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Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR)

 NR1H2_RAT               Reviewed;         446 AA.
Q62755; Q62694;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
28-MAR-2018, entry version 152.
RecName: Full=Oxysterols receptor LXR-beta;
AltName: Full=Liver X receptor beta;
AltName: Full=Nuclear receptor subfamily 1 group H member 2;
AltName: Full=Orphan nuclear receptor OR-1;
AltName: Full=Ubiquitously-expressed nuclear receptor;
Short=UR;
Name=Nr1h2; Synonyms=Lxrb;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Liver;
PubMed=7892230; DOI=10.1073/pnas.92.6.2096;
Teboul M., Enmark E., Li Q., Wikstroem A.-C., Pelto-Huikko M.,
Gustafsson J.-A.;
"OR-1, a member of the nuclear receptor superfamily that interacts
with the 9-cis-retinoic acid receptor.";
Proc. Natl. Acad. Sci. U.S.A. 92:2096-2100(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Vagina;
PubMed=7971966; DOI=10.1073/pnas.91.23.10809;
Song C., Kokontis J.M., Hiipakka R.A., Liao S.;
"Ubiquitous receptor: a receptor that modulates gene activation by
retinoic acid and thyroid hormone receptors.";
Proc. Natl. Acad. Sci. U.S.A. 91:10809-10813(1994).
-!- FUNCTION: Nuclear receptor. Binds preferentially to double-
stranded oligonucleotide direct repeats having the consensus half-
site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates
cholesterol uptake through MYLIP-dependent ubiquitination of LDLR,
VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA
for the regulation of genes involved in liver metabolism. Exhibits
a ligand-dependent transcriptional activation activity (By
similarity). {ECO:0000250|UniProtKB:P55055,
ECO:0000250|UniProtKB:Q60644}.
-!- SUBUNIT: Forms a heterodimer with RXR. Interacts with CCAR2 (via
N-terminus) in a ligand-independent manner.
{ECO:0000250|UniProtKB:P55055}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00407}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U20389; AAA69522.1; -; mRNA.
EMBL; U14533; AAA52361.1; -; mRNA.
PIR; I59354; I59354.
RefSeq; NP_113814.1; NM_031626.1.
UniGene; Rn.786; -.
ProteinModelPortal; Q62755; -.
SMR; Q62755; -.
STRING; 10116.ENSRNOP00000026862; -.
PhosphoSitePlus; Q62755; -.
PaxDb; Q62755; -.
Ensembl; ENSRNOT00000026862; ENSRNOP00000026862; ENSRNOG00000019812.
GeneID; 58851; -.
KEGG; rno:58851; -.
UCSC; RGD:61906; rat.
CTD; 7376; -.
RGD; 61906; Nr1h2.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00870000136372; -.
HOGENOM; HOG000220845; -.
HOVERGEN; HBG108655; -.
InParanoid; Q62755; -.
KO; K08535; -.
OMA; RRYACRG; -.
OrthoDB; EOG091G0I4P; -.
PhylomeDB; Q62755; -.
TreeFam; TF352167; -.
Reactome; R-RNO-383280; Nuclear Receptor transcription pathway.
Reactome; R-RNO-8866427; VLDLR internalisation and degradation.
PRO; PR:Q62755; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000019812; -.
Genevisible; Q62755; RN.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0005634; C:nucleus; ISO:RGD.
GO; GO:0034191; F:apolipoprotein A-I receptor binding; ISO:RGD.
GO; GO:0051117; F:ATPase binding; ISO:RGD.
GO; GO:0003677; F:DNA binding; ISO:RGD.
GO; GO:0003700; F:DNA binding transcription factor activity; ISO:RGD.
GO; GO:0004879; F:nuclear receptor activity; ISO:RGD.
GO; GO:0046965; F:retinoid X receptor binding; IDA:RGD.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IMP:NTNU_SB.
GO; GO:0001133; F:RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding; IDA:RGD.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0044255; P:cellular lipid metabolic process; ISO:RGD.
GO; GO:0042632; P:cholesterol homeostasis; ISO:RGD.
GO; GO:0055088; P:lipid homeostasis; ISO:RGD.
GO; GO:0010887; P:negative regulation of cholesterol storage; ISO:RGD.
GO; GO:0010629; P:negative regulation of gene expression; IDA:RGD.
GO; GO:0032369; P:negative regulation of lipid transport; ISO:RGD.
GO; GO:0048550; P:negative regulation of pinocytosis; ISO:RGD.
GO; GO:0045861; P:negative regulation of proteolysis; ISO:RGD.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0032270; P:positive regulation of cellular protein metabolic process; ISO:RGD.
GO; GO:0010875; P:positive regulation of cholesterol efflux; ISO:RGD.
GO; GO:0032376; P:positive regulation of cholesterol transport; ISO:RGD.
GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; ISO:RGD.
GO; GO:0010628; P:positive regulation of gene expression; IDA:RGD.
GO; GO:0090108; P:positive regulation of high-density lipoprotein particle assembly; ISO:RGD.
GO; GO:0010884; P:positive regulation of lipid storage; ISO:RGD.
GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; ISO:RGD.
GO; GO:0090187; P:positive regulation of pancreatic juice secretion; ISO:RGD.
GO; GO:0090340; P:positive regulation of secretion of lysosomal enzymes; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; ISO:RGD.
GO; GO:2000188; P:regulation of cholesterol homeostasis; ISS:UniProtKB.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IDA:RGD.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR023257; Liver_X_rcpt.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR02034; LIVERXRECPTR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus;
Receptor; Reference proteome; Transcription; Transcription regulation;
Zinc; Zinc-finger.
CHAIN 1 446 Oxysterols receptor LXR-beta.
/FTId=PRO_0000053534.
DOMAIN 208 446 NR LBD. {ECO:0000255|PROSITE-
ProRule:PRU01189}.
DNA_BIND 75 152 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 78 98 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 116 140 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 1 76 Transactivation AF-1; required for
ligand-independent transactivation
function. {ECO:0000250|UniProtKB:P55055}.
REGION 205 446 Transactivation AF-2; required for
ligand-dependent transactivation
function; mediates interaction with
CCAR2. {ECO:0000250|UniProtKB:P55055}.
COMPBIAS 162 168 Poly-Gln.
COMPBIAS 169 172 Poly-Pro.
CONFLICT 33 33 G -> V (in Ref. 2; AAA52361).
{ECO:0000305}.
CONFLICT 52 54 Missing (in Ref. 2; AAA52361).
{ECO:0000305}.
CONFLICT 219 219 A -> V (in Ref. 2; AAA52361).
{ECO:0000305}.
SEQUENCE 446 AA; 49736 MW; 13DF6DC2F0F5FA4D CRC64;
MSSPTSSLDT PLPGNGSPQP STSSTSPTIK EEGQETDPPP GSEGSSSAYI VVILEPEDEP
ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG FFRRSVVHGG AGRYACRGSG
TCQMDAFMRR KCQLCRLRKC KEAGMREQCV LSEEQIRKKK IQKQQQQQPP PPTEPASGSS
ARPAASPGTS EASSQGSGEG EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG
ADPQSRDARQ QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE
TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL DDAEYALLIA
INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ LRFPRMLMKL VSLRTLSSVH
SEQVFALRLQ DKKLPPLLSE IWDVHE


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