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Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR)

 NR1H2_RAT               Reviewed;         446 AA.
Q62755; Q62694;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
05-DEC-2018, entry version 159.
RecName: Full=Oxysterols receptor LXR-beta;
AltName: Full=Liver X receptor beta;
AltName: Full=Nuclear receptor subfamily 1 group H member 2;
AltName: Full=Orphan nuclear receptor OR-1;
AltName: Full=Ubiquitously-expressed nuclear receptor;
Short=UR;
Name=Nr1h2; Synonyms=Lxrb;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Liver;
PubMed=7892230; DOI=10.1073/pnas.92.6.2096;
Teboul M., Enmark E., Li Q., Wikstroem A.-C., Pelto-Huikko M.,
Gustafsson J.-A.;
"OR-1, a member of the nuclear receptor superfamily that interacts
with the 9-cis-retinoic acid receptor.";
Proc. Natl. Acad. Sci. U.S.A. 92:2096-2100(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Vagina;
PubMed=7971966; DOI=10.1073/pnas.91.23.10809;
Song C., Kokontis J.M., Hiipakka R.A., Liao S.;
"Ubiquitous receptor: a receptor that modulates gene activation by
retinoic acid and thyroid hormone receptors.";
Proc. Natl. Acad. Sci. U.S.A. 91:10809-10813(1994).
-!- FUNCTION: Nuclear receptor that exhibits a ligand-dependent
transcriptional activation activity (By similarity). Binds
preferentially to double-stranded oligonucleotide direct repeats
having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt
spacing (DR-4). Regulates cholesterol uptake through MYLIP-
dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8.
Interplays functionally with RORA for the regulation of genes
involved in liver metabolism (By similarity). Plays an anti-
inflammatory role during the hepatic acute phase response by
acting as a corepressor: inhibits the hepatic acute phase response
by preventing dissociation of the N-Cor corepressor complex (By
similarity). {ECO:0000250|UniProtKB:P55055,
ECO:0000250|UniProtKB:Q60644}.
-!- SUBUNIT: Forms a heterodimer with RXR. Interacts with CCAR2 (via
N-terminus) in a ligand-independent manner. Interacts (when
sumoylated) with GPS2; interaction with GPS2 onto hepatic acute
phase protein promoters prevents N-Cor corepressor complex
dissociation. {ECO:0000250|UniProtKB:P55055}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00407}.
-!- PTM: Sumoylated by SUMO2 at Lys-395 and Lys-433 during the hepatic
acute phase response, leading to promote interaction with GPS2 and
prevent N-Cor corepressor complex dissociation.
{ECO:0000250|UniProtKB:P55055}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; U20389; AAA69522.1; -; mRNA.
EMBL; U14533; AAA52361.1; -; mRNA.
PIR; I59354; I59354.
RefSeq; NP_113814.1; NM_031626.1.
UniGene; Rn.786; -.
ProteinModelPortal; Q62755; -.
SMR; Q62755; -.
STRING; 10116.ENSRNOP00000026862; -.
PhosphoSitePlus; Q62755; -.
PaxDb; Q62755; -.
PRIDE; Q62755; -.
Ensembl; ENSRNOT00000026862; ENSRNOP00000026862; ENSRNOG00000019812.
GeneID; 58851; -.
KEGG; rno:58851; -.
UCSC; RGD:61906; rat.
CTD; 7376; -.
RGD; 61906; Nr1h2.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00940000161465; -.
HOGENOM; HOG000220845; -.
HOVERGEN; HBG108655; -.
InParanoid; Q62755; -.
KO; K08535; -.
OMA; ELCQVCG; -.
OrthoDB; EOG091G0I4P; -.
PhylomeDB; Q62755; -.
TreeFam; TF352167; -.
Reactome; R-RNO-383280; Nuclear Receptor transcription pathway.
Reactome; R-RNO-4090294; SUMOylation of intracellular receptors.
Reactome; R-RNO-8866427; VLDLR internalisation and degradation.
PRO; PR:Q62755; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000019812; Expressed in 10 organ(s), highest expression level in adult mammalian kidney.
Genevisible; Q62755; RN.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; IBA:GO_Central.
GO; GO:0034191; F:apolipoprotein A-I receptor binding; IEA:Ensembl.
GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:RGD.
GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl.
GO; GO:0030374; F:nuclear receptor transcription coactivator activity; IBA:GO_Central.
GO; GO:0001077; F:proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
GO; GO:0046965; F:retinoid X receptor binding; IDA:RGD.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IMP:NTNU_SB.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0008134; F:transcription factor binding; IBA:GO_Central.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0044255; P:cellular lipid metabolic process; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; IBA:GO_Central.
GO; GO:0010887; P:negative regulation of cholesterol storage; IEA:Ensembl.
GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
GO; GO:0010629; P:negative regulation of gene expression; IDA:RGD.
GO; GO:0032369; P:negative regulation of lipid transport; IEA:Ensembl.
GO; GO:0048550; P:negative regulation of pinocytosis; IEA:Ensembl.
GO; GO:0045861; P:negative regulation of proteolysis; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0032270; P:positive regulation of cellular protein metabolic process; IEA:Ensembl.
GO; GO:0010875; P:positive regulation of cholesterol efflux; IEA:Ensembl.
GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IDA:RGD.
GO; GO:0090108; P:positive regulation of high-density lipoprotein particle assembly; IEA:Ensembl.
GO; GO:0010884; P:positive regulation of lipid storage; IEA:Ensembl.
GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Ensembl.
GO; GO:0090187; P:positive regulation of pancreatic juice secretion; IEA:Ensembl.
GO; GO:0090340; P:positive regulation of secretion of lysosomal enzymes; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; IEA:Ensembl.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IDA:RGD.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR023257; Liver_X_rcpt.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR02034; LIVERXRECPTR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
Activator; Complete proteome; DNA-binding; Isopeptide bond;
Metal-binding; Nucleus; Receptor; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
CHAIN 1 446 Oxysterols receptor LXR-beta.
/FTId=PRO_0000053534.
DOMAIN 208 446 NR LBD. {ECO:0000255|PROSITE-
ProRule:PRU01189}.
DNA_BIND 75 152 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 78 98 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 116 140 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 1 76 Transactivation AF-1; required for
ligand-independent transactivation
function. {ECO:0000250|UniProtKB:P55055}.
REGION 205 446 Transactivation AF-2; required for
ligand-dependent transactivation
function; mediates interaction with
CCAR2. {ECO:0000250|UniProtKB:P55055}.
COMPBIAS 162 168 Poly-Gln.
COMPBIAS 169 172 Poly-Pro.
CROSSLNK 395 395 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P55055}.
CROSSLNK 433 433 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P55055}.
CONFLICT 33 33 G -> V (in Ref. 2; AAA52361).
{ECO:0000305}.
CONFLICT 52 54 Missing (in Ref. 2; AAA52361).
{ECO:0000305}.
CONFLICT 219 219 A -> V (in Ref. 2; AAA52361).
{ECO:0000305}.
SEQUENCE 446 AA; 49736 MW; 13DF6DC2F0F5FA4D CRC64;
MSSPTSSLDT PLPGNGSPQP STSSTSPTIK EEGQETDPPP GSEGSSSAYI VVILEPEDEP
ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG FFRRSVVHGG AGRYACRGSG
TCQMDAFMRR KCQLCRLRKC KEAGMREQCV LSEEQIRKKK IQKQQQQQPP PPTEPASGSS
ARPAASPGTS EASSQGSGEG EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG
ADPQSRDARQ QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE
TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL DDAEYALLIA
INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ LRFPRMLMKL VSLRTLSSVH
SEQVFALRLQ DKKLPPLLSE IWDVHE


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