; BC137147; AAI37148.1; -; mRNA.
EMBL; BC137162; AAI37163.1; -; mRNA.
EMBL; BK004226; DAA04624.1; -; Genomic_DNA.
CCDS; CCDS32901.1; -.
RefSeq; NP_001005191.1; NM_001005191.2.
UniGene; Hs.446910; -.
ProteinModelPortal; Q8NG98; -.
STRING; 9606.ENSP00000310488; -.
BioMuta; OR7D4; -.
DMDM; 71153032; -.
PaxDb; Q8NG98; -.
PRIDE; Q8NG98; -.
Ensembl; ENST00000308682; ENSP00000310488; ENSG00000174667.
GeneID; 125958; -.
KEGG; hsa:125958; -.
UCSC; uc002mla.2; human.
CTD; 125958; -.
DisGeNET; 125958; -.
EuPathDB; HostDB:ENSG00000174667.3; -.
GeneCards; OR7D4; -.
HGNC; HGNC:8380; OR7D4.
MIM; 611538; gene.
neXtProt; NX_Q8NG98; -.
OpenTargets; ENSG00000174667; -.
PharmGKB; PA32628; -.
eggNOG; ENOG410IVB1; Eukaryota.
eggNOG; ENOG410YBQN; LUCA.
GeneTree; ENSGT00760000118801; -.
HOGENOM; HOG000041365; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8NG98; -.
KO; K04257; -.
OMA; NNICLYV; -.
OrthoDB; EOG091G0B53; -.
PhylomeDB; Q8NG98; -.
TreeFam; TF337210; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR7D4; -.
GenomeRNAi; 125958; -.
PRO; PR:Q8NG98; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000174667; -.
CleanEx; HS_OR7D4; -.
ExpressionAtlas; Q8NG98; baseline and differential.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 312 Olfactory receptor 7D4.
/FTId=PRO_0000150649.
TOPO_DOM 1 25 Extracellular. {ECO:0000255}.
TRANSMEM 26 46 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 47 54 Cytoplasmic. {ECO:0000255}.
TRANSMEM 55 75 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 76 99 Extracellular. {ECO:0000255}.
TRANSMEM 100 120 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 121 139 Cytoplasmic. {ECO:0000255}.
TRANSMEM 140 160 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 161 197 Extracellular. {ECO:0000255}.
TRANSMEM 198 217 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 218 237 Cytoplasmic. {ECO:0000255}.
TRANSMEM 238 258 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 259 271 Extracellular. {ECO:0000255}.
TRANSMEM 272 292 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 293 312 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 189 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 17 17 L -> F (in dbSNP:rs57568862).
/FTId=VAR_062056.
VARIANT 52 52 D -> G (in dbSNP:rs144165121).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037778.
VARIANT 75 75 S -> C (in dbSNP:rs778417216).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037779.
VARIANT 79 79 P -> L (impaired response to androstenone
and androstadienone; dbSNP:rs61732668).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037780.
VARIANT 84 84 S -> N (high sensitivity to androstenone
and androstadienone; dbSNP:rs5020280).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037781.
VARIANT 88 88 R -> W (impaired response to androstenone
and androstadienone; when associated with
M-133; dbSNP:rs61729907).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037782.
VARIANT 131 131 H -> Q (in dbSNP:rs748899150).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037783.
VARIANT 133 133 T -> M (impaired response to androstenone
and androstadienone; when associated with
W-88; dbSNP:rs5020278).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037784.
VARIANT 136 136 M -> I (in dbSNP:rs5020277).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037785.
VARIANT 139 139 C -> R. {ECO:0000269|PubMed:17873857}.
/FTId=VAR_037786.
VARIANT 139 139 C -> Y. {ECO:0000269|PubMed:17873857}.
/FTId=VAR_037787.
VARIANT 162 162 L -> P. {ECO:0000269|PubMed:17873857}.
/FTId=VAR_037788.
VARIANT 279 279 A -> D (in dbSNP:rs138510982).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037789.
VARIANT 292 292 L -> M (in dbSNP:rs4564704).
{ECO:0000269|PubMed:17873857}.
/FTId=VAR_037790.
SEQUENCE 312 AA; 34448 MW; FD97DD41B890B085 CRC64;
MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS SDSHLHTPMY
FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ VYFLMMFAGM DTFLLAVMAY
DRFVAICHPL HYTVIMNPCL CGLLVLASWF IIFWFSLVHI LLMKRLTFST GTEIPHFFCE
PAQVLKVACS NTLLNNIVLY VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST
CGSHLCVVSL FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA
LERLLSRADS CP


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