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Origin recognition complex subunit 5

 ORC5_SCHPO              Reviewed;         455 AA.
O43114; Q9UQW3;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
21-FEB-2001, sequence version 2.
23-MAY-2018, entry version 115.
RecName: Full=Origin recognition complex subunit 5;
Name=orc5; Synonyms=orp5; ORFNames=SPBC646.14c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=972 / ATCC 24843;
PubMed=9417919; DOI=10.1006/geno.1997.5003;
Ishiai M., Dean F.B., Okumura K., Abe M., Moon K.-Y., Amin A.A.,
Kagotani K., Taguchi H., Murakami Y., Hanaoka F., O'Donnell M.,
Hurwitz J., Eki T.;
"Isolation of human and fission yeast homologues of the budding yeast
origin recognition complex subunit ORC5: human homologue (ORC5L) maps
to 7q22.";
Genomics 46:294-298(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
SUBUNIT.
PubMed=10535928; DOI=10.1073/pnas.96.22.12367;
Moon K.-Y., Kong D., Lee J.-K., Raychaudhuri S., Hurwitz J.;
"Identification and reconstitution of the origin recognition complex
from Schizosaccharomyces pombe.";
Proc. Natl. Acad. Sci. U.S.A. 96:12367-12372(1999).
[4]
CHARACTERIZATION OF ORC, AND INTERACTION WITH CDC18.
PubMed=11850415; DOI=10.1074/jbc.M107710200;
Chuang R.-Y., Chretien L., Dai J., Kelly T.J.;
"Purification and characterization of the Schizosaccharomyces pombe
origin recognition complex: interaction with origin DNA and Cdc18
protein.";
J. Biol. Chem. 277:16920-16927(2002).
-!- FUNCTION: Component of the origin recognition complex (ORC) that
binds origins of replication. It has a role in both chromosomal
replication and mating type transcriptional silencing. ORC binds
to multiple sites within the ars1 origin of DNA replication in an
ATP-independent manner.
-!- SUBUNIT: ORC is composed of six subunits. ORC interacts with
cdc18, recruiting it to the ars1 origin of replication.
{ECO:0000269|PubMed:10535928, ECO:0000269|PubMed:11850415}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- SIMILARITY: Belongs to the ORC5 family. {ECO:0000305}.
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EMBL; U92539; AAC49897.1; -; mRNA.
EMBL; CU329671; CAA22818.1; -; Genomic_DNA.
PIR; T40590; T40590.
RefSeq; NP_595372.1; NM_001021280.2.
ProteinModelPortal; O43114; -.
BioGrid; 277622; 11.
STRING; 4896.SPBC646.14c.1; -.
MaxQB; O43114; -.
PaxDb; O43114; -.
PRIDE; O43114; -.
EnsemblFungi; SPBC646.14c.1; SPBC646.14c.1:pep; SPBC646.14c.
GeneID; 2541107; -.
KEGG; spo:SPBC646.14c; -.
EuPathDB; FungiDB:SPBC646.14c; -.
PomBase; SPBC646.14c; orc5.
InParanoid; O43114; -.
KO; K02607; -.
OMA; GEQNIMD; -.
OrthoDB; EOG092C1SOC; -.
PhylomeDB; O43114; -.
Reactome; R-SPO-68616; Assembly of the ORC complex at the origin of replication.
Reactome; R-SPO-68962; Activation of the pre-replicative complex.
PRO; PR:O43114; -.
Proteomes; UP000002485; Chromosome II.
GO; GO:0031261; C:DNA replication preinitiation complex; IC:PomBase.
GO; GO:0000790; C:nuclear chromatin; IDA:PomBase.
GO; GO:0005664; C:nuclear origin of replication recognition complex; IDA:UniProtKB.
GO; GO:0005656; C:nuclear pre-replicative complex; IC:PomBase.
GO; GO:0043596; C:nuclear replication fork; IC:PomBase.
GO; GO:0005634; C:nucleus; HDA:PomBase.
GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
GO; GO:0016887; F:ATPase activity; NAS:PomBase.
GO; GO:0003688; F:DNA replication origin binding; IDA:UniProtKB.
GO; GO:1902975; P:mitotic DNA replication initiation; IMP:PomBase.
GO; GO:0007064; P:mitotic sister chromatid cohesion; IGI:PomBase.
InterPro; IPR020796; ORC5.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR12705; PTHR12705; 1.
Pfam; PF14630; ORC5_C; 1.
SUPFAM; SSF52540; SSF52540; 2.
1: Evidence at protein level;
ATP-binding; Complete proteome; DNA replication; Nucleotide-binding;
Nucleus; Reference proteome.
CHAIN 1 455 Origin recognition complex subunit 5.
/FTId=PRO_0000127095.
NP_BIND 42 49 ATP. {ECO:0000255}.
CONFLICT 328 328 F -> S (in Ref. 1; AAC49897).
{ECO:0000305}.
SEQUENCE 455 AA; 51762 MW; B7A6AC2CFF7D2FB5 CRC64;
MHLYQLEDEL KKNVFCREDQ IKKLSCLLFN KDCRVPSIVL YGVASTAKTF LLRTAFDLSK
EENVWINLQD CFTVAHFWYR ILIKVGVDKD IALKKGINIS GFIYLLEQAM SKRDYHTFLV
LDQIDDFAEA STILFSQLAQ LPIVANIPNL SIIFVLHSHP AQYLGTLSIA VIFFPQYTQA
EILEICQKTP PNLDFLDRSG DSVFEDEIEL SVWMQYCSFL WSVFGVQCLN DYRSFRSVLD
RYWPKFIQPI VEGDIHPADY AQLHKLAKNF LVSDATVTKR LHIINPTEIK NLLDSKSINL
SLVSKYLLVS AFLASYNPSR LDAQFFSFSK TSKRRGRKRK QIQDEGVLFS KIPRTAGSKG
RSAVKISQLT LGPKPFEVER LIAIYYAISS PVEKVLTADV FVQIATLASL KMILSASKGV
LRSLDSPRYI VNVSREYVLK IADSLSFPLD SYLAG


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