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Orf1ab polyprotein (Replicase polyprotein 1ab)

 D2E1D0_9BETC            Unreviewed;      7073 AA.
D2E1D0;
09-FEB-2010, integrated into UniProtKB/TrEMBL.
09-FEB-2010, sequence version 1.
22-NOV-2017, entry version 65.
SubName: Full=Orf1ab polyprotein {ECO:0000313|EMBL:ACZ71751.1};
SubName: Full=Replicase polyprotein 1ab {ECO:0000313|EMBL:AGT20807.1};
Name=Pp1ab {ECO:0000313|EMBL:AGT20807.1};
SARS coronavirus ExoN1.
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Nidovirales; Coronaviridae; Coronavirinae; Betacoronavirus.
NCBI_TaxID=627440 {ECO:0000313|EMBL:ACZ71751.1};
[1] {ECO:0000313|EMBL:ACZ71751.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ExoN1 mutant {ECO:0000313|EMBL:ACZ71751.1};
PubMed=14569023; DOI=10.1073/pnas.1735582100;
Yount B., Curtis K.M., Fritz E.A., Hensley L.E., Jahrling P.B.,
Prentice E., Denison M.R., Geisbert T.W., Baric R.S.;
"Reverse genetics with a full-length infectious cDNA of severe acute
respiratory syndrome coronavirus.";
Proc. Natl. Acad. Sci. U.S.A. 100:12995-13000(2003).
[2] {ECO:0000313|EMBL:ACZ71751.1}
NUCLEOTIDE SEQUENCE.
STRAIN=ExoN1 mutant {ECO:0000313|EMBL:ACZ71751.1};
Spiro D., Halpin R., McAllen J., Wang S., Hostetler J., Hine E.,
Overton L., Tsitrin T., Katzel D., Sarmiento M., Sitz J., Amedeo P.,
Caler E., Lorenzi H., Schobel S., Sundaram J., Becker M.M.,
Eckerle L.D., Denison M.R.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:ACZ71751.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ExoN1 mutant {ECO:0000313|EMBL:ACZ71751.1};
PubMed=20463816; DOI=10.1371/journal.ppat.1000896;
Eckerle L.D., Becker M.M., Halpin R.A., Li K., Venter E., Lu X.,
Scherbakova S., Graham R.L., Baric R.S., Stockwell T.B., Spiro D.J.,
Denison M.R.;
"Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is
revealed by complete genome sequencing.";
PLoS Pathog. 6:E1000896-E1000896(2010).
[4] {ECO:0000313|Proteomes:UP000097852, ECO:0000313|Proteomes:UP000106870, ECO:0000313|Proteomes:UP000117796}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SARS/VeroE6_lab/USA/ExoN1_c13P1/2009
{ECO:0000313|EMBL:AGT21062.1},
SARS/VeroE6_lab/USA/ExoN1_c13P10/2009 {ECO:0000313|EMBL:AGT21137.1},
SARS/VeroE6_lab/USA/ExoN1_c13P20/2009 {ECO:0000313|EMBL:AGT21152.1},
SARS/VeroE6_lab/USA/ExoN1_c5.10P20/2010 {ECO:0000313|EMBL:AGT20867.1},
SARS/VeroE6_lab/USA/ExoN1_c5.1P20/2010 {ECO:0000313|EMBL:AGT21017.1},
SARS/VeroE6_lab/USA/ExoN1_c5.2P20/2010 {ECO:0000313|EMBL:AGT21047.1},
SARS/VeroE6_lab/USA/ExoN1_c5.3P20/2010 {ECO:0000313|EMBL:AGT21227.1},
SARS/VeroE6_lab/USA/ExoN1_c5.4P20/2010 {ECO:0000313|EMBL:AGT20822.1},
SARS/VeroE6_lab/USA/ExoN1_c5.5P20/2010 {ECO:0000313|EMBL:AGT20987.1},
SARS/VeroE6_lab/USA/ExoN1_c5.6P20/2010 {ECO:0000313|EMBL:AGT21002.1},
SARS/VeroE6_lab/USA/ExoN1_c5.8P20/2010 {ECO:0000313|EMBL:AGT21212.1},
SARS/VeroE6_lab/USA/ExoN1_c5.9P20/2010 {ECO:0000313|EMBL:AGT20837.1},
SARS/VeroE6_lab/USA/ExoN1_c5P10/2009 {ECO:0000313|EMBL:AGT21272.1},
SARS/VeroE6_lab/USA/ExoN1_c5P20/2009 {ECO:0000313|EMBL:AGT21182.1},
SARS/VeroE6_lab/USA/ExoN1_c8P1/2009 {ECO:0000313|EMBL:AGT20897.1},
SARS/VeroE6_lab/USA/ExoN1_c8P10/2009 {ECO:0000313|EMBL:AGT20807.1},
and SARS/VeroE6_lab/USA/ExoN1_c8P20/2009
{ECO:0000313|EMBL:AGT21122.1};
Town C.D., Halpin R.A., Motley J., Ransier A., Fedorova N.,
Overton L., Tsitrin T., Stockwell T., Amedeo P., Bishop B.,
Edworthy P., Gupta N., Katzel D., Li K., Schobel S., Shrivastava S.,
Thovarai V., Wang S., Eckerle L.D., Becker M.M., Donaldson E.F.,
Lu X., Graham R.L., Baric R.S., Wentworth D.E., Denison M.R.;
Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
-!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
{ECO:0000256|SAAS:SAAS00580605}.
-!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
+ RNA(n+1). {ECO:0000256|SAAS:SAAS00383097}.
-!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
{ECO:0000256|SAAS:SAAS00534249}.
-!- SUBCELLULAR LOCATION: Host endoplasmic reticulum
{ECO:0000256|SAAS:SAAS00941764}.
-!- SUBCELLULAR LOCATION: Host membrane
{ECO:0000256|SAAS:SAAS00581319}; Multi-pass membrane protein
{ECO:0000256|SAAS:SAAS00581319}.
-!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
{ECO:0000256|SAAS:SAAS00534255}.
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EMBL; FJ882926; ACZ71751.1; -; Genomic_RNA.
EMBL; FJ882930; ACZ71810.1; -; Genomic_RNA.
EMBL; KF514389; AGT20807.1; -; Genomic_RNA.
EMBL; KF514390; AGT20822.1; -; Genomic_RNA.
EMBL; KF514391; AGT20837.1; -; Genomic_RNA.
EMBL; KF514393; AGT20867.1; -; Genomic_RNA.
EMBL; KF514395; AGT20897.1; -; Genomic_RNA.
EMBL; KF514401; AGT20987.1; -; Genomic_RNA.
EMBL; KF514402; AGT21002.1; -; Genomic_RNA.
EMBL; KF514403; AGT21017.1; -; Genomic_RNA.
EMBL; KF514405; AGT21047.1; -; Genomic_RNA.
EMBL; KF514406; AGT21062.1; -; Genomic_RNA.
EMBL; KF514410; AGT21122.1; -; Genomic_RNA.
EMBL; KF514411; AGT21137.1; -; Genomic_RNA.
EMBL; KF514412; AGT21152.1; -; Genomic_RNA.
EMBL; KF514414; AGT21182.1; -; Genomic_RNA.
EMBL; KF514416; AGT21212.1; -; Genomic_RNA.
EMBL; KF514417; AGT21227.1; -; Genomic_RNA.
EMBL; KF514420; AGT21272.1; -; Genomic_RNA.
MEROPS; C30.005; -.
Proteomes; UP000097852; Genome.
Proteomes; UP000106870; Genome.
Proteomes; UP000117796; Genome.
Proteomes; UP000119316; Genome.
Proteomes; UP000119820; Genome.
Proteomes; UP000124542; Genome.
Proteomes; UP000125968; Genome.
Proteomes; UP000130610; Genome.
Proteomes; UP000133348; Genome.
Proteomes; UP000141212; Genome.
Proteomes; UP000143912; Genome.
Proteomes; UP000145152; Genome.
Proteomes; UP000149516; Genome.
Proteomes; UP000166143; Genome.
Proteomes; UP000171773; Genome.
GO; GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
GO; GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO; GO:0008242; F:omega peptidase activity; IEA:InterPro.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0039520; P:induction by virus of host autophagy; IEA:UniProtKB-KW.
GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
GO; GO:0019082; P:viral protein processing; IEA:InterPro.
GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
Gene3D; 2.40.10.250; -; 1.
InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
InterPro; IPR032505; Corona_NSP4_C.
InterPro; IPR009461; Coronavirus_NSP16.
InterPro; IPR027352; CV_ZBD.
InterPro; IPR037227; EndoU-like.
InterPro; IPR002589; Macro_dom.
InterPro; IPR032592; NAR_dom.
InterPro; IPR021590; NSP1.
InterPro; IPR036333; NSP10_sf.
InterPro; IPR009466; NSP11.
InterPro; IPR024375; Nsp3_coronavir.
InterPro; IPR014828; NSP7.
InterPro; IPR037204; NSP7_sf.
InterPro; IPR014829; NSP8.
InterPro; IPR037230; NSP8_sf.
InterPro; IPR014822; NSP9.
InterPro; IPR036499; NSP9_sf.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR008740; Peptidase_C30.
InterPro; IPR013016; Peptidase_C30/C16.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR007094; RNA-dir_pol_PSvirus.
InterPro; IPR009469; RNA_pol_N_coronovir.
InterPro; IPR018995; RNA_synth_NSP10_coronavirus.
InterPro; IPR029063; SAM-dependent_MTases.
InterPro; IPR024358; SARS-CoV_Nsp3_N.
InterPro; IPR022733; SARS_polyprot_cleavage.
InterPro; IPR014827; Viral_protease.
Pfam; PF16348; Corona_NSP4_C; 1.
Pfam; PF06478; Corona_RPol_N; 1.
Pfam; PF12379; DUF3655; 1.
Pfam; PF01661; Macro; 1.
Pfam; PF16251; NAR; 1.
Pfam; PF11501; Nsp1; 1.
Pfam; PF09401; NSP10; 1.
Pfam; PF06471; NSP11; 1.
Pfam; PF06460; NSP13; 1.
Pfam; PF12124; Nsp3_PL2pro; 1.
Pfam; PF08716; nsp7; 1.
Pfam; PF08717; nsp8; 1.
Pfam; PF08710; nsp9; 1.
Pfam; PF05409; Peptidase_C30; 1.
Pfam; PF11633; SUD-M; 1.
Pfam; PF08715; Viral_protease; 1.
SMART; SM00506; A1pp; 1.
SUPFAM; SSF101816; SSF101816; 1.
SUPFAM; SSF140367; SSF140367; 1.
SUPFAM; SSF142877; SSF142877; 1.
SUPFAM; SSF143076; SSF143076; 1.
SUPFAM; SSF144246; SSF144246; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF52540; SSF52540; 1.
SUPFAM; SSF53335; SSF53335; 1.
PROSITE; PS51653; CV_ZBD; 1.
PROSITE; PS51442; M_PRO; 1.
PROSITE; PS51154; MACRO; 1.
PROSITE; PS51124; PEPTIDASE_C16; 1.
PROSITE; PS51657; PSRV_HELICASE; 1.
PROSITE; PS50507; RDRP_SSRNA_POS; 1.
3: Inferred from homology;
Activation of host autophagy by virus {ECO:0000256|SAAS:SAAS00025897};
ATP-binding {ECO:0000256|SAAS:SAAS00581494};
Complete proteome {ECO:0000313|Proteomes:UP000097852,
ECO:0000313|Proteomes:UP000106870, ECO:0000313|Proteomes:UP000117796,
ECO:0000313|Proteomes:UP000119316};
Helicase {ECO:0000256|SAAS:SAAS00581494};
Host cytoplasm {ECO:0000256|SAAS:SAAS00025917};
Host membrane {ECO:0000256|SAAS:SAAS00539966};
Host-virus interaction {ECO:0000256|SAAS:SAAS00025897,
ECO:0000256|SAAS:SAAS00941647};
Hydrolase {ECO:0000256|SAAS:SAAS00539752,
ECO:0000256|SAAS:SAAS00581494};
Inhibition of host innate immune response by virus
{ECO:0000256|SAAS:SAAS00941647};
Membrane {ECO:0000256|SAAS:SAAS00539966,
ECO:0000256|SAAS:SAAS00580305, ECO:0000256|SAM:Phobius};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00986,
ECO:0000256|SAAS:SAAS00025926};
Methyltransferase {ECO:0000256|SAAS:SAAS00817755};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00581494};
Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00510600};
Protease {ECO:0000256|SAAS:SAAS00539752};
Repeat {ECO:0000256|SAAS:SAAS00581532};
Ribosomal frameshifting {ECO:0000256|SAAS:SAAS00580710};
RNA-binding {ECO:0000256|SAAS:SAAS00076745};
RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00510600};
Thiol protease {ECO:0000256|SAAS:SAAS00539752};
Transferase {ECO:0000256|SAAS:SAAS00510600,
ECO:0000256|SAAS:SAAS00817755};
Transmembrane {ECO:0000256|SAAS:SAAS00580305,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00580305,
ECO:0000256|SAM:Phobius};
Viral immunoevasion {ECO:0000256|SAAS:SAAS00941647};
Viral RNA replication {ECO:0000256|SAAS:SAAS00664279};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00986,
ECO:0000256|SAAS:SAAS00025926};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00986,
ECO:0000256|SAAS:SAAS00025926}.
TRANSMEM 2206 2231 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 2314 2333 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 2340 2371 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 2749 2768 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3020 3042 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3054 3078 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3115 3134 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3559 3582 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3588 3606 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3613 3634 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3660 3678 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3685 3701 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3721 3743 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 3755 3774 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 1003 1169 Macro. {ECO:0000259|PROSITE:PS51154}.
DOMAIN 1611 1875 Peptidase C16.
{ECO:0000259|PROSITE:PS51124}.
DOMAIN 3241 3546 Peptidase C30.
{ECO:0000259|PROSITE:PS51442}.
DOMAIN 4981 5143 RdRp catalytic.
{ECO:0000259|PROSITE:PS50507}.
DOMAIN 5302 5385 CV ZBD. {ECO:0000259|PROSITE:PS51653}.
DOMAIN 5558 5909 (+)RNA virus helicase C-terminal.
{ECO:0000259|PROSITE:PS51657}.
SEQUENCE 7073 AA; 790174 MW; 91ED48F970A3DD5D CRC64;
MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT CGLVELEKGV
LPQLEQPYVF IKRSDALSTN HGHKVVELVA EMDGIQYGRS GITLGVLVPH VGETPIAYRN
VLLRKNGNKG AGGHSYGIDL KSYDLGDELG TDPIEDYEQN WNTKHGSGAL RELTRELNGG
AVTRYVDNNF CGPDGYPLDC IKDFLARAGK SMCTLSEQLD YIESKRGVYC CRDHEHEIAW
FTERSDKSYE HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI
RSVYPVASPQ ECNNMHLSTL MKCNHCDEVS WQTCDFLKAT CEHCGTENLV IEGPTTCGYL
PTNAVVKMPC PACQDPEIGP EHSVADYHNH SNIETRLRKG GRTRCFGGCV FAYVGCYNKR
AYWVPRASAD IGSGHTGITG DNVETLNEDL LEILSRERVN INIVGDFHLN EEVAIILASF
SASTSAFIDT IKSLDYKSFK TIVESCGNYK VTKGKPVKGA WNIGQQRSVL TPLCGFPSQA
AGVIRSIFAR TLDAANHSIP DLQRAAVTIL DGISEQSLRL VDAMVYTSDL LTNSVIIMAY
VTGGLVQQTS QWLSNLLGTT VEKLRPIFEW IEAKLSAGVE FLKDAWEILK FLITGVFDIV
KGQIQVASDN IKDCVKCFID VVNKALEMCI DQVTIAGAKL RSLNLGEVFI AQSKGLYRQC
IRGKEQLQLL MPLKAPKEVT FLEGDSHDTV LTSEEVVLKN GELEALETPV DSFTNGAIVG
TPVCVNGLML LEIKDKEQYC ALSPGLLATN NVFRLKGGAP IKGVTFGEDT VWEVQGYKNV
RITFELDERV DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE
WSVATFYLFD DAGEENFSSR MYCSFYPPDE EEEDDAECEE EEIDETCEHE YGTEDDYQGL
PLEFGASAET VRVEEEEEED WLDDTTEQSE IEPEPEPTPE EPVNQFTGYL KLTDNVAIKC
VDIVKEAQSA NPMVIVNAAN IHLKHGGGVA GALNKATNGA MQKESDDYIK LNGPLTVGGS
CLLSGHNLAK KCLHVVGPNL NAGEDIQLLK AAYENFNSQD ILLAPLLSAG IFGAKPLQSL
QVCVQTVRTQ VYIAVNDKAL YEQVVMDYLD NLKPRVEAPK QEEPPNTEDS KTEEKSVVQK
PVDVKPKIKA CIDEVTTTLE ETKFLTNKLL LFADINGKLY HDSQNMLRGE DMSFLEKDAP
YMVGDVITSG DITCVVIPSK KAGGTTEMLS RALKKVPVDE YITTYPGQGC AGYTLEEAKT
ALKKCKSAFY VLPSEAPNAK EEILGTVSWN LREMLAHAEE TRKLMPICMD VRAIMATIQR
KYKGIKIQEG IVDYGVRFFF YTSKEPVASI ITKLNSLNEP LVTMPIGYVT HGFNLEEAAR
CMRSLKAPAV VSVSSPDAVT TYNGYLTSSS KTSEEHFVET VSLAGSYRDW SYSGQRTELG
VEFLKRGDKI VYHTLESPVE FHLDGEVLSL DKLKSLLSLR EVKTIKVFTT VDNTNLHTQL
VDMSMTYGQQ FGPTYLDGAD VTKIKPHVNH EGKTFFVLPS DDTLRSEAFE YYHTLDESFL
GRYMSALNHT KKWKFPQVGG LTSIKWADNN CYLSSVLLAL QQLEVKFNAP ALQEAYYRAR
AGDAANFCAL ILAYSNKTVG ELGDVRETMT HLLQHANLES AKRVLNVVCK HCGQKTTTLT
GVEAVMYMGT LSYDNLKTGV SIPCVCGRDA TQYLVQQESS FVMMSAPPAE YKLQQGTFLC
ANEYTGNYQC GHYTHITAKE TLYRIDGAHL TKMSEYKGPV TDVFYKETSY TTTIKPVSYK
LDGVTYTEIE PKLDGYYKKD NAYYTEQPID LVPTQPLPNA SFDNFKLTCS NTKFADDLNQ
MTGFTKPASR ELSVTFFPDL NGDVVAIDYR HYSASFKKGA KLLHKPIVWH INQATTKTTF
KPNTWCLRCL WSTKPVDTSN SFEVLAVEDT QGMDNLACES QQPTSEEVVE NPTIQKEVIE
CDVKTTEVVG NVILKPSDEG VKVTQELGHE DLMAAYVENT SITIKKPNEL SLALGLKTIA
THGIAAINSV PWSKILAYVK PFLGQAAITT SNCAKRLAQR VFNNYMPYVF TLLFQLCTFT
KSTNSRIRAS LPTTIAKNSV KSVAKLCLDA GINYVKSPKF SKLFTIAMWL LLLSICLGSL
ICVTAAFGVL LSNFGAPSYC NGVRELYLNS SNVTTMDFCE GSFPCSICLS GLDSLDSYPA
LETIQVTISS YKLDLTILGL AAEWVLAYML FTKFFYLLGL SAIMQVFFGY FASHFISNSW
LMWFIISIVQ MAPVSAMVRM YIFFASFYYI WKSYVHIMDG CTSSTCMMCY KRNRATRVEC
TTIVNGMKRS FYVYANGGRG FCKTHNWNCL NCDTFCTGST FISDEVARDL SLQFKRPINP
TDQSSYIVDS VAVKNGALHL YFDKAGQKTY ERHPLSHFVN LDNLRANNTK GSLPINVIVF
DGKSKCDESA SKSASVYYSQ LMCQPILLLD QVLVSDVGDS TEVSVKMFDA YVDTFSATFS
VPMEKLKALV ATAHSELAKG VALDGVLSTF VSAARQGVVD TDVDTKDVIE CLKLSHHSDL
EVTGDSCNNF MLTYNKVENM TPRDLGACID CNARHINAQV AKSHNVSLIW NVKDYMSLSE
QLRKQIRSAA KKNNIPFRLT CATTRQVVNV ITTKISLKGG KIVSTCFKLM LKATLLCVLA
ALVCYIVMPV HTLSIHDGYT NEIIGYKAIQ DGVTRDIIST DDCFANKHAG FDAWFSQRGG
SYKNDKSCPV VAAIITREIG FIVPGLPGTV LRAINGDFLH FLPRVFSAVG NICYTPSKLI
EYSDFATSAC VLAAECTIFK DAMGKPVPYC YDTNLLEGSI SYSELRPDTR YVLMDGSIIQ
FPNTYLEGSV RVVTTFDAEY CRHGTCERSE VGICLSTSGR WVLNNEHYRA LSGVFCGVDA
MNLIANIFTP LVQPVGALDV SASVVAGGII AILVTCAAYY FMKFRRVFGE YNHVVAANAL
LFLMSFTILC LVPAYSFLPG VYSVFYLYLT FYFTNDVSFL AHLQWFAMFS PIVPFWITAI
YVFCISLKHC HWFFNNYLRK RVMFNGVTFS TFEEAALCTF LLNKEMYLKL RSETLLPLTQ
YNRYLALYNK YKYFSGALDT TSYREAACCH LAKALNDFSN SGADVLYQPP QTSITSAVLQ
SGFRKMAFPS GKVEGCMVQV TCGTTTLNGL WLDDTVYCPR HVICTAEDML NPNYEDLLIR
KSNHSFLVQA GNVQLRVIGH SMQNCLLRLK VDTSNPKTPK YKFVRIQPGQ TFSVLACYNG
SPSGVYQCAM RPNHTIKGSF LNGSCGSVGF NIDYDCVSFC YMHHMELPTG VHAGTDLEGK
FYGPFVDRQT AQAAGTDTTI TLNVLAWLYA AVINGDRWFL NRFTTTLNDF NLVAMKYNYE
PLTQDHVDIL GPLSAQTGIA VLDMCAALKE LLQNGMNGRT ILGSTILEDE FTPFDVVRQC
SGVTFQGKFK KIVKGTHHWM LLTFLTSLLI LVQSTQWSLF FFVYENAFLP FTLGIMAIAA
CAMLLVKHKH AFLCLFLLPS LATVAYFNMV YMPASWVMRI MTWLELADTS LSGYRLKDCV
MYASALVLLI LMTARTVYDD AARRVWTLMN VITLVYKVYY GNALDQAISM WALVISVTSN
YSGVVTTIMF LARAIVFVCV EYYPLLFITG NTLQCIMLVY CFLGYCCCCY FGLFCLLNRY
FRLTLGVYDY LVSTQEFRYM NSQGLLPPKS SIDAFKLNIK LLGIGGKPCI KVATVQSKMS
DVKCTSVVLL SVLQQLRVES SSKLWAQCVQ LHNDILLAKD TTEAFEKMVS LLSVLLSMQG
AVDINRLCEE MLDNRATLQA IASEFSSLPS YAAYATAQEA YEQAVANGDS EVVLKKLKKS
LNVAKSEFDR DAAMQRKLEK MADQAMTQMY KQARSEDKRA KVTSAMQTML FTMLRKLDND
ALNNIINNAR DGCVPLNIIP LTTAAKLMVV VPDYGTYKNT CDGNTFTYAS ALWEIQQVVD
ADSKIVQLSE INMDNSPNLA WPLIVTALRA NSAVKLQNNE LSPVALRQMS CAAGTTQTAC
TDDNALAYYN NSKGGRFVLA LLSDHQDLKW ARFPKSDGTG TIYTELEPPC RFVTDTPKGP
KVKYLYFIKG LNNLNRGMVL GSLAATVRLQ AGNATEVPAN STVLSFCAFA VDPAKAYKDY
LASGGQPITN CVKMLCTHTG TGQAITVTPE ANMDQESFGG ASCCLYCRCH IDHPNPKGFC
DLKGKYVQIP TTCANDPVGF TLRNTVCTVC GMWKGYGCSC DQLREPLMQS ADASTFLNRV
CGVSAARLTP CGTGTSTDVV YRAFDIYNEK VAGFAKFLKT NCCRFQEKDE EGNLLDSYFV
VKRHTMSNYQ HEETIYNLVK DCPAVAVHDF FKFRVDGDMV PHISRQRLTK YTMADLVYAL
RHFDEGNCDT LKEILVTYNC CDDDYFNKKD WYDFVENPDI LRVYANLGER VRQSLLKTVQ
FCDAMRDAGI VGVLTLDNQD LNGNWYDFGD FVQVAPGCGV PIVDSYYSLL MPILTLTRAL
AAESHMDADL AKPLIKWDLL KYDFTEERLC LFDRYFKYWD QTYHPNCINC LDDRCILHCA
NFNVLFSTVF PPTSFGPLVR KIFVDGVPFV VSTGYHFREL GVVHNQDVNL HSSRLSFKEL
LVYAADPAMH AASGNLLLDK RTTCFSVAAL TNNVAFQTVK PGNFNKDFYD FAVSKGFFKE
GSSVELKHFF FAQDGNAAIS DYDYYRYNLP TMCDIRQLLF VVEVVDKYFD CYDGGCINAN
QVIVNNLDKS AGFPFNKWGK ARLYYDSMSY EDQDALFAYT KRNVIPTITQ MNLKYAISAK
NRARTVAGVS ICSTMTNRQF HQKLLKSIAA TRGATVVIGT SKFYGGWHNM LKTVYSDVET
PHLMGWDYPK CDRAMPNMLR IMASLVLARK HNTCCNLSHR FYRLANECAQ VLSEMVMCGG
SLYVKPGGTS SGDATTAYAN SVFNICQAVT ANVNALLSTD GNKIADKYVR NLQHRLYECL
YRNRDVDHEF VDEFYAYLRK HFSMMILSDD AVVCYNSNYA AQGLVASIKN FKAVLYYQNN
VFMSEAKCWT ETDLTKGPHE FCSQHTMLVK QGDDYVYLPY PDPSRILGAG CFVDDIVKTD
GTLMIERFVS LAIDAYPLTK HPNQEYADVF HLYLQYIRKL HDELTGHMLD MYSVMLTNDN
TSRYWEPEFY EAMYTPHTVL QAVGACVLCN SQTSLRCGAC IRRPFLCCKC CYDHVISTSH
KLVLSVNPYV CNAPGCDVTD VTQLYLGGMS YYCKSHKPPI SFPLCANGQV FGLYKNTCVG
SDNVTDFNAI ATCDWTNAGD YILANTCTER LKLFAAETLK ATEETFKLSY GIATVREVLS
DRELHLSWEV GKPRPPLNRN YVFTGYRVTK NSKVQIGEYT FEKGDYGDAV VYRGTTTYKL
NVGDYFVLTS HTVMPLSAPT LVPQEHYVRI TGLYPTLNIS DEFSSNVANY QKVGMQKYST
LQGPPGTGKS HFAIGLALYY PSARIVYTAC SHAAVDALCE KALKYLPIDK CSRIIPARAR
VECFDKFKVN STLEQYVFCT VNALPETTAD IVVFDEISMA TNYDLSVVNA RLRAKHYVYI
GDPAQLPAPR TLLTKGTLEP EYFNSVCRLM KTIGPDMFLG TCRRCPAEIV DTVSALVYDN
KLKAHKDKSA QCFKMFYKGV ITHDVSSAIN RPQIGVVREF LTRNPAWRKA VFISPYNSQN
AVASKILGLP TQTVDSSQGS EYDYVIFTQT TETAHSCNVN RFNVAITRAK IGILCIMSDR
DLYDKLQFTS LEIPRRNVAT LQAENVTGLF KDCSKIITGL HPTQAPTHLS VDIKFKTEGL
CVDIPGIPKD MTYRRLISMM GFKMNYQVNG YPNMFITREE AIRHVRAWIG FAVAGCHATR
DAVGTNLPLQ LGFSTGVNLV AVPTGYVDTE NNTEFTRVNA KPPPGDQFKH LIPLMYKGLP
WNVVRIKIVQ MLSDTLKGLS DRVVFVLWAH GFELTSMKYF VKIGPERTCC LCDKRATCFS
TSSDTYACWN HSVGFDYVYN PFMIDVQQWG FTGNLQSNHD QHCQVHGNAH VASCDAIMTR
CLAVHECFVK RVDWSVEYPI IGDELRVNSA CRKVQHMVVK SALLADKFPV LHDIGNPKAI
KCVPQAEVEW KFYDAQPCSD KAYKIEELFY SYATHHDKFT DGVCLFWNCN VDRYPANAIV
CRFDTRVLSN LNLPGCDGGS LYVNKHAFHT PAFDKSAFTN LKQLPFFYYS DSPCESHGKQ
VVSDIDYVPL KSATCITRCN LGGAVCRHHA NEYRQYLDAY NMMISAGFSL WIYKQFDTYN
LWNTFTRLQS LENVAYNVVN KGHFDGHAGE APVSIINNAV YTKVDGIDVE IFENKTTLPV
NVAFELWAKR NIKPVPEIKI LNNLGVDIAA NTVIWDYKRE APAHVSTIGV CTMTDIAKKP
TESACSSLTV LFDGRVEGQV DLFRNARNGV LITEGSVKGL TPSKGPAQAS VNGVTLIGES
VKTQFNYFKK VDGIIQQLPE TYFTQSRDLE DFKPRSQMET DFLELAMDEF IQRYKLEGYA
FEHIVYGDFS HGQLGGLHLM IGLAKRSQDS PLKLEDFIPM DSTVKNYFIT DAQTGSSKCV
CSVIDLLLDD FVEIIKSQDL SVISKVVKVT IDYAEISFML WCKDGHVETF YPKLQASQAW
QPGVAMPNLY KMQRMLLEKC DLQNYGENAV IPKGIMMNVA KYTQLCQYLN TLTLAVPYNM
RVIHFGAGSD KGVAPGTAVL RQWLPTGTLL VDSDLNDFVS DADSTLIGDC ATVHTANKWD
LIISDMYDPR TKHVTKENDS KEGFFTYLCG FIKQKLALGG SIAVKITEHS WNADLYKLMG
HFSWWTAFVT NVNASSSEAF LIGANYLGKP KEQIDGYTMH ANYIFWRNTN PIQLSSYSLF
DMSKFPLKLR GTAVMSLKEN QINDMIYSLL EKGRLIIREN NRVVVSSDIL VNN


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