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Olivetolic acid cyclase (EC 4.4.1.26)

 OLIAC_CANSA             Reviewed;         101 AA.
I6WU39;
06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 1.
05-DEC-2018, entry version 18.
RecName: Full=Olivetolic acid cyclase;
EC=4.4.1.26;
Name=OAC;
Cannabis sativa (Hemp) (Marijuana).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Cannabis.
NCBI_TaxID=3483;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR
LOCATION, 3D-STRUCTURE MODELING, SUBUNIT, AND MUTAGENESIS OF LYS-4;
HIS-5; LYS-12; LYS-38; ASP-45; HIS-57; HIS-75; HIS-78 AND ASP-96.
STRAIN=cv. Finola;
PubMed=22802619; DOI=10.1073/pnas.1200330109;
Gagne S.J., Stout J.M., Liu E., Boubakir Z., Clark S.M., Page J.E.;
"Identification of olivetolic acid cyclase from Cannabis sativa
reveals a unique catalytic route to plant polyketides.";
Proc. Natl. Acad. Sci. U.S.A. 109:12811-12816(2012).
-!- FUNCTION: Polyketide cyclase which functions in concert with
OLS/TKS to form olivetolic acid. Has no intrinsic polyketide
synthase activity and requires the presence of OLS to produce
olivetolic acid. {ECO:0000269|PubMed:22802619}.
-!- CATALYTIC ACTIVITY:
Reaction=3,5,7-trioxododecanoyl-CoA = CoA + H(+) + olivetolate;
Xref=Rhea:RHEA:34123, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
ChEBI:CHEBI:66950, ChEBI:CHEBI:66957; EC=4.4.1.26;
-!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:22802619}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22802619}.
-!- TISSUE SPECIFICITY: Expressed in glandular trichomes and at lower
levels in female flowers. {ECO:0000269|PubMed:22802619}.
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EMBL; JN679224; AFN42527.1; -; mRNA.
PDB; 5B08; X-ray; 1.32 A; A/B=1-101.
PDB; 5B09; X-ray; 1.70 A; A=1-101.
PDB; 5B0A; X-ray; 2.10 A; A/B=1-101.
PDB; 5B0B; X-ray; 2.19 A; A/B/C/D=1-101.
PDB; 5B0C; X-ray; 1.60 A; A/B=1-101.
PDB; 5B0D; X-ray; 1.80 A; A/B=1-101.
PDB; 5B0E; X-ray; 1.60 A; A/B=1-101.
PDB; 5B0F; X-ray; 1.60 A; A/B=1-101.
PDB; 5B0G; X-ray; 1.40 A; A=1-101.
PDBsum; 5B08; -.
PDBsum; 5B09; -.
PDBsum; 5B0A; -.
PDBsum; 5B0B; -.
PDBsum; 5B0C; -.
PDBsum; 5B0D; -.
PDBsum; 5B0E; -.
PDBsum; 5B0F; -.
PDBsum; 5B0G; -.
ProteinModelPortal; I6WU39; -.
SMR; I6WU39; -.
KEGG; ag:AFN42527; -.
KO; K20508; -.
BioCyc; MetaCyc:MONOMER-17640; -.
BRENDA; 4.4.1.26; 1159.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0009975; F:cyclase activity; IDA:UniProtKB.
GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:1901696; P:cannabinoid biosynthetic process; IDA:UniProtKB.
GO; GO:1901697; P:olivetolic acid biosynthetic process; IDA:UniProtKB.
InterPro; IPR013097; Dabb.
InterPro; IPR011008; Dimeric_a/b-barrel.
Pfam; PF07876; Dabb; 1.
SMART; SM00886; Dabb; 1.
SUPFAM; SSF54909; SSF54909; 1.
PROSITE; PS51502; S_R_A_B_BARREL; 1.
1: Evidence at protein level;
3D-structure; Cytoplasm; Lyase; Magnesium; Metal-binding.
CHAIN 1 101 Olivetolic acid cyclase.
/FTId=PRO_0000421155.
DOMAIN 3 97 Stress-response A/B barrel.
{ECO:0000255|PROSITE-ProRule:PRU00835}.
METAL 31 31 Magnesium; via carbonyl oxygen.
{ECO:0000250}.
METAL 34 34 Magnesium; via carbonyl oxygen.
{ECO:0000250}.
METAL 37 37 Magnesium; via carbonyl oxygen.
{ECO:0000250}.
MUTAGEN 4 4 K->A: No effect.
{ECO:0000269|PubMed:22802619}.
MUTAGEN 5 5 H->A: Total loss of activity.
{ECO:0000269|PubMed:22802619}.
MUTAGEN 12 12 K->A: No effect.
{ECO:0000269|PubMed:22802619}.
MUTAGEN 38 38 K->A: No effect.
{ECO:0000269|PubMed:22802619}.
MUTAGEN 45 45 D->A: No effect.
{ECO:0000269|PubMed:22802619}.
MUTAGEN 57 57 H->A: Total loss of activity.
{ECO:0000269|PubMed:22802619}.
MUTAGEN 75 75 H->A: 99% loss of activity.
{ECO:0000269|PubMed:22802619}.
MUTAGEN 78 78 H->A: Total loss of activity.
{ECO:0000269|PubMed:22802619}.
MUTAGEN 96 96 D->A: No effect.
{ECO:0000269|PubMed:22802619}.
STRAND 3 11 {ECO:0000244|PDB:5B08}.
HELIX 17 29 {ECO:0000244|PDB:5B08}.
HELIX 30 32 {ECO:0000244|PDB:5B08}.
STRAND 40 44 {ECO:0000244|PDB:5B08}.
HELIX 48 51 {ECO:0000244|PDB:5B08}.
STRAND 57 65 {ECO:0000244|PDB:5B08}.
HELIX 66 73 {ECO:0000244|PDB:5B08}.
HELIX 76 85 {ECO:0000244|PDB:5B08}.
HELIX 86 88 {ECO:0000244|PDB:5B08}.
STRAND 89 97 {ECO:0000244|PDB:5B08}.
SEQUENCE 101 AA; 12002 MW; 9AB0CCAFDA217482 CRC64;
MAVKHLIVLK FKDEITEAQK EEFFKTYVNL VNIIPAMKDV YWGKDVTQKN KEEGYTHIVE
VTFESVETIQ DYIIHPAHVG FGDVYRSFWE KLLIFDYTPR K


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