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Oligodendrocyte transcription factor 3 (Oligo3) (Class B basic helix-loop-helix protein 7) (bHLHb7) (Oligodendrocyte-specific bHLH transcription factor 3)

 OLIG3_MOUSE             Reviewed;         273 AA.
Q6PFG8; Q9EQW5;
31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
25-OCT-2017, entry version 107.
RecName: Full=Oligodendrocyte transcription factor 3;
Short=Oligo3;
AltName: Full=Class B basic helix-loop-helix protein 7;
Short=bHLHb7;
AltName: Full=Oligodendrocyte-specific bHLH transcription factor 3;
Name=Olig3; Synonyms=Bhlhb7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
STRAIN=Swiss Webster; TISSUE=Embryo;
PubMed=11091082; DOI=10.1016/S0925-4773(00)00466-4;
Takebayashi H., Yoshida S., Sugimori M., Kosako H., Kominami R.,
Nakafuku M., Nabeshima Y.;
"Dynamic expression of basic helix-loop-helix Olig family members:
implication of Olig2 in neuron and oligodendrocyte differentiation and
identification of a new member, Olig3.";
Mech. Dev. 99:143-148(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND TISSUE SPECIFICITY.
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
PubMed=11960707; DOI=10.1016/S0925-4773(02)00021-7;
Takebayashi H., Ohtsuki T., Uchida T., Kawamoto S., Okubo K.,
Ikenaka K., Takeichi M., Chisaka O., Nabeshima Y.;
"Non-overlapping expression of Olig3 and Olig2 in the embryonic neural
tube.";
Mech. Dev. 113:169-174(2002).
[4]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=15769945; DOI=10.1101/gad.326105;
Mueller T., Anlag K., Wildner H., Britsch S., Treier M.,
Birchmeier C.;
"The bHLH factor Olig3 coordinates the specification of dorsal neurons
in the spinal cord.";
Genes Dev. 19:733-743(2005).
-!- FUNCTION: May determine the distinct specification program of
class A neurons in the dorsal part of the spinal cord and suppress
specification of class B neurons. {ECO:0000269|PubMed:15769945}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981, ECO:0000269|PubMed:11091082,
ECO:0000269|PubMed:11960707}.
-!- TISSUE SPECIFICITY: Weakly expressed, mainly in non-neural
tissues. {ECO:0000269|PubMed:15489334}.
-!- DEVELOPMENTAL STAGE: Restricted to the CNS. At 9.25 and 10.5 dpc,
specifically expressed in the dorsal neural tube from the
midbrain/hindbrain boundary to the spinal cord. At 10.5 dpc,
expressed continuously from the upper rhombic lip to the tail.
From 10.5 to 12.5 dpc, located in the most dorsal aspect of the
spinal cord, excluding the roof plate, mainly in proliferating
progenitor cells; quickly down-regulated in postmitotic neurons.
At 11.5 dpc, 3 ventral expression clusters, corresponding to p3,
p2 and p0 domains, transiently appear on the lateral margin of the
subventricular zone, in addition to dorsal expression. At 14.5
dpc, weakly expressed in cells scattered in the mantle zone.
Expression declines after 15.5 dpc. In the 11.5 dpc forebrain,
expressed in the ventricular zone of the dorsal thalamus. In the
11.5 to 14.5 dpc hindbrain, dorsally expressed in the upper and
lower rhombic lip, in the cerebellar neuroepithelium.
{ECO:0000269|PubMed:11960707, ECO:0000269|PubMed:15769945}.
-!- SEQUENCE CAUTION:
Sequence=BAB18908.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; AB038698; BAB18908.1; ALT_INIT; mRNA.
EMBL; BC057564; AAH57564.1; -; mRNA.
CCDS; CCDS35855.1; -.
RefSeq; NP_443734.2; NM_053008.3.
UniGene; Mm.156946; -.
ProteinModelPortal; Q6PFG8; -.
SMR; Q6PFG8; -.
PhosphoSitePlus; Q6PFG8; -.
PaxDb; Q6PFG8; -.
PRIDE; Q6PFG8; -.
Ensembl; ENSMUST00000053225; ENSMUSP00000057106; ENSMUSG00000045591.
GeneID; 94222; -.
KEGG; mmu:94222; -.
UCSC; uc007ene.1; mouse.
CTD; 167826; -.
MGI; MGI:2149955; Olig3.
eggNOG; KOG3898; Eukaryota.
eggNOG; ENOG4111U26; LUCA.
GeneTree; ENSGT00530000063239; -.
HOGENOM; HOG000015765; -.
HOVERGEN; HBG053370; -.
InParanoid; Q6PFG8; -.
KO; K09085; -.
OMA; VQKMPGE; -.
OrthoDB; EOG091G129L; -.
PhylomeDB; Q6PFG8; -.
TreeFam; TF322733; -.
PRO; PR:Q6PFG8; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000045591; -.
CleanEx; MM_OLIG3; -.
Genevisible; Q6PFG8; MM.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0001106; F:RNA polymerase II transcription corepressor activity; IDA:MGI.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IMP:MGI.
GO; GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI.
GO; GO:0097476; P:spinal cord motor neuron migration; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR032659; Olig3.
PANTHER; PTHR19290:SF96; PTHR19290:SF96; 1.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
2: Evidence at transcript level;
Coiled coil; Complete proteome; DNA-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 273 Oligodendrocyte transcription factor 3.
/FTId=PRO_0000127418.
DOMAIN 84 138 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COILED 69 90 {ECO:0000255}.
COMPBIAS 25 33 Poly-His.
COMPBIAS 248 251 Poly-Pro.
SEQUENCE 273 AA; 29507 MW; 5795CF3FC23121DD CRC64;
MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHHQESRLNS VSSTQGDMVQ KMPGESLSRA
GAKAAGESSK YKIKKQLSEQ DLQQLRLKIN GRERKRMHDL NLAMDGLREV MPYAHGPSVR
KLSKIATLLL ARNYILMLTS SLEEMKRLVG EIYGGHHSAF HCGTVGHSAG HPAHAANAVH
PVHPILGGAL SSGNASSPLS ATSLPTIGTI RPPHSLLKAP STPPALQLGS GFQHWAGLPC
PCTICQMPPP PHLSALSTAN MARLSAESKD LLK


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