Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Omega-conotoxin-like CnVIIH [Cleaved into: Omega-conotoxin CnVIIA]

 CO7A_CONCN              Reviewed;          28 AA.
P58916;
26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
31-OCT-2012, sequence version 2.
10-MAY-2017, entry version 55.
RecName: Full=Omega-conotoxin-like CnVIIH;
Contains:
RecName: Full=Omega-conotoxin CnVIIA;
Conus consors (Singed cone).
Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
Caenogastropoda; Hypsogastropoda; Neogastropoda; Conoidea; Conidae;
Conus.
NCBI_TaxID=101297;
[1]
PROTEIN SEQUENCE, SYNTHESIS, FUNCTION, AND MASS SPECTROMETRY.
TISSUE=Venom;
PubMed=11724570; DOI=10.1021/bi002871r;
Favreau P., Gilles N., Lamthanh H., Bournaud R., Shimahara T.,
Bouet F., Laboute P., Letourneux Y., Menez A., Molgo J., Le Gall F.;
"A new omega-conotoxin that targets N-type voltage-sensitive calcium
channels with unusual specificity.";
Biochemistry 40:14567-14575(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA], HYDROXYLATION AT PRO-7, OXIDATION AT
MET-12, AMIDATION AT CYS-27, MASS SPECTROMETRY, AND IDENTIFICATION BY
MASS SPECTROMETRY.
TISSUE=Venom, and Venom duct;
PubMed=22705119; DOI=10.1016/j.jprot.2012.06.001;
Violette A., Biass D., Dutertre S., Koua D., Piquemal D., Pierrat F.,
Stocklin R., Favreau P.;
"Large-scale discovery of conopeptides and conoproteins in the
injectable venom of a fish-hunting cone snail using a combined
proteomic and transcriptomic approach.";
J. Proteomics 75:5215-5225(2012).
-!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind
and block voltage-gated calcium channels (Cav). This toxin blocks
N-type calcium channels (Cav2.2/CACNA1B), but unexpectedly, does
not show any blocking activity at amphibian neuromuscular
junction. Causes shaking activity, and, at higher doses, causes
mild tremors when injected intracerebroventricularly into mice.
Causes paralysis, and, at higher doses, causes death when injected
intramuscularly into fish. {ECO:0000269|PubMed:11724570}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom duct.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin. {ECO:0000250}.
-!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
-!- MASS SPECTROMETRY: Mass=2847.74; Method=Electrospray; Range=1-27;
Evidence={ECO:0000269|PubMed:11724570};
-!- MASS SPECTROMETRY: Mass=2904.17; Method=Electrospray; Range=1-28;
Note=CnVIIH.; Evidence={ECO:0000269|PubMed:22705119};
-!- MASS SPECTROMETRY: Mass=2846.14; Method=Electrospray; Range=1-27;
Note=[Hyp7]-CnVIIA and [Pro7, oxMet12]-CnVIIA.;
Evidence={ECO:0000269|PubMed:22705119};
-!- MASS SPECTROMETRY: Mass=2830.19; Method=Electrospray; Range=1-27;
Note=[Pro7]CnVIIA.; Evidence={ECO:0000269|PubMed:22705119};
-!- MISCELLANEOUS: Found in injectable (milked) (IV) venom.
{ECO:0000305|PubMed:22705119}.
-!- SIMILARITY: Belongs to the conotoxin O1 superfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
SMR; P58916; -.
ConoServer; 1632; CnVIIA.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0072556; C:other organism presynaptic membrane; IEA:UniProtKB-KW.
GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
GO; GO:0009405; P:pathogenesis; IEA:InterPro.
InterPro; IPR012321; Conotoxin_omega-typ_CS.
PROSITE; PS60004; OMEGA_CONOTOXIN; 1.
1: Evidence at protein level;
Amidation; Calcium channel impairing toxin; Direct protein sequencing;
Disulfide bond; Hydroxylation; Ion channel impairing toxin; Knottin;
Neurotoxin; Oxidation; Presynaptic neurotoxin; Secreted; Toxin;
Voltage-gated calcium channel impairing toxin.
PEPTIDE 1 28 Omega-conotoxin-like CnVIIH.
/FTId=PRO_0000419828.
PEPTIDE 1 27 Omega-conotoxin CnVIIA.
/FTId=PRO_0000044481.
SITE 13 13 Essential for calcium channel binding.
{ECO:0000250}.
MOD_RES 7 7 4-hydroxyproline; partial.
{ECO:0000269|PubMed:22705119}.
MOD_RES 12 12 Methionine sulfoxide.
{ECO:0000269|PubMed:22705119}.
MOD_RES 27 27 Cysteine amide.
{ECO:0000269|PubMed:22705119}.
DISULFID 1 16 {ECO:0000250}.
DISULFID 8 20 {ECO:0000250}.
DISULFID 15 27 {ECO:0000250}.
SEQUENCE 28 AA; 2896 MW; 0A49DEFD1491F2CB CRC64;
CKGKGAPCTR LMYDCCHGSC SSSKGRCG


Related products :

Catalog number Product name Quantity
08CON001-00100 ω-Conotoxin MVIIA (omega conotoxin MVIIA), ω-Conotoxin MVIIA is a Cav2.2 channel blocker 100 ug
08CON001-00500 ω-Conotoxin MVIIA (omega conotoxin MVIIA), ω-Conotoxin MVIIA is a Cav2.2 channel blocker 500 ug
08CON002-00500 ω-conotoxin MVIIC (omega contoxin MVIIC), ω-conotoxin MVIIC is a calcium channel blocker 500 ug
08CON002-00100 ω-conotoxin MVIIC (omega contoxin MVIIC), ω-conotoxin MVIIC is a calcium channel blocker 100 ug
08CON002-01000 ω-conotoxin MVIIC (omega contoxin MVIIC), ω-conotoxin MVIIC is a calcium channel blocker 1000 ug
SP-4342-1 Peptides: omega Conotoxin GVIA 1 mg
SP-4342-05 Peptides: omega Conotoxin GVIA 0.5 mg
SP-4343-01 Peptides: omega Conotoxin MVIIC 0.1 mg
SP-4341-1 Peptides: omega Conotoxin MVIIA 1 mg
SP-4341-05 Peptides: omega Conotoxin MVIIA 0.5 mg
SP-4343-05 Peptides: omega Conotoxin MVIIC 0.5 mg
063-15 Conotoxin MVIIC _ Omega (Conus magus) _ 100ug 100 µg
063-06 Conotoxin GVIA _ Omega (Marine Snail _ Conus geographus) _ 100ug 100 µg
063-16 Conotoxin SVIB _ Omega (Cone Snail _ Conus striatus) _ 100ug 100 µg
08CON015-00500 α-conotoxin GI (alpha conotoxin GI), α-conotoxin G blocks nAChR receptors 500 ug
08CON015-01000 α-conotoxin GI (alpha conotoxin GI), α-conotoxin G blocks nAChR receptors 1000 ug
08CON011-00500 α-conotoxin IMI (alpha conotoxin IMI), α-conotoxin IMI blocks nAChR 500 ug
08CON012-00500 α-conotoxin MI (alpha conotoxin MI), α-conotoxin MI blocks nAChR 500 ug
08CON011-01000 α-conotoxin IMI (alpha conotoxin IMI), α-conotoxin IMI blocks nAChR 1000 ug
08CON012-01000 α-conotoxin MI (alpha conotoxin MI), α-conotoxin MI blocks nAChR 1000 ug
08CON003-01000 ω-conotoxin GVIA, ω-conotoxin GVIA blocks Cav2.2 1000 ug
08CON003-00100 ω-conotoxin GVIA, ω-conotoxin GVIA blocks Cav2.2 100 ug
08CON003-00500 ω-conotoxin GVIA, ω-conotoxin GVIA blocks Cav2.2 500 ug
EIAAB08996 20-HETE synthase,20-hydroxyeicosatetraenoic acid synthase,CYP4A11,CYP4A2,CYP4AII,CYPIVA11,Cytochrome P450 4A11,Cytochrome P-450HK-omega,Cytochrome P450HL-omega,Fatty acid omega-hydroxylase,Homo sapien
100-384 IFN-omega, Host: E. coli, Species: Human, Synonyms: IFNW1; Interferon omega 100 ug


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur