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Osteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid-containing protein)

 OSTCN_FELCA             Reviewed;          49 AA.
P02821;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
12-SEP-2018, entry version 100.
RecName: Full=Osteocalcin;
AltName: Full=Bone Gla protein;
Short=BGP;
AltName: Full=Gamma-carboxyglutamic acid-containing protein;
Name=BGLAP;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
PROTEIN SEQUENCE, HYDROXYLATION AT PRO-9, AND GAMMA-CARBOXYGLUTAMATION
AT GLU-17; GLU-21 AND GLU-24.
PubMed=6334077;
Shimomura H., Kanai Y., Sanada K.;
"Primary structure of cat osteocalcin.";
J. Biochem. 96:405-411(1984).
-!- FUNCTION: Constitutes 1-2% of the total bone protein. It binds
strongly to apatite and calcium.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Gamma-carboxyglutamate residues are formed by vitamin K
dependent carboxylation. These residues are essential for the
binding of calcium. {ECO:0000255|PROSITE-ProRule:PRU00463,
ECO:0000269|PubMed:6334077}.
-!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
{ECO:0000305}.
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PIR; A03304; GECT.
ProteinModelPortal; P02821; -.
SMR; P02821; -.
STRING; 9685.ENSFCAP00000018678; -.
eggNOG; ENOG410J11Z; Eukaryota.
eggNOG; ENOG410ZS6W; LUCA.
InParanoid; P02821; -.
OrthoDB; EOG091G13UG; -.
Proteomes; UP000011712; Unplaced.
Bgee; ENSFCAG00000030619; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
GO; GO:0060348; P:bone development; IEA:InterPro.
GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
GO; GO:1900076; P:regulation of cellular response to insulin stimulus; IEA:InterPro.
GO; GO:0032571; P:response to vitamin K; IEA:InterPro.
InterPro; IPR035972; GLA-like_dom_SF.
InterPro; IPR000294; GLA_domain.
InterPro; IPR039176; Osteocalcin.
InterPro; IPR002384; Osteocalcin/MGP.
PANTHER; PTHR14235; PTHR14235; 1.
PRINTS; PR00002; GLABONE.
SMART; SM00069; GLA; 1.
SUPFAM; SSF57630; SSF57630; 1.
PROSITE; PS00011; GLA_1; 1.
PROSITE; PS50998; GLA_2; 1.
1: Evidence at protein level;
Biomineralization; Calcium; Complete proteome;
Direct protein sequencing; Disulfide bond; Gamma-carboxyglutamic acid;
Hydroxylation; Metal-binding; Reference proteome; Secreted.
CHAIN 1 49 Osteocalcin.
/FTId=PRO_0000148897.
DOMAIN 1 47 Gla. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
METAL 17 17 Calcium 3. {ECO:0000250}.
METAL 21 21 Calcium 2. {ECO:0000250}.
METAL 24 24 Calcium 1. {ECO:0000250}.
METAL 24 24 Calcium 2. {ECO:0000250}.
METAL 30 30 Calcium 1. {ECO:0000250}.
MOD_RES 9 9 4-hydroxyproline.
{ECO:0000269|PubMed:6334077}.
MOD_RES 17 17 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463,
ECO:0000269|PubMed:6334077}.
MOD_RES 21 21 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463,
ECO:0000269|PubMed:6334077}.
MOD_RES 24 24 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463,
ECO:0000269|PubMed:6334077}.
DISULFID 23 29
SEQUENCE 49 AA; 5495 MW; 93D2131FA9F656D3 CRC64;
YLAPGLGAPA PYPDPLEPKR EICELNPDCD ELADHIGFQD AYRRFYGTV


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