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Ornithine decarboxylase (ODC) (EC 4.1.1.17)

 DCOR_CRIGR              Reviewed;         455 AA.
P14019;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 3.
12-SEP-2018, entry version 106.
RecName: Full=Ornithine decarboxylase;
Short=ODC;
EC=4.1.1.17;
Name=ODC1; Synonyms=ODC;
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2602162; DOI=10.1093/nar/17.24.10497;
Grens A., Steglich C., Pilz R., Scheffler I.E.;
"Nucleotide sequence of the Chinese hamster ornithine decarboxylase
gene.";
Nucleic Acids Res. 17:10497-10497(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 163-455.
PubMed=2887574;
Srinivasan P.R., Tonin P.N., Wensing E.J., Lewis W.H.;
"The gene for ornithine decarboxylase is co-amplified in hydroxyurea-
resistant hamster cells.";
J. Biol. Chem. 262:12871-12878(1987).
-!- FUNCTION: Catalyzes the first and rate-limiting step of polyamine
biosynthesis that converts ornithine into putrescine, which is the
precursor for the polyamines, spermidine and spermine. Polyamines
are essential for cell proliferation and are implicated in
cellular processes, ranging from DNA replication to apoptosis.
{ECO:0000250|UniProtKB:P11926}.
-!- CATALYTIC ACTIVITY: L-ornithine = putrescine + CO(2).
{ECO:0000250|UniProtKB:P11926}.
-!- COFACTOR:
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Evidence={ECO:0000250|UniProtKB:P11926};
-!- ACTIVITY REGULATION: Inhibited by antizymes (AZs) OAZ1, OAZ2 and
OAZ3 in response to polyamine levels. AZs inhibit the assembly of
the functional homodimer by binding to ODC monomers. Additionally,
OAZ1 targets ODC monomers for ubiquitin-independent proteolytic
destruction by the 26S proteasome. {ECO:0000250|UniProtKB:P11926}.
-!- PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis
via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
-!- SUBUNIT: Homodimer. Only the dimer is catalytically active, as the
active sites are constructed of residues from both monomers.
{ECO:0000250|UniProtKB:P00860}.
-!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II
family. {ECO:0000305}.
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EMBL; X16910; CAA34784.1; -; mRNA.
EMBL; J02813; AAA36963.1; -; mRNA.
PIR; S09574; DCHYOC.
ProteinModelPortal; P14019; -.
SMR; P14019; -.
PRIDE; P14019; -.
HOVERGEN; HBG005456; -.
UniPathway; UPA00535; UER00288.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0004586; F:ornithine decarboxylase activity; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0033387; P:putrescine biosynthetic process from ornithine; ISS:UniProtKB.
GO; GO:0042176; P:regulation of protein catabolic process; ISS:UniProtKB.
Gene3D; 2.40.37.10; -; 2.
Gene3D; 3.20.20.10; -; 1.
InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
InterPro; IPR022643; De-COase2_C.
InterPro; IPR022644; De-COase2_N.
InterPro; IPR022653; De-COase2_pyr-phos_BS.
InterPro; IPR000183; Orn/DAP/Arg_de-COase.
InterPro; IPR002433; Orn_de-COase.
InterPro; IPR029066; PLP-binding_barrel.
PANTHER; PTHR11482; PTHR11482; 1.
Pfam; PF02784; Orn_Arg_deC_N; 1.
Pfam; PF00278; Orn_DAP_Arg_deC; 1.
PRINTS; PR01179; ODADCRBXLASE.
PRINTS; PR01182; ORNDCRBXLASE.
SUPFAM; SSF50621; SSF50621; 1.
SUPFAM; SSF51419; SSF51419; 1.
PROSITE; PS00878; ODR_DC_2_1; 1.
PROSITE; PS00879; ODR_DC_2_2; 1.
2: Evidence at transcript level;
Decarboxylase; Lyase; Phosphoprotein; Polyamine biosynthesis;
Pyridoxal phosphate; S-nitrosylation.
CHAIN 1 455 Ornithine decarboxylase.
/FTId=PRO_0000149890.
REGION 271 274 Pyridoxal phosphate binding.
{ECO:0000250|UniProtKB:P11926}.
REGION 325 326 Substrate binding.
{ECO:0000250|UniProtKB:P07805}.
ACT_SITE 354 354 Proton donor; shared with dimeric
partner. {ECO:0000250|UniProtKB:P11926}.
BINDING 197 197 Pyridoxal phosphate.
{ECO:0000250|UniProtKB:P11926}.
BINDING 234 234 Pyridoxal phosphate; via amino nitrogen.
{ECO:0000250|UniProtKB:P11926}.
BINDING 355 355 Substrate; shared with dimeric partner.
{ECO:0000250|UniProtKB:P07805}.
BINDING 383 383 Pyridoxal phosphate.
{ECO:0000250|UniProtKB:P11926}.
SITE 194 194 Stacks against the aromatic ring of
pyridoxal phosphate and stabilizes
reaction intermediates.
{ECO:0000250|UniProtKB:P00860}.
MOD_RES 67 67 N6-(pyridoxal phosphate)lysine.
{ECO:0000250|UniProtKB:P11926}.
MOD_RES 297 297 Phosphoserine; by CK2.
{ECO:0000250|UniProtKB:P00860}.
MOD_RES 354 354 S-nitrosocysteine.
{ECO:0000250|UniProtKB:P11926}.
CONFLICT 452 452 S -> R (in Ref. 2). {ECO:0000305}.
SEQUENCE 455 AA; 50454 MW; 14162985F188C89F CRC64;
MNSFNKDEFD CHILDEGFTA KDILDQKINE VSSDDKDAFY VADLGDVLKK HLRWLKALPV
TPFYAVKCND SRALVNTLAA ITVDCASKTE IQLVQGLGVP PERVIYANPC KQVSQIKYAA
SNGVQMMTFD SEIELMKVAR AHPKVTKLVL RIATDDSKAV CRLSVKFGAT LRTSRLLLER
AKELNIDVIG VSFHVGSGCT DPETFVQALS DARCVFDMGT EVGFSMYLLD IGGGFPGSED
TKLKFEEITS VINPALDKYF PPDSGVRVIA EPGRYYVASA FTLAVNIIAK KIVSKGSDDE
DESSEQTFMY YVNDGVYGSF NCILYDHAHV KPLLPKRPKP DEKYYSSSIW GPTCDGLDRI
VERCNLPEMH VGDWMLFENM GAYTVAAAST FNGFQRPSIY YVMSRPMWQL MKQIQNHGFP
PEVEEQDVGT LPISCAQESG MDRHPAACAS ASINV


Related products :

Catalog number Product name Quantity
MA1073 Monoclonal Anti-Ornithine Decarboxylase (ODC), Clone number: ODC-22, Ig type: mouse IgG2b, Immunogen: Recombinant mouse ornithine decarboxylase., Specificity: Human. No cross reactivity with other pro 100μg/vial
LF-MA50073 anti-Ornithine Decarboxylase (ODC-22), Mouse monoclonal to Ornithine Decarboxylase, Isotype IgG2b, Host Mouse 200 ul
20-272-191151 Ornithine Decarboxylase - Mouse monoclonal [3F293] to Ornithine Decarboxylase Monoclonal 0.05 ml
B513I Ornithine Decarboxylase Broth USE For detection of the ability of microorganisms to decarboxylate ornithine. Qty per Litre of Medium: 9
B513I Ornithine Decarboxylase Broth USE : For detection of the ability of microorganisms to decarboxylate ornithine. 5x500gm
MCA3310Z MOUSE ANTI HUMAN ORNITHINE DECARBOXYLASE Azide Free, Product Type Monoclonal Antibody, Specificity ORNITHINE DECARBOXYLASE 1, Target Species Human, Host Mouse, Format Azide Free, Isotypes IgG2b, 0.1 mg
B233 MIO Medium (Motility Indole Ornithine Medium) USE : For the identification of Enterobacteriaceae on the basis of motility,indole production and ornithine decarboxylase activity. 5x500gm
B233 MIO Medium (Motility Indole Ornithine Medium) USE For the identification of Enterobacteriaceae on the basis of motility,indole production and ornithine decarboxylase activity. Qty per Litre of Medium: 31
Y105298 Ornithine Decarboxylase 50ug
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E02O0013 Rat Ornithine Decarboxylase Elisa Kit (ODC) 96 Tests/kit
E-EL-R0694 Rat ODC (Ornithine Decarboxylase) ELISA Kit 96T
EH1503 Ornithine decarboxylase Elisa Kit 96T
CG81 Ornithine decarboxylase ODC1 lmg
GTX23141 Ornithine Decarboxylase (ODC1) 500 µl
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Y103692 Ornithine Decarboxylase (ODC) AB1 Antibody 100ug
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DL-ODC-Hu Human Ornithine Decarboxylase (ODC) ELISA Kit 96T
GWB-A17693 Ornithine Decarboxylase, Antibody


 

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