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Ornithine decarboxylase antizyme 1 (ODC-Az)

 OAZ1_MOUSE              Reviewed;         227 AA.
P54369; O08610;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
28-MAR-2018, entry version 123.
RecName: Full=Ornithine decarboxylase antizyme 1;
Short=ODC-Az;
Name=Oaz1; Synonyms=Oaz;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=9428668; DOI=10.1111/j.1432-1033.1997.0223a.x;
Nilsson J., Koskiniemi S., Persson K., Grahn B., Holm I.;
"Polyamines regulate both transcription and translation of the gene
encoding ornithine decarboxylase antizyme in mouse.";
Eur. J. Biochem. 250:223-231(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/SvJ;
Kankare K., Uusi-Oukari M., Janne O.A.;
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
[3]
FUNCTION, AND INTERACTION WITH AZIN2.
PubMed=16916800; DOI=10.1074/jbc.M602840200;
Lopez-Contreras A.J., Lopez-Garcia C., Jimenez-Cervantes C.,
Cremades A., Penafiel R.;
"Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor
devoid of ornithine and arginine decarboxylating activity.";
J. Biol. Chem. 281:30896-30906(2006).
[4]
FUNCTION, AND INTERACTION WITH AZIN2.
PubMed=18062773; DOI=10.1042/BJ20071423;
Snapir Z., Keren-Paz A., Bercovich Z., Kahana C.;
"ODCp, a brain- and testis-specific ornithine decarboxylase paralogue,
functions as an antizyme inhibitor, although less efficiently than
AzI1.";
Biochem. J. 410:613-619(2008).
[5]
FUNCTION.
PubMed=18508777; DOI=10.1074/jbc.M801024200;
Lopez-Contreras A.J., Ramos-Molina B., Cremades A., Penafiel R.;
"Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in
mammalian cells.";
J. Biol. Chem. 283:20761-20769(2008).
[6]
FUNCTION.
PubMed=19449338; DOI=10.1002/jcb.22168;
Lopez-Contreras A.J., Sanchez-Laorden B.L., Ramos-Molina B.,
de la Morena M.E., Cremades A., Penafiel R.;
"Subcellular localization of antizyme inhibitor 2 in mammalian cells:
Influence of intrinsic sequences and interaction with antizymes.";
J. Cell. Biochem. 107:732-740(2009).
[7]
INTERACTION WITH AZIN2.
PubMed=24967154; DOI=10.1016/j.fob.2014.05.004;
Ramos-Molina B., Lambertos A., Lopez-Contreras A.J., Kasprzak J.M.,
Czerwoniec A., Bujnicki J.M., Cremades A., Penafiel R.;
"Structural and degradative aspects of ornithine decarboxylase
antizyme inhibitor 2.";
FEBS Open Bio 4:510-521(2014).
-!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
negatively regulates ODC activity and intracellular polyamine
biosynthesis and uptake in response to increased intracellular
polyamine levels. Binds to ODC monomers, inhibiting the assembly
of the functional ODC homodimer, and targets the monomers for
ubiquitin-independent proteolytic destruction by the 26S
proteasome (PubMed:16916800, PubMed:18508777). Triggers ODC
degradation by inducing the exposure of a cryptic proteasome-
interacting surface of ODC (By similarity). Stabilizes AZIN2 by
interfering with its ubiquitination (PubMed:18062773). Also
inhibits cellular uptake of polyamines by inactivating the
polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates
the degradation of the CREBBP/EP300 repressor SNIP1. Involved in
the translocation of AZIN2 from ER-Golgi intermediate compartment
(ERGIC) to the cytosol (PubMed:19449338).
{ECO:0000250|UniProtKB:P54368, ECO:0000269|PubMed:16916800,
ECO:0000269|PubMed:18062773, ECO:0000269|PubMed:18508777,
ECO:0000269|PubMed:19449338}.
-!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
homodimerization (By similarity). Forms a ternary complex with
PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S
proteasome (By similarity). Interacts with AZIN2; this interaction
disrupts the interaction between the antizyme and ODC1
(PubMed:16916800, PubMed:18062773, PubMed:24967154).
{ECO:0000250|UniProtKB:P54368, ECO:0000269|PubMed:16916800,
ECO:0000269|PubMed:18062773, ECO:0000269|PubMed:24967154}.
-!- ALTERNATIVE PRODUCTS:
Event=Ribosomal frameshifting; Named isoforms=1;
Comment=A ribosomal frameshift occurs between the codons for
Ser-68 and Asp-69. An autoregulatory mechanism enables
modulation of frameshifting according to the cellular
concentration of polyamines.;
Name=1;
IsoId=P54369-1; Sequence=Displayed;
-!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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EMBL; U52822; AAB96329.1; -; mRNA.
EMBL; U52823; AAB96330.1; -; Genomic_DNA.
EMBL; U84291; AAC53307.1; -; Genomic_DNA.
CCDS; CCDS56736.1; -. [P54369-1]
PIR; PC4378; PC4378.
RefSeq; NP_032779.2; NM_008753.4. [P54369-1]
UniGene; Mm.398119; -.
ProteinModelPortal; P54369; -.
SMR; P54369; -.
IntAct; P54369; 1.
STRING; 10090.ENSMUSP00000137400; -.
iPTMnet; P54369; -.
PhosphoSitePlus; P54369; -.
PaxDb; P54369; -.
PRIDE; P54369; -.
Ensembl; ENSMUST00000180036; ENSMUSP00000137400; ENSMUSG00000035242. [P54369-1]
GeneID; 18245; -.
KEGG; mmu:18245; -.
UCSC; uc033frg.1; mouse. [P54369-1]
CTD; 4946; -.
MGI; MGI:109433; Oaz1.
eggNOG; KOG4387; Eukaryota.
eggNOG; ENOG4112791; LUCA.
GeneTree; ENSGT00390000009476; -.
HOGENOM; HOG000115253; -.
HOVERGEN; HBG007857; -.
InParanoid; P54369; -.
KO; K16548; -.
OMA; CDVPHPP; -.
OrthoDB; EOG091G0SR0; -.
PhylomeDB; P54369; -.
TreeFam; TF314741; -.
Reactome; R-MMU-350562; Regulation of ornithine decarboxylase (ODC).
PRO; PR:P54369; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000035242; -.
CleanEx; MM_OAZ1; -.
ExpressionAtlas; P54369; baseline and differential.
Genevisible; P54369; MM.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IEA:InterPro.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IDA:UniProtKB.
GO; GO:1902268; P:negative regulation of polyamine transmembrane transport; IDA:UniProtKB.
GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0006595; P:polyamine metabolic process; TAS:MGI.
GO; GO:0090316; P:positive regulation of intracellular protein transport; IDA:UniProtKB.
GO; GO:0045732; P:positive regulation of protein catabolic process; IDA:UniProtKB.
Gene3D; 3.40.630.60; -; 1.
InterPro; IPR016181; Acyl_CoA_acyltransferase.
InterPro; IPR029914; ODC-AZ_1.
InterPro; IPR002993; ODC_AZ.
InterPro; IPR038581; ODC_AZ_sf.
PANTHER; PTHR10279; PTHR10279; 1.
PANTHER; PTHR10279:SF8; PTHR10279:SF8; 1.
Pfam; PF02100; ODC_AZ; 1.
SUPFAM; SSF55729; SSF55729; 1.
PROSITE; PS01337; ODC_AZ; 1.
1: Evidence at protein level;
Complete proteome; Polyamine biosynthesis; Reference proteome;
Ribosomal frameshifting; Transport.
CHAIN 1 227 Ornithine decarboxylase antizyme 1.
/FTId=PRO_0000220851.
CONFLICT 69 69 D -> C (in Ref. 1; AAB96330).
{ECO:0000305}.
SEQUENCE 227 AA; 25133 MW; C2D0E1614C5F28A5 CRC64;
MVKSSLQRIL NSHCFAREKE GDKRSATLHA SRTMPLLSQH SRGGCSSESS RVALNCCSNL
GPGPRWCSDV PHPPLKIPGG RGNSQRDHSL SASILYSDER LNVTEEPTSN DKTRVLSIQS
TLTEAKQVTW RAVWSGGGLY IELPAGPLPE GSKDSFAALL EFAEEQLQAD HVFICFPKNR
EDRAALLRTF SFLGFEIVRP GHPLVPKRPD ACFMVYTLER EDPGEED


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