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PE-PGRS family protein PE_PGRS47

 PG47_MYCTU              Reviewed;         525 AA.
Q79FB3;
02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
07-JUN-2017, entry version 69.
RecName: Full=PE-PGRS family protein PE_PGRS47 {ECO:0000305};
Name=PE_PGRS47 {ECO:0000312|EMBL:CCP45540.1};
OrderedLocusNames=Rv2741 {ECO:0000312|EMBL:CCP45540.1};
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=83332;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
PubMed=9634230; DOI=10.1038/31159;
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence.";
Nature 393:537-544(1998).
[2]
FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
PubMed=27562263; DOI=10.1038/nmicrobiol.2016.133;
Saini N.K., Baena A., Ng T.W., Venkataswamy M.M., Kennedy S.C.,
Kunnath-Velayudhan S., Carreno L.J., Xu J., Chan J., Larsen M.H.,
Jacobs W.R. Jr., Porcelli S.A.;
"Suppression of autophagy and antigen presentation by Mycobacterium
tuberculosis PE_PGRS47.";
Nat. Microbiol. 1:16133-16133(2016).
-!- FUNCTION: Contributes to evasion of both innate and adaptive
immunity. Inhibits autophagy in infected host phagocytes and
inhibits major histocompatibility complex (MHC) class II antigen
presentation by mycobacteria-infected dendritic cells. Has an
important role in the growth and survival of M.tuberculosis,
particularly during intracellular growth and in the later chronic
phase of infection. {ECO:0000269|PubMed:27562263}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27562263}. Cell
surface {ECO:0000269|PubMed:27562263}. Host cytoplasm, host
cytosol {ECO:0000269|PubMed:27562263}. Note=Loosely attached to
the cell surface, with the potential to detach during growth
within infected cells. {ECO:0000269|PubMed:27562263}.
-!- DISRUPTION PHENOTYPE: Deletion mutant is attenuated in vitro and
in vivo, and shows enhanced MHC class II-restricted antigen
presentation during in vivo infection of mice. Also shows a
reduced capability to inhibit autophagy and an increased
acidification and lysosomal fusion of phagosomes during infection
of phagocytic cells. {ECO:0000269|PubMed:27562263}.
-!- SIMILARITY: Belongs to the mycobacterial PE family. PGRS
subfamily. {ECO:0000305}.
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EMBL; AL123456; CCP45540.1; -; Genomic_DNA.
RefSeq; WP_010886154.1; NC_000962.3.
RefSeq; YP_177902.1; NC_000962.3.
ProteinModelPortal; Q79FB3; -.
SMR; Q79FB3; -.
PaxDb; Q79FB3; -.
PRIDE; Q79FB3; -.
EnsemblBacteria; CCP45540; CCP45540; Rv2741.
GeneID; 888339; -.
KEGG; mtu:Rv2741; -.
PATRIC; fig|83332.12.peg.3054; -.
TubercuList; Rv2741; -.
InParanoid; Q79FB3; -.
OMA; DPEHHWD; -.
Proteomes; UP000001584; Chromosome.
GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
InterPro; IPR000084; PE-PGRS_N.
Pfam; PF00934; PE; 1.
3: Inferred from homology;
Complete proteome; Host cytoplasm; Reference proteome; Secreted;
Virulence.
CHAIN 1 525 PE-PGRS family protein PE_PGRS47.
/FTId=PRO_5004287628.
DOMAIN 1 93 PE. {ECO:0000255}.
SEQUENCE 525 AA; 44210 MW; E727C9F593DB78FC CRC64;
MSFVIAAPEF LTAAAMDLAS IGSTVSAASA AASAPTVAIL AAGADEVSIA VAALFGMHGQ
AYQALSVQAS AFHQQFVQAL TAGAYSYASA EAAAVTPLQQ LVDVINAPFR SALGRPLIGN
GANGKPGTGQ DGGAGGLLYG SGGNGGSGLA GSGQKGGNGG AAGLFGNGGA GGAGASNQAG
NGGAGGNGGA GGLIWGTAGT GGNGGFTTFL DAAGGAGGAG GAGGLFGAGG AGGVGGAALG
GGAQAAGGNG GAGGVGGLFG AGGAGGAGGF SDTGGTGGAG GAGGLFGPGG GSGGVGGFGD
TGGTGGDGGS GGLFGVGGAG GHGGFGSAAG GDGGAGGAGG TVFGSGGAGG AGGVATVAGH
GGHGGNAGLL YGTGGAGGAG GFGGFGGDGG DGGIGGLVGS GGAGGSGGTG TLSGGRGGAG
GNAGTFYGSG GAGGAGGESD NGDGGNGGVG GKAGLVGEGG NGGDGGATIA GKGGSGGNGG
NAWLTGQGGN GGNAAFGKAG TGSVGVGGAG GLLEGQNGEN GLLPS


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