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Olfactory receptor 7G1 (Olfactory receptor 19-15) (OR19-15) (Olfactory receptor OR19-8)

 OR7G1_HUMAN             Reviewed;         311 AA.
Q8NGA0; Q6IFJ5; Q96RA1;
10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
16-DEC-2008, sequence version 2.
10-OCT-2018, entry version 134.
RecName: Full=Olfactory receptor 7G1;
AltName: Full=Olfactory receptor 19-15;
Short=OR19-15;
AltName: Full=Olfactory receptor OR19-8;
Name=OR7G1; Synonyms=OR7G1P;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
"Genome-wide discovery and analysis of human seven transmembrane helix
receptor genes.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
PubMed=12213199; DOI=10.1006/geno.2002.6830;
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
Lehrach H., Lancet D., Shamir R.;
"DEFOG: a practical scheme for deciphering families of genes.";
Genomics 80:295-302(2002).
[4]
IDENTIFICATION.
PubMed=14983052; DOI=10.1073/pnas.0307882100;
Malnic B., Godfrey P.A., Buck L.B.;
"The human olfactory receptor gene family.";
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[5]
ERRATUM.
Malnic B., Godfrey P.A., Buck L.B.;
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
-!- FUNCTION: Odorant receptor. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- SEQUENCE CAUTION:
Sequence=BAC06141.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7G1";
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AB065926; BAC06141.1; ALT_SEQ; Genomic_DNA.
EMBL; AC011464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AF399538; AAK95023.1; -; Genomic_DNA.
EMBL; BK004267; DAA04665.1; -; Genomic_DNA.
CCDS; CCDS32898.2; -.
RefSeq; NP_001005192.2; NM_001005192.2.
UniGene; Hs.553576; -.
ProteinModelPortal; Q8NGA0; -.
STRING; 9606.ENSP00000444134; -.
BioMuta; OR7G1; -.
DMDM; 218511731; -.
PaxDb; Q8NGA0; -.
PRIDE; Q8NGA0; -.
ProteomicsDB; 73458; -.
Ensembl; ENST00000541538; ENSP00000444134; ENSG00000161807.
GeneID; 125962; -.
KEGG; hsa:125962; -.
UCSC; uc021uoi.1; human.
CTD; 125962; -.
EuPathDB; HostDB:ENSG00000161807.3; -.
GeneCards; OR7G1; -.
HGNC; HGNC:8465; OR7G1.
neXtProt; NX_Q8NGA0; -.
PharmGKB; PA32737; -.
eggNOG; ENOG410IVB1; Eukaryota.
eggNOG; ENOG410YBQN; LUCA.
GeneTree; ENSGT00840000129792; -.
HOGENOM; HOG000041364; -.
HOVERGEN; HBG017625; -.
InParanoid; Q8NGA0; -.
KO; K04257; -.
OMA; ESCFLAV; -.
OrthoDB; EOG091G0B53; -.
PhylomeDB; Q8NGA0; -.
TreeFam; TF337210; -.
Reactome; R-HSA-381753; Olfactory Signaling Pathway.
GeneWiki; OR7G1; -.
GenomeRNAi; 125962; -.
PRO; PR:Q8NGA0; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000161807; Expressed in 1 organ(s), highest expression level in blood.
CleanEx; HS_OR7G1; -.
ExpressionAtlas; Q8NGA0; baseline and differential.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR000725; Olfact_rcpt.
Pfam; PF13853; 7tm_4; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00245; OLFACTORYR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Olfaction;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 311 Olfactory receptor 7G1.
/FTId=PRO_0000150650.
TOPO_DOM 1 29 Extracellular. {ECO:0000255}.
TRANSMEM 30 50 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 51 57 Cytoplasmic. {ECO:0000255}.
TRANSMEM 58 78 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 79 97 Extracellular. {ECO:0000255}.
TRANSMEM 98 118 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 119 133 Cytoplasmic. {ECO:0000255}.
TRANSMEM 134 154 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 155 196 Extracellular. {ECO:0000255}.
TRANSMEM 197 217 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 218 244 Cytoplasmic. {ECO:0000255}.
TRANSMEM 245 265 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 266 269 Extracellular. {ECO:0000255}.
TRANSMEM 270 290 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 291 311 Cytoplasmic. {ECO:0000255}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 89 89 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 97 179 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 83 83 V -> A (in dbSNP:rs6511874).
/FTId=VAR_048074.
VARIANT 141 141 W -> C (in dbSNP:rs2217657).
/FTId=VAR_034255.
VARIANT 156 156 A -> V (in dbSNP:rs7246980).
/FTId=VAR_048075.
VARIANT 167 167 S -> F (in dbSNP:rs7246969).
/FTId=VAR_048076.
VARIANT 252 252 Y -> C (in dbSNP:rs2195951).
/FTId=VAR_034256.
SEQUENCE 311 AA; 34803 MW; C408FFF590A95340 CRC64;
MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY
FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ ICLVLVFAGL ESCFLAVMAY
DRYVAICHPL RYTVLMNVHF WGLLILLSMF MSTMDALVQS LMVLQLSFCK NVEIPLFFCE
VVQVIKLACS DTLINNILIY FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST
CGCHLSVFSL FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA
LRKLIGRLFP F


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