Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

PAN2-PAN3 deadenylation complex subunit pan3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)

 PAN3_EMENI              Reviewed;         661 AA.
Q5BFB1; C8VQW3; C8VQW4;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
16-NOV-2011, sequence version 3.
20-JUN-2018, entry version 91.
RecName: Full=PAN2-PAN3 deadenylation complex subunit pan3 {ECO:0000255|HAMAP-Rule:MF_03181};
AltName: Full=PAB1P-dependent poly(A)-specific ribonuclease {ECO:0000255|HAMAP-Rule:MF_03181};
AltName: Full=Poly(A)-nuclease deadenylation complex subunit 3 {ECO:0000255|HAMAP-Rule:MF_03181};
Short=PAN deadenylation complex subunit 3 {ECO:0000255|HAMAP-Rule:MF_03181};
Name=pan3 {ECO:0000255|HAMAP-Rule:MF_03181};
ORFNames=AN0769, AN10121/AN10119;
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
194 / M139) (Aspergillus nidulans).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
NCBI_TaxID=227321;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
PubMed=16372000; DOI=10.1038/nature04341;
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
"Sequencing of Aspergillus nidulans and comparative analysis with A.
fumigatus and A. oryzae.";
Nature 438:1105-1115(2005).
[2]
GENOME REANNOTATION.
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
"The 2008 update of the Aspergillus nidulans genome annotation: a
community effort.";
Fungal Genet. Biol. 46:S2-13(2009).
-!- FUNCTION: Regulatory subunit of the poly(A)-nuclease (PAN)
deadenylation complex, one of two cytoplasmic mRNA deadenylases
involved in mRNA turnover. PAN specifically shortens poly(A) tails
of RNA and the activity is stimulated by poly(A)-binding protein
pab1. PAN deadenylation is followed by rapid degradation of the
shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs
are then degraded by two alternative mechanisms, namely exosome-
mediated 3'-5' exonucleolytic degradation, or deadenlyation-
dependent mRNA decaping and subsequent 5'-3' exonucleolytic
degradation by XRN1. May also be involved in post-transcriptional
maturation of mRNA poly(A) tails. pan3 acts as a positive
regulator for PAN activity, recruiting the catalytic subunit pan2
to mRNA via its interaction with RNA and with pab1.
{ECO:0000255|HAMAP-Rule:MF_03181}.
-!- SUBUNIT: Homodimer. Forms a heterotrimer with a catalytic subunit
pan2 to form the poly(a)-nuclease (PAN) deadenylation complex.
Interacts (via PAM-2 motif) with poly(A)-binding protein pab1 (via
PABC domain), conferring substrate specificity of the enzyme
complex. {ECO:0000255|HAMAP-Rule:MF_03181}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03181}.
-!- DOMAIN: The N-terminal zinc finger binds to poly(A) RNA.
{ECO:0000255|HAMAP-Rule:MF_03181}.
-!- DOMAIN: Contains a pseudokinase domain. The protein kinase domain
is predicted to be catalytically inactive because some of the
residues important for catalytic activity are substituted and it
lacks the equivalent of the binding site for a peptide substrate.
However, it has retained an ATP-binding site and ATP-binding is
required for mRNA degradation, stimulating the activity of the
pan2 nuclease in vitro. The nucleotide-binding site is juxtaposed
to the RNase active site of pan2 in the complex and may actually
bind nucleosides of a poly(A) RNA rather than ATP, feeding the
poly(A)-tail to the active site of the deadenylase and thus
increasing the efficiency with which this distributive enzyme
degrades oligo(A) RNAs. {ECO:0000255|HAMAP-Rule:MF_03181}.
-!- DOMAIN: The pseudokinase domain, the coiled-coil (CC), and C-
terminal knob domain (CK) form a structural unit (PKC) that forms
an extensive high-affinity interaction surface for pan2.
{ECO:0000255|HAMAP-Rule:MF_03181}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. PAN3
family. {ECO:0000255|HAMAP-Rule:MF_03181}.
-!- SEQUENCE CAUTION:
Sequence=CBF88820.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CBF88822.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=EAA65411.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AACD01000012; EAA65411.1; ALT_SEQ; Genomic_DNA.
EMBL; BN001308; CBF88822.1; ALT_SEQ; Genomic_DNA.
EMBL; BN001308; CBF88820.1; ALT_SEQ; Genomic_DNA.
RefSeq; XP_658373.1; XM_653281.1.
SMR; Q5BFB1; -.
STRING; 162425.CADANIAP00001896; -.
EnsemblFungi; EAA65411; EAA65411; AN0769.2.
GeneID; 2876545; -.
KEGG; ani:AN0769.2; -.
HOGENOM; HOG000007619; -.
InParanoid; Q5BFB1; -.
KO; K12572; -.
OrthoDB; EOG092C1R5J; -.
Proteomes; UP000000560; Chromosome VIII.
Proteomes; UP000005890; Unassembled WGS sequence.
GO; GO:0000932; C:P-body; IBA:GO_Central.
GO; GO:0031251; C:PAN complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
GO; GO:0010606; P:positive regulation of cytoplasmic mRNA processing body assembly; IBA:GO_Central.
GO; GO:0090503; P:RNA phosphodiester bond hydrolysis, exonucleolytic; IEA:GOC.
HAMAP; MF_03181; PAN3; 1.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR030844; PAN3.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR000571; Znf_CCCH.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS50103; ZF_C3H1; 1.
3: Inferred from homology;
ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Metal-binding;
mRNA processing; Nucleotide-binding; Reference proteome; Zinc;
Zinc-finger.
CHAIN 1 661 PAN2-PAN3 deadenylation complex subunit
pan3.
/FTId=PRO_0000295368.
ZN_FING 26 55 C3H1-type. {ECO:0000255|HAMAP-
Rule:MF_03181}.
NP_BIND 364 371 ATP. {ECO:0000255|HAMAP-Rule:MF_03181}.
NP_BIND 424 425 ATP. {ECO:0000255|HAMAP-Rule:MF_03181}.
REGION 263 524 Pseudokinase domain. {ECO:0000255|HAMAP-
Rule:MF_03181}.
REGION 564 661 Knob domain. {ECO:0000255|HAMAP-
Rule:MF_03181}.
COILED 525 563 {ECO:0000255|HAMAP-Rule:MF_03181}.
MOTIF 63 83 PABPC-interacting motif-2 (PAM-2).
{ECO:0000305}.
BINDING 315 315 ATP. {ECO:0000255|HAMAP-Rule:MF_03181}.
SEQUENCE 661 AA; 73162 MW; 117DB622830E046E CRC64;
MASVGKPSLE DARRGTGSPK MKARENAKDT LCRNVTIYGR CRYEDKGCAF NHDPHKNSNQ
SDNASKKRFN VDSPSFTPSL LPSNGSSPTS SSSSLKKSST ISPKAANAAP FQPRTAASRS
NTSTPGVRQD AVAPDWSVAE AQEFIPQGFD PTHMSPLHGN GNPGVASANA FDPFVSTPNP
LAAPGAVGPV QANPFSHDAA AATLGGAYYA NQAGFQQPVQ YHLYAPIGPH NQNALAYQRN
VHDLFLPNDF REELQKKAAA TLQTLPNTQL PAQVDYFHSL VPLDLNHQKN AAIFGYPSWV
YKAQSTKDGS YYALRRLEGF RLTNEKAIRS VQAWKRIASG SMVTIHDAFT SRSFQDSSLI
FVTDYHPLSK TLAEQHLSAG GPRFQARHNA HVPEQILWGY ITQIANALKC IHSAGLAARI
IDPSKILLTG RNRIRLNACA IMDVVQYDAQ RSVADLQRQD LVNFGQLILT LGANQPNVIH
NPSKAMEHFT RAYSPQLKNT VMWLLGGMQK DQERNIDILI NGISSQLMST FDSALHLDDQ
LTSDLGRELE NGRLVRLLTK LNFINERPEH EHDRQWSENG ERFYLKIFRD YVFHQVDASG
DPVVDLGHVL TCLNKLDAGT DERITLVSRD EQTCFVVSYK ELKKGLESSF QALLRPSRRP
H


Related products :

Catalog number Product name Quantity
PARP10 PARN Gene poly(A)-specific ribonuclease (deadenylation nuclease)
201-20-4039 PARN{poly(A)-specific ribonuclease (deadenylation nuclease)}rabbit.pAb 0.2ml
PAND2 PAN3 Gene PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
EIAAB29922 DAN,Deadenylating nuclease,Deadenylation nuclease,Homo sapiens,Human,PARN,Poly(A)-specific ribonuclease PARN,Polyadenylate-specific ribonuclease
EIAAB29921 Bos taurus,Bovine,DAN,Deadenylating nuclease,Deadenylation nuclease,PARN,Poly(A)-specific ribonuclease PARN,Polyadenylate-specific ribonuclease
orb41715 PABP1 dependent poly A specific ribonuclease subunit PAN3 antibody 100 ug
EIAAB29808 Mouse,Mus musculus,PAB-dependent poly(A)-specific ribonuclease subunit 3,Pan3
PAN3_MOUSE ELISA Kit FOR PAB-dependent poly(A)-specific ribonuclease subunit 3; organism: Mouse; gene name: Pan3 96T
EIAAB29809 Homo sapiens,hPan3,Human,PAB-dependent poly(A)-specific ribonuclease subunit 3,PAN3
CSB-EL017420MO Mouse PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (PAN3) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL017420HU Human PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (PAN3) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL017456BO Bovine poly(A)-specific ribonuclease (deadenylation nuclease) (PARN) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
CSB-EL017456MO Mouse poly(A)-specific ribonuclease (deadenylation nuclease) (PARN) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL017456HU Human poly(A)-specific ribonuclease (deadenylation nuclease) (PARN) ELISA kit, Species Human, Sample Type serum, plasma 96T
22199 PABP1-dependent poly A-specific ribonuclease subunit PAN3 antibody Source Rabbit Polyconal Ab Species Human Application WB IF 100ul
CSB-PA017456GA01HU Rabbit anti-human poly(A)-specific ribonuclease (deadenylation nuclease) polyclonal Antibody Primary antibody Host:Rabbit IgG 150ul
CSB-PA017456GA01HU Rabbit anti-human poly(A)-specific ribonuclease (deadenylation nuclease) polyclonal Antibody Primary antibody Host:Rabbit IgG 50ul
orb41715 PABP1 dependent poly A specific ribonuclease subunit PAN3 antibody Polyclonal Antibodies Primary antibodies 100
22199 Primary antibody PABP1-dependent poly A-specific ribonuclease subunit PAN3 antibody, Source Rabbit Polyconal Ab, Species Reactivity Human 100ul
GTX111927 PABP1_dependent poly A_specific ribonuclease subunit PAN3 100 µg
GTX111927 PABP1_dependent poly A_specific ribonuclease subunit PAN3 100 µg
PAN2_RAT ELISA Kit FOR PAB-dependent poly(A)-specific ribonuclease subunit 2; organism: Rat; gene name: Pan2 96T
PAN2_MOUSE ELISA Kit FOR PAB-dependent poly(A)-specific ribonuclease subunit 2; organism: Mouse; gene name: Pan2 96T
EIAAB33312 Complex III subunit 8,Complex III subunit VIII,Cytochrome b-c1 complex subunit 8,Low molecular mass ubiquinone-binding protein,Qpc,Rat,Rattus norvegicus,Ubiquinol-cytochrome c reductase complex 9.5 kD
EIAAB33310 Complex III subunit 7,Complex III subunit VII,Cytochrome b-c1 complex subunit 7,Homo sapiens,Human,QP-C,Ubiquinol-cytochrome c reductase complex 14 kDa protein,UQBP,UQCRB


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur