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PE family protein PE9

 PE09_MYCTU              Reviewed;         144 AA.
Q79FS8; F2GGV1; I6Y9L0; L0T5N7;
02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
22-NOV-2017, entry version 75.
RecName: Full=PE family protein PE9 {ECO:0000305};
Name=PE9 {ECO:0000312|EMBL:CCP43840.1};
OrderedLocusNames=Rv1088 {ECO:0000312|EMBL:CCP43840.1};
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=83332;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
PubMed=9634230; DOI=10.1038/31159;
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence.";
Nature 393:537-544(1998).
[2]
FUNCTION, INTERACTION WITH PE10 AND TLR4, AND SUBCELLULAR LOCATION.
PubMed=26031846; DOI=10.1111/cmi.12462;
Tiwari B., Ramakrishnan U.M., Raghunand T.R.;
"The Mycobacterium tuberculosis protein pair PE9 (Rv1088)-PE10
(Rv1089) forms heterodimers and induces macrophage apoptosis through
Toll-like receptor 4.";
Cell. Microbiol. 17:1653-1669(2015).
[3]
SUBCELLULAR LOCATION.
PubMed=26851205; DOI=10.1016/j.ijbiomac.2015.12.081;
Diaz D.P., Ocampo M., Pabon L., Herrera C., Patarroyo M.A., Munoz M.,
Patarroyo M.E.;
"Mycobacterium tuberculosis PE9 protein has high activity binding
peptides which inhibit target cell invasion.";
Int. J. Biol. Macromol. 86:646-655(2016).
-!- FUNCTION: Together with PE10, induces macrophage apoptosis through
human Toll-like receptor 4 (TLR4) signaling pathway. Interaction
with TLR4 leads to increased levels of phospho-IRF-3, increase in
the transcript levels of IFN-beta and pro-apoptotic genes, up-
regulation of IL-10, down-regulation of IL-1b and enhanced levels
of macrophage apoptosis. {ECO:0000269|PubMed:26031846}.
-!- SUBUNIT: Forms a complex with PE10. The complex interacts with
human TLR4. {ECO:0000269|PubMed:26031846}.
-!- SUBCELLULAR LOCATION: Secreted, cell wall
{ECO:0000269|PubMed:26031846}. Cell surface
{ECO:0000269|PubMed:26851205}.
-!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
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EMBL; AL123456; CCP43840.1; -; Genomic_DNA.
RefSeq; WP_003900271.1; NZ_KK339370.1.
RefSeq; YP_177784.1; NC_000962.3.
ProteinModelPortal; Q79FS8; -.
SMR; Q79FS8; -.
STRING; 83332.Rv1088; -.
PaxDb; Q79FS8; -.
PRIDE; Q79FS8; -.
EnsemblBacteria; CCP43840; CCP43840; Rv1088.
GeneID; 887096; -.
KEGG; mtu:Rv1088; -.
KEGG; mtv:RVBD_1088; -.
PATRIC; fig|83332.115.peg.1215; -.
TubercuList; Rv1088; -.
HOGENOM; HOG000220392; -.
Proteomes; UP000001584; Chromosome.
GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO; GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
InterPro; IPR000084; PE-PGRS_N.
Pfam; PF00934; PE; 1.
1: Evidence at protein level;
Cell wall; Complete proteome; Reference proteome; Secreted; Virulence.
CHAIN 1 144 PE family protein PE9.
/FTId=PRO_0000438135.
DOMAIN 1 87 PE. {ECO:0000255}.
COMPBIAS 88 126 Arg-rich. {ECO:0000255|PROSITE-
ProRule:PRU00002}.
SEQUENCE 144 AA; 15376 MW; 8201C5443BFCCAFF CRC64;
MSYMIATPAA LTAAATDIDG IGSAVSVANA AAVAATTGVL AAGGDEVLAA IARLFNANAE
EYHALSAQVA AFQTLFVRTL TGGCGVFRRR RGRQCVTAAE HRAAGAGRRQ RRRRSGDGQW
RLRQQRHFGC GGQPEFRQHS EHRR


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