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PE family immunomodulator PE35

 PE35_MYCTU              Reviewed;          99 AA.
P9WIG7; L0TGV1; Q79F93; Q8VIR8;
16-APR-2014, integrated into UniProtKB/Swiss-Prot.
16-APR-2014, sequence version 1.
15-FEB-2017, entry version 18.
RecName: Full=PE family immunomodulator PE35 {ECO:0000305};
Name=PE35; OrderedLocusNames=Rv3872;
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=83332;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
PubMed=9634230; DOI=10.1038/31159;
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence.";
Nature 393:537-544(1998).
[2]
IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=ATCC 25618 / H37Rv;
PubMed=16030141; DOI=10.1073/pnas.0504922102;
Fortune S.M., Jaeger A., Sarracino D.A., Chase M.R., Sassetti C.M.,
Sherman D.R., Bloom B.R., Rubin E.J.;
"Mutually dependent secretion of proteins required for mycobacterial
virulence.";
Proc. Natl. Acad. Sci. U.S.A. 102:10676-10681(2005).
[3]
DISRUPTION PHENOTYPE.
PubMed=16368961; DOI=10.1128/IAI.74.1.88-98.2006;
Brodin P., Majlessi L., Marsollier L., de Jonge M.I., Bottai D.,
Demangel C., Hinds J., Neyrolles O., Butcher P.D., Leclerc C.,
Cole S.T., Brosch R.;
"Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and
impact on immunogenicity and virulence.";
Infect. Immun. 74:88-98(2006).
[4]
IDENTIFICATION AS A POTENTIAL CANDIDATE FOR SERODIAGNOSIS.
STRAIN=ATCC 25618 / H37Rv;
PubMed=17328726; DOI=10.1111/j.1469-0691.2006.01660.x;
Mukherjee P., Dutta M., Datta P., Dasgupta A., Pradhan R., Pradhan M.,
Kundu M., Basu J., Chakrabarti P.;
"The RD1-encoded antigen Rv3872 of Mycobacterium tuberculosis as a
potential candidate for serodiagnosis of tuberculosis.";
Clin. Microbiol. Infect. 13:146-152(2007).
[5]
IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
STRAIN=ATCC 27294 / TMC 102 / H37Rv;
PubMed=17443846; DOI=10.1002/pmic.200600853;
Malen H., Berven F.S., Fladmark K.E., Wiker H.G.;
"Comprehensive analysis of exported proteins from Mycobacterium
tuberculosis H37Rv.";
Proteomics 7:1702-1718(2007).
[6]
FUNCTION, INTERACTION WITH PPE68 AND TLR2, AND SUBCELLULAR LOCATION.
STRAIN=H37Rv;
PubMed=24467650; DOI=10.1111/febs.12723;
Tiwari B., Soory A., Raghunand T.R.;
"An immunomodulatory role for the Mycobacterium tuberculosis region of
difference 1 locus proteins PE35 (Rv3872) and PPE68 (Rv3873).";
FEBS J. 281:1556-1570(2014).
-!- FUNCTION: Plays a major role in RD1-associated pathogenesis, and
may contribute to the establishment and maintenance of
M.tuberculosis infection. Together with PPE68, stimulates the
secretion of IL-10 and MCP-1 from human macrophages, via the
interaction with human Toll-like receptor 2 (TLR2).
{ECO:0000269|PubMed:24467650}.
-!- SUBUNIT: Interacts with PPE68. PE35/PPE68 complex interacts with
human TLR2. {ECO:0000269|PubMed:24467650}.
-!- INTERACTION:
P9WHW9:PPE68; NbExp=3; IntAct=EBI-9086211, EBI-9086224;
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17443846}. Cell
surface {ECO:0000269|PubMed:24467650}.
-!- DISRUPTION PHENOTYPE: Inactivation impairs expression of EsxA
(ESAT-6) and EsxB (CFP-10). {ECO:0000269|PubMed:16368961}.
-!- MISCELLANEOUS: Could be used for serodiagnosis of both pulmonary
and extra-pulmonary tuberculosis. {ECO:0000269|PubMed:17328726}.
-!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
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EMBL; AL123456; CCP46701.1; -; Genomic_DNA.
PIR; F70802; F70802.
RefSeq; WP_003912361.1; NZ_KK339374.1.
RefSeq; YP_178021.1; NC_000962.3.
ProteinModelPortal; P9WIG7; -.
IntAct; P9WIG7; 2.
STRING; 83332.Rv3872; -.
PaxDb; P9WIG7; -.
EnsemblBacteria; CCP46701; CCP46701; Rv3872.
GeneID; 886191; -.
KEGG; mtu:Rv3872; -.
TubercuList; Rv3872; -.
OMA; MEIAGIY; -.
Proteomes; UP000001584; Chromosome.
GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IDA:MTBBASE.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
InterPro; IPR000084; PE-PGRS_N.
Pfam; PF00934; PE; 1.
1: Evidence at protein level;
Complete proteome; Reference proteome; Secreted; Virulence.
CHAIN 1 99 PE family immunomodulator PE35.
/FTId=PRO_0000394202.
DOMAIN 1 90 PE. {ECO:0000255}.
SEQUENCE 99 AA; 9928 MW; 9ABAEB9988A8BFFB CRC64;
MEKMSHDPIA ADIGTQVSDN ALHGVTAGST ALTSVTGLVP AGADEVSAQA ATAFTSEGIQ
LLASNASAQD QLHRAGEAVQ DVARTYSQID DGAAGVFAE


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