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PE family immunomodulator PE5

 PE05_MYCTU              Reviewed;         102 AA.
L7N695; I6Y7F5;
02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
06-MAR-2013, sequence version 1.
07-JUN-2017, entry version 43.
RecName: Full=PE family immunomodulator PE5 {ECO:0000305};
Name=PE5 {ECO:0000303|PubMed:23284742, ECO:0000312|EMBL:CCP43015.1};
OrderedLocusNames=Rv0285 {ECO:0000312|EMBL:CCP43015.1};
ORFNames=LH57_01560 {ECO:0000312|EMBL:AIR13008.1};
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=83332;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
PubMed=9634230; DOI=10.1038/31159;
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence.";
Nature 393:537-544(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 27294 / TMC 102 / H37Rv;
Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
Monaco A., King S., Sohrabi A.;
"Phylogenetic analysis of Mycobacterial species using whole genome
sequences.";
Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=ATCC 25618 / H37Rv;
PubMed=21969609; DOI=10.1074/mcp.M111.011627;
Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B.,
Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H.,
Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S.,
Katoch K., Katoch V.M., Kumar P., Chaerkady R., Ramachandran S.,
Dash D., Pandey A.;
"Proteogenomic analysis of Mycobacterium tuberculosis by high
resolution mass spectrometry.";
Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
[4]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=23284742; DOI=10.1371/journal.pone.0051686;
Tiwari B.M., Kannan N., Vemu L., Raghunand T.R.;
"The Mycobacterium tuberculosis PE proteins Rv0285 and Rv1386 modulate
innate immunity and mediate bacillary survival in macrophages.";
PLoS ONE 7:E51686-E51686(2012).
[5]
FUNCTION IN IRON ACQUISITION, SUBCELLULAR LOCATION, AND DISRUPTION
PHENOTYPE.
PubMed=26729876; DOI=10.1073/pnas.1523321113;
Tufariello J.M., Chapman J.R., Kerantzas C.A., Wong K.W., Vilcheze C.,
Jones C.M., Cole L.E., Tinaztepe E., Thompson V., Fenyoe D.,
Niederweis M., Ueberheide B., Philips J.A., Jacobs W.R. Jr.;
"Separable roles for Mycobacterium tuberculosis ESX-3 effectors in
iron acquisition and virulence.";
Proc. Natl. Acad. Sci. U.S.A. 113:E348-E357(2016).
-!- FUNCTION: Important for the siderophore-mediated iron-acquisition
function of ESX-3 (PubMed:26729876). May play a pivotal role in
the evasion of host immune response by M.tuberculosis. Mediates
production of IL-10 via activation of the p38 and ERK1/2 mitogen-
activated protein kinase (MAPK) signaling pathways
(PubMed:23284742). {ECO:0000269|PubMed:23284742,
ECO:0000269|PubMed:26729876}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26729876}. Cell
envelope {ECO:0000269|PubMed:23284742}. Cell surface
{ECO:0000269|PubMed:23284742}. Note=Secreted via the ESX-3 / type
VII secretion system (T7SS) (PubMed:26729876). Secretion is
dependent on EsxG and EsxH (PubMed:26729876).
{ECO:0000269|PubMed:26729876}.
-!- DISRUPTION PHENOTYPE: PE5-PPE4 double mutant exhibits a severe
iron phenotype but secretes EsxG and EsxH normally. Mildly
attenuated in vivo. {ECO:0000269|PubMed:26729876}.
-!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
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EMBL; AL123456; CCP43015.1; -; Genomic_DNA.
EMBL; CP009480; AIR13008.1; -; Genomic_DNA.
RefSeq; WP_003401485.1; NZ_KK339370.1.
RefSeq; YP_177710.1; NC_000962.3.
ProteinModelPortal; L7N695; -.
SMR; L7N695; -.
STRING; 83332.Rv0285; -.
PaxDb; L7N695; -.
EnsemblBacteria; AIR13008; AIR13008; LH57_01560.
EnsemblBacteria; CCP43015; CCP43015; Rv0285.
GeneID; 886608; -.
KEGG; mtu:Rv0285; -.
KEGG; mtv:RVBD_0285; -.
PATRIC; fig|83332.111.peg.321; -.
TubercuList; Rv0285; -.
OMA; APMISTV; -.
Proteomes; UP000001584; Chromosome.
Proteomes; UP000031768; Chromosome.
GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO; GO:0031975; C:envelope; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
InterPro; IPR000084; PE-PGRS_N.
Pfam; PF00934; PE; 1.
1: Evidence at protein level;
Complete proteome; Reference proteome; Secreted; Virulence.
CHAIN 1 102 PE family immunomodulator PE5.
/FTId=PRO_5007687871.
DOMAIN 3 92 PE. {ECO:0000255}.
SEQUENCE 102 AA; 9566 MW; 29F298118C7CAE07 CRC64;
MTLRVVPEGL AAASAAVEAL TARLAAAHAS AAPVITAVVP PAADPVSLQT AAGFSAQGVE
HAVVTAEGVE ELGRAGVGVG ESGASYLAGD AAAAATYGVV GG


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