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Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2) (Seizure-related protein 15)

 OAZ2_MOUSE              Reviewed;         189 AA.
O08608;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
05-DEC-2018, entry version 121.
RecName: Full=Ornithine decarboxylase antizyme 2;
Short=AZ2;
Short=ODC-Az 2;
AltName: Full=Seizure-related protein 15;
Name=Oaz2; Synonyms=Sez15;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9782076; DOI=10.1006/geno.1998.5434;
Ivanov I.P., Gesteland R.F., Atkins J.F.;
"A second mammalian antizyme: conservation of programmed ribosomal
frameshifting.";
Genomics 52:119-129(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 50-189.
STRAIN=C57BL/6J; TISSUE=Brain cortex;
PubMed=8645260; DOI=10.1006/bbrc.1996.0313;
Kajiwara K., Nagawawa H., Shimizu-Nishikawa K., Ookura T., Kimura M.,
Sugaya E.;
"Molecular characterization of seizure-related genes isolated by
differential screening.";
Biochem. Biophys. Res. Commun. 219:795-799(1996).
[3]
FUNCTION, AND INTERACTION WITH AZIN2.
PubMed=16916800; DOI=10.1074/jbc.M602840200;
Lopez-Contreras A.J., Lopez-Garcia C., Jimenez-Cervantes C.,
Cremades A., Penafiel R.;
"Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor
devoid of ornithine and arginine decarboxylating activity.";
J. Biol. Chem. 281:30896-30906(2006).
[4]
FUNCTION.
PubMed=18508777; DOI=10.1074/jbc.M801024200;
Lopez-Contreras A.J., Ramos-Molina B., Cremades A., Penafiel R.;
"Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in
mammalian cells.";
J. Biol. Chem. 283:20761-20769(2008).
[5]
FUNCTION.
PubMed=19449338; DOI=10.1002/jcb.22168;
Lopez-Contreras A.J., Sanchez-Laorden B.L., Ramos-Molina B.,
de la Morena M.E., Cremades A., Penafiel R.;
"Subcellular localization of antizyme inhibitor 2 in mammalian cells:
Influence of intrinsic sequences and interaction with antizymes.";
J. Cell. Biochem. 107:732-740(2009).
[6]
SUBCELLULAR LOCATION, AND PHOSPHORYLATION AT SER-186.
PubMed=19725046; DOI=10.1002/jcb.22334;
Murai N., Shimizu A., Murakami Y., Matsufuji S.;
"Subcellular localization and phosphorylation of antizyme 2.";
J. Cell. Biochem. 108:1012-1021(2009).
[7]
FUNCTION.
PubMed=24967154; DOI=10.1016/j.fob.2014.05.004;
Ramos-Molina B., Lambertos A., Lopez-Contreras A.J., Kasprzak J.M.,
Czerwoniec A., Bujnicki J.M., Cremades A., Penafiel R.;
"Structural and degradative aspects of ornithine decarboxylase
antizyme inhibitor 2.";
FEBS Open Bio 4:510-521(2014).
-!- FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that
negatively regulates ODC activity and intracellular polyamine
biosynthesis and uptake in response to increased intracellular
polyamine levels. Binds to ODC monomers, inhibiting the assembly
of the functional ODC homodimers. Does not target the ODC monomers
for degradation, which allows a protein synthesis-independent
restoration of ODC activity (PubMed:16916800, PubMed:18508777,
PubMed:24967154). Involved in the translocation of AZIN2 from ER-
Golgi intermediate compartment (ERGIC) to the cytosol
(PubMed:19449338). {ECO:0000269|PubMed:16916800,
ECO:0000269|PubMed:18508777, ECO:0000269|PubMed:19449338,
ECO:0000269|PubMed:24967154}.
-!- SUBUNIT: Interacts with ODC1 and thereby sterically blocks ODC
homodimerization (By similarity). Interacts with AZIN2; this
interaction disrupts the interaction between the antizyme and ODC1
(PubMed:16916800). {ECO:0000250|UniProtKB:P54368,
ECO:0000269|PubMed:16916800}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19725046}.
-!- ALTERNATIVE PRODUCTS:
Event=Ribosomal frameshifting; Named isoforms=1;
Comment=A ribosomal frameshift occurs between the codons for
Ser-32 and Asp-33. An autoregulatory mechanism enables
modulation of frameshifting according to the cellular
concentration of polyamines.;
Name=1;
IsoId=O08608-1; Sequence=Displayed;
-!- SIMILARITY: Belongs to the ODC antizyme family. {ECO:0000305}.
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EMBL; AF057298; AAD03266.1; -; mRNA.
EMBL; D78643; BAA19569.1; -; mRNA.
CCDS; CCDS57683.1; -. [O08608-1]
RefSeq; NP_035082.1; NM_010952.3. [O08608-1]
UniGene; Mm.116749; -.
ProteinModelPortal; O08608; -.
IntAct; O08608; 1.
STRING; 10090.ENSMUSP00000136914; -.
iPTMnet; O08608; -.
PhosphoSitePlus; O08608; -.
MaxQB; O08608; -.
PaxDb; O08608; -.
PRIDE; O08608; -.
Ensembl; ENSMUST00000153700; ENSMUSP00000136914; ENSMUSG00000040652. [O08608-1]
GeneID; 18247; -.
KEGG; mmu:18247; -.
UCSC; uc009qdu.2; mouse. [O08608-1]
CTD; 4947; -.
MGI; MGI:109492; Oaz2.
eggNOG; KOG4387; Eukaryota.
eggNOG; ENOG4112791; LUCA.
GeneTree; ENSGT00940000157725; -.
HOVERGEN; HBG007857; -.
InParanoid; O08608; -.
KO; K16613; -.
OMA; FICFRKS; -.
OrthoDB; EOG091G0SR0; -.
TreeFam; TF314741; -.
Reactome; R-MMU-350562; Regulation of ornithine decarboxylase (ODC).
PRO; PR:O08608; -.
Proteomes; UP000000589; Chromosome 9.
Bgee; ENSMUSG00000040652; Expressed in 33 organ(s), highest expression level in lung.
CleanEx; MM_OAZ2; -.
ExpressionAtlas; O08608; baseline and differential.
Genevisible; O08608; MM.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IEA:InterPro.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0008073; F:ornithine decarboxylase inhibitor activity; IGI:MGI.
GO; GO:1902268; P:negative regulation of polyamine transmembrane transport; IDA:UniProtKB.
GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0006595; P:polyamine metabolic process; TAS:MGI.
GO; GO:0090316; P:positive regulation of intracellular protein transport; IDA:UniProtKB.
GO; GO:0045732; P:positive regulation of protein catabolic process; IDA:UniProtKB.
Gene3D; 3.40.630.60; -; 1.
InterPro; IPR016181; Acyl_CoA_acyltransferase.
InterPro; IPR029916; ODC-AZ_2.
InterPro; IPR002993; ODC_AZ.
InterPro; IPR038581; ODC_AZ_sf.
PANTHER; PTHR10279; PTHR10279; 1.
PANTHER; PTHR10279:SF6; PTHR10279:SF6; 1.
Pfam; PF02100; ODC_AZ; 1.
SUPFAM; SSF55729; SSF55729; 1.
PROSITE; PS01337; ODC_AZ; 1.
1: Evidence at protein level;
Complete proteome; Nucleus; Phosphoprotein; Polyamine biosynthesis;
Reference proteome; Ribosomal frameshifting.
CHAIN 1 189 Ornithine decarboxylase antizyme 2.
/FTId=PRO_0000220858.
MOD_RES 186 186 Phosphoserine.
{ECO:0000269|PubMed:19725046}.
SEQUENCE 189 AA; 21025 MW; 7B8C08843686163B CRC64;
MINTQDSSIL PLSKCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD PSLSALIYKD
EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ SLFVEIPDGL LADGSKEGLL
ALLEFAEEKM KVNYVFICFR KGREDRAPLL KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP
LDQNLSDED


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