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Osteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid-containing protein)

 OSTCN_BISPR             Reviewed;          49 AA.
P83489;
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
22-NOV-2017, entry version 60.
RecName: Full=Osteocalcin;
AltName: Full=Bone Gla protein;
Short=BGP;
AltName: Full=Gamma-carboxyglutamic acid-containing protein;
Name=BGLAP;
Bison priscus (Steppe wisent) (Steppe bison).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bison.
NCBI_TaxID=268291;
[1] {ECO:0000305}
PROTEIN SEQUENCE, HYDROXYLATION AT PRO-9, GAMMA-CARBOXYGLUTAMATION AT
GLU-17; GLU-21 AND GLU-24, AND MASS SPECTROMETRY.
TISSUE=Bone;
Nielsen-Marsh C.M., Ostrom P.H., Gandhi H., Shapiro B., Cooper A.,
Hauschka P.V., Collins M.J.;
"Sequence preservation of osteocalcin protein and mitochondrial DNA in
bison bones older than 55 ka.";
Geology 30:1099-1102(2002).
-!- FUNCTION: Constitutes 1-2% of the total bone protein. It binds
strongly to apatite and calcium (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02820}.
-!- PTM: Gamma-carboxyglutamic acid residues are formed by vitamin K
dependent carboxylation. These residues are essential for the
binding of calcium (By similarity). {ECO:0000250}.
-!- MASS SPECTROMETRY: Mass=5590; Method=MALDI; Range=1-49;
Evidence={ECO:0000269|Ref.1};
-!- MISCELLANEOUS: Sequence data obtained by MS from permafrost
fossilized bones about 55.6 thousand years old.
-!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
{ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=A small blast from the
past - Issue 46 of May 2004;
URL="https://web.expasy.org/spotlight/back_issues/046";
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ProteinModelPortal; P83489; -.
SMR; P83489; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
InterPro; IPR035972; GLA-like_dom_SF.
InterPro; IPR000294; GLA_domain.
InterPro; IPR002384; Osteocalcin/MGP.
PRINTS; PR00002; GLABONE.
SMART; SM00069; GLA; 1.
SUPFAM; SSF57630; SSF57630; 1.
PROSITE; PS00011; GLA_1; 1.
PROSITE; PS50998; GLA_2; 1.
1: Evidence at protein level;
Biomineralization; Calcium; Direct protein sequencing; Disulfide bond;
Extinct organism protein; Gamma-carboxyglutamic acid; Hydroxylation;
Metal-binding; Secreted.
CHAIN 1 49 Osteocalcin.
/FTId=PRO_0000148895.
DOMAIN 1 47 Gla. {ECO:0000255|PROSITE-
ProRule:PRU00463}.
METAL 17 17 Calcium 3. {ECO:0000250}.
METAL 21 21 Calcium 2. {ECO:0000250}.
METAL 24 24 Calcium 1. {ECO:0000250}.
METAL 24 24 Calcium 2. {ECO:0000250}.
METAL 30 30 Calcium 1. {ECO:0000250}.
MOD_RES 9 9 Hydroxyproline. {ECO:0000269|Ref.1}.
MOD_RES 17 17 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463, ECO:0000269|Ref.1}.
MOD_RES 21 21 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463, ECO:0000269|Ref.1}.
MOD_RES 24 24 4-carboxyglutamate. {ECO:0000255|PROSITE-
ProRule:PRU00463, ECO:0000269|Ref.1}.
DISULFID 23 29
SEQUENCE 49 AA; 5575 MW; 718826015806CCBE CRC64;
YLDHGLGAPA PYPDPLEPKR EVCELNPDCD ELADHIGFQE AYRRFYGPV


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E0471Rb ELISA BGLAP,BGP,Bone Gla protein,Gamma-carboxyglutamic acid-containing protein,Oryctolagus cuniculus,Osteocalcin,Rabbit 96T
E0471h ELISA kit BGLAP,BGP,Bone Gla protein,Gamma-carboxyglutamic acid-containing protein,Homo sapiens,Human,Osteocalcin 96T
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